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Abstracts tagged "Erosions"

  • Abstract Number: 0160 • ACR Convergence 2021

    Identifying Erosive Disease from Radiology Reports of Veterans with Inflammatory Arthritis with Natural Language Processing

    Gopi Penmetsa1, Jessica Walsh2, Shaobo Pei3, Brian Sauer4, Kevin Douglas5, Jodi Walker5, Jerry Clewell6 and Bingjian Feng1, 1Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, 2Salt Lake City Veteran Affairs Medical Center (VAMC)/University of Utah Hospital, Salt Lake City, UT, 3VAMC, Salt Lake City, SLC, 4Veterans Affairs Medical Center, Salt Lake City, UT, 5AbbVie Inc., North Chicago, IL, 6Abbvie Inc, North Chicago, IL

    Background/Purpose: The presence of erosive disease influences diagnosis, management, & prognosis in inflammatory arthritis (IA). Inflammatory arthritis research in large datasets is limited by a…
  • Abstract Number: 0168 • ACR Convergence 2021

    A Crowdsourcing Approach to Develop Machine Learning Models to Quantify Radiographic Joint Damage in Rheumatoid Arthritis

    Dongmei Sun1, Robert Allaway2, Jelai Wang1, Verena Chung2, Thomas Yu2, Isaac Dimitrovsky3, Lars Ericson4, Yuanfang Guan5, Ariel Israel6, Hongyang Li5, Michael Mason7, Alex Olar8, Balint Pataki8, Stephanie Ledbetter1, RA2 DREAM Challenge Community9, Gustavo Stolovitzky10, Justin Guinney2, Percio Gulko11, Mason Frazier1, James Costello12, Jake Chen1 and S. Louis Bridges, Jr.13, 1University of Alabama at Birmingham, Birmingham, AL, 2Sage Bionetworks, Seattle, WA, 3Self-employed, New York, NY, 4Catskills Research, Charlotte, NC, 5University of Michigan, Ann Arbor, MI, 6Hebrew University, Jerusalem, Israel, 7BMS, Seattle, WA, 8Eotvos Lorand University, Budapest, Hungary, 9RA2 DREAM Challenge Community, New York, NY, 10IBM, New York, NY, 11Icahn School of Medicine at Mount Sinai, New York, NY, 12University of Colorado Anschutz Medical Campus, Denver, CO, 13Hospital for Special Surgery, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a common chronic autoimmune disease characterized by inflammation of the synovium, leading to joint space narrowing and osseous erosions. The…
  • Abstract Number: 0171 • ACR Convergence 2021

    Bone Erosions and Osteophytes in Premenopausal Women with Long-standing Rheumatoid Arthritis: Association with Systemic Bone Involvement Using HR-pQCT

    Mariana Perez1, Camille Figueiredo1, Lucas Sales1, ANA MEDEIROS-RIBEIRO1, Liliam Takayama1, Diogo Domiciano1, Karina Bonfiglioli1, Valeria Caparbo1 and Rosa Pereira2, 1Rheumatology Division, University of São Paulo, São Paulo, SP, Brazil, 2Rheumatology Division, University of São Paulo, São Paulo, Brazil

    Background/Purpose: Two patterns of bone involvement are described in rheumatoid arthritis (RA), systemic and localized. Systemic bone involvement is characterized by loss of generalized bone…
  • Abstract Number: 1669 • ACR Convergence 2021

    Minimal Erosive Volume Needed for Radiographic Identification of Erosions in the Metacarpophalangeal Joints in Rheumatoid Arthritis. a Comparative Analysis of High Resolution Peripheral Quantitative Computed Tomography and Conventional Radiography

    Rasmus Klose-Jensen, Josephine Therkildsen, Anne-Birgitte Garm Blavnsfeldt, Bente L. Langdahl, Anna Zejden, Jesper Thygensen, Kresten Krarup Keller and Ellen-Margrethe Hauge, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: The purpose of this study was to estimate the minimal erosive volume identified by High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) needed in order to…
  • Abstract Number: 1805 • ACR Convergence 2021

    Low Rates of Radiographic Progression with 2 Years of Guselkumab (TREMFYA®), a Selective Inhibitor of the Interleukin-23p19 Subunit: Results from a Phase 3, Randomized, Double-blind, Placebo-controlled Study of Biologic-naïve Patients with Active Psoriatic Arthritis

    Philip Mease1, Alice Gottlieb2, Iain McInnes3, Proton Rahman4, Alexa Kollmeier5, Xie Xu6, Yusang Jiang6, Shihong Sheng6, May Shawi7, Soumya Chakravarty8, Frederic Lavie9 and Désirée van der Heijde10, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom, 4Department of Medicine, Eastern Health and Memorial University of Newfoundland, St John's, NL, Canada, 5Janssen Research & Development, LLC, La Jolla, CA, 6Janssen Research & Development, LLC, Spring House, PA, 7Janssen Immunology Global Commercial Strategy Organization, Toronto, ON, Canada, 8Janssen Scientific Affairs, LLC and Drexel University College of Medicine, Horsham, PA, 9Janssen Global Services, LLC, Horsham, PA, 10Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands

    Background/Purpose: Guselkumab (GUS), an IL-23p19-subunit inhibitor, is efficacious in treating patients (pts) with psoriasis and psoriatic arthritis (PsA). In the Phase 3, double-blind, placebo (PBO)-controlled…
  • Abstract Number: 0312 • ACR Convergence 2020

    Dactylitis Is Associated with Greater Disease Severity, Ultrasound Synovitis, and Erosive Damage, in Very Early DMARD Naïve Psoriatic Arthritis

    Sayam Dubash1, Oras Alabas2, Xabier Michelena2, Gabriele De Marco3, Leticia Garcia-Montoya2, Richard Wakefield2, Ai Lyn Tan2, Philip Helliwell4, Paul Emery5, Dennis McGonagle2 and Helena Marzo-Ortega2, 1The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, England, United Kingdom, 2The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, 3The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Treviglio, Italy, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom

    Background/Purpose: Dactylitis is a hallmark feature of Psoriatic arthritis (PsA), defined as a uniform swelling of a finger or toe (“sausage digit”). It is associated…
  • Abstract Number: 0669 • ACR Convergence 2020

    Calcium Pyrophosphate Crystal Deposition in Gouty Tophi

    Hang-Korng Ea1, Alan Gauffenic2, Quand Nguyen3, Nhu Pham3, Oceane Olivier2, Vincent Frochot4, Dominique Bazin5, Nghia Le3, Caroline Marty2, Agnès Ostertag2, Martine Cohen-Solal1, Jean-Denis Laredo6, Pascal Richette7 and Thomas Bardin8, 1Université de Paris, INSERM UMR 1132, BIOSCAR, AP-HP, DMU Locomoteur, Paris, France, 2Université de Paris, INSERM UMR 1132, BIOSCAR, Paris, France, 3Vien Gut Medical Center and French-Vietnamese research center on gout and chronic diseases, Ho Chi Ming, Vietnam, 4Hôpital Tenon, Service des explorations fonctionnelles multidisciplinaires, Sorbonne université, UMR_S1155, Paris, France, 5Institut de Chimie Physique, Université Paris-Saclay et CNRS - UMR8000, Orsay, France, 6AP-HP Université de Paris, Paris, 7Department of Rheumatology, Lariboisière Hospital, AP-HP Université de Paris, INSERM U1132, Paris, 8Université de Paris, INSERM U1132 and Hôpital Lariboisièe, Paris, France, Paris, France

    Background/Purpose: The coexistence of calcium pyrophosphate (CPP) and monosodium urate crystals is rarely reported in gouty tophi. We investigated CPP crystal deposits in a series…
  • Abstract Number: 0691 • ACR Convergence 2020

    Denosumab Did Not Improve Computerized Tomography Erosion Scores When Added to Intensive Urate-Lowering Therapy in Gout: Results from a Pilot Study

    Angelo Gaffo1, Kenneth Saag2, Anthony Doyle3, Joshua Melnick4, Anne Horne5, Jeffrey Foster1, Amy Mudano1, Stephanie Biggers1, David Redden1 and Nicola Dalbeth6, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, 3University of Auckland, Grafton, Auckland, New Zealand, 4University of Alabama at Birmingham (UAB), Vestavia Hills, AL, 5The University of Auckland, Auckland, New Zealand, 6University of Auckland, Auckland, New Zealand

    Background/Purpose: Bone erosion is a common complication of tophaceous gout. Disordered osteoclast activity has been implicated in the pathogenesis of gouty bone erosion.  We sought…
  • Abstract Number: 0760 • ACR Convergence 2020

    X-rays Bone Erosions Are Uncommon in Anti-CCP Positive Individuals At-risk of Rheumatoid Arthritis with Musculoskeletal Symptoms Without Clinical Synovitis, and Do Not Predict the Development of Inflammatory Arthritis

    Andrea Di Matteo1, Kulveer Mankia1, Jacqueline L Nam1, Edoardo Cipolletta2, Leticia Garcia-Montoya3, Laurence Duquenne1, Emma Rowbotham4 and Paul Emery5, 1University of Leeds and Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 2Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi (AN), Italy, 3The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, 4Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom

    Background/Purpose: In individuals at-risk of RA, the identification of reliable biomarkers for the future development of clinical arthritis is of critical importance for risk-stratification and…
  • Abstract Number: 1105 • ACR Convergence 2020

    RANK-L Activity: Understanding the Pathogenesis of Erosive Osteoarthritis

    Kalyna Jakibchuk1, Javier Rangel-Moreno1, Bethany Marston2, Jennifer Anolik1 and Allen Anandarajah1, 1University of Rochester Medical Center, Rochester, NY, 2University of Rochester Medical Center, Rochester

    Background/Purpose: Erosive osteoarthritis (EOA) is characterized by osteoarthritic findings with central erosions and collapse of the interphalangeal joint subchondral bone plate.  A number of studies…
  • Abstract Number: 1719 • ACR Convergence 2020

    Prevalence and Trajectory of Erosions, Synovitis, and Bone Marrow Edema in Feet of Patients with Early Rheumatoid Arthritis

    Zechen Ma1, Hanyan Zou2, Mary-Clair Yelovich2, Saara Totterman3, Karen Beattie2 and Maggie Larche2, 1McMaster University, Mississauga, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3QMetrics Technologies, Rochester, NY

    Background/Purpose: Imaging studies have shown that erosions emerge early in RA and is associated with worsening pain and function. Despite erosions being just as prevalent…
  • Abstract Number: 1759 • ACR Convergence 2020

    Rheumatoid Arthritis Affects the Ossicular Joints: A Human Otopathologic Study

    Melissa Castillo-Bustamante1, Marc Polanik1, Dhrumi Gandhi1, Elliott Kozin1 and Aaron Remenschneider1, 1Massachusetts Eye and Ear Infirmary/Harvard University, Boston, MA

    Background/Purpose: Inflammation of synovial joints in small and large extremities is commonly seen in Rheumatoid arthritis (RA). To date little is known about how this disease…
  • Abstract Number: 2024 • ACR Convergence 2020

    Effects of Filgotinib on Spinal Lesions in Patients with Ankylosing Spondylitis: Magnetic Resonance Imaging Data from the Placebo-Controlled, Double‑Blind, Randomized TORTUGA Trial

    Walter Maksymowych1, Mikkel Østergaard2, Robert Landewé3, William Barchuk4, Ke Liu4, Chantal Tasset5, Leen Gilles5, Thijs Hendrikx6, Robin Besuyen6 and Xenofon Baraliakos7, 1University of Alberta, Edmonton, AB, Canada, 2Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 3Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, 4Gilead Sciences, Inc., Foster City, CA, 5Galapagos NV, Mechelen, Belgium, 6Galapagos BV, Leiden, Netherlands, 7Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany

    Background/Purpose: The oral, selective Janus kinase 1 inhibitor filgotinib (FIL) significantly improved Spondyloarthritis Research Consortium of Canada (SPARCC) MRI inflammation scores (bone marrow edema) in…
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