ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "Fibroblasts"

  • Abstract Number: 1417 • 2017 ACR/ARHP Annual Meeting

    Mitophagy Defect in Fibroblast-like Synoviocytes of Rheumatoid Arthritis Is Improved By Pyruvate Treatment

    Jeong Yeon Kim1,2, ShinEui Kang3,4, Hyun Jung Yoo1,5, Ji Soo Park1,2, Sehui Shon1,2, Eun Young Lee2, Eun Bong Lee5 and Yeong Wook Song1,6, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea., Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Korea, Republic of (South), 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea., seoul, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., seoul, Korea, Republic of (South), 5Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), 6Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)

    Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining produce pro-inflammatory cytokines resulting in increase of joint inflammation. Recent studies about the cellular metabolism in…
  • Abstract Number: 171 • 2017 ACR/ARHP Annual Meeting

    Finding Transcriptional Regulators Central to RA with Transcriptomics of IL17 Dose Response, Time Series, and siRNA Silencing in Stromal Cells

    Kamil Slowikowski1, Hung Nguyen2, Gerald Watts2, Fumitaka Mizoguchi3, Erika H. Noss4, Michael Brenner5 and Soumya Raychaudhuri6, 1Harvard University, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 4Division of Rheumatology, University of Washington, Seattle, WA, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 6Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by immune cell infiltration into the synovial membrane of the joint, where they engage stromal cells such as synovial…
  • Abstract Number: 1714 • 2017 ACR/ARHP Annual Meeting

    Inhibition of Hedgehog Acyltransferase Alleviates the Profibrotic Effects of Transforming Growth Factor β in Systemic Sclerosis

    Ruifang Liang1, Rosebeth Kagwiria2, Clara Dees3, Yun Zhang4, Oliver Distler5, Georg Schett6 and Jörg Distler7, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 2Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 3Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 4Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 5Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 6Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 7Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany

    Background/Purpose: Hedgehog acyltransferase (Hhat) catalyzes the attachment of the fatty acid palmitate onto Sonic Hedgehog (Shh), a modification essential for Shh signaling activity. Palmitoylation of…
  • Abstract Number: 642 • 2017 ACR/ARHP Annual Meeting

    Downstream Effects of Apremilast in Human Arthritic Ex Vivo Models

    Tue Wenzel Kragstrup1,2, Søren Lomholt2, Morten Aagaard Nielsen2, Line Dam Heftdal2, Peter H. Schafer3 and Bent Deleuran2,4, 1Randers Regional Hospital, Randers, Denmark, 2Department of Biomedicine, Aarhus University, Aarhus, Denmark, 3Department of Translational Development, Celgene Corporation, Summit, NJ, 4Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Apremilast (Otezla) is a PDE4 inhibitor approved for the treatment of psoriasis and psoriatic arthritis, but the mechanisms of action of apremilast are not…
  • Abstract Number: 1717 • 2017 ACR/ARHP Annual Meeting

    Skin Commensal Bacteria Might Affect Wound Repair in SSc By Preventing Fibroblast Activation and By Provoking Chronic Inflammatory Reaction

    Masaya Yokota1, Janine Schniering1, Oliver Distler2 and Britta Maurer3, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 2Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Chronic digital ulcers (DU) due to peripheral microangiopathy are a major complication in systemic sclerosis (SSc). Chronic wounds are often enriched in bacteria without…
  • Abstract Number: 763 • 2017 ACR/ARHP Annual Meeting

    Mechanisms of Insulin-like Growth Factor-II-Mediated Fibrosis

    Sara Garrett1, Justin Thomas2, Eileen Hsu3 and Carol A. Feghali-Bostwick4, 1Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 2Eisenhower Medical Center, Rancho Mirage, CA, 3Kaiser Permanente Medical Group, Mclean, VT, 4Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC

    Background/Purpose: Previous work has shown that insulin-like growth factor (IGF)-II is increased in fibrosing lung diseases, including idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis (SSc)-associated…
  • Abstract Number: 1721 • 2017 ACR/ARHP Annual Meeting

    Long Noncoding RNA H19X Is a Key Regulator of Apoptosis and Proliferation of Fibroblasts in Systemic Sclerosis and Other TGFβ-Driven Fibrotic Diseases

    Elena Pachera1, Adam Wunderlin1, Shervin Assassi2, Gloria Salazar2, Mojca Frank Bertoncelj1, Rucsandra Dobrota1, Matthias Brock3, Carol A. Feghali-Bostwick4, Gerard Dijkstra5, Gerhard Rogler6, Tobias van Haaften Wouter6, Jörg Distler7, Gabriela Kania1 and Oliver Distler1, 1Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 3Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland, 4Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC, 5Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Switzerland, 6Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland, 7Internal Medicine 3, University of Erlangen, Erlangen, Germany

    Background/Purpose: Long noncoding RNAs (lncRNAs) are a class of transcripts regulating gene expression. We have recently identified a novel lncRNA, H19X, which was upregulated in…
  • Abstract Number: 769 • 2017 ACR/ARHP Annual Meeting

    Proteomic Analysis of Human Fibroblasts in Systemic Sclerosis Reinforces the Role of Transforming Growth Factor-ß and Points Toward Epidermal Growth Factor Receptor / Phosphatidylinositol 3 Kinase Pathway Inhibition

    Benjamin Chaigne1, Guilhem Clary2, Morgane Le Gall3, Nicolas Dumoitier4, Sebastien Lofek5, Philippe Chafey2, Pia Moinzadeh6, Thomas Krieg7, Christopher Denton8 and Luc Mouthon9, 1Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d’Ile de France, hôpital Cochin, DHU Authors, Assistance Publique-Hôpitaux de Paris, Paris, France, 2INSERM U1016, Institut Cochin,, Paris, France, 3INSERM U1016 Institut Cochin, Paris, France, 4INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, 5INSERM U1016, paris, France, 6Department of Rheumatology, UCL Division of Medicine, London, United Kingdom, 7Universität zu Köln, Köln, Germany, 8Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom, 9Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France

    Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune connective tissue disorder characterized by autoimmunity, vasculopathy and fibrosis. Fibrosis is due to an exaggerated activation of…
  • Abstract Number: 1927 • 2017 ACR/ARHP Annual Meeting

    Anti-Fibrotic Mechanisms of Endostatin-Derived Peptide Are the Result of Reduction in Pro-Fibrotic Mediators and Promotion of Extracellular Matrix Degradation

    Tomoya Watanabe1, Tetsuya Nishimoto2, Takahisa Takihara3, Logan Mlakar4, Yunyun Su5 and Carol A. Feghali-Bostwick6, 1Rheumatology, Medical University of South Carolina, Charleston, SC, 2Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 3Division of Pulmonary Medicine, Tokai University School of Medicine, Isehara, Japan, 4Medical University of South Carolina, Charleston, SC, 5Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, charleston, SC, 6Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC

    Background/Purpose: Fibrotic disorders such as systemic sclerosis (SSc) result in end-stage organ failure and loss of function, consequently causing high morbidity and mortality. We recently…
  • Abstract Number: 774 • 2017 ACR/ARHP Annual Meeting

    The αV Integrin Inhibitor Abituzumab Inhibits Myofibroblast Differentiation

    Eileen Samy1, Yin Wu1, Georgianna Higginbotham2, Roland Grenningloh2 and Daigen Xu2, 1TIP Immunology, EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 2EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA

    Background/Purpose: Scleroderma is a progressive fibrotic multi-organ disease characterized by the hardening and tightening of the skin and connective tissues. TGF-β1 is a potent mediator…
  • Abstract Number: 1928 • 2017 ACR/ARHP Annual Meeting

    Fibroblast-like Synovial Cell Production of ED-a Fibronectin Contributes to Inflammation in Osteoarthritis

    Tue Wenzel Kragstrup1,2,3, Dong Hyun Sohn4, Christin Lepus3, Kazuhiro Onuma5, Qian Wang3, William H. Robinson3 and Jeremy Sokolove3, 1Randers Regional Hospital, Randers, Denmark, 2Department of Biomedicine, Aarhus University, Aarhus, Denmark, 3VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 4Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Korea, Republic of (South), 5VA Palo Alto Healthcare System and Stanford University, Stanford, CA

    Background/Purpose: The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Wear and tear leads to tissue degradation followed by…
  • Abstract Number: 863 • 2017 ACR/ARHP Annual Meeting

    Functionally Distinct Pathogenic Subsets of Fibroblasts Exist within the Inflamed Synovial Membrane and Mediate Specific Aspects of Inflammatory Disease Pathology

    Adam Paul Croft1, Joana Campos2, Loriane Savary2, Emma Bishop2, Jason Turner1, Guillaume Desanti2, Francesca Barone3, Andrew Filer3 and Chris Buckley2, 1Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 2University of Birmingham, Birmingham, United Kingdom, 3Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Fibroblasts are key effector cells in the persistence of synovial inflammation and joint damage. It is not yet known whether specific subsets of synovial…
  • Abstract Number: 2789 • 2017 ACR/ARHP Annual Meeting

    Deficiency of the Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Induces Replication Stress in RA Fibroblast-like Synoviocytes (FLS) and Exacerbates Arthritis Severity

    Shinji Matsuda1, Deepa Hammaker2, Katheryn Topolewski3, Karoline Briegel4, Steven Dowdy5, David L. Boyle6, Wei Wang7 and Gary S. Firestein8, 1Medicine, UC San Diego, La Jolla, CA, 2Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 3UC San Diego, La Jolla, CA, 4University of Miami, Miami, FL, 5UC San Diego School of Medicine, La Jolla, CA, 6University of California San Diego, La Jolla, CA, 7Chemistry and Biochemistry, UC San Diego, La Jolla, CA, 8Medicine, University of California San Diego, La Jolla, CA

    Background/Purpose: LBH (Limb-bud and heart development) was recently identified as an RA risk gene that has abnormally methylated loci and a functional enhancer SNP in…
  • Abstract Number: 960 • 2017 ACR/ARHP Annual Meeting

    ADAM-17 Is Expressed on Rheumatoid Arthritis Synovial Fibroblasts and Mediates Monocyte Migration and Adhesion

    Sho Ishii, Takeo Isozaki, Airi Nishimi, Shinichiro Nishimi, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: A disintegrin and metalloproteinase 17 (ADAM-17), also known as tumor necrosis factor-α converting enzyme (TACE), have been reported to be involved in a number…
  • Abstract Number: 2790 • 2017 ACR/ARHP Annual Meeting

    Regulation of ASK1 Expression and Its Role in Rheumatoid Arthritis (RA)

    Gyrid Nygaard1, Deepa Hammaker2, David L. Boyle3, Li Li4, Julie Di Paolo5 and Gary S. Firestein6, 1Medicine, UC San Diego, La Jolla, CA, 2Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 3University of California San Diego, La Jolla, CA, 4Gilead Sciences, South San Francisco, CA, 5Immunology and Inflammation Biology, Gilead Sciences, Foster City, CA, 6Medicine, University of California San Diego, La Jolla, CA

    Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) reside in the synovial intimal lining. They display a unique aggressive phenotype, invading the articular cartilage and promoting…
  • « Previous Page
  • 1
  • 2
  • 3
  • 4
  • 5
  • …
  • 12
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

Copyright Policy

View ACR Policies.

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology