ACR Meeting Abstracts

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Abstracts tagged "Fibroblasts, Dermal"

  • Abstract Number: 2473 • ACR Convergence 2024

    Criterion Validity of Modified Rodnan Skin Score: Does It Capture Skin Thickness or Hardening? Results of a Large Skin Histology Study

    Shervin Assassi1, Ruhani Desai2, Jeffrey Browning3, Samuel Theodore1, Meng Zhang1, Brian Skaug1, Jerry Alonso1, Zsuzsanna McMahan1, Maureen Mayes1 and Minghua Wu1, 1UTHealth Houston Division of Rheumatology, Houston, TX, 2UTHealth Houston Division of Rheumatology, DeLand, FL, 3Boston University, Cambridge, MA

    Background/Purpose: Modified Rodnan Skin Score is a widely used outcome measure for skin involvement in systemic sclerosis (SSc). Its criterion validity (comparison to the gold…
  • Abstract Number: 0970 • ACR Convergence 2024

    Deubiquitylase (DUB) BRCC36 Isopeptidase Complex (BRISC) Inhibitors Prevent IFNAR1 Deubiquitination to Restore Natural Type I IFN Response in Autoimmunity

    Rebecca Ross1, Poli Adi Narayanna Reddy2, Joseph Salvino2, Elton Zeqiraj3 and Francesco Del Galdo3, 1Medicine and Health, University of Leeds, Leeds, United Kingdom, 2The Wistar Institute, Philadelphia, PA, 3University of Leeds, Leeds, United Kingdom

    Background/Purpose: Increased Type I IFN activation plays a key role in Scleroderma (SSc), Systemic Lupus Erythematosus and Inflammatory Myositis. Deubiquitylase (DUB) BRCC36 isopeptidase complex (BRISC)…
  • Abstract Number: 2643 • ACR Convergence 2024

    Integrated Bulk and Single Cell RNA Sequencing Defines Key Pathways Regulating Myofibroblast Differentiation Across ANA Subgroups in Diffuse Systemic Sclerosis

    Kristina Clark1, Corrado Campochiaro2, Emma Derrett-Smith3, Voon Ong4, Christopher Buckley5 and Christopher Denton6, 1University of Oxford, Oxford, United Kingdom, 2IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milan, Milan, Italy, 3University College London Division of Medicine, Birmingham, United Kingdom, 4University College London, London, England, United Kingdom, 5Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 6University College London, Northwood, United Kingdom

    Background/Purpose: Myofibroblasts are key cells in the pathogenesis of systemic sclerosis (SSc).  TGFβ is a key growth factor driving myofibroblast formation in SSc.  The main…
  • Abstract Number: 1643 • ACR Convergence 2024

    Single Nuclei Multiome and Spatial Transcriptomic Analysis of Early, Untreated SSc Skin Identifies Signaling Interactions Between Macrophages and Fibroblasts

    Helen Jarnagin1, Dillon Popovich2, Rezvan Parvizi3, Rosemary Gedert4, Lam C. Tsoi5, Rachael Wasikowski5, Zhiyun Gong1, Madeline Morrisson6, Laurent Perreard7, Fred Kolling IV7, Dinesh Khanna4, Johann Gudjonsson4 and Michael Whitfield3, 1Dartmouth College, Lebanon, NH, 2Dartmouth College, West Lebanon, NH, 3Geisel School of Medicine at Dartmouth, Hanover, NH, 4University of Michigan, Ann Arbor, MI, 5Michigan, Dept. of Dermatology, Ann Arbor, MI, 6Geisel School of Medicine at Dartmouth College, Hanover, NH, 7Geisel School of Medicine, Dartmouth College, Lebanon

    Background/Purpose: We generated a vertically integrated dataset on treatment naïve patients with dcSSc (diffuse Systemic Sclerosis) skin that includes bulk RNA-seq, single nuclei multiome, and…
  • Abstract Number: 2644 • ACR Convergence 2024

    Baseline Fibroblast Immunophenotype Predicts Clinical Improvement Among Individuals with Early Diffuse Cutaneous Systemic Sclerosis

    Kimberly Lakin1, Robert Spiera2, John Spivack1, Yaxia Zhang1, Jessica Gordon3 and dana Orange4, 1Hospital for Special Surgery, New York, NY, 2Scleroderma, Vasculitis, and Myositis Center, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, 3Division of Rheumatology, Weill Cornell Medical College, New York, NY, 4Rockefeller University, New York, NY

    Background/Purpose: We have previously shown that fibroblast CD34 is low and alpha-smooth muscle actin (aSMA) is high in severe diffuse cutaneous systemic sclerosis (dcSSc) skin,…
  • Abstract Number: 1770 • ACR Convergence 2024

    Assessing S100A4 and Myofibroblast Phenotypes in the Pathogenesis of Cardiac and Cutaneous Neonatal Lupus

    Nalani Sachan1, Christina Firl2, Philip Carlucci3, Nicola Fraser2, Robert Clancy4 and Jill Buyon5, 1NYU Grossman School of Medicine, New York, NY, 2NYU Langone Health, New York, NY, 3New York University School of Medicine, New York, NY, 4Columbia University Medical Center, New York, NY, 5New York University Grossman School of Medicine, New York, NY

    Background/Purpose: Neonatal lupus (NL), driven by fetal exposure to maternal anti-SSA/Ro autoantibodies, typically results in permanent cardiac manifestations in utero and/or a transient rash postnatally.…
  • Abstract Number: 1815 • ACR Convergence 2024

    Leveraging Novel Systemic Sclerosis Disease Signatures to Build a Humanized Drug Discovery Funnel

    Lauren Reinke-Breen1, Laura Leys1, Sunhwa Kim2, Lauren Olson1, Anastasia Marinopoulos1, Chris Butler1, Jennifer Van Camp1 and Lisa Hazelwood1, 1AbbVie, North Chicago, IL, 2AbbVie, South San Francisco, CA

    Background/Purpose: Systemic sclerosis (SSc) is a chronic, progressive autoimmune disorder with significant morbidity and mortality. The lack of effective therapies for SSc is, in part,…
  • Abstract Number: 1818 • ACR Convergence 2024

    Distribution and Morphological Changes of Adventitial Fibroblasts in Healthy and Scleroderma Skin

    Banafsheh Nazari1, Tracy Tabib2, Christina Morse3 and Robert Lafyatis2, 1UPMC-Mercy, Pittsburgh, 2University of Pittsburgh, Pittsburgh, PA, 3University of Pittsburgh, Pittsburgh

    Background/Purpose: Our previous single-cell RNA-sequencing study identified two major fibroblast subpopulations in healthy skin biopsies: SFRP2/DPP4 and FMO1/LSP1 fibroblasts¹. Additionally, we discovered that adventitial fibroblasts…
  • Abstract Number: 0957 • ACR Convergence 2023

    Rationale for Targeting Insulin-like Growth Factor Signalling in Systemic Sclerosis

    Voon Ong1, Shiwen Xu2, Li Xue2, Brajesh Kumar3 and Christopher Denton2, 1UCL Medical School Royal Free Campus, London, United Kingdom, 2University College London, London, United Kingdom, 3Horizon Therapeutics, South San Francisco, CA

    Background/Purpose: Previous studies have shown that insulin like growth factor (IGF) pathways may promote extracellular matrix deposition and be upregulated in systemic sclerosis (SSc). Teprotumumab,…
  • Abstract Number: 0960 • ACR Convergence 2023

    MiR-3606-3p Alleviates Skin Fibrosis by Suppressing Fibroblast Inflammation and Migration via Inhibiting GAB1 and ITGAV

    yahui chen1, Mengkun shi1, Wei Wang1, Chenyi Shi1, Xueyi Xia1, wenyu Wu2, Jiucun Wang3 and Xiangguang Shi3, 1Fudan University, Shanghai, China, 2Huashan Hospital, Shanghai, China, 3Shanghai, Shanghai, China

    Background/Purpose: Systemic sclerosis (SSc) and keloid are typical skin fibrotic diseases with unclear epigenetic mechanisms and clinical targets. As an important epigenetic regulatory factor, microRNAs…
  • Abstract Number: 0085 • ACR Convergence 2023

    Fibroblasts Promote Upregulation of Cannabinoid Type 2 Receptor on Inflammatory Cells in Dermatomyositis

    DeAnna Diaz1, Muhammad Bashir1, Rohan Dhiman2, Avital Baniel1, Julianne Kleitsch1, Rachita Pandya1, Meena Sharma1, Thomas Vazquez1, Ming-Lin Liu2, Mariko Momohara2 and Victoria Werth3, 1Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3University of Pennsylvania and Corporal Michael J. Crescenz VAMC, Philadelphia, PA

    Background/Purpose: Dermatomyositis (DM) is a chronic, systemic autoimmune disease affecting the skin, muscle, and lungs. The activation of CB2R has been shown to reduce several,…
  • Abstract Number: 0963 • ACR Convergence 2023

    Anti-Topoisomerase Antibody in dcSSc: Unravelling Its Intracellular Effects in Systemic Sclerosis

    Maithri Aspari1, Josephine Geertsen Keller-Socin1, Stinne Greisen2, Esben Naeser3, Klaus Soendergaard4, Birgitta R Knudsen5, Voon Ong6, Christopher Denton7, David Abraham7 and Bent Deleuran1, 1Aarhus University, Aarhus, Denmark, 2Aarhus University/Aarhus University Hospital, Aarhus, Denmark, 3Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 4Aarhus University Hospital, Aarhus, Denmark, 5Institute for molecular Biology, Aarhus University, Aarhus, Denmark, 6UCL Medical School Royal Free Campus, London, United Kingdom, 7University College London, London, United Kingdom

    Background/Purpose: The presence of autoantibodies, especially directed towards topoisomerase I (ATA), in diffuse cutaneous Systemic Sclerosis (dcSSc) is known to be associated with severe clinical…
  • Abstract Number: 0787 • ACR Convergence 2023

    Understanding Distinct Resident and Migratory Fibroblast Populations in Systemic Sclerosis Skin Through Single-cell RNAseq and Immunohistochemistry

    Kristina Clark1, Shiwen Xu2, Voon Ong3, Christopher Buckley4 and Christopher Denton2, 1Barts Health NHS Trust, London, United Kingdom, 2University College London, London, United Kingdom, 3UCL Medical School Royal Free Campus, London, United Kingdom, 4University of Oxford, Oxford, United Kingdom

    Background/Purpose: We previously described distinct migratory and resident fibroblast populations from lesional skin biopsies in SSc patients. Both populations are profibrotic compared with those from…
  • Abstract Number: 0964 • ACR Convergence 2023

    Systemic Sclerosis (SSc) Dermal Fibroblasts Show Shortened Primary Cilia Due to Aberrant Aurora a Kinase Activation Independently of Transforming Growth Factor β Signalling

    Rebecca Wells1, Rebecca Ross2, Alex Timmis1, Ioanna Georgiou1, Colin Johnson1, Natalia Riobo-Del Galdo1 and Francesco Del Galdo3, 1University of Leeds, Leeds, United Kingdom, 2Medicine and Health, University of Leeds, Leeds, United Kingdom, 3University of Leeds - Leeds Institute of Rheumatic and Muskuloskeletal Medicine, Leeds, United Kingdom

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder characterised by abnormal activation of tissue fibroblasts, resulting in tissue and vascular fibrosis of the skin and…
  • Abstract Number: 0892 • ACR Convergence 2023

    Single-Cell RNA Sequencing Reveals Keratinocytes and Fibroblasts Drive Hippo and TGFb Dysregulation and Fibrosis in Epidermal Overexpression of VGLL3 in Cutaneous Lupus

    Mehrnaz Gharaee-Kermani1, Allison Billi1, Jacob Martens1, Marisa Hildebrandt1, Amanda Victory1, Mitra Maz2, Shannon Loftus1, J. Michelle Kahlenberg1 and Johann E. Gudjonsson1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Fibrosis is characterized by collagen deposition, fibro/myofibroblast (MYOFB) accumulation, and extracellular matrix remodeling. In some subtypes of cutaneous lupus erythematosus (CLE), particularly discoid lupus…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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