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Abstracts tagged "etanercept"

  • Abstract Number: 515 • 2017 ACR/ARHP Annual Meeting

    Leukopenia and Tumor Necrosis Factor Alpha Inhibitor Therapy

    Wenlu Xiong1, Rochella A. Ostrowski2, William Adams3 and Rodney Tehrani4, 1Rheumatology, Vanderbilt University Medical Center, Nashville, TN, 2Rheumatology, Loyola University Medical Center, Maywood, IL, 3Clinical Research Office, Loyola University Medical Center, Maywood, IL, 4Rheumatology & Immunology, Loyola University Medical Center, Maywood, IL

    -      Background/Purpose:  Tumor necrosis factor (TNF) alpha, a key proinflammatory cytokine in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), has been a major target in…
  • Abstract Number: 2274 • 2017 ACR/ARHP Annual Meeting

    Risk of Serious Events, Serious Infections, Uveitis, Crohn’s Disease, Colitis and Malignancies in Patients with Juvenile Idiopathic Arthritis on Continuous Treatment with Etanercept over Time: A Report from a Biologics Registry

    Gerd Horneff1, Frank Weller-Heinemann2, Toni Hospach3, Prasad Oommen4, Gerd Ganser5, Johannes Peter Haas6, K Minden7 and Ariane Klein8, 1Asklepios Clinic, Sankt Augustin, Germany, 2PRINTO, Genoa, Italy, 3Pediatrics, Olgahospital, Klinikum Stuttgart, Stuttgard, Germany, 4University Duesseldorf, Duesseldorf, Germany, 5Pediatric Rheumatology, Sankt Josef Stift Sendenhorst, Sendenhorst, Germany, 6Centre for Pediatric Rheumatology Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany, 7Charité – University of Medicine Berlin, Berlin, Germany, 8Center of Pediatrics and Neonatology, Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany

    Background/Purpose: To investigate changes in the risk for adverse events of special interest in juvenile idiopathic arthritis (JIA) patients treated with Etanercept documented in the…
  • Abstract Number: 2279 • 2017 ACR/ARHP Annual Meeting

    Dynamics of Concomitant Therapy in Children with Juvenile Idiopathic Arthritis Treated with Etanercept

    Ekaterina Alexeeva1,2, Tatiana Dvoryakovskaya1,2, Victor Gladkikh3,4, Andrei Moskalev4,5, Rina Denisova2, Ksenia Isaeva2, Olga Lomakina2, Margarita Soloshenko2 and Anna Karaseva2, 1Pediatrics, The Federal State Autonomous Educational Institution of Higher Education The First Moscow State Medical University named after I.M. Sechenov Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation, 2Reumatology department, Federal State Autonomous Institution"National Scientific and Practical Center of Children's Health"Of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, 3Department of Biostatistics, EOL Labs ltd, Novosibirsk, Rwanda, 4Laboratory of Computational Physics, Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russian Federation, 5Department of Biostatistics, EOL Labs ltd, Novosibirsk, Russian Federation

    Background/Purpose: The effectiveness of target use of biological medications depends on how personalized they are to fit patient’s individual parameters with juvenile idiopathic arthritis (JIA).…
  • Abstract Number: 2298 • 2017 ACR/ARHP Annual Meeting

    Etanercept, Adalimumab and Methotexate Utilization By Juvenile Idopathic Arthritis Patients and the Occurrence of Uveitis

    Katherine Roshak1, Joan M Sopczynski2, Ricardo Suehiro2 and Lisa Marshall1, 1Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, 2Pfizer, Collegeville, PA

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is a chronic arthritis with onset before 16 years of age, that persists for at least 6 weeks, and has…
  • Abstract Number: 2455 • 2017 ACR/ARHP Annual Meeting

    Efficacy of Etanercept in Elderly Patients with Rheumatoid Arthritis

    Christopher J. Edwards1, Katherine Roshak2, Jack F Bukowski3, Ronald Pedersen4, Mazhar Thakur5, Lisa Marshall2 and Heather Jones2, 1University Hospital Southampton, Southampton, United Kingdom, 2Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, 3Clinical Affairs, Pfizer, Collegeville, PA, 4Department of Biostatistics, Pfizer, Collegeville, PA, 5Pfizer Ltd, Sandwich, United Kingdom

    Background/Purpose: Ageing is associated with declining immune cell function and age-related comorbidities.1,2 In the US, the prevalence of rheumatoid arthritis (RA) is ~2% in individuals…
  • Abstract Number: 2492 • 2017 ACR/ARHP Annual Meeting

    The Long-Term Safety and Durability of Response of Chs-0214, a Proposed Biosimilar to Etanercept: An Open-Label Safety Extension Study

    Ingrid Louw1, Alan J. Kivitz2, Tsutomu Takeuchi3, Yoshiya Tanaka4, Satoshi Nakashima5, Jennifer Hodge6, Hong Tang6, Paula O'Connor6 and Barbara Finck6, 1Panorama Medical Centre, Cape Town, South Africa, 2Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, 3Keio University School of Medicine, Tokyo, Japan, 4School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, 5Daiichi Sankyo, Tokyo, Japan, 6Coherus BioSciences, Inc., Redwood City, CA

    Background/Purpose: CHS-0214 is a proposed biosimilar to etanercept for the treatment of rheumatoid arthritis and other auto-immune diseases. Two randomized, double-blind studies demonstrated equivalence of…
  • Abstract Number: 75 • 2017 ACR/ARHP Annual Meeting

    Factors Associated with TNF Receptor 2 Levels Above the Measurable Range in Rheumatoid Arthritis

    Michelle Frits1, Gary Bradwin2, Nancy A. Shadick1, Christine Iannaccone3, Michael Weinblatt1, Nader Rifai2 and Katherine P. Liao4, 1Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Laboratory Medicine, Childrens Hospital Boston, Boston, MA, 3Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 4Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Tumor necrosis factor-alpha (TNFa) is involved in the pathogenesis of RA and is increasingly being studied as a biomarker of cardiovascular disease (CVD).  While…
  • Abstract Number: 50 • 2017 Pediatric Rheumatology Symposium

    Tumor necrosis factor-α (TNFα) inhibitor-induced psoriasis in juvenile idiopathic arthritis (JIA) patients

    Daniel Groth1, Sivia Lapidus2, Simona Nativ2 and Maria Perez3, 1Goryeb Children's Hospital, Morristown, NJ, 2Pediatric Rheumatology, Goryeb Children's Hospital, Morristown, NJ, 3Pediatric Gastroenterology, Goryeb Children's Hospital, Morristown, NJ

    Background/Purpose: Occurrence of psoriasis while on TNFα antagonists is a paradoxical effect of agents that treat psoriasis, and is described in larger cohorts of inflammatory…
  • Abstract Number: 3L • 2016 ACR/ARHP Annual Meeting

    Comparative Cardiovascular Safety of Tocilizumab Vs Etanercept in Rheumatoid Arthritis: Results of a Randomized, Parallel-Group, Multicenter, Noninferiority, Phase 4 Clinical Trial

    Jon T. Giles1, Naveed Sattar2, Sherine E. Gabriel3, Paul M. Ridker4, Steffen Gay5, Charles Warne6, David Musselman7, Laura Brockwell6, Emma Shittu6, Micki Klearman7 and Thomas Fleming8, 1Columbia University, College of Physicians and Surgeons, New York, NY, 2Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, 3Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 4Center for Cardiovascular Disease Prevention, Harvard Medical School, Boston, MA, 5University Hospital Zurich, Department of Rheumatology, Zurich, Switzerland, 6Roche Products Ltd., Welwyn Garden City, United Kingdom, 7Genentech, South San Francisco, CA, 8University of Washington, Department of Biostatistics, Seattle, WA

    Background/Purpose: Treatment of rheumatoid arthritis (RA) with tocilizumab (TCZ), a humanized monoclonal antibody directed against the IL-6 receptor, is associated with clinical efficacy and marked…
  • Abstract Number: 631 • 2016 ACR/ARHP Annual Meeting

    Biologic Free Remission Rate with Etanercept in Rheumatoid Arthritis: A Potential Role of Gender

    Alfredomaria Lurati1, Magda Scarpellini2, Katia Angela re3, Mariagrazia Marrazza3, Daniela Mazzocchi3 and Antonella Laria4, 1Fornaroli Hospital Rheumatology Unit Magenta Italy, Magenta, Italy, 2Rheumatology Unit, Ospedale Fornaroli, Magenta, Italy, 3Fornaroli Hospital, Rheumatology Unit, MAgenta, Italy, 4Fornaroli Hospital, Rheumatology Unit, Magenta, Italy

    Biologic free remission rate with etanercept in rheumatoid arthritis: a potential role of gender A.M. Lurati and A. Laria, D. Mazzocchi, K.A. Re, M. Marrazza,…
  • Abstract Number: 642 • 2016 ACR/ARHP Annual Meeting

    Quality of Life Outcomes Following Therapy with Chs-0214 and Etanercept (Enbrel): Randomized, Double-Blind Study in Subjects with Rheumatoid Arthritis

    Alan J. Kivitz1,2, James R. O'Dell3, Tsutomu Takeuchi4, Yoshiya Tanaka5, Satoshi Nakashima6, Cass Kelleher7, Jennifer Hodge8, Barbara Finck7 and RApsody Study Group, 1Altoona Center for Clinical Research, Duncansville, PA, 2Altoona Arthritis & Osteoporosis Center, Duncansville, PA, 3Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 4Division of Rheumatology, Department of Internal Medicine,, Keio University School of Medicine, Tokyo, Japan, 5The First Department of Internal Medicine,, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, 6Daiishi Sankyo, Shinagawa-Ku Tokyo, Japan, 7Clinical Science, Coherus BioSciences, Redwood City, CA, 8Coherus BioSciences, Redwood City, CA

    Background/Purpose:  CHS-0214 is in development as a proposed biosimilar of etanercept. This Phase III confirmatory, safety and efficacy study randomized and dosed 644 subjects with…
  • Abstract Number: 736 • 2016 ACR/ARHP Annual Meeting

    A Multi-Center, Open Label, Randomized Clinical Tries of Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Ankylosing Spondylitis

    Jieruo Gu1, Liudan Tu2, Minjing Zhao3, Zhiming Lin4, Zetao Liao5, Shuangyan Cao6, Qinghong Yu7 and Zhizhong Ye8, 1Rheumatology, Third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, 2The Third Hospital of Sun Yat-sen University, Guangzhou, China, 3The Third Affiliated Hospital of Sun Yat-sen University, guangzhou, China, 4Rheumatology, 3rd Affiliated Hospital of Sun Yat-Sen Uni, Guangzhou, China, 5Rheumatology, 3rd Affiliated Hoapital of Sun Yat-Sen Uni, Guangzhou, China, 6Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 7Department of Rheumatology, Fourth People’s Hospital of Shenzhen City, Xiangmi Lake branch, Guangzhou, China, 8Department of Rheumatology,ZhuJiang Hospital of Southern Medical University, Guangzhou, China

    Background/Purpose: To compare the clinical、radiographic and magnatic resonance imaging change in active ankylosing spondylitis patients with etanercept and celecoxib alone/combined treatment,and to evaluate the effectiveness…
  • Abstract Number: 1101 • 2016 ACR/ARHP Annual Meeting

    Adalimumab:TNF Complexes Induce a Divergent Proteomic Profile in Human Osteoclast Precursors to That Resembling a Monocytic Cell

    Bohdan P. Harvey1, Chenqi Hu2, Dongdong Wang2, Yu Tian2 and Zehra Kaymakcalan1, 1Global Biologics, AbbVie Bioresearch Center, Worcester, MA, 2DMPK-BA, AbbVie Bioresearch Center, Worcester, MA

    Background/Purpose:  TNF has been shown to contribute to osteoclastogenesis independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast (OC) development.…
  • Abstract Number: 1709 • 2016 ACR/ARHP Annual Meeting

    Randomized, Double-Blind Study Comparing Chs-0214 with Etanercept (Enbrel) in Patients with Psoriasis and Psoriatic Arthritis

    Alan J. Kivitz1, Kim Papp2, Alim Devani3, Andreas Pinter4, Rodney Sinclair5,6,7, Michael Ziv8, John Caminis9, Cass Kelleher10, Helen Tang11, Barbara Finck10 and RaPsOdy study group , 1Altoona Center for Clinical Research, Duncansville, PA, 2K Papp Clinical Research, Inc. and Probity Medical Research, Waterloo, ON, Canada, 3Institute for Skin Advancement, Surgical and Cosmetic Dermatology, Calgary, AB, Canada, 4Dept. of Dermatology, Venereology and Allergology, Theodor-Stern-Kai 7, Frankfurt, Germany, 5University of Melbourne, E. Melbourne, Australia, 6Epworth Healthcare, E. Melbourne, Australia, 7Sinclair Dermatology Investigational Research, Education and Clinical Trials, E. Melbourne, Australia, 8Dept of Dermatology, Emek Medical Center, Afula, Israel, 9Shire, cambridge, MA, 10Clinical Science, Coherus BioSciences, Redwood City, CA, 11Coherus BioSciences, Redwood City, CA

    Background/Purpose:  CHS-0214 is a proposed biosimilar of etanercept, a fusion protein inhibiting tumor necrosis factor. This Phase III multi-center study compared the efficacy and safety…
  • Abstract Number: 2231 • 2016 ACR/ARHP Annual Meeting

    Change in Health Care Utilization after Etanercept Initiation in Patients with Rheumatoid Arthritis

    Neil Accortt1, Jennifer Schenfeld2,3, Eunice Chang4, Elya Papoyan4 and Michael S. Broder4, 1Center for Observational Research, Amgen, Inc, Thousand Oaks, CA, 2Docs Global, Inc, North Wales, PA, 3Amgen Inc., Thousand Oaks, CA, 4Partnership for Health Analytic Research, LLC, Beverly Hills, CA

    Background/Purpose: Patients with rheumatoid arthritis (RA) have higher healthcare utilization (HCU) and costs than patients without RA1. Evidence is mixed as to the impact of…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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