Abstracts tagged "Fibroblasts"

Abstract Number: 1029 • 2018 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes As Immune Effectors in the Pathogenesis of Synovial Lesion in Antibiotic-Refractory Lyme Arthritis
Klemen Strle¹, Robert Lochhead², Ruslan Sadreyev³, Allen C. Steere⁴ and John Aversa⁵, ¹Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA, ²Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA, ³Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, ⁴Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Orthopaedics and Rehabilitation, Yale Medical Group , Yale University School of Medicine, New Haven, CT
Background/Purpose: Antibiotic-refractory Lyme arthritis (LA) is characterized by marked proliferative synovitis that persists for months-to-years after oral and IV antibiotic therapy for Borrelia burgdorferi. Although…
Abstract Number: 1051 • 2018 ACR/ARHP Annual Meeting
Hoxd Genes Regulate Arthritis-Relevant Pathways
Kerstin Klein¹, Mojca Frank Bertoncelj¹, Monika Krošel¹, Matija Tomšič², Christoph Kolling³, Oliver Distler⁴ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, ³Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ⁴Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Gene expression and functions of synovial fibroblasts (SF) differ profoundly between distinct joints. This might lead to site-specific activation of arthritis-relevant pathways with implications…
Abstract Number: 1059 • 2018 ACR/ARHP Annual Meeting
Differentially-Utilized Transcription Factors and Enhancers in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes
Jonathan Mills¹, Gary S. Firestein² and Brian Pedersen², ¹Rheumatology, University of California, San Diego, San Diego, CA, ²Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display a unique aggressive phenotype with a distinct epigenetic profile marked by altered chromatin accessibility. We hypothesized that differentially utilized…
Abstract Number: 1063 • 2018 ACR/ARHP Annual Meeting
Role of Mitochondrial-Bound HK2 in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Patricia Oliveira¹, Marta Fernandez Bustmanate², Ricard Garcia Carbonell³, Elsa Sanchez-Lopez⁴, Teresina Laragione⁵, Percio S. Gulko⁶, Gary S. Firestein⁷, Anne N Murphy³, Shigeki Miyamoto⁸ and Monica Guma^7,9, ¹Medicine, UCSD, San Diego, CA, ²Medicine, UCSD, La Jolla, CA, ³Pharmacology, UCSD, San Diego, CA, ⁴Department of Pharmacology, School of Medicine. UCSD., La Jolla, CA, ⁵Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Medicine, University of California San Diego, La Jolla, CA, ⁸Pharmacology, UCSD, La Jolla, CA, ⁹Medicine, Autonomous University of Barcelona, Bellatera, Spain
Background/Purpose: Hexokinases (HKs) catalyze the first step in glucose metabolism. HK2 constitutes the principal inducible isoform with a restricted distribution in normal adult tissues. Fibroblast-like…
Abstract Number: 1065 • 2018 ACR/ARHP Annual Meeting
Artesunate Can Synergize with Methotrexate on Inhibiting Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis
Jian-Da Ma¹, Jun Jing¹, Jun-Wei Wang¹, Tao Yan², Yun-Shan Mou², Ying-Qian Mo¹ and Lie Dai¹, ¹Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, ²Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: Fibroblast-like synoviocytes (FLS) play important roles on joint destruction in rheumatoid arthritis (RA). Recent reports showed that antimalaria drug artesunate presents anti-cancer potential by…
Abstract Number: 1068 • 2018 ACR/ARHP Annual Meeting
Characterization of the Role of Endocannabinoid System Using Jwh-133, a Selective Cannabinoid CB2 Receptor Agonist, in IL-1β-Induced Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts
Sabrina Fechtner¹, Anil K. Singh¹ and Salahuddin Ahmed^1,2, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA
Background/Purpose: The endocannabinoid system (ECS) is comprised of two evolutionary conserved cannabinoid receptors 1 and 2 (CB1 and CB2) which participate in pain management through…
Abstract Number: 50 • 2018 ACR/ARHP Annual Meeting
Intra-Articularly Delivering Lentivirus-Based CRISPR Interference Targeting Long Non-Coding RNA H19 in Synovial Fibroblasts Ameliorates Experimental Arthritis
Chrong-Reen Wang¹, Shih-Yao Chen², Yu-Ting Lo³, Yu-Chi Chou⁴, Ming-Fei Liu¹, Chao-Liang Wu⁵ and Ai-Li Shiau³, ¹Internal Medicine, National Cheng Kung University Hospital and Medical College, Tainan, Taiwan, ²Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ³Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Core Facility for Manipulation of Gene Function, Academia Sinica, Taipei, Taiwan, ⁵Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose: Aberrantly higher expression of long non-coding RNAs (lncRNAs) in synovial fibroblasts (SFs) plays pathogenic roles in rheumatoid joint. Studying the effects on knocking down…
Abstract Number: 1822 • 2018 ACR/ARHP Annual Meeting
RNA-Sequencing of Mouse and Human Synovial Fibroblasts Reveals Fibroblast Subset-Specific Responses to Inflammation
Anqi Gao¹, Kevin Wei², Ilya Korsunsky³ and Michael Brenner⁴, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts secrete inflammatory cytokines, degrade cartilage and mediate bone destruction. We have previously identified three synovial fibroblasts subsets with…
Abstract Number: 81 • 2018 ACR/ARHP Annual Meeting
Additive Effects of Functional Rheumatoid Arthritis (RA) LBH Risk Alleles on LBH Gene Transcription
Gyrid Nygaard, Deepa Hammaker, David L. Boyle and Gary S. Firestein, Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: LBH (Limb-bud and heart development gene) is dysregulated in RA, with a SNP associated with increased RA risk located in an upstream enhancer. This…
Abstract Number: 1964 • 2018 ACR/ARHP Annual Meeting
Epigenetic Changes of Energy Metabolism-Related Genes in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Brian Pedersen¹, Roxana Coras^1,2, Wei Wang³, Gary S. Firestein¹ and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³Chemistry and Biochemistry, University of California San Diego, La Jolla, CA
Background/Purpose: Epigenetic changes contribute to the pathogenesis of rheumatoid arthritis (RA) and a comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS) has recently been described.…
Abstract Number: 114 • 2018 ACR/ARHP Annual Meeting
Antifibrotic Regulation By Response Gene to Complement 32 Protein
Sergei Atamas, Violeta Rus, Virginia Lockatell, Horea Rus and Irina Luzina, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Pulmonary fibrosis is a serious problem in patients with scleroderma lung disease (SLD). Better therapies for pulmonary fibrosis are urgently needed. Identification of new…
Abstract Number: 1981 • 2018 ACR/ARHP Annual Meeting
A Molecular Bayesian Network for Rheumatoid Arthritis Reveals Multiple Candidate Key Regulators for Disease Severity
Wenhui Wang¹, Amit Lahiri², Teresina Laragione², Jun Zhu¹ and Percio S. Gulko^2,3, ¹Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, ²Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ³Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune joint disease. RA is pathologically heterogeneous with multiple contributing factors. While there has been a…
Abstract Number: 115 • 2018 ACR/ARHP Annual Meeting
CTLA4-Ig/CD86 Interaction on Cultered Human Fibrocytes and Fibroblasts from Systemic Sclerosis Patients
Maurizio Cutolo¹, Paola Montagna², Stefano Soldano¹, Amelia Chiara Trombetta³, Barbara Ruaro⁴, Paola Contini⁵, Sabrina Paolino⁶, Carmen Pizzorni⁴, Elisa Alessandri⁴, Massimo Patanè¹, Alberto Sulli⁴, Stefano Scabini⁷, Emanuela Stratta⁷ and Renata Brizzolara¹, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Polyclinic San Martino Hospital, Genova, Italy, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genova, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genoa, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ⁵Division of Clinical Immunology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino, Genova, Italy, Genova, Italy, ⁶Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genova, Italy, ⁷Oncologic Surgery, Department of Surgery, IRCCS Polyclinic San Martino, Genova, Italy, Genoa, Italy
Background/Purpose: CTLA4-Ig interacts with the cell surface costimulatory molecule CD86 and can downregulate the target cell activation [1]. Circulating fibrocytes (CFs) express markers of both…
Abstract Number: 1409 • 2017 ACR/ARHP Annual Meeting
Ursolic Acid Promotes Apoptosis of Rheumatoid Athritis Synovial Fibroblasts By Upregulating Noxa Expression and Recruiting E3 Ligase Mule to Degrade Mcl-1
Eugene Kim¹, Solomon Agere¹, Sadik Khuder² and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Department of Medicine, University of Toledo, Toledo, OH
Background/Purpose: In our previous study, we discovered that ursolic acid (UA), a pentacyclic triterpenoid with anti-inflammatory properties, induces apoptosis in synovial fibroblasts from rheumatoid arthritis…
Abstract Number: 1415 • 2017 ACR/ARHP Annual Meeting
TNF-Induced IRF1 Is Critical for the Inflammatory Gene Expression in Fibroblast-like Synoviocytes
Michael Bonelli¹, Karolina von Dalwigk², Birgit Niederreiter¹, Thomas Pap³, Josef S. Smolen⁴, Hans Peter Kiener¹ and Thomas Karonitsch¹, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁴Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria
Background/Purpose: Fibroblast-like synoviocytes (FLS) are increasingly recognised as major pathogenic cells in synovial inflammation of patients with Rheumatoid Arthritis (RA). In response to pro-inflammatory stimuli,…

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