Abstracts tagged "Fracture risk"

Abstract Number: 338 • 2016 ACR/ARHP Annual Meeting
Abaloparatide-SC Significantly Reduces Vertebral and Nonvertebral Fractures and Increases Bone Mineral Density (BMD) Regardless of Age, BMD T-Score, or Prior Fracture at Baseline
F Cosman¹, Gary Hattersley², PD Miller³, Ming-Yu Hu⁴, Luis Augusto Tavares Russo⁵, Bente Riis⁶, Greg Williams⁷ and Lorraine Fitzpatrick⁸, ¹Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY, ²Research, Radius Health, Inc., Waltham, MA, ³Colorado Center for Bone Research, Lakewood, CO, ⁴Biometrics, Radius Health, Inc., Waltham, MA, ⁵CCBR Brasil, Rua Mena Barreto, 33 Botofogo, 22271, Rio de Janeiro, Brazil, ⁶Nordic Biosciences A/S, 2730 Herlev, Denmark, ⁷Clinical Development, Radius Health, Inc., Waltham, MA, ⁸Chief Medical Officer, Radius Health, Inc., Waltham, MA
Background/Purpose: Abaloparatide is a novel 34 amino acid peptide created to be a potent and selective activator of the PTH 1 receptor signaling pathway and…
Abstract Number: 344 • 2016 ACR/ARHP Annual Meeting
Is Rheumatoid Arthritis a Risk Factor for Fractures: A Systematic Review of Observational Studies
Ambika Gupta¹, Stephanie Pipe², Tanveer Towheed³ and Tassos Anastassiades², ¹Internal Medicine, Queen's University, Kingston, ON, Canada, ²Queen's University, Kingston, ON, Canada, ³Dept of Medicine, Queen's University, Kingston, ON, Canada
Background/Purpose: Rheumatoid Arthritis (RA) is a known risk factor for osteoporosis. There are many factors that contribute to this increased risk, including the use of…
Abstract Number: 355 • 2016 ACR/ARHP Annual Meeting
Fracture Incidence Rates in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis
Raveendhara R. Bannuru¹, Elizaveta Vaysbrot², Mikala Osani², Lenore Buckley³, Howard Fink⁴ and Timothy E. McAlindon⁵, ¹Rheumatology, Tufts Med Ctr, Boston, MA, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Rheumatology, Yale University, North Haven, CT, ⁴Minneapolis VA Health Care System, Washington, DC, ⁵Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Transplants increase risk of bone loss and fractures and reduce quality of life. Information on fracture incidence is important when making clinical decisions about…
Abstract Number: 356 • 2016 ACR/ARHP Annual Meeting
Osteoporotic Fracture As the Main Risk Factor in the Detection of Osteoporosis in Men Under 70 Years
JUAN MARIA BLANCO MADRIGAL^1,2, MARIA LUZ GARCIA VIVAR³, Eva Galindez-Agirregoikoa³, OLAIA BEGOÑA FERNANDEZ BERRIZBEITIA⁴, Itziar Calvo Zorrilla³, Edurne Guerrero Basterretxea³, Esther Ruíz Lucea⁵, Ignacio Torre Salaberri⁶, Lidia Estopiñán-Fortea³, Catalina Gómez Arango⁷ and Amaia Bilbao-González⁸, ¹Rheumatology Department, Basurto University Hospital, VITORIA, Spain, ²Rheumatology, Rheumatology Department, Basurto University Hospital, VITORIA, Spain, ³Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ⁴Rheumatology Department, Basurto University Hospital, BILBAO, Spain, ⁵Rheumatology Department, Basurto University Hospital., Bilbao, Spain, ⁶Rheumatology, Hospital Universitario de Basurto. Bilbao., Bilbao, Spain, ⁷Rheumatology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ⁸Research Department, Basurto University Hospital, Bilbao, Spain
Background/Purpose: Osteoporosis (OP) in males under 70 years is less common than postmenopausal and senile, but generates significant social and health costs associated with morbidity…
Abstract Number: 228 • 2015 ACR/ARHP Annual Meeting
Gout and Risk of Non-Vertebral Osteoporotic Fracture
Seoyoung C. Kim¹, Julie M. Paik², Jun Liu³, Gary C. Curhan² and Daniel H. Solomon⁴, ¹Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Renal Division, Brigham and Women's Hospital, Boston, MA, ³Division of Pharmaoepidemiology, Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Prior studies suggest an association between osteoporosis, systemic inflammation and pro-inflammatory cytokines such as IL-1 and IL-6. Gout is a common inflammatory arthritis characterized…
Abstract Number: 353 • 2015 ACR/ARHP Annual Meeting
A Longitudinal Cohort Study of Weekly Teriparatide, Denosmab, and Bisphosphonates for Prevention of Vertebral Fractures in Glucocorticoid-Induced Osteoporosis
Hisaji Oshima¹, Mari Ushikubo¹, Kumiko Akiya¹, Ikuko Tanaka², Shigenori Tamaki² and Keisuke Izumi³, ¹Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ²NAGOYA Rheumatology Clinic, Nagoya, Japan, ³National Tokyo Medical Center, Tokyo, Japan
Background/Purpose: Although weekly teriparatide (56.5ug, wTPTD) and denosmab (DMAB) have been developed as potent anti-osteoporotic agents, effects of these agents on prevention of osteoporotic fractures…
Abstract Number: 364 • 2015 ACR/ARHP Annual Meeting
Very High Frequency of Fragility Fractures Associated with High-Dose Glucocorticoids in Postmenopausal Women: A Retrospective Study
Goichi Kageyama¹, Takaichi Okano¹, Yuzuru Yamamoto¹, Keisuke Nishimura¹, Daisuke Sugiyama², Jun Saegusa¹, Goh Tsuji³, Shunichi Kumagai⁴ and Akio Morinobu¹, ¹Department of Rheumatology, Kobe University Hospital, Kobe, Japan, ²Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan, ³The Center for Rheumatic Diseases, Shinko Hospital, Kobe, Japan, ⁴The Center of Rheumatic Diseases, Shinko Hospital, Kobe, Japan
Background/Purpose: To evaluate the incidence of fragility fractures associated with high-dose glucocorticoid therapy in patients with systemic rheumatic disease.Methods: A retrospective study of patients who were treated with high-dose…
Abstract Number: 369 • 2015 ACR/ARHP Annual Meeting
Incidence of Fragility Hip Fractures over 10 Years (2004-13) in Three UK Centres with Reference to Local Fracture Prevention (‘fracture liaison’) Service Activity
Gavin Clunie¹ and Jonathan Belsey², ¹Rheumatology, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom, ²JB Medical, Sudbury, United Kingdom
Background/Purpose: Fracture Liaison Services systematically identify patients with fragility fracture and screen patients for osteoporosis and associated conditions and instigate evidence-based 'secondary' fracture prevention management.…
Abstract Number: 373 • 2015 ACR/ARHP Annual Meeting
Compared to Non-Users, Current Glucocorticoids Users Have Less Prevalent Fractures at the Same Bone Mass: Results of a Large Cross-Sectional Study
Marwan Bukhari¹, Nicola Goodson^2,3 and Maarten Boers⁴, ¹Rheumatology, Royal Lancaster Infirmary, Consultant and Honorary Senior Lecturer, Lancaster, United Kingdom, ²Rheumatology, University of Liverpool, Liverpool, United Kingdom, ³Rheumatology, University Hospital Aintree, Liverpool, United Kingdom, ⁴Amsterdam Rheumatology and Immunology Center, VU University Medical center, Amsterdam, Netherlands
Background/Purpose: It is widely believed that use of glucocorticoids (GC) increase risk of fracture through reduction in bone quality as well as reduction in bone…
Abstract Number: 378 • 2015 ACR/ARHP Annual Meeting
Osteoporotic Fragility Tibia/Fibula Fractures Are Not Asociated with a Low Body Mass Index: An Observational Study
Vishnu Kammath¹ and Marwan Bukhari², ¹Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom, ²Rheumatology, Royal Lancaster Infirmary, Consultant and Honorary Senior Lecturer, Lancaster, United Kingdom
Background/Purpose: Tibia/Fibula (Tib/Fib) fractures are one of osteoporotic fragility fractures. They have been suggested to be more likely to occur secondary to osteoporosis (OP) than…
Abstract Number: 2233 • 2015 ACR/ARHP Annual Meeting
Predictors of Imminent Fracture Risk in Women Aged >=65 Years with Osteoporosis
Derek Weycker¹, Richard Barron², Alex Kartashov¹, John Edelsberg¹, DB Crittenden³ and A Grauer³, ¹Policy Analysis Inc. (PAI), Brookline, MA, ²Amgen, Inc., Thousand Oaks, CA, ³Amgen Inc., Thousand Oaks, CA
Background/Purpose: Fractures are the major source of morbidity among women with osteoporosis. However, evidence on factors leading to imminent risk for hip or other non-vertebral…
Abstract Number: 224 • 2014 ACR/ARHP Annual Meeting
Is the Protective Effect of Obesity Against Hip Fracture Due to Changes of Proximal Femur Shape?
Alexander Oldroyd¹ and Marwan Bukhari^1,2, ¹Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, ²Rheumatology, Royal Lancaster Infirmary, Lancaster, United Kingdom
Background/Purpose: The association between increasing body mass index (BMI), increasing bone mineral density (BMD) and lower hip fracture risk has been demonstrated by previous research. Studies…
Abstract Number: 223 • 2014 ACR/ARHP Annual Meeting
Risk Factors for Clinical Vertebral Fractures in Japanese Men and Women with Rheumatoid Arthritis: Results from a Large Prospective Observational Cohort Study
Osamu Ishida¹, Takefumi Furuya², Eisuke Inoue³, Kensuke Ochi², Katsunori Ikari², Atsuo Taniguchi⁴, Hisashi Yamanaka² and Shigeki Momohara⁴, ¹Orthopedics, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Rheumatology, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ⁴Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Patients with rheumatoid arthritis (RA) are at high risk of developing vertebral fractures. Previously, utilizing data from our Institute of Rheumatology Rheumatoid Arthritis (IORRA)…
Abstract Number: 2047 • 2014 ACR/ARHP Annual Meeting
No Association of Serum Uric Acid with Hip Fracture Risk in Older Men and Women from the Framingham Original Cohort
Shivani Sahni¹, Kelsey Mangano², Katherine Tucker³, Caroline Fox⁴, Douglas P. Kiel⁵, Xiaochun Zhang⁶ and Marian T. Hannan¹, ¹Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Musculoskeletal Research, Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Clinical Laboratory & Nutritional Sciences, Center for Population Health & Health Disparities, University of Massachusetts, Lowell, MA, ⁴Institute of Genetics and Biophysics, NHLBI's Framingham Heart Study and Center for Population Studies, Framingham, MA, ⁵Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁶Musculoskeletal Research, Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA
Background/Purpose: Serum uric acid (UA) has been linked with fractures in older men. Three different studies in older men showed conflicting results. The objective…
Abstract Number: 2004 • 2014 ACR/ARHP Annual Meeting
Osteoporosis Screening and Fracture Risk Assessment Tool Usage Among House Staff
Jordan Brodsky¹, Meghan Greenfield² and Erin Patton³, ¹Medicine, Albert Einstein College of Medicine, Woodmere, NY, ²279 E 10th St, Beth Israel Medical Center, New York, NY, ³Rheumatology, Beth Israel Medical Center, New York, NY
Background/Purpose: Despite increased awareness of the magnitude and consequences of osteoporosis and the availability of recommendations for screening and treatment by multiple organizations, osteoporosis is…

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