ACR Meeting Abstracts

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Abstracts tagged "Fc receptors"

  • Abstract Number: 0006 • ACR Convergence 2024

    NX-5948, a Clinical-Stage BTK Degrader, Achieves Deep Suppression of BCR, TLR, and FcR Signaling in Immune Cells and Demonstrates Efficacy in Preclinical Models of Arthritis and Other Inflammatory Diseases

    Mark Noviski1, Jun Ma1, Nivetha Brathaban1, Aishwarya Kumar1, Dhwani Haria1, Jenny McKinnell1, Robert Cass1, Frederick Cohen1, Davorka Messmer2, Gwenn Hansen1 and Ryan Rountree1, 1Nurix Therapeutics, San Francisco, CA, 2Nurix Therapeutics, San Diego, CA

    Background/Purpose: Bruton’s tyrosine kinase (BTK) mediates signaling downstream of the B cell receptor (BCR), toll-like receptors (TLRs), and Fc receptors (FcRs). This makes BTK an…
  • Abstract Number: 0808 • ACR Convergence 2024

    Confirmation of Second Trimester Trophoblast Transport of Maternal Anti-SSA/Ro52 and 60kD Autoantibodies in Cardiac Neonatal Lupus: Implications for FcRn Blockade

    Nicola Fraser1, Mala Masson2, Robert Clancy3, Philip Carlucci4, Peter Izmirly5, Nalani Sachan6, Justin Brandt1, Kristen Thomas1, Melanie Fox7, Colin Phoon1, Achiau Ludomirsky1, Ranjini Srinivasan1, Garrett Lam8, Bettina Cuneo9 and Jill Buyon10, 1NYU Langone Health, New York, NY, 2NYU Langone Medical Center- Division of Rheumatology, New York, NY, 3Columbia University Medical Center, New York, NY, 4New York University School of Medicine, New York, NY, 5New York University Grossman School of Medicine, New York, NY, 6NYU Grossman School of Medicine, New York, NY, 7Renown Health, Reno, NV, 8Intermountain Health, Provo, UT, 9University of Arizona College of Medicine, Tucson, AZ, 10New York University Grossman School of Medicine, New York, NY

    Background/Purpose: The nearly invariant finding of anti-SSA/Ro52/60kD autoantibodies in pregnancies complicated by cardiac neonatal lupus (cardiac-NL), which manifests as fetal atrioventricular block and endocardial fibroelastosis…
  • Abstract Number: 0840 • ACR Convergence 2024

    The Platelet Adenosinergic Axis as a Novel Therapeutic Target for Thrombotic APS

    NaveenKumar Somanathapura K1, Thalia Newman2, Srilakshmi Yalavarthi1, Bruna Mazetto Fonseca1, Kaitlyn Sabb1, Katarina Kmetova3, Emily Chong1, Caroline Ranger1, Cyrus Sarosh4, Jacqueline Madison1, Ajay Tambralli1, Jordan Schaefer1, Michael Holinstat1, Yu Zuo1 and Jason Knight1, 1University of Michigan, Ann arbor, MI, 2University of Michigan, Ann Arbor, MI, 3Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, MI, 4University of Michigan, Temperance, MI

    Background/Purpose: How to most effectively inhibit antiphospholipid antibodies (aPL)-mediated platelet activation remains incompletely understood. CD73 is an ectoenzyme expressed on the platelet surface that generates…
  • Abstract Number: 1795 • ACR Convergence 2024

    Immune Complexes-Mediated Activation of Neutrophils in Systemic Lupus Erythematosus Is Dependent on RNA Recognition by TLR8

    Ting Wang1, Runa Kuley2, Payton Hermanson2, Gundula Min-oo3, Natasha Crellin4, Ching Shang3 and Christian Lood1, 1University of Washington, Seattle, WA, 2University of Washington, Seattle, 3Gilead Sciences, Foster City, CA, 4Gilead, Foster City, CA

    Background/Purpose: Neutrophil activation has been implicated to contribute to the systemic lupus erythematosus (SLE) pathogenesis. However, factors and mechanisms promoting neutrophil activation in SLE have…
  • Abstract Number: 1864 • ACR Convergence 2024

    S-4321, a Novel Dual-cell Bidirectional PD-1:FcγRIIb Selective Agonist Antibody for the Treatment of Autoimmune Disease

    Julia Manasson1, Marisella Panduro2, Michael Cianci2, Minasri Borah2, Stephanie Grebinoski2, Joshua Vitlip2, Stephen Lutz2, Ishan Sharma2, Elliott Wittenberg2, Allison Colthart2, Samuel Perry2, Maria Cecilia Ramello2, Chelsea R. Parker Harp2, Jyothsna Visweswaraiah2, Ryan Peckner2, Alex Pellerin2, Heather Vital3, John Sundy4, Nathan Higginson-Scott2, Kevin L. Otipoby2 and Daniela Cipolletta2, 1Seismic Therapeutic, New York, NY, 2Seismic Therapeutic, Watertown, MA, 3Seismic Therapeutic, Lexington, MA, 4Seismic Therapeutic, Chapel Hill, NC

    Background/Purpose: The dysregulation of immune checkpoint receptors on T cells and antigen presenting cells (APCs) drives autoimmunity while receptor agonism is expected to restore immune…
  • Abstract Number: 1978.5 • ACR Convergence 2024

    Post-Hoc Analysis of Clinically Relevant Anti-Vaccine Antibodies in Participants with Rheumatoid Arthritis Treated with Nipocalimab

    Faye Yu1, Eugene Myshkin2, Carolina Bobadilla Mendez3, Marta Cossu4, Kaiyin Fei5, Qingmin Wang6, Matthew J. Loza6, Dessislava Dimitrova3 and Sheng Gao3, 1Janssen Research & Development, LLC, a Johnson & Johnson company, Cambridge, MA, USA, MA, MA, 2Janssen Research & Development, LLC, a Johnson & Johnson company, Cambridge, MA, 3Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, 4Janssen Pharmaceutical Research and Development, a Johnson & Johnson company, Leiden, Netherlands, 5Janssen Research & Development, LLC, Spring House, PA, 6Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, USA, Spring House, PA

    Background/Purpose: Nipocalimab is a fully human, high affinity, aglycosylated, effectorless IgG1 monoclonal antibody designed to selectively block neonatal fragment crystallizable receptor (FcRn), thereby lowering IgG…
  • Abstract Number: 1988 • ACR Convergence 2024

    A Randomized, Open-Label Study on the Effect of Nipocalimab on Vaccine Responses in Healthy Participants

    Marta Cossu1, Carolina Bobadilla Mendez2, Amanda Jackson3, Eugene Myshkin4, Grace Liu5, Edwin Lam6, Ulf H. Beier2, Kathleen Weisel2, Brittney Scott2, Jocelyn H. Leu6, Sheng Gao2 and Dessislava Dimitrova2, 1Janssen Pharmaceutical Research and Development, a Johnson & Johnson company, Leiden, Netherlands, 2Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, 3Janssen Research & Development, LLC, La Jolla, CA, 4Janssen Research & Development, LLC, a Johnson & Johnson company, Cambridge, MA, 5Janssen Research & Development, LLC, a Johnson & Johnson company, Raritan, NJ, 6Janssen Research & Development, LLC, a Johnson & Johnson company, Spring House, PA, PA

    Background/Purpose: Nipocalimab is a human IgG1 monoclonal antibody targeting the neonatal Fc receptor (FcRn) that selectively reduces IgG levels without impacting antigen presentation, T- and…
  • Abstract Number: 2254 • ACR Convergence 2024

    A Phase 1 Single Ascending Dose Study to Evaluate the Safety and Pharmacokinetics of ZB004, a CTLA-4-Ig Fusion Protein Designed for Increased Binding Affinity and Extended Half-life, in Healthy Volunteers

    Cory Sellwood1, Minggeng Gao2, Sheen Zhang2, Mark Matijevic2, Stephen Wax3, Mason Yamashita2, Shan Yu2, Sujata Arora2 and Rachel Kirk2, 1New Zealand Clinical Research, Christchurch, New Zealand, 2Zenas BioPharma, Waltham, MA, 3Former Employee of Zenas Biopharma, Newton, MA

    Background/Purpose: ZB004 is a bioengineered cytotoxic T-lymphocyte-associated antigen 4 ‑immunoglobulin (CTLA-4-Ig) fusion protein. Its mechanism of action is selective inhibition of T lymphocyte (T cell)…
  • Abstract Number: 2527 • ACR Convergence 2024

    Efficacy and Safety of Nipocalimab, an Anti-FcRn Monoclonal Antibody, in Primary Sjogren’s Disease: Results from a Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study (DAHLIAS)

    Jacques-Eric Gottenberg1, Kathy Sivils2, Kim Campbell3, Jada Idokogi3, Kim Lo3, Sophia G. Liva3, Jonathan Shelton4, Harman Dhatt5, Jonathan J. Hubbard3 and Ghaith Noaiseh6, 1Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, 2Johnson & Johnson Innovative Medicine, Edmond, OK, 3Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, PA, 4Janssen Scientific Affairs, LLC, San Diego, CA, USA, San Diego, 5Janssen Global Services, LLC, a Johnson & Johnson Company, Raritan, NJ, USA, Raritan, NJ, 6University of Kansas Medical Center, Kansas City, KS

    Background/Purpose: Sjögren’s disease (SjD) is a chronic, systemic autoimmune disease characterized by the presence of specific autoantibodies (AAb) and lymphocytic infiltration of exocrine glandular tissues.…
  • Abstract Number: 0051 • ACR Convergence 2023

    CD14+CD64+ Classical Monocytes Are the Main Producers of IL-23 at the Enthesis

    Nicole McDermott1, Thomas Macleod1, Ala Altaie1, Liz Straszynski2, Robert Dunsmuir3, Vishal Borse3, Peter Loughenbury3, Davide Simone4, Stevephen Sansom4, Christopher Buckley4 and Dennis McGonagle5, 1University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 2Leeds Institute of Medical Research at St. James’s, Leeds, United Kingdom, 3Leeds Teaching Hospital NHS Trust, Leeds, United Kingdom, 4Kennedy Institute of Rheumatology, Oxford, United Kingdom, 5Leeds Biomedical Research Centre, University of Leeds, Leeds, United Kingdom

    Background/Purpose: IL-23 is a key cytokine involved in diseases such as psoriasis, psoriatic arthritis and spondyloarthropathies (SpA) and inflammatory bowel disease.IL-23 is produced by activated…
  • Abstract Number: 2144 • ACR Convergence 2023

    Pharmacodynamic Effects of Nipocalimab in Patients with Moderate to Severe Active Rheumatoid Arthritis (RA): Results from the Multicenter, Randomized, Double-blinded, Placebo-controlled Phase 2A IRIS-RA Study

    Rohit Panchakshari1, Matthew Loza2, Thomas Huizinga3, Georg Schett4, Keying Ma2, Jocelyn H. Leu2, Sophia G. Liva2, Fowzia Ibrahim5, Bei Zhou6, Qingmin Wang2, Ricardo Rojo Cella2, Chetan S. Karyekar2, Kaiyin Fei2, Carolyn Cuff7 and Sheng Gao2, 1Janssen Research & Development, LLC, La Jolla, CA, 2Janssen Research & Development, LLC, Spring House, PA, 3Leiden University Medical Center, Leiden, Netherlands, 4Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 5Janssen Research & Development, LLC, High Wycombe, United Kingdom, 6Janssen Research & Development, LLC, Chesterbrook, PA, 7Janssen Research & Development, LLC, Cambridge, MA

    Background/Purpose: Nipocalimab is a fully human, immunoglobulin G (IgG) 1 monoclonal antibody that blocks the neonatal crystallizable fragment receptor (FcRn), thereby lowering IgG levels. RA…
  • Abstract Number: 2232 • ACR Convergence 2023

    Guselkumab, an IL-23p19 Subunit–specific Monoclonal Antibody, Is Able to Bind CD64+ Myeloid Cells, Potently Neutralize IL-23 Produced from the Cells, and Mediate Internalization of IL-23

    Dennis McGonagle1, raja atreya2, Maria Abreu3, James Krueger4, Kilian Eyerich5, Robert Bissonnette6, Kacey Sachen7, Carrie Greving7, Brian Stoveken8, Deepa Hammaker7, Kristin Leppard8, John Hartman8, Phuc Bao7, Eilyn Lacy8, Indra Sarabia7, Janise Deming7, Matthew Duprie8, Joseph Brown7, Christopher T Ritchlin9, Iain McInnes10, Matthieu Allez11 and Anne Fourie7, 1Leeds Biomedical Research Centre, University of Leeds, Leeds, United Kingdom, 2Erlangen University Hospital, Friedrich-Alexander-Univrsität Erlangen-Nürnberg, Erlangen, Germany, 3University of Miami, Leonard Miller School of Medicine, Miami, FL, 4The Rockefeller University, Laboratory for Investigative Dermatology, New York, NY, 5Medical Center, University of Freiburg; Karolinska Institute, Department of Medicine - Division of Dermatology and Venereology, Stockholm, Sweden, 6Innovaderm Research Inc, Medical Director, Montréal, QC, Canada, 7Janssen Research and Development, LLC, Immunology, San Diego, CA, 8Janssen Research & Development, LLC, Therapeutics Discovery, Spring House, PA, 9University of Rochester Medical School, Allergy, Immunology & Rheumatology Division, Canandaigua, NY, 10University of Glasgow, Glasgow, United Kingdom, 11Hôpital Saint-Louis, Université Paris Cité, Paris, France

    Background/Purpose: Monoclonal antibodies (mAbs) targeting the interleukin (IL)-23p19 subunit are effective in treating psoriatic disease; however, their molecular attributes may translate to differences in clinical…
  • Abstract Number: 1854 • ACR Convergence 2022

    Nipocalimab’s Selective Targeting of FcRn and IgG Clearance Preserves Key Immune Functions

    Leona Ling1, Steven Tyler2, Christopher J. Beneduce3, Federico Zazzetti4, Faye Yu3, Julia Brown3, Sujatha Kumar5, Rui Xu6, Jay Duffner7 and William Avery8, 1Janssen Research & Development, LLC, Cambridge, MA, 2Genevant Therapeutics, Cambridge, MA, 3Janssen Research and Development, Cambridge, MA, 4Janssen Medical Affairs Global Services, LLC, Buenos Aires, Argentina, 5GlaxoSmithKline, Boston, MA, 6Janssen Research and Development, San Diego, CA, 7Faze Medicines, Cambridge, MA, 8Kisbee Therapeutics, Boston, MA

    Background/Purpose: Nipocalimab, a fully human, effectorless IgG1 anti-neonatal Fc receptor (FcRn) monoclonal antibody, binds to FcRn with high affinity which prevents IgG recycling, leading to…
  • Abstract Number: 2030 • ACR Convergence 2022

    Designing of a Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Assess the Efficacy and Safety of Nipocalimab, an FcRn Inhibitor, in Adults with Primary Sjögren’s Syndrome

    Jonathan Hubbard1, Kim Campbell1, Kathy Sivils1, Robert Hoffman1, Kim Hung Lo1, Jocelyn Leu1, Sophia Liva1, Qing Zuraw1, Anne Stevens1, Leona Ling2, Keith Karcher3, Sindhu Ramchandren3, Hong Sun3, Hal Scofield4, Daniel Wallace5 and Raphaèle Seror6, 1Janssen Research and Development, LLC, Spring House, PA, 2Janssen Research & Development, LLC, Cambridge, MA, 3Janssen Research & Development, LLC, Titusville, NJ, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Cedars-Sinai Medical Center, Los Angeles, CA, 6University Hospital Paris-Saclay, Le Kremlin Bicêtre, France

    Background/Purpose: Dysregulated humoral immunity is a hallmark of primary Sjögren's Syndrome (pSS). This dysregulation involves aberrant B-lymphocyte activity resulting in abnormally high immunoglobulin G (IgG)…
  • Abstract Number: 0044 • ACR Convergence 2021

    Autoantibodies Against Malondialdehyde-modifications Promote Osteoclast Development by Reprogramming Cellular Metabolism

    Koji Sakuraba1, Akilan Krishnamurthy1, Alexandra Circiumaru2, Jitong Sun1, Vijay Joshua1, Heidi Wähämaa1, Marianne Engström1, Meng Sun1, Xiaowei Zheng1, Cheng Xu1, khaled amara1, Vivianne Malmström1, Sergiu Catrina1, Caroline Grönwall1, Anca Catrina1 and Bence Réthi1, 1Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 2Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm Region, Stockholm, Sweden

    Background/Purpose: Malondialdehyde (MDA) is a highly reactive compound generated during lipid-peroxidation in conditions associated with oxidative stress. MDA can irreversibly modify proteins (e.g. lysine, arginine…
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