ACR Meeting Abstracts

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Abstracts tagged "etanercept"

  • Abstract Number: 0249 • ACR Convergence 2021

    Open-label, Long-term (10-year) Study of the Safety of Etanercept in Children with Extended Oligoarticular Arthritis, Enthesitis-related Arthritis, or Psoriatic Arthritis

    Jelena Vojinović1, Joke Dehoorne2, Violeta Panaviene3, Gordana Susic4, Gerd Horneff5, Valda Stanevicha6, Katarzyna Kobusinska7, Zbigniew Zuber8, Bogna Dobrzyniecka9, Jonathan Akikusa10, Tadej Avcin11, Alberto Martini12, Cecilia Borlenghi13, Edmund Arthur14, Svitlana Tatulych15, Chuanbo Zang16, Bonnie Vlahos16 and Nicolino Ruperto17, 1Paediatric Rheumatology International Trials Organisation (PRINTO), Nis, Serbia, 2Paediatric Rheumatology International Trials Organisation (PRINTO), Gent, Belgium, 3Paediatric Rheumatology International Trials Organisation (PRINTO), Vilnius, Lithuania, 4Paediatric Rheumatology International Trials Organisation (PRINTO), Belgrade, Serbia, 5Paediatric Rheumatology International Trials Organisation (PRINTO), Sankt Augustin, Germany, 6Paediatric Rheumatology International Trials Organisation (PRINTO), Riga, Latvia, 7Paediatric Rheumatology International Trials Organisation (PRINTO), Bydgoszcz, Poland, 8Paediatric Rheumatology International Trials Organisation (PRINTO), Lodz, Poland, 9Paediatric Rheumatology International Trials Organisation (PRINTO), Warsaw, Poland, 10Paediatric Rheumatology International Trials Organisation (PRINTO), Melbourne, Australia, 11Paediatric Rheumatology International Trials Organisation (PRINTO), Ljubljana, Slovenia, 12Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, 13Pfizer, Buenos Aires, Argentina, Buenos Aires, Argentina, 14Pfizer, Peapack, NJ, 15Pfizer, Groton, CT, 16Pfizer, Collegeville, PA, 17IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy

    Background/Purpose: CLIPPER2 was an 8-year, open-label extension of the phase 3b, multicenter, 2-year CLIPPER study of the safety and efficacy of etanercept (ETN) in the…
  • Abstract Number: 1885 • ACR Convergence 2020

    Performance of SASDAS (Simplified Axial Spondyloarthritis Disease Activity Score) versus ASDAS in a Post Hoc Analysis of a Randomized Controlled Clinical Trial

    Emilce Schneeberger1, Gustavo Citera2, Dario Ponce de Leon3, Annette Szumski4, Kenneth Kwok5, Mariel Cutri6 and Maxime Dougados7, 1Department of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 2Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 3PFIZER, LIMA, Peru, 4Syneos Health, Princeton, 5Pfizer, New York, NY, 6Pfizer, Buenos Aires, Argentina, 7Department of Rheumatology, Hopital Cochin, Université de Paris, Paris, France

    Background/Purpose: The Ankylosing Spondylitis Disease Activity Score (ASDAS) assesses axial spondyloarthritis (axSpA) with good internal consistency and discriminative capacity. However, a scientific calculator or electronic…
  • Abstract Number: 116 • 2020 Pediatric Rheumatology Symposium

    Patterns of Etanercept Use in the Childhood Arthritis and Rheumatology Research Alliance Juvenile Idiopathic Arthritis Registry

    Natalie Shiff1, Aimee Lougee 2, Roland Matsouaka 2, David Collier 3, Yukiko Kimura 4, Dax Rumsey 5, Jennifer Schenfeld 6, Scott Stryker 7, Marinka Twilt 8 and Timothy Beukelman 9, 1Florida, Gainesville, 2Duke University, Durham, 3Amgen, Thousand Oaks, 4Hackensack Meridian School of Medicine, Hackensack, 5University of Alberta, Edmonton, Canada, 6Amgen, Long Beach, 7Amgen, Inc, San Francisco, 8Alberta Children's Hospital, Calgary, Canada, 9University of Alabama at Birmingham, Birmingham

    Background/Purpose: Etanercept (ETN) is an anti-tumor necrosis factor (anti-TNF) therapy that is FDA approved for the treatment of polyarticular juvenile idiopathic arthritis (JIA). This study…
  • Abstract Number: 206 • 2019 ACR/ARP Annual Meeting

    Efficacy of Etanercept on Radiographic Progression in Adult Patients with Rheumatoid Arthritis or Psoriatic Arthritis: Final Results from a German Non-Interventional, Prospective, Multi-Center Study

    Siegfried Wassenberg1, Thilo Klopsch 2, Anja Plenske 3, Silke Behnck-Knoblau 4, Jürgen Jobst 4, Pascal Klaus 4, Thomas Meng 4, Peter-Andreas Löschmann 4 and Rolf Rau 5, 1Centre of Rheumatology, Ratingen, Germany, 2Internal Medicine Practice, Neubrandenburg, Germany, 3Pfizer Pharma GmbH, Berlin, Germany, 4Pfizer Pharma GmbH, Berlin, Berlin, Germany, 5Dusseldorf, Dusseldorf, Germany

    Background/Purpose: Clinical trials showed that Etanercept (ETN) is highly effective in reducing clinical disease activity and often leading to remission and radiographic non-progression in patients…
  • Abstract Number: 251 • 2019 ACR/ARP Annual Meeting

    Long-term Financial Impact of Switching from Reference to Biosimilar Etanercept When Considering Short-term Formulary Management Costs in the US

    Dylan Mezzio 1, Edward Li2 and Sanjeev Balu 3, 1Xcenda, Pleasant Hill, CA, 2Sandoz Inc., Princeton, NJ, 3Sandoz Inc, Princeton, NJ

    Background/Purpose: Biosimilars have enabled some US institutions and payers to achieve significant financial savings after implementing a formulary change from the reference biologic. However, within…
  • Abstract Number: 542 • 2019 ACR/ARP Annual Meeting

    ‘BENEFIT’ Pan-European Observational Study to Evaluate the Real-world Effectiveness of SB4 Transition from Originator Etanercept (ETN) in Patients with Rheumatoid Arthritis or Axial Spondyloarthritis: A Switch Success Story

    Carlo Selmi 1, Klaus Krüger2, Alain Cantagrel 3, Abad Hernández 4, Ulrich Freudensprung 5, Mourad Farouk Rezk 5 and Janet Addison 6, 1Humanitas Research Hospital, University of Milan, Milan, Italy, 2Medical Centre of Rheumatology, Munich, Germany, 3Center of Rheumatology of CHU, Toulouse, France, 4FEA Reumatología, Hospital Virgen del Puerto, Cáceres, Spain, 5Biogen International GmbH, Zug, Switzerland, 6Biogen UK, Maidenhead, United Kingdom

    Background/Purpose: SB4, a biosimilar to the reference ETN, received EU marketing authorisation in January 2016, based on the totality of evidence from pre-clinical and clinical…
  • Abstract Number: 552 • 2019 ACR/ARP Annual Meeting

    In the Real World Clinical Setting Etanercept Biosimilar SB4(BENEPAIL®) Demonstrates Equivalent Safety and Effectiveness in Biological Naïve as Well as with ENBREL® Pretreated RA,SPA, and PSA Patients

    Herbert Kellner1, 1Praxis Prof. Herbert Kellner, Munich, Germany

    Background/Purpose: Background: Biosimilar TNFα inhibitors have only become available in the last few years. Etanercept bisosimilar SB-4 Benepali® has been launched in March 2016 in…
  • Abstract Number: 1116 • 2019 ACR/ARP Annual Meeting

    Non-medical Switching from Reference to Biosimilar Etanercept – No Evidence for Nocebo Effect – a Retrospective Analysis of Real-life Data

    Uta Kiltz1, Styliani Tsiami 1, Xenofon Baraliakos 2 and Jürgen Braun 3, 1Rheumazentrum Ruhrgebiet/Ruhr University Bochum, Herne, Germany, Herne, Germany, 2Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany, 3Rheumazentrum Ruhrgebiet/Ruhr University, Herne, Germany

    Background/Purpose: Real-world data about switching patients from originator product to a biosimilars are important to assess and to document the outcome of switches in clinical…
  • Abstract Number: 1443 • 2019 ACR/ARP Annual Meeting

    Real World Switching Patterns of Etanercept Original and Biosilmilar in Germany

    Rieke Alten1, Miriam Tarallo 2, Christen Gray 3 and Cristiana Miglio 3, 1Schlosspark-Klinik University Medicine, Berlin, Germany, 2Pfizer Inc., Rome, Italy, 3IQVIA, London, United Kingdom

    Background/Purpose: We have previously evaluated switching dynamics between etanercept biologic original (EtnBO) and etanercept biosimilars (EtnBS) over approximately 18 months following the first EtnBS launch…
  • Abstract Number: 1491 • 2019 ACR/ARP Annual Meeting

    Long-term Clinical Outcome of Anti-TNF Treatment in Patients with Early Axial Spondyloarthritis: 10-year Data of the Etanercept vs. Sulfasalazin in Early Axial Spondyloarthritis Trial

    Fabian Proft1, Murat Torgutalp 2, Anja Weiß 3, Mikhail Protopopov 4, Valeria Rios Rodriguez 5, Hildrun Haibel 1, Olaf Behmer 6, Joachim Sieper 1 and Denis Poddubnyy 7, 1Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, 2Charité Universitätsmedizin Berlin, Germany and Ankara University Faculty of Medicine, Ankara, Turkey., Berlin, Germany, 3German Rheumatism Research Center (DRFZ), Berlin, Germany, 4Charité Universitätsmedizin Berlin, Germany, Berlin, Berlin, Germany, 5Charité Universitätsmedizin, Berlin, Germany, 6Pfizer Inc., Berlin, Germany, 7Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany

    Background/Purpose: Long-term data on anti-TNF treatment in patients with early axial spondyloarthritis (SpA) is scarce. The objective of this analysis was to assess the long-term…
  • Abstract Number: 1505 • 2019 ACR/ARP Annual Meeting

    Persistence with Etanercept in Patients with Ankylosing Spondylitis or Psoriatic Arthritis in Germany: A Real-World Analysis

    Xenofon Baraliakos1, Denis Poddubnyy 2, Frank Behrens 3, Cinzia Curiale 4, Miriam Tarallo 4, Ana Cristina Hernandez Daly 5, Olaf Behmer 6, Joseph Cappelleri 7, Nicholas Hudson 8 and Christen Gray 8, 1Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, 2Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, 3Rheumatology Goethe-University Frankfurt & Fraunhofer IME-TMP, Frankfurt, Germany, 4Pfizer Inc., Rome, Italy, 5Pfizer Inc., Athens, Greece, 6Pfizer Inc., Berlin, Germany, 7Pfizer Inc, Groton, CT, 8IQVIA, London, United Kingdom

    Background/Purpose: Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) treatment includes biologics, prescribed on a long-term basis. As persistence data from real-world practice are limited, the…
  • Abstract Number: 2145 • 2019 ACR/ARP Annual Meeting

    Long-term Safety of Tildrakizumab in Patients with Moderate-to-Severe Plaque Psoriasis: Incidence of Severe Infections Through 3 Years (148 Weeks) from 2 Phase 3 Trials

    Diamant Thaçi 1, Kristian Reich 2, Jo Lydie Lambert 3, Lars Iversen 4, Andrea Peserico 5, Ignasi Pau-Charles 6, Andrew Blauvelt7 and Christopher Griffiths 8, 1Institute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany, Lübeck, Germany, 2University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Skinflammation®, Hamburg, Germany; Dermatologikum Berlin, Berlin, Germany, Hamburg, Germany, 3Department of Dermatology, Ghent University Hospital, Ghent, Belgium, Ghent, Belgium, 4Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark, Aarhus, Denmark, 5Clinica Dermatologica, Department of Medicine-DIMED University of Padua, Padua, Italy, Padua, Italy, 6Almirall R&D, Barcelona, Spain, Barcelona, Spain, 7Oregon Medical Research Center, Portland, OR, USA, Portland, OR, 8Centre for Dermatology Research, The University of Manchester, Manchester, UK, Manchester, United Kingdom

    Background/Purpose: Tildrakizumab (TIL) is a high-affinity anti–interleukin-23p19 monoclonal antibody approved for the treatment of moderate-to-severe plaque psoriasis. The objective of this study was to evaluate…
  • Abstract Number: 2382 • 2019 ACR/ARP Annual Meeting

    Relationships Between DAS28 Response and Clinical, Functional and Radiographic Outcomes in Year 2 of the COMET Study of Etanercept in Patients with Rheumatoid Arthritis

    Paul Emery1, Ferdinand Breedveld 2, Ronald Pedersen 3, Eduardo Jose Campos 4, Annette Szumski 5 and Tomohiro Hirose 4, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 2Leids Universitair Medisch Centrum, Leiden, Netherlands, 3Pfizer, Collegeville, 4Pfizer Japan Inc, Toyko, Japan, 5Syneos Health, Princeton, NJ

    Background/Purpose: For patients with rheumatoid arthritis (RA) who are treated with etanercept (ETN) plus methotrexate (MTX), dosing down of ETN or withdrawal of MTX are…
  • Abstract Number: 2712 • 2019 ACR/ARP Annual Meeting

    Patterns of Etanercept Use in the Childhood Arthritis and Rheumatology Research Alliance Juvenile Idiopathic Arthritis Registry

    Natalie Shiff1, Aimee Lougee 2, Roland Matsouaka 2, David Collier 3, Yukiko Kimura 4, Dax Rumsey 5, Jennifer Schenfeld 6, Scott Stryker 3, Marinka Twilt 7 and Timothy Beukelman 8, 1University of Florida, Gainesville, FL, 2Duke University, Durham, NC, 3Amgen Inc., Thousand Oaks, CA, 4Joseph M Sanzari Children's Hospital, Hackensack University Medical Center, Cincinnati, OH, 5University of Alberta, Edmonton, AB, Canada, 6Amgen, Inc, Thousand Oaks, CA, 7University of Calgary, Calgary, AB, Canada, 8University of Alabama Birmingham, Birmingham, AL

    Background/Purpose: Etanercept (ETN) is an anti-tumor necrosis factor (anti-TNF) therapy that is FDA approved for the treatment of polyarticular juvenile idiopathic arthritis (JIA). This study…
  • Abstract Number: L11 • 2018 ACR/ARHP Annual Meeting

    Etanercept and Methotrexate As Monotherapy or in Combination in Patients with Psoriatic Arthritis: A Phase 3, Double-Blind, Randomized Controlled Study

    Philip J. Mease1, Dafna D. Gladman2, David H. Collier3, Christopher T. Ritchlin4, Philip S. Helliwell5, Lyrica Liu6, Gregory J. Kricorian3 and James B. Chung3, 1Swedish Medical Center and University of Washington, Seattle, WA, 2University of Toronto, Toronto, ON, Canada, 3Amgen Inc., Thousand Oaks, CA, 4University of Rochester Medical Center, Rochester, NY, 5University of Leeds, Leeds, United Kingdom, 6Amgen Inc., South San Francisco, CA

    Background/Purpose:  Methotrexate (MTX) and tumor necrosis factor inhibitors (TNFi) such as etanercept (ETN) are often prescribed for psoriatic arthritis (PsA) either alone or in combination,…
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