Abstracts tagged "Erosions"

Abstract Number: 0312 • ACR Convergence 2020
Dactylitis Is Associated with Greater Disease Severity, Ultrasound Synovitis, and Erosive Damage, in Very Early DMARD Naïve Psoriatic Arthritis
Sayam Dubash¹, Oras Alabas², Xabier Michelena², Gabriele De Marco³, Leticia Garcia-Montoya², Richard Wakefield², Ai Lyn Tan², Philip Helliwell⁴, Paul Emery⁵, Dennis McGonagle² and Helena Marzo-Ortega², ¹The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, England, United Kingdom, ²The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ³The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Treviglio, Italy, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom
Background/Purpose: Dactylitis is a hallmark feature of Psoriatic arthritis (PsA), defined as a uniform swelling of a finger or toe (“sausage digit”). It is associated…
Abstract Number: 0669 • ACR Convergence 2020
Calcium Pyrophosphate Crystal Deposition in Gouty Tophi
Hang-Korng Ea¹, Alan Gauffenic², Quand Nguyen³, Nhu Pham³, Oceane Olivier², Vincent Frochot⁴, Dominique Bazin⁵, Nghia Le³, Caroline Marty², Agnès Ostertag², Martine Cohen-Solal¹, Jean-Denis Laredo⁶, Pascal Richette⁷ and Thomas Bardin⁸, ¹Université de Paris, INSERM UMR 1132, BIOSCAR, AP-HP, DMU Locomoteur, Paris, France, ²Université de Paris, INSERM UMR 1132, BIOSCAR, Paris, France, ³Vien Gut Medical Center and French-Vietnamese research center on gout and chronic diseases, Ho Chi Ming, Vietnam, ⁴Hôpital Tenon, Service des explorations fonctionnelles multidisciplinaires, Sorbonne université, UMR_S1155, Paris, France, ⁵Institut de Chimie Physique, Université Paris-Saclay et CNRS - UMR8000, Orsay, France, ⁶AP-HP Université de Paris, Paris, ⁷Department of Rheumatology, Lariboisière Hospital, AP-HP Université de Paris, INSERM U1132, Paris, ⁸Université de Paris, INSERM U1132 and Hôpital Lariboisièe, Paris, France, Paris, France
Background/Purpose: The coexistence of calcium pyrophosphate (CPP) and monosodium urate crystals is rarely reported in gouty tophi. We investigated CPP crystal deposits in a series…
Abstract Number: 0691 • ACR Convergence 2020
Denosumab Did Not Improve Computerized Tomography Erosion Scores When Added to Intensive Urate-Lowering Therapy in Gout: Results from a Pilot Study
Angelo Gaffo¹, Kenneth Saag², Anthony Doyle³, Joshua Melnick⁴, Anne Horne⁵, Jeffrey Foster¹, Amy Mudano¹, Stephanie Biggers¹, David Redden¹ and Nicola Dalbeth⁶, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, ³University of Auckland, Grafton, Auckland, New Zealand, ⁴University of Alabama at Birmingham (UAB), Vestavia Hills, AL, ⁵The University of Auckland, Auckland, New Zealand, ⁶University of Auckland, Auckland, New Zealand
Background/Purpose: Bone erosion is a common complication of tophaceous gout. Disordered osteoclast activity has been implicated in the pathogenesis of gouty bone erosion. We sought…
Abstract Number: 0760 • ACR Convergence 2020
X-rays Bone Erosions Are Uncommon in Anti-CCP Positive Individuals At-risk of Rheumatoid Arthritis with Musculoskeletal Symptoms Without Clinical Synovitis, and Do Not Predict the Development of Inflammatory Arthritis
Andrea Di Matteo¹, Kulveer Mankia¹, Jacqueline L Nam¹, Edoardo Cipolletta², Leticia Garcia-Montoya³, Laurence Duquenne¹, Emma Rowbotham⁴ and Paul Emery⁵, ¹University of Leeds and Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ²Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi (AN), Italy, ³The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ⁴Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom
Background/Purpose: In individuals at-risk of RA, the identification of reliable biomarkers for the future development of clinical arthritis is of critical importance for risk-stratification and…
Abstract Number: 1105 • ACR Convergence 2020
RANK-L Activity: Understanding the Pathogenesis of Erosive Osteoarthritis
Kalyna Jakibchuk¹, Javier Rangel-Moreno¹, Bethany Marston², Jennifer Anolik¹ and Allen Anandarajah¹, ¹University of Rochester Medical Center, Rochester, NY, ²University of Rochester Medical Center, Rochester
Background/Purpose: Erosive osteoarthritis (EOA) is characterized by osteoarthritic findings with central erosions and collapse of the interphalangeal joint subchondral bone plate. A number of studies…
Abstract Number: 1719 • ACR Convergence 2020
Prevalence and Trajectory of Erosions, Synovitis, and Bone Marrow Edema in Feet of Patients with Early Rheumatoid Arthritis
Zechen Ma¹, Hanyan Zou², Mary-Clair Yelovich², Saara Totterman³, Karen Beattie² and Maggie Larche², ¹McMaster University, Mississauga, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³QMetrics Technologies, Rochester, NY
Background/Purpose: Imaging studies have shown that erosions emerge early in RA and is associated with worsening pain and function. Despite erosions being just as prevalent…
Abstract Number: 1759 • ACR Convergence 2020
Rheumatoid Arthritis Affects the Ossicular Joints: A Human Otopathologic Study
Melissa Castillo-Bustamante¹, Marc Polanik¹, Dhrumi Gandhi¹, Elliott Kozin¹ and Aaron Remenschneider¹, ¹Massachusetts Eye and Ear Infirmary/Harvard University, Boston, MA
Background/Purpose: Inflammation of synovial joints in small and large extremities is commonly seen in Rheumatoid arthritis (RA). To date little is known about how this disease…
Abstract Number: 2024 • ACR Convergence 2020
Effects of Filgotinib on Spinal Lesions in Patients with Ankylosing Spondylitis: Magnetic Resonance Imaging Data from the Placebo-Controlled, Double‑Blind, Randomized TORTUGA Trial
Walter Maksymowych¹, Mikkel Østergaard², Robert Landewé³, William Barchuk⁴, Ke Liu⁴, Chantal Tasset⁵, Leen Gilles⁵, Thijs Hendrikx⁶, Robin Besuyen⁶ and Xenofon Baraliakos⁷, ¹University of Alberta, Edmonton, AB, Canada, ²Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ³Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ⁴Gilead Sciences, Inc., Foster City, CA, ⁵Galapagos NV, Mechelen, Belgium, ⁶Galapagos BV, Leiden, Netherlands, ⁷Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany
Background/Purpose: The oral, selective Janus kinase 1 inhibitor filgotinib (FIL) significantly improved Spondyloarthritis Research Consortium of Canada (SPARCC) MRI inflammation scores (bone marrow edema) in…