Abstracts tagged "Fibroblasts"

Abstract Number: 2568 • 2013 ACR/ARHP Annual Meeting
Involvement Of Collagen-Binding Heat Shock Protein 47 In The Scleroderma-Associated Fibrosis
Haiyan Chu¹, Ting Wu¹, Wenyu Wu², Wenzhen Tu³, Yanyun Ma¹, Qingmei Liu¹, Hejian Zou⁴, Li Jin¹ and Jiu-Cun Wang¹, ¹Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, ²Division of Dermatology, Division of Dermatology, Huashan Hospital, Fudan University, Shanghai, Shanghai, China, ³Medicine, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shang hai, China, ⁴Rheumatology, Huashan Hospital, Shanghai, China
Background/Purpose: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs, especially the uncontrolled fibrosis of multiple organs. Collagen is…
Abstract Number: 2418 • 2013 ACR/ARHP Annual Meeting
The Transmembrane Protein Tyrosine Phosphatase Kappa Promotes Aggressiveness Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Stephanie M. Stanford¹, William B. Kiosses², Amanda M. Campbell³, Michael F. Maestre³, David L. Boyle⁴, Gary S. Firestein⁴ and Nunzio Bottini³, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA these cells…
Abstract Number: 2231 • 2013 ACR/ARHP Annual Meeting
The Actin-Crosslinking Protein Lasp-1 Regulates Synovial Fibroblast Migration and Cartilage Destruction In Arthritis
Denise Beckmann¹, Jan Hillen², Marianne Heitzmann², Catherine S. Chew³, Stefan Butz⁴, Dietmar Vestweber⁵, Hermann Pavenstädt⁶, Thomas Pap⁷ and Adelheid Korb-Pap², ¹1nstitute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Institute of Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ³Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, ⁴Max Planck Institute of Molecular Biomedicine, Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁵Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁶Internal Medicine D, Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany, ⁷Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Lasp-1 localizes at focal adhesions along stress fibres and leading edges of migrating cells and regulates the metastatic dissemination of tumors. Although rheumatoid arthritis…
Abstract Number: 2216 • 2013 ACR/ARHP Annual Meeting
Tubastatin A, a Selective Histone Deacetylase-6 Inhibitor, Suppresses Synovial Inflammation and Joint Destruction In a Collagen Antibody-Induced Arthritis Mouse Model
Joong Kyong Ahn¹, Jaejoon Lee², Hyemin Jeong², Jiwon Hwang², Seulkee Lee², Ji Young Chai³, Inyoung Kim^2,4, Eun Chung Hong⁵, Eun-Kyung Bae⁵, Hoon-Suk Cha² and Eun-Mi Koh², ¹Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Division of Rheumatology, Jesang Hospital, Seongnam-si Gyeonggi-do, South Korea, ⁴MD, Seoul, South Korea, ⁵Samsung Biomedical Research Institute, Seoul, South Korea
Background/Purpose: Histone deacetylases (HDAC) play a key role in regulating gene expression by deacetylasing histones, and HDAC inhibitors induce various cellular effects, including apoptosis, cell…
Abstract Number: 2227 • 2013 ACR/ARHP Annual Meeting
The Anti-Proliferative Function of RSK2 in Synovial Fibroblasts Protects Against TNF-á-Induced Joint Destruction in Inflammatory Arthritis
Anja Derer¹, Christina Boehm¹, Bettina Groetsch¹, Michael Stock¹, Kirsten Neubert², Sybille Boehm³, Bettina Sehnert¹, Georg Schett¹, Axel J. Hueber⁴ and Jean-Pierre David⁵, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Clinical Research Group, Nikolaus-Fiebiger Center, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Genetics, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Group Genes and Transcription, Institute of Osteology and Biomechanics (IOBM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Background/Purpose: The pro-inflammatory cytokine Tumor Necrosis Factor alpha (TNF-α) directly activates the ribosomal S6 kinase RSK2 in vitro. We recently demonstrated the protective effect of…
Abstract Number: 2906 • 2013 ACR/ARHP Annual Meeting
Peripheral Blood Mononuclear Cells Co-Cultured With Autologous Skin Fibroblasts Up-Regulate IL-17A and Play Anti-Fibrotic Effects In Systemic Sclerosis
Serena Vettori¹, Giuseppe Pasquale², Michele Iudici³, Giovanna Cuomo³, Giusi Barra², Barbara Russo⁴, Raffaele De Palma² and Gabriele Valentini¹, ¹Department of Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ²Clinical and Experimental Medicine, Immunology Unit, Second University of Naples, Naples, Italy, ³Department of Internal and Experimental Medicine, Second University of Naples, Naples, Italy, ⁴Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy
Background/Purpose: IL-17A has been recently implicated in the pathogenesis of systemic sclerosis (SSc). Therefore, we explored its expression and effects in peripheral blood mononuclear cells…
Abstract Number: 1835 • 2013 ACR/ARHP Annual Meeting
Dynamic Visualization Of Monocyte Migration In 3D Synovial Micromass Tissue Cultures
Clemens Scheinecker¹, Ruth Byrne¹, Karolina Dalwigk², Anastasiya Hladik¹, Gunter Steiner³, Josef S. Smolen⁴ and Hans Peter Kiener¹, ¹Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Medicine 3, Division of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: Monocytes (Mo) are among the first hematopoietic cells to migrate into the inflamed synovial tissue of arthritic joints. Monocyte migration appears to be associated…
Abstract Number: 2865 • 2013 ACR/ARHP Annual Meeting
Gene Expression Profiles Of Fibroblast-Like Synoviocytes In Early Stage Of Oligoarticular Juvenile Idiopathic Arthritis Are Different In Extended Versus Persistent Course
AnneMarie C. Brescia¹, Megan M. Simonds², Suzanne M. McCahan², Paul T. Fawcett² and Carlos D. Rose¹, ¹Pediatric Rheumatology, Thomas Jefferson University/ AI duPont Hospital for Children, Wilmington, DE, ²Nemours Research, Nemours/AI duPont Hospital for Children, Wilmington, DE
Background/Purpose: Our goal is the identification of informative synovial biomarkers to predict persistent vs extended course in oligoarticular JIA patients. Methods: Stored remnant synovial fluid…
Abstract Number: 1690 • 2013 ACR/ARHP Annual Meeting
Impaired Vitamin D Receptor Signaling Upregulates Transforming Growth Factor Beta (TGFβ) Signaling In Systemic Sclerosis
Pawel Zerr¹, Stefan Vollath¹, Katrin Palumbo-Zerr¹, Michal Tomcik², Jingang Huang¹, Alfiya Distler¹, Christian Beyer¹, Clara Dees¹, Oliver Distler³, Georg Schett⁴ and Joerg H. W. Distler¹, ¹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ³Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Vitamin D receptor (VDR) is a member of the nuclear receptor superfamily. Its ligand, 1,25-(OH)2D, is a metabolically active hormone derived from vitamin D3.…
Abstract Number: 2874 • 2013 ACR/ARHP Annual Meeting
Biological Roles of C5orf30 In Rheumatoid Arthritis Synovial Fibroblasts
Munitta Muthana¹, Holly Davies², Sachin Khetan³, Gbadebo Adeleke Adeleke⁴, Sarah Hawtree¹ and Anthony G. Wilson⁵, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²University of Sheffield, Sheffield, United Kingdom, ³Infection and immunity, Dr, Sheffield, United Kingdom, ⁴Infection and Immunity, Dr, Sheffield, United Kingdom, ⁵Infection & Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: A recent genome wide association study identified the variant rs26232 in the first intron of an uncharacterized gene C5orf30 as a rheumatoid arthritis susceptibility…
Abstract Number: 1392 • 2013 ACR/ARHP Annual Meeting
The Expression Of Proto-Oncogene Survivin Splicing Variant 2B In Synovial Tissues and Blood From Patients With Rheumatoid Arthritis
Sho Mokuda^1,2, Tatsuhiko Miyazaki³, Junya Masumoto³, Masamoto Kanno⁴ and Kiyoshi Takasugi⁵, ¹Department of Immunology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan, ²Department of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, Matsuyama, Japan, ³Department of Pathology, Division of Analyticalpathology, Ehime University Graduate School of Medicine, Toon, Japan, ⁴Department of Immunology, Graduate School of Biomedical Sciences, Hiroshima University, Hirosima, Japan, ⁵Center for Rheumatic Diseases, Dohgo Spa Hospital, Matsuyama, Japan
Background/Purpose: It has been reported that serum survivin level was an independent risk factor for predicting joint destruction in early rheumatoid arthritis (RA). The proto-oncogene…
Abstract Number: 2876 • 2013 ACR/ARHP Annual Meeting
Key Rheumatoid Arthritis-Associated Pathogenic Pathways Revealed By Integrative Analysis Of RA Omics Datasets
John Whitaker¹, Wei Wang² and Gary S. Firestein³, ¹Chemistry, UCSD School of Medicine, La Jolla, CA, ²Chemistry, UCSD, La Jolla, CA, ³Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Genome-wide analysis of RA has independently evaluated DNA sequence variation, differential RNA expression, and differential DNA methylation. Each approach alone implicates promising pathways…
Abstract Number: 1153 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Synovial Fibroblasts Lack Tolerization Of Inflammatory Cytokines and Matrix Degrading Enzymes After Repeated LPS Stimulation
Kerstin Klein¹, Renate E. Gay², Christoph Kolling³, Adrian Ciurea⁴, Beat A. Michel⁵, Lih-Ling Lin⁶, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ³Schultess Clinic, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Inflammation and Remodeling Research Unit, Pfizer, Cambridge, MA
Background/Purpose: In macrophages, repeated stimulation of Toll-like receptor (TLR) 4 leads to adaptation of signaling pathways and epigenetic modifications resulting in a tolerant state of…
Abstract Number: 2735 • 2013 ACR/ARHP Annual Meeting
Integrative Analysis Of Multiple Omics Technologies Reveals a Novel Therapeutic Target For Rheumatoid Arthritis (RA)
David L. Boyle¹, John Whitaker², Beatrix Bartok³, Wei Wang⁴ and Gary S. Firestein⁵, ¹Div of Rheum, UCSD School of Medicine, La Jolla, CA, ²Chemistry, UCSD School of Medicine, La Jolla, CA, ³Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁴Chemistry, UCSD, La Jolla, CA, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Identifying novel therapeutic targets for immune-mediated disease has become increasingly challenging. We used an unbiased method to integrate multiple “omics” methodologies and evaluate…
Abstract Number: 948 • 2013 ACR/ARHP Annual Meeting
Dual Neutralization Of TNF and IL-17 Provides Greater Efficacy In Collagen Induced Arthritis Through Regulation Of a Gene Transcription Program That Includes CXCL1 and CXCL5
Carolyn Cuff¹, Chung-Ming Hsieh², Suzanne Mathieu³, Anwar Murtaza⁴, Margaret Hugunin³, Shaughn Bryant³, Robert O'brien³, Lisa Olson⁵ and Jeffrey Voss³, ¹Immunology, AbbVie, Inc, Worcester, MA, ²Biologics, AbbVie Pharmaceuticals, Worcester, MA, ³Immunology, AbbVie Pharmaceuticals, Worcester, MA, ⁴Broad Institute, Cambridge, MA, ⁵AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: Dual neutralization of TNF and IL-17 is hypothesized to provide greater efficacy in rheumatoid arthritis (RA) and inflammatory diseases compared to either monotherapy as…

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