ACR Meeting Abstracts

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Abstracts tagged "Erosions"

  • Abstract Number: 0227 • ACR Convergence 2024

    Active Hand Inflammation: Differing Clinical and Ultrasound Patterns in Patients with Rheumatoid Arthritis and Psoriatic Arthritis. A Cross-Sectional and Multicenter Study

    Julio Ramírez1, Vicenç Torrente-Segarra2, Andrea Cuervo3, Mireia Moreno4, Ana Belén Azuaga1, Lourdes Mateo5, Beatriz Frade-Sosa6, Andrea Zacarias1, Noemí Busquets Pérez7, Susana Holgado8, Paula Estrada-Alarcón9, Delia Reina10, Juan José De Agustín11, Carme Moragues12, María Bonet13, Sandra Farietta1, Patricia Corzo1, Andrés Ponce14, Virginia Ruiz Esquide1, Lucia Alascio1 and Juan Cañete15, and ECOCAT group, 1Hospital Clinic Barcelona, Barcelona, Spain, 2Hospital Comarcal Alt Penedès-Garraf, Vilafranca, Spain, 3Hospital General Granollers, Granollers, Spain, 4Hospital Parc Taulí, Sabadell, Spain, 5Hospital Germans Trias i Pujol, Badalona, Spain, 6Hospital Clínic, Barcelona, Spain, 7HOSP. GENERAL DE GRANOLLERS, GRANOLLERS, Spain, 8Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 9Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, 10Hospital Moises Broggi, Barcelona, Spain, 11Image and Technics Unit, Department of Rheumatology. Hospital Universitari Vall d’Hebron, Barcelona, Spain, 12Hospital Bellvitge, Barcelona, Spain, 13Hospital Alt Penedés i Garraf, Barcelona, Spain, 14Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 15Hospital Clinic an IDIBAPS, Barcelona, Spain

    Background/Purpose: The ultrasound (US) finding of proliferative synovitis (PS) in Rheumatoid Arthritis (RA), is associated with ACPA, erosions and changes in therapy [1]. However, no…
  • Abstract Number: 0379 • ACR Convergence 2024

    Effectiveness and Safety of Baricitinib for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis or Chronic Anterior Antinuclear Antibody Positive Uveitis in Children

    Athimalaipet Ramanan1, Catherine Guly2, Gabriele Simonini3, Stuart Keller4, Priyanka Sen4, Thorsten Holzkaemper4 and PIERRE QUARTIER5, 1Bristol Royal Hosp for Children, Bristol, United Kingdom, 2University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom, 3Meyer Children’s Hospital IRCCS; University of Florence, Florence, Toscana, Italy, 4Eli Lilly and Company, Indianapolis, IN, 5Université Paris-Cite, IMAGINE Institute, Necker Children’s Hospital, Paris Cedex 15, France

    Background/Purpose: Baricitinib could target multiple cytokine pathways associated with juvenile idiopathic arthritis associated uveitis (JIA-U) and antinuclear antibody (ANA)-positive uveitis, providing a novel therapeutic approach.…
  • Abstract Number: 0866 • ACR Convergence 2024

    Cross-sectional Analysis of Erosive Hand Osteoarthritis and Fracture Risk

    Avanika Mahajan1, carolyn mead harvey2, Chris Grilli3 and Megan Sullivan3, 1Mayo Clinic - - Scottsdale, AZ, Phoenix, AZ, 2Mayo Clinic Florida, Jacksonville, FL, 3Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose: Erosive hand osteoarthritis (EHOA) is a subtype of hand OA that primarily impacts the interphalangeal joints resulting in subchondral bone erosion and cortical destruction.…
  • Abstract Number: 0937 • ACR Convergence 2024

    A Novel Quantitative Method Reveals Bone-Structural Changes During Course of Inflammatory Arthritis

    Anders Nguyen1, David McBride2, Miriam Bollmann1, Agnieszka Lastowska3 and Mattias Svensson4, 1University of Gothenburg, Göteborg, Sweden, 2Calibr-Skaggs Institute for Innovative Medicines, La Jolla, CA, 3University of Gothenburg, Goteborg, Sweden, 4University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by both localized and generalized bone loss. The inhibition of Receptor Activator of Nuclear Factor…
  • Abstract Number: 1346 • ACR Convergence 2024

    Early Diagnosis of Rheumatoid Arthritis: Role of Joint Ultrasound Assessment

    Cristina Corrales Selaya1, Carmen Secada Gómez2, Sabela Fernandez-Aguado3, Isla Morante-bolado4, Montserrat Santos-gomez5, Sara Alonso-Castro6, Virginia Portilla-González7, Ricardo Blanco-Alonso8, Javier Rueda Gotor4 and alfonso Corrales-Martínez9, 1Rheumatology, Marques de Valdecilla University Hospital. IDIVAL, Santander, Cantabria, Spain, 2Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Hospital Universitario Montecelo, Pontevedra, Galicia, Spain, 4Hospital Sierrallana, Torrelavega, Cantabria, Spain, 5Hospital universitario Central de Asturias, Oviedo, Asturias, Spain, 6Hospital Universitario Central de Asturias., Oviedo, Asturias, Spain, 7Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, 8Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, 9Hospital Universitario Marques de Valdecilla, Santander, Spain

    Background/Purpose: Early diagnosis of Rheumatoid Arthritis (RA) is essential to establish treatment to improve long-term disease outcomes. Musculoskeletal ultrasound (US) is able to detect subclinical…
  • Abstract Number: 1429 • ACR Convergence 2024

    Association of Bone Erosion and Microarchitecture with Disease Activity and Damage in Sjögren’s Disease

    Andre Franco1, Igor Murai2, Thomas Yang2, Valeria Caparbo3, Virginia Bonoldi2, Diogo Domiciano1, Lissiane Guedes2, Sandra Pasoto1, Camille Figueiredo3 and Rosa M R Pereira3, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, 2Hospital das Clinicas HCFMUSP, Faculdade de Medicina da USP, São Paulo, SP, Brazil, 3Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, SP, Brazil

    Background/Purpose: Sjögren's disease (SjD) is a chronic multisystem autoimmune condition characterized by sicca syndrome and inflammatory arthralgia, more common in women. Bone involvement can result…
  • Abstract Number: 1456 • ACR Convergence 2024

    Real-World Treat-to-Target Strategy in Psoriatic Arthritis: Baseline Characteristics from the MONITOR-PsA Cohort

    Lija James1, Elnaz Saeedi2, Jean-Guillaume Letarouilly1, Nicola Gullick3, Anne Francis2, Deepak Jadon4, William Tillett5, Yvonne Sinomati2, Laura Tucker1, Nadia Mian2, Ines Rombach2, Ioana Marian2, Maria Sofia Massa2 and Laura Coates6, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Oxford Clinical Trials Research Unit, University of Oxford, Oxford, United Kingdom, 3Rheumatology Department, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, Coventry, United Kingdom, 4Cambridge University, Cambridge, United Kingdom, 5Royal National Hospital of Rheumatic Diseases; Department of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom, 6University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic musculoskeletal disease, which can lead to progressive joint pain, joint destruction, and loss of function. Evidence suggests that…
  • Abstract Number: 2224 • ACR Convergence 2024

    Age of Onset of Rheumatoid Arthritis and Radiographic Changes

    Masaru Shimizu1, Misti Paudel2, Nancy Shadick3, Michael Weinblatt4 and Daniel Solomon5, 1University of Tsukuba, Yokohama, Kanagawa, Japan, 2Brigham and Women's Hospital, Division of Rheumatology, Inflammation, and Immunity, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham and Women's Hospital/ Harvard Medical School, Waban, MA, 5Brigham and Women's Hospital, Newton, MA

    Background/Purpose: Epidemiological studies have shown that the age of onset for rheumatoid arthritis (RA) is increasing. However, associations between age of onset and joint erosion…
  • Abstract Number: 2549 • ACR Convergence 2023

    Effect of Ixekizumab Treatment on MRI Structural Lesions in the Sacroiliac Joints of Patients with Radiographic Axial Spondyloarthritis; A Post-hoc Analysis of a Placebo and Active Controlled RCT

    Walter P. Maksymowych1, Robert Lambert2, Eswar Krishnan3, Baojin Zhu3, Rebecca Bolce3 and Mikkel Østergaard4, 1University of Alberta, Edmonton, AB, Canada, 2Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 3Eli Lilly and Company, Indianapolis, IN, 4Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: The effect of Ixekizumab (IXE) on structural lesions in the sacroiliac joints (SIJ) of patients (pts) with radiographic Axial Spondylarthritis (r-axSpA) assessed by magnetic…
  • Abstract Number: 0745 • ACR Convergence 2023

    Artificial Intelligence Models for Computer-Assisted Joint Detection and Sharp-van Der Heijde Score Prediction in Hand Radiographs from Patients with Rheumatoid Arthritis

    Carol Hitchon1, Saqib Al Islam1, Daryl LX Fung1, Qian Liu1, Leann Lac1, Susan Bartlett2, Louis Bessette3, Gilles Boire4, Vivian Bykerk5, Glen Hazlewood6, Edward Keystone7, Janet Pope8, Orit Schieir9, Carter Thorne10, Diane Tin11, Marie-France Valois12, Désirée van der Heijde13, Canadian Early Arthritis Cohort (CATCH) Investigators14, Liam O'Neil1 and Pingzhao Hu15, 1University of Manitoba, Winnipeg, MB, Canada, 2McGill University, Montreal, QC, Canada, 3Centre de l'Ostéoporose et de Rhumatologie de Québec, Quebec City, QC, Canada, 4Université de Sherbrooke, Sherbrooke, QC, Canada, 5Hospital for Special Surgery, New York, NY, 6University of Calgary, Calgary, AB, Canada, 7Keystone Consulting Enterprises Inc., Toronto, ON, Canada, 8University of Western Ontario, London, ON, Canada, 9McGill University, Montréal, QC, Canada, 10Southlake Regional Health Centre, Newmarket, ON, Canada, 11The Arthritis Program Research Group, Newmarket, ON, Canada, 12McGill University, Pointe-Claire, QC, Canada, 13Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 14CATCH, Winnipeg, MB, Canada, 15Western University, London, ON, Canada

    Background/Purpose: Radiographs are used to detect and monitor joint damage due to rheumatoid arthritis (RA).Scoring methods such as the Sharp van der Heijde tool (SVH)…
  • Abstract Number: 1051 • ACR Convergence 2023

    Validation of Handheld Ultrasound Devices for Point of Care Use in Rheumatology: Interim Analysis

    sibel aydin1, seyyid acikgoz2, Ummugulsum Oguz3, antonio Vieira4, patrick Leclerc4, Suharsh Shah4, Lihi Eder5 and Gurjit S Kaeley6, 1University of Ottawa - Ottawa, Ottawa, ON, Canada, 2University of Ottawa, Rheumatology, Ottawa, ON, Canada, 3University of Ottawa, Ottawa, ON, Canada, 4Novartis Pharmaceuticals Canada Inc., Montreal, QC, Canada, 5Women’s College Research Institute, Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 6University of Florida College of Medicine – Jacksonville, Ponte Vedra Beach, FL

    Background/Purpose: Ultrasonography (US) has experienced a rapid evolution in rheumatology. Despite many advantages being shown repeatedly, several barriers persist and stand in the way of…
  • Abstract Number: 1715 • ACR Convergence 2023

    Androgen Treatment Exhibits a Protective Role Against Focal Erosions in TNF-Induced Inflammatory Arthritis in Mice

    Kiana Chen1, Adelaide Weidner2, Olga Astapova2, Edward Schwarz2 and Homaira Rahimi2, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and bone erosion and is female predominant. The TNF-transgenic (TNF-Tg) murine model of RA develops…
  • Abstract Number: 1716 • ACR Convergence 2023

    High-Throughput Semi-Automated Micro-CT Analysis Identifies the Cuboid Bone as a Sex-Dependent Biomarker of Inflammatory-Erosive Arthritis in TNF-Tg Mice

    H. Mark Kenney1, Kiana Chen2, Lindsay Schnur3, Jeffrey Fox3, Ronald Wood3, Lianping Xing4, Christopher T Ritchlin5, Homaira Rahimi6, Edward Schwarz6 and Hani Awad3, 1University of Rochester School of Medicine and Dentistry, Henrietta, NY, 2University of Rochester School of Medicine and Dentistry, Rochester, NY, 3University of Rochester Medical Center, Rochester, NY, 4University of Rochester Medical Center, Webster, NY, 5University of Rochester Medical School, Allergy, Immunology & Rheumatology Division, Canandaigua, NY, 6University of Rochester, Rochester, NY

    Background/Purpose: Development of reliable disease activity biomarkers is critical for diagnostics, prognostics, and novel drug development. In the case of preclinical models of inflammatory-erosive arthritis,…
  • Abstract Number: 1718 • ACR Convergence 2023

    Longitudinal Quantification of Bone Erosions, Pulmonary Disease, Pain, Gait and Sarcopenia to Holistically Assess Decreased Ad Libitum Physical Activity and Effects of Exercise in the TNF-Transgenic Murine Model of Rheumatoid Arthritis

    Calvin Cole1, H. Mark Kenney2, Zachary Sechrist1, Yue Peng1, Kiana Chen3, Megan Falsetta1, Ronald Wood1, Homaira Rahimi4, Christopher T Ritchlin5 and Edward Schwarz4, 1University of Rochester Medical Center, Rochester, NY, 2University of Rochester School of Medicine and Dentistry, Henrietta, NY, 3University of Rochester School of Medicine and Dentistry, Rochester, NY, 4University of Rochester, Rochester, NY, 5University of Rochester Medical School, Allergy, Immunology & Rheumatology Division, Canandaigua, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by pain, swelling, and joint destruction that decreases mobility.RA patients also suffer from pulmonary disease…
  • Abstract Number: 1867 • ACR Convergence 2023

    Peripheral Volumetric Bone Mineral Density and Erosive Disease in Patients with Established Rheumatoid Arthritis: A Cross-Sectional Study Using High-Resolution Peripheral Quantitative Computed Tomography

    Mathias Hänel1, Rasmus Klose-Jensen2, Josephine Therkildsen3, Anne-Birgitte Garm Blavnsfeldt3, Bente Langdahl3, Stinus Gadegaard Hansen4, Kresten Keller5 and Ellen Margrethe Hauge3, 1Rheumatollogy, Aarhus University Hospital, Aarhus, Denmark, 2Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 3Aarhus University Hospital, Aarhus, Denmark, 4Odense University Hospital, Svendborg Sygehus, Svendborg, Denmark, 5Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

    Background/Purpose: High resolution peripheral quantitative computed tomography (HR-pQCT) is a promising imaging modality for assessing volumetric bone mineral density (BMD) in rheumatoid arthritis (RA), and…
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