Abstract Number: 2707 • 2013 ACR/ARHP Annual Meeting
Downregulation Of KLF5 and Fli1 Cooperatively Contribute To Distinct Manifestations Of Systemic Sclerosis In Vitro and In Vivo
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by initial vascular injuries and resultant fibrosis of skin and certain internal organs. Although the…Abstract Number: 823 • 2013 ACR/ARHP Annual Meeting
Activation Of Liver X Receptors Inhibits Experimental Fibrosis By Interfering With Interleukin-6 Release From Macrophages
Background/Purpose: Liver X receptors (LXRs) are orphan nuclear receptors with emerging roles in metabolic and autoimmune diseases. Here, we investigated the role of LXRs in…Abstract Number: 2562 • 2013 ACR/ARHP Annual Meeting
Inhibition Of SOX9 Phosphorylation Abrogates The Increased Expression Of Profibrotic Genes In Systemic Sclerosis Dermal Fibroblasts
Background/Purpose: SOX9, a high mobility group transcription factor is a master regulator of chondrogenesis and plays a crucial role in the regulation of chondrocyte gene…Abstract Number: 776 • 2013 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Alpha Modifies Chromatin Landscape and Amplifies Inflammatory Responses To Subsequent Stimuli In Synovial Fibroblasts
Background/Purpose: Fibroblast-like synoviocytes (FLS) cross-talk with macrophages (Mf) during the course of rheumatoid arthritis (RA). Our group has shown that TNFa, primarily Mf-derived within synovium,…Abstract Number: 2564 • 2013 ACR/ARHP Annual Meeting
Functional Activation Of The TRPV1 and TRPV2 Non-Selective Cation Channels Potentiates TGF-β1-Induced Endothelial-To-Mesenchymal Transition In Murine Pulmonary Endothelial Cells Suggest a Potential Role Of Trpv Channels In The Pathogenesis Of Systemic Sclerosis
Background/Purpose: Transient receptor potential (Trp) cation channel, subfamily V (TRPV) members can impact a diverse range of vascular functions, including vascular tone, vascular permeability, mechanosensing,…Abstract Number: 652 • 2013 ACR/ARHP Annual Meeting
Pirfenidone and BIBF1120 Suppress Collagen Synthesis In Skin Fibroblast From Patients With Systemic Sclerosis
Background/Purpose: Pirfenidone (5-methyle-1-phenyl-2- [1H]-pyridone) and BIBF1120 (Nintedanib) are currently evaluated in clinical trials as a potential idiopathic pulmonary fibrosis (IPF). Pirfenidone was approved as the…Abstract Number: 2565 • 2013 ACR/ARHP Annual Meeting
Synergistic Effects Of Endothelin-1 On Transforming Growth Factor-β1 (TGF-β1) Induced Endothelial-To-Mesenchymal Transition. A Novel Mechanism For The Fibrogenic Effects Of Endothelin
Background/Purpose: The process of endothelial-to-mesenchymal transition (EndoMT) may be a crucial pathway in the generation of activated myofibroblasts, cells that play a pivotal role in…Abstract Number: 2560 • 2013 ACR/ARHP Annual Meeting
Analysis Of Global Gene Expression Of Pulmonary Endothelial Cells From Caveolin-1 Knock-Out Mice
Background/Purpose: Caveolin-1 (Cav-1) deficiency has recently been shown to participate in the pathogenesis of tissue fibrosis in Systemic Sclerosis (SSc). Although the mechanisms involved have…Abstract Number: 2568 • 2013 ACR/ARHP Annual Meeting
Involvement Of Collagen-Binding Heat Shock Protein 47 In The Scleroderma-Associated Fibrosis
Background/Purpose: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs, especially the uncontrolled fibrosis of multiple organs. Collagen is…Abstract Number: 2418 • 2013 ACR/ARHP Annual Meeting
The Transmembrane Protein Tyrosine Phosphatase Kappa Promotes Aggressiveness Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA these cells…Abstract Number: 2231 • 2013 ACR/ARHP Annual Meeting
The Actin-Crosslinking Protein Lasp-1 Regulates Synovial Fibroblast Migration and Cartilage Destruction In Arthritis
Background/Purpose: Lasp-1 localizes at focal adhesions along stress fibres and leading edges of migrating cells and regulates the metastatic dissemination of tumors. Although rheumatoid arthritis…Abstract Number: 2216 • 2013 ACR/ARHP Annual Meeting
Tubastatin A, a Selective Histone Deacetylase-6 Inhibitor, Suppresses Synovial Inflammation and Joint Destruction In a Collagen Antibody-Induced Arthritis Mouse Model
Background/Purpose: Histone deacetylases (HDAC) play a key role in regulating gene expression by deacetylasing histones, and HDAC inhibitors induce various cellular effects, including apoptosis, cell…Abstract Number: 2227 • 2013 ACR/ARHP Annual Meeting
The Anti-Proliferative Function of RSK2 in Synovial Fibroblasts Protects Against TNF-á-Induced Joint Destruction in Inflammatory Arthritis
Background/Purpose: The pro-inflammatory cytokine Tumor Necrosis Factor alpha (TNF-α) directly activates the ribosomal S6 kinase RSK2 in vitro. We recently demonstrated the protective effect of…Abstract Number: 2906 • 2013 ACR/ARHP Annual Meeting
Peripheral Blood Mononuclear Cells Co-Cultured With Autologous Skin Fibroblasts Up-Regulate IL-17A and Play Anti-Fibrotic Effects In Systemic Sclerosis
Background/Purpose: IL-17A has been recently implicated in the pathogenesis of systemic sclerosis (SSc). Therefore, we explored its expression and effects in peripheral blood mononuclear cells…Abstract Number: 1835 • 2013 ACR/ARHP Annual Meeting
Dynamic Visualization Of Monocyte Migration In 3D Synovial Micromass Tissue Cultures
Background/Purpose: Monocytes (Mo) are among the first hematopoietic cells to migrate into the inflamed synovial tissue of arthritic joints. Monocyte migration appears to be associated…
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