Abstracts tagged "fibrosis"

Abstract Number: 829 • 2016 ACR/ARHP Annual Meeting
High Level of Chemokine CCL2 Is Associated with Lung Fibrosis Progression and Reduced Survival in Two Independent Systemic Sclerosis Cohorts
Anna Hoffmann-Vold¹, Richard Huyen², Elizabeth R. Volkmann², Oyvind Midtvedt¹, Vyacheslav Palchevskiy², May Brit Lund³, Torhild Garen¹, Trond Mogens Aalokken⁴, Anders Heiervang Tennøe¹, Stephen Samuel Weigt², Mike Shino², Rajan Saggar⁵, David Ross², Joseph Lynch III², Thor Ueland⁶, Michael Fishbein⁷, Pål Aukrust⁸, Øyvind Molberg¹ and John A Belperio², ¹Rheumatology, Oslo University Hospital, Oslo, Norway, ²University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³Respiratory Medicine, Oslo University Hospital, Oslo, Norway, ⁴Radiology, Oslo University Hospital, Oslo, Norway, ⁵Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁶Research, Oslo University Hospital, Oslo, Norway, ⁷Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ⁸Research Intitute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Background/Purpose: Markers for early identification of progressive interstitial lung disease (ILD) in systemic sclerosis (SSc) are in demand. The proto-typical inflammatory chemokine CCL2 has been linked…
Abstract Number: 2704 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Psoriasis
Vishal Deshmukh¹, Melinda Pedraza¹, Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, Timothy Seo¹, Benoit Melchior¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Psoriasis is an auto-immune disease of the skin, characterized by inflammation and fibrosis producing patches of red, itchy and scaly skin. Wnt signaling plays…
Abstract Number: 1104 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Chronic Tendinopathy
Vishal Deshmukh¹, Timothy Seo¹, Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Chronic tendinopathy is an inflammatory and degenerative condition caused by injuries or overuse. Current therapeutic options focus on alleviating the symptoms and pain rather…
Abstract Number: 3177 • 2016 ACR/ARHP Annual Meeting
Targeted Nuclear Imaging for the Early Detection of Lung Involvement in Systemic Sclerosis
Janine Schniering¹, Stephanie Haller², Zhongning Guo¹, Martina Benesova^2,3, Carol A. Feghali-Bostwick⁴, Roger Schibli^2,3, Oliver Distler⁵, Cristina Müller^2,3 and Britta Maurer⁵, ¹Department of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ²Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen PSI, Switzerland, ³Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland, ⁴Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Interstitial lung disease (ILD) is one of the main causes of systemic sclerosis (SSc)-related deaths. Since routine diagnostics such as high resolution computed tomography…
Abstract Number: 1671 • 2016 ACR/ARHP Annual Meeting
Pirfenidone Might Inhibit New Bone Formation in Spondyloarthritis: Proof of Concept Study Using Cell Culture Models
Julie Laustsen¹, Søren Lomholt¹, Pernille Andersen², Jens Kelsen³ and Tue Wenzel Kragstrup^1,4, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark, ³Department of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark, ⁴Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized…
Abstract Number: 3178 • 2016 ACR/ARHP Annual Meeting
Heart Dysfunction in Systemic Sclerosis: Involvement of a Novel Fibrogenic Stromal Cell Subset
Mara Stellato¹, Michal Rudnik¹, Florian Renoux², Elena Pachera¹, Karl Sotlar³, Karin Klingel⁴, Joerg C. Henes⁵, Przemyslaw Blyszczuk⁶, Oliver Distler¹ and Gabriela Kania¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ³Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ⁴Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁵Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ⁶Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland
Background/Purpose: Cardiac dysfunction is a significant cause of the high mortality in systemic sclerosis (SSc). Heart involvement in SSc patients resembles inflammatory dilated cardiomyopathy (iDCM)…
Abstract Number: 1845 • 2016 ACR/ARHP Annual Meeting
TGF-β-Induced Tissue Fibrosis Is Abrogated in Mice Containing a Constitutive Genetic Deletion of Nox4 (Nox4 knockout)
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Excessive deposition of collagen and other connective tissue components in the skin and multiple internal organs is characteristic of Systemic Sclerosis (SSc). Besides the…
Abstract Number: 1846 • 2016 ACR/ARHP Annual Meeting
Cutaneous and Visceral Fibrosis Induced By Endothelial Cell-Specific Constitutive Activation of TGF-β1 Signaling in Mice
Peter J. Wermuth, Kellan R. Carney, Fabian A. Mendoza, Sonsoles Piera-Velazquez and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Microvascular damage is an early event in Systemic Sclerosis (SSc) pathogenesis and may represent the initiating stimulus for the subsequent establishment and progression of…
Abstract Number: 1850 • 2016 ACR/ARHP Annual Meeting
Optimization of a Murine Model to Recapitulate Dermal and Pulmonary Features of SSc
Tomoya Watanabe¹, Tetsuya Nishimoto², Jonathan Heywood³, Stanley Hoffman⁴, Logan Mlakar⁴ and Carol A. Feghali-Bostwick⁵, ¹Rheumatology, Medical University of South Carolina, Charleston, SC, ²Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Rheumataology, Medical University of South Carolina, Chareston, SC, ⁴Medical University of South Carolina, Charleston, SC, ⁵Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc) studies. Traditionally, daily subcutaneous injections of BLM for 4-6…
Abstract Number: 1852 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Sirtuin 7 By Lung Fibroblasts from Patients with Scleroderma Contributes to Elevated Collagen Production
Anne E. Wyman^1,2, Zahid Noor¹, Nevins W. Todd^1,2, Irina G. Luzina^1,2 and Sergei P. Atamas^1,2, ¹University of Maryland School of Medicine, Baltimore, MD, ²Baltimore VA Medical Center, Baltimore, MD
Background/Purpose: Pulmonary fibrosis is a severe complication of systemic sclerosis (SSc). Changes in the expression levels of sirtuins (SIRTs), a family of NAD+-dependent histone deacetylases,…
Abstract Number: 1859 • 2016 ACR/ARHP Annual Meeting
Fucosyltransferase-1 Mediated Fucosylation of TGF-βR1 Is Critical to TGF-β Signaling in Scleroderma and in Bleomycin-Induced Fibrosis
W. Alexander Stinson¹, Pei-Suen Tsou^1,2, Yuxuan Du³, Huadong Cui¹, Ellen Cealey³, Nicholas Lepore⁴, Ray A. Ohara¹, Gautam Edhayan¹, Sarah Arwani¹, Rachel Morgan¹, Dinesh Khanna^1,2, David A. Fox¹ and M. Asif Amin⁵, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Scleroderma Program, Ann Arbor, MI, ³Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by systemic fibrosis. The dysregulation of transforming growth factor-β (TGF-β) signaling causes proliferation of myofibroblasts…
Abstract Number: 1860 • 2016 ACR/ARHP Annual Meeting
Activating Transcription Factor 3 – a New Linkage Between Vasculopathy and Organ Fibrosis in Systemic Sclerosis
Thomas Wohlfahrt¹, Alina Soare², Tatjana Mallano², Morgane Gourlaouen³, Stephen Moss³, Britta Maurer⁴, Oliver Distler⁴, Tsonwin Hai⁵, Georg Schett², Jörg Distler² and Andreas Ramming², ¹Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Ophthalmology, Department of Cell Biology, University College London, London, United Kingdom, ⁴Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Department of Molecular and Cellular Biochemistry, The Ohio State University, Colombus, OH
Background/Purpose: Since vascular manifestations such as Raynaud’s phenomenon and morphological changes on nailfold capillaroscopy often precede the onset of other clinical manifestations of systemic sclerosis…
Abstract Number: 1862 • 2016 ACR/ARHP Annual Meeting
Modelling Healthy and Scleroderma Fibrotic Skin in Vitro: Mechanical Stress Alters Macrophage Cytokine Expression and Triggers Signalling Via the Mechano-Sensing Transcription Factor Myocardin-Related Transcription Factor-a
Angela Tam¹, Shiwen Xu¹, Henry Lopez¹, Korsa Khan², Bahja Ahmed Abdi³, Henrique Rosario⁴, Nikita Arumalla², Mark Gibson², Christopher Denton², David Abraham², Barbara D Smith⁵ and Richard J Stratton², ¹Division of Medicine, Centre for Rheumatology and Connective tissue disease, University College London, London, United Kingdom, ²Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ³Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁴Division of Medicine, Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Skin involvement is one of the most prominent clinical features in scleroderma. There is a marked contrast in mechanical stiffness between healthy forearm skin…
Abstract Number: 2068 • 2016 ACR/ARHP Annual Meeting
Type 2 Innate Lymphoid Cells – Cellular Source of Profibrotic Mediators Rapidly and Persistently Recruited in Experimental Fibrosis and Systemic Sclerosis
Stefanie Weber¹, Thomas Wohlfahrt¹, Simon Rauber¹, Markus Luber¹, Matthias Englbrecht², Clara Dees³, Christian Beyer⁴, Oliver Distler⁵, Georg Schett³, Joerg HW Distler³ and Andreas Ramming⁴, ¹Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology & Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: We aimed to profile ILC2s in fibrotic tissues and to evaluate the functional impact of IC2s in the pathogenesis of systemic sclerosis (SSc). Methods:…
Abstract Number: 2069 • 2016 ACR/ARHP Annual Meeting
Dipeptidyl-Peptidase-4 (DPP4) Positive Fibroblast Subpopulation Promotes Fibrosis and Are a Molecular Target for Treatment of Fibrosis
Alina Soare^1,2, Simon Rauber³, Thomas Wohlfahrt¹, Clara Dees⁴, Ruifang Liang⁴, Yun Zhang¹, Chih-Wei Chen¹, Andreas Ramming⁵, Oliver Distler⁶, Carina Mihai⁷, Georg Schett⁴ and Joerg HW Distler⁴, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucharest, Romania, ³Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁵Department of Internal Medicine 3, Rheumatology and Immunology, Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁷Department of Internal Medicine and Rheumatology, Carol Davila University of Medicine and Pharmacy, Cantacuzino Hospital, Bucharest, Romania
Background/Purpose: Dipeptidyl-peptidase-4 (DPP4) has been recently shown to identify a distinct dermal lineage with intrinsic fibrogenic potential and its targeted inhibition leads to reduced scar…

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