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Abstracts tagged "Fibroblasts"

  • Abstract Number: 963 • 2017 ACR/ARHP Annual Meeting

    Artesunate Inhabits Migration and Invasion of Fibroblast-like Synoviocytes and Matrix Metalloproteinases Expression Via Suppression of PI3K/Akt Pathway in Rheumatoid Arthritis

    Jian-Da Ma1, Jun Jing1, Tao Yan2, Ying-Qian Mo1 and Lie Dai1, 1Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, 2Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

    Background/Purpose: Fibroblast-like synoviocytes (FLS) play major roles on joint destruction in rheumatoid arthritis (RA) through migrating and invasing cartilage and bone by secreting proteases such…
  • Abstract Number: 2829 • 2017 ACR/ARHP Annual Meeting

    Complete Epigenetic Landscape of Rheumatoid Arthritis Fibroblast-like Synoviocytes Reveals Unanticipated Critical Pathogenic Pathways

    Rizi Ai1, Teresina Laragione2, Deepa Hammaker3, David L. Boyle4, Andre ‎ Wildberg5, Keisuke Maeshima3, Emmanuele Palescandolo6, Vinod Krishna6, Bryan Linggi7, David Pocalyko8, John W. Whitaker9, Percio S. Gulko2, Wei Wang10 and Gary S. Firestein11, 1UC San Diego, La Jolla, CA, 2Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 3Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 4University of California San Diego, La Jolla, CA, 5Chemistry and Biochemistry, UNIVERSITY OF CALIFORNIA SAN DIEGO, LA JOLLA, CA, 6Janssen Pharmaceuticals, Spring House, PA, 7janssen Pharmaceuticals, Spring House, PA, 8Janssen Research, Spring House, PA, 9Janssen Pharmaceuticals, La Jolla, CA, 10Chemistry and Biochemistry, UC San Diego, La Jolla, CA, 11Medicine, University of California San Diego, La Jolla, CA

    Background/Purpose: Epigenetics participates in the pathogenesis of rheumatoid arthritis (RA). Epigenetic marks, gene expression and DNA polymorphisms have been investigated but the analyses are limited…
  • Abstract Number: 966 • 2017 ACR/ARHP Annual Meeting

    In Search of Mechanisms Underlying Fibroblast-like Synoviocyte Cell-to-Cell Cargo Transfer

    Ruth Byrne1, Isabel Olmos Calvo2, Felix Kartnig3, Uwe Hansen4, Denise Beckmann4, Adelheid Korb-Pap4, Bernhard Brandstätter1, Thomas Karonitsch1, Günter Steiner1, Johannes Holinka5, Peter Ertl6, Thomas Pap4, Josef S. Smolen7 and Hans Peter Kiener1, 1Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Chemical Technologies and Analytics, Vienna University of Technology, Vienna, Austria, 3CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 4Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, 5Orthopaedics, Medical University of Vienna, Vienna, Austria, 6Vienna University of Technology, Vienna, Austria, 7Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria

    Background/Purpose: The synovium is primarily built by fibroblast-like-synoviocytes (FLS). These cells form a complex tissue network via long-distance connections (nanotubes) and wide intercellular matrix spaces.…
  • Abstract Number: 2928 • 2017 ACR/ARHP Annual Meeting

    STAT3 As an Important Integrator of Profibrotic Pathways in Systemic Sclerosis

    Debomita Chakraborty1, Barbora Šumová2, Tatjana Mallano3, Chih-Wei Chen3, Alfiya Distler3, Christina Bergmann3, Andreas Ramming4, Oliver Distler5, Georg Schett3, Ladislav Senolt6 and Jörg Distler3, 1Department of Internal Medicine 3- Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 2Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 5Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 6Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    Background/Purpose: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates key cellular processes such as proliferation, apoptosis, invasion, angiogenesis, metastasis…
  • Abstract Number: 970 • 2017 ACR/ARHP Annual Meeting

    ACPA Activate Challenged Synovial Fibroblasts through a PAD Dependent Mechanism: A Potential Explanation of the “Second Hit Model” in RA

    Meng Sun1, Vijay Joshua1, Akilan Krishnamurthy1, Aase Hensvold1, Yanying Liu2, Sergiu-Bogdan Catrina3, Caroline Ospelt4, Vivianne Malmström1, Johanna Steen1, Marianne Engström1, Heidi Wähämaa1, Bence Rethi1 and Anca I. Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, 3Molecular Medicine and Surgery, Molecular Medicine and Surgery, Stockholm, Sweden, 4Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland

    Background/Purpose: Anti-citrullinated proteins antibodies (ACPAs) injected in mice induce IL-8 dependent bone loss and arthralgia, but no synovial changes. We hypothesized that additional stimulus, sensitizing…
  • Abstract Number: 973 • 2017 ACR/ARHP Annual Meeting

    IL-6 and TNF-a Cooperate to Modulate the Cell Cycle of RA-Fibroblast-like Synoviocytes Via Cyclin Dependent Kinase Inhibitors

    Kenta Kaneshiro1, Kohsuke Yoshida1, Ayako Nakai1, Kohjin Suzuki1, Koto Uchida1, Teppei Hashimoto2, Yoshiko Kawasaki3, Natsuko Nakagawa4, Koji Tateishi5, Nao Shibanuma6, Yoshitada Sakai7 and Akira Hashiramoto1, 1Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, 2Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, 3The Center of Rheumatic Diseases, Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, 4Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, 5Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 6Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, 7Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: IL-6 and TNF-α play an important role in the pathogenesis of RA, and the proliferation of RA-synoviocytes (FLS) is controlled by cell cycle regulators…
  • Abstract Number: 974 • 2017 ACR/ARHP Annual Meeting

    Leucine-Rich α-2 Glycoprotein Promotes Lung Fibrosis By Modulating TGF-β Signaling in Fibroblasts

    Hiromi Honda, Minoru Fujimoto, Satoshi Serada, Hyun Lee, Tomoharu Ohkawara and Tetsuji Naka, Center for Intractable Immune Disease, Kochi University, Nankoku, Japan

    Background/Purpose: Interstitial lung disease (ILD) is one of the most common extraarticular manifestation of rheumatoid arthritis. ILD is characterized by progressive fibrosis of the lung…
  • Abstract Number: 975 • 2017 ACR/ARHP Annual Meeting

    IL-17A Induced Autophagy That the Proliferation of Rheumatoid Arthritis Fibroblast-like Synoviocytes through Down-Regulation of PI3K/AKT/mTOR Signaling Pathway

    Sang-Hyon Kim1, Jihye Bang2, Ji-Min Kim1, Chang-Nam Son1, Jin-Nyeong Chae1 and Hye-Jin Jeong3, 1Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea, Daegu, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, Republic of (South), 3Department of Rheumatology, Keimyung University Dongsan Medical Center, Daegu, Korea, Republic of (South)

    Background/Purpose: Autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Fibroblast-like synoviocytes (FLS) resistance to…
  • Abstract Number: 1131 • 2016 ACR/ARHP Annual Meeting

    Regulation of Rheumatoid Arthritis Synovial Fibroblast Cytokine Production By Inhibitor of DNA Binding-1 Via Crispr/Cas9 Transfection

    Ray A. Ohara1, Gautam Edhayan1, Thomas L. Saunders2, Thomas M. Lanigan3, Rachel Morgan1, W. Alexander Stinson4, Phillip L. Campbell5, Jerry Graham4, David A. Fox5 and Jeffrey H. Ruth5, 1Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI, 3Vector Core, University of Michigan Medical School, Ann Arbor, MI, 4Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 5Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Inhibitor of DNA binding-1 (Id1) is a nuclear protein actively transcribed in endothelial progenitor cells (EPCs) and synovial fibroblasts. We previously identified Id1 as…
  • Abstract Number: 3146 • 2016 ACR/ARHP Annual Meeting

    Selective Deletion of a Pathogenic Subset Synovial Fibroblasts Attenuates Synovial Inflammation

    Adam Paul Croft, Joana Campos, Andrew Filer, Francesca Barone and Chris Buckley, Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom

    Background/Purpose:  Despite their role as key effector cells driving synovial inflammation and joint damage, fibroblast like synoviocytes (FLS) have yet to be targeted therapeutically. Fibroblast…
  • Abstract Number: 1435 • 2016 ACR/ARHP Annual Meeting

    KCa1.1 Potassium Channels Are a Novel Therapeutic Target on Fibroblast-like Synoviocytes in Rheumatoid Arthritis

    Mark Tanner1, Redwan Huq1, Rajeev Tajhya1, Michael Pennington2, Teresina Laragione3, Pércio Gulko4 and Christine Beeton5, 1Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, 2Peptides International, Louisville, KY, 3Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 4Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 5Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX

    Background/Purpose: Fibroblast-like synoviocytes (FLS) develop a high degree of invasiveness during rheumatoid arthritis (RA), leading to joint degradation. There are currently no therapeutics that specifically…
  • Abstract Number: 3178 • 2016 ACR/ARHP Annual Meeting

    Heart Dysfunction in Systemic Sclerosis: Involvement of a Novel Fibrogenic Stromal Cell Subset

    Mara Stellato1, Michal Rudnik1, Florian Renoux2, Elena Pachera1, Karl Sotlar3, Karin Klingel4, Joerg C. Henes5, Przemyslaw Blyszczuk6, Oliver Distler1 and Gabriela Kania1, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, 3Institute of Pathology, Ludwig Maximilians University, Munich, Germany, 4Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, 5Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, 6Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland

    Background/Purpose: Cardiac dysfunction is a significant cause of the high mortality in systemic sclerosis (SSc). Heart involvement in SSc patients resembles inflammatory dilated cardiomyopathy (iDCM)…
  • Abstract Number: 1558 • 2016 ACR/ARHP Annual Meeting

    Lower Expression of a Novel Cytoplasmic Long Noncoding RNA NR_122076 Contributes to Proliferation, Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis

    Yaoyao Zou, Siqi Xu, Qian Qiu, Shan Zeng, Maohua Shi, Youjun Xiao, Mingcheng Huang and Hanshi Xu, Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Guangzhou, China

    Background/Purpose:  Emerging evidence indicates that long noncoding RNAs (lncRNAs) play critical regulatory roles in various human diseases, especially in cancers and inflammatory disorders. However, the…
  • Abstract Number: 3215 • 2016 ACR/ARHP Annual Meeting

    ASK1 Is Regulated By IL-1β and TNF and Modulates Key Rheumatoid Arthritis (RA) Fibroblast-like Synoviocyte Functions (FLS)

    Gyrid Nygaard1, Deepa Hammaker2, David L. Boyle3, Astrid Clarke4, Li Li5, Julie Dipaolo6 and Gary Firestein7, 1Medicine, UC San Diego, La Jolla, CA, 2Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 3Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, 4GIlead, South San Francisco, CA, 5Gilead Sciences, South San Francisco, CA, 6Gilead, South San Francisco, CA, 7Medicine, UCSD, La Jolla, CA

    Background/Purpose: RA fibroblast-like synoviocytes (FLS) possess a unique aggressive phenotype characterized by increased cell growth, cytokine production and invasion. Previous unsuccessful attempts to target the…
  • Abstract Number: 1564 • 2016 ACR/ARHP Annual Meeting

    The Comprehensive Analysis for the Transcriptional Organization of Stimuli Responses in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients

    Haruka Tsuchiya1, Shuji Sumitomo1, Kazuyoshi Ishigaki2, Akari Suzuki2, Yuta Kochi2, Mineto Ota1, Yumi Tsuchida1, Hiroshi Inui3, Shuji Taketomi3, Yuho Kadono4, Sakae Tanaka3, Keishi Fujio1 and Kazuhiko Yamamoto1,2, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 3Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 4Department of Orthopaedic Surgery, Graduate School of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose:   Fibroblast-like synoviocyte (FLS) is expected to be a novel therapeutic target for rheumatoid arthritis (RA) because of their contribution to pathogenesis. FLS expresses…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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