Abstracts tagged "fibrosis"

Abstract Number: 731 • 2017 ACR/ARHP Annual Meeting
Prediction of Progression of Interstitial Lung Disease in Patients with Systemic Sclerosis
Wanlong Wu¹, Suzana Jordan², Mike Oliver Becker³, Rucsandra Dobrota³, Shuang Ye⁴, Britta Maurer⁵ and Oliver Distler², ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich; Department of Rheumatology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ⁵Department of Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: No data are available to distinguish between progressive and stable patients when mild lung fibrosis is diagnosed in systemic sclerosis (SSc) patients. This study…
Abstract Number: 1925 • 2017 ACR/ARHP Annual Meeting
TGFβ Promotes Fibrosis By MYST1-Dependent Epigenetic Regulation of Autophagy
Ariella Zehender¹, Neng-Yu Lin², Adrian Stefanica³, Chih-Wei Chen⁴, Alina Soare⁵, Thomas Wohlfahrt⁶, Simon Rauber⁶, Christina Bergmann⁷, Andreas Ramming⁸, Oliver Distler⁹, Georg Schett¹⁰ and Jörg Distler⁵, ¹1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ²Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³1Department of Internal Medicine 3 – Rheumatology and Immunology, University of Erlangen, Erlangen, Germany, ⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ⁵Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁶Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁷Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁸Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹⁰Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Autophagy (Atg) is catabolic process allowing cells to degrade unnecessary or dysfunctional cellular organelles. Aberrant activation of Atg has been implicated into the pathogenesis…
Abstract Number: 742 • 2017 ACR/ARHP Annual Meeting
Quantitative CT Evalutation in Diffuse Interstitial Lung Involvement in Systemic Sclerosis: Usefulness of Lung Texture Analysis to Predict the Functional Change over Time
Silvia Bosello¹, Maria Elena Occhipinti², Giovanni Canestrari¹, Enrico De Lorenzis¹, Federico Parisi¹, Gerlando Natalello³, Grazia Leuconeo⁴, Anna Rita larici⁴, Chiara De Waure⁴, Gianfranco Ferraccioli⁵ and Elisa Gremese⁶, ¹Division of Rheumatology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ²University of Florence, Florence, Italy, ³Division of Rhematology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ⁴Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ⁵Institute of Rheumatology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ⁶Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy
Background/Purpose: The prognosis of patients with scleroderma and interstitial lung involvement (SSc-ILD) can be evaluated by combining data of pulmonary function tests (PFTs) and high-resolution…
Abstract Number: 1926 • 2017 ACR/ARHP Annual Meeting
Cardiac Remodeling in Systemic Sclerosis: TGF-β/Fra2-Dependent Autophagy As a Novel Target for Heart Fibrosis
Mara Stellato¹, Michal Rudnik¹, Florian Renoux¹, Elena Pachera¹, Karl Sotlar², Karin Klingel³, Joerg C. Henes⁴, Przemyslaw Blyszczuk^1,5, Oliver Distler¹ and Gabriela Kania¹, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ³Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁴Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ⁵Department of Clinical Immunology, Jagiellonian University Medical College, Krakow, Poland
Background/Purpose: SSc patients frequently suffer from primary cardiac involvement. The main histological feature is fibrosis, but the mechanisms responsible for the heart failure remain unclear.…
Abstract Number: 763 • 2017 ACR/ARHP Annual Meeting
Mechanisms of Insulin-like Growth Factor-II-Mediated Fibrosis
Sara Garrett¹, Justin Thomas², Eileen Hsu³ and Carol A. Feghali-Bostwick⁴, ¹Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ²Eisenhower Medical Center, Rancho Mirage, CA, ³Kaiser Permanente Medical Group, Mclean, VT, ⁴Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: Previous work has shown that insulin-like growth factor (IGF)-II is increased in fibrosing lung diseases, including idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis (SSc)-associated…
Abstract Number: 2677 • 2017 ACR/ARHP Annual Meeting
Impact of Rheumatologic Evaluation and Serologic Testing on Patients with Fibrotic Interstitial Lung Disease: A Single Center Retrospective Experience
Lindsey A. MacFarlane¹ and Paul F. Dellaripa², ¹Rheumatology, Brigham & Women's Hospital, Boston, MA, ²Rheumatology, Brigham and Women’s Hospital, Boston, MD
Background/Purpose: The evaluation of patients who develop interstitial lung disease (ILD) includes an assessment for underlying rheumatic disease or connective tissue disease (CTD). Delineating a…
Abstract Number: 766 • 2017 ACR/ARHP Annual Meeting
Increased Plasma Levels of Hsp90 Are Associated with More Severe Organ Involvement in Patients with Systemic Sclerosis
Hana Storkanova¹, Sabina Oreska¹, Maja Spiritovic^1,2, Karel Pavelka¹, Jiri Vencovsky¹, Jörg Distler³, Ladislav Senolt¹, Radim Becvar¹ and Michal Tomcik¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Our previous study demonstrated that Heat shock protein 90 (Hsp90) is overexpressed in the skin of patients with systemic sclerosis (SSc), in cultured SSc…
Abstract Number: 2776 • 2017 ACR/ARHP Annual Meeting
Plasmacytoid Dendritic Cells in Systemic Fibrosis: Pathogenic Role in Bleomycin-Induced Fibrosis Model and Correlation with Disease in Patients with Systemic Sclerosis
Suzanne Kafaja¹, Isela Valera², Anagha Divekar³, Rajan Saggar⁴, Dinesh Khanna⁵, Daniel E. Furst⁶ and Ram R. Singh⁷, ¹Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ²Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ³Biolegend, Sa Diego, CA, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵University of Michigan, Ann Arbor, MI, ⁶David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁷Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA
Background/Purpose: Fibrosis is the end-result of most inflammatory conditions, but its pathogenesis remains unclear. Studies in patients and animal models suggest a role for T-cells…
Abstract Number: 768 • 2017 ACR/ARHP Annual Meeting
A Positive Feedback Loop between Estrogen and IL-6 Leads to Fibrosis in Human Skin
DeAnna Baker Frost¹ and Carol A. Feghali-Bostwick², ¹Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: Systemic Sclerosis (SSc) is a disease characterized by an increase in the synthesis of extracellular matrix (ECM) components in various organs, including the skin,…
Abstract Number: 2926 • 2017 ACR/ARHP Annual Meeting
Fucosyltransferase-1 Mediates Macrophage Driven Myofibroblast Differentiation and TGF-β Signaling in Systemic Sclerosis and Bleomycin-Induced Fibrosis
W. Alexander Stinson¹, Ellen Cealey¹, Pei-Suen Tsou¹, Ray A. Ohara¹, Yuxuan Du², Jonatan Hervoso¹, Nicholas Lepore¹, Sarah Arwani¹, Dinesh Khanna¹, David A. Fox¹ and M. Asif Amin¹, ¹Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, MI
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by dysregulated fibrosis of the skin. During fibrosis, macrophage release of transforming growth factor (TGF-β)…
Abstract Number: 774 • 2017 ACR/ARHP Annual Meeting
The αV Integrin Inhibitor Abituzumab Inhibits Myofibroblast Differentiation
Eileen Samy¹, Yin Wu¹, Georgianna Higginbotham², Roland Grenningloh² and Daigen Xu², ¹TIP Immunology, EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ²EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA
Background/Purpose: Scleroderma is a progressive fibrotic multi-organ disease characterized by the hardening and tightening of the skin and connective tissues. TGF-β1 is a potent mediator…
Abstract Number: 2929 • 2017 ACR/ARHP Annual Meeting
WNT5A Promotes Tissue Fibrosis By Wnt/PCP-Dependent Activation of Latent TGF-β
Chih-Wei Chen¹, Thuong Trinh-Minh², Neng-Yu Lin², Yun Zhang³, Florian Groeber⁴, Christian Beyer⁵, Georg Schett⁶ and Jörg Distler⁷, ¹Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ²Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁴Translational Center Würzburg, Fraunhofer Ins. IGB, Würzburg, Germany, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁶Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
Background/Purpose: Canonical Wnt/β-catenin signaling has emerged as a core pathway of fibrosis. They role of non-canonical Wnt signaling, however, has not been systematically studied. In…
Abstract Number: 1679 • 2017 ACR/ARHP Annual Meeting
Different Cut-Offs for Renal Resistive Index Reflect Renal and Other Organ Involvement and Predict Worsening in SSc Patients
Cosimo Bruni¹, Vanessa Maestripieri², Giulia Tesei³, Marco Chiostri⁴, Serena Guiducci³, Silvia Bellando-Randone¹, Maria Boddi⁴ and Marco Matucci-Cerinic³, ¹Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Firenze, Italy, ²Department of Internal Medicine, Division of Medicine for Care Complexity III, University of Florence, Florence, Italy, ³Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ⁴Department of Heart and Vessels, Division of Cardiology I, University of Florence, Florence, Italy
Background/Purpose: Renal Resistive Index (RRI), measured by Doppler ultrasound, reflects changes in both renal vascular and tubular-interstitial compartments and systemic vascular compliance related to age…
Abstract Number: 1688 • 2017 ACR/ARHP Annual Meeting
Stem Cell-Enriched Lipotransfer Substantially Improves Measures of Appearance and Function Due to Facial Fibrosis in Systemic Sclerosis
Aurora Almadori^1,2, Caroline Ryan², Michelle Griffin³, Esther Hansen⁴, Christopher Denton⁵ and Peter Butler^6,7, ¹Plastic Surgery, Royal Free NHS Foundation Trust London Hospital, London, United Kingdom, ²Division of Surgery and Interventional Science, UCL, London, United Kingdom, ³Division of Surgery and Interventional Sclemce, UCL, london, United Kingdom, ⁴Clinical Psychology, Plastic Surgery, Royal Free London NHS Foundation Trust Hospital, London, United Kingdom, ⁵Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom, ⁶Plastic Surgery, Royal Free London NHS Foundation Trust Hospital, London, United Kingdom, ⁷Division of Surgery and Interveitional Science, UCL, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is characterised by fibrosis of the skin and underlying connective tissue structures, together with localised loss of subcutaneous fat. Oro-facial fibrosis…
Abstract Number: 1706 • 2017 ACR/ARHP Annual Meeting
Dipeptidyl-Peptidase-4 (DPP4) Promotes Fibroblast Activation and Is a Potential Molecular Target for Treatment of Fibrosis
Alina Soare¹, Hermina Györfy¹, Alexandru Matei¹, Clara Dees¹, Chih-Wei Chen¹, Andreas Ramming², Georg Schett³ and Jörg Distler¹, ¹Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ³Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany
Background/Purpose: Dipeptidyl-peptidase-4 (DPP4) has been reported to identify a dermal fibroblast lineage involved in scaring and its inhibition leads to reduced scar formation. Its role…

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