Abstracts tagged "Epigenetics"

Abstract Number: 137 • 2017 Pediatric Rheumatology Symposium
Chromatin Landscapes and Genetic Risk For Juvenile Idiopathic Arthritis
James Jarvis¹, Lisha Zhu², Lai Ping Wong³, Tao Liu⁴, Kaiyu Jiang³ and Yanmin Chen³, ¹Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Department of Biochemistry, University at Buffalo, Buffalo, NY
Background/Purpose: The transcriptomes of peripheral blood cells in children with juvenile idiopathic arthritis (JIA) show distinct transcriptional aberrations that suggest impairment of transcriptional regulation. To…
Abstract Number: 1665 • 2016 ACR/ARHP Annual Meeting
Validation of Germ Line Epigenetic Variants Associated with Psoriatic Disease
Remy Pollock¹, Laila Zaman¹, Vinod Chandran² and Dafna D Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Heritable epigenetic phenomena may play a role in the parent-of-origin effect observed in psoriasis and psoriatic arthritis (PsA). A previous epigenome-wide association study (EWAS)…
Abstract Number: 1825 • 2016 ACR/ARHP Annual Meeting
the Non-Coding Genome and the Genetics of Systemic Lupus
Joyce Hui-Yuen¹, Lisha Zhu², Lai Ping Wong³, Kaiyu Jiang⁴, Yanmin Chen⁴, Tao Liu⁵ and James Jarvis⁶, ¹North Shore-Long Island Jewish Health System, Lake Success, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Pediatrics, The University at Buffalo, Buffalo, NY, ⁵Department of Biochemistry, University at Buffalo, Buffalo, NY, ⁶Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-system, complex disease believed to be triggered by gene-environment interactions. While we have made considerable progress in investigation…
Abstract Number: 2033 • 2016 ACR/ARHP Annual Meeting
A Multi-Dimensional Genomic Map for Polyarticular Juvenile Idiopathic Arthritis
James Jarvis¹, Lisha Zhu², Kaiyu Jiang³, Michael Buck², Yanmin Chen³, Halima Moncrieffe⁴, Laura Brungs⁴, Tao Liu⁵ and Ting Wang⁶, ¹Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Department of Biochemistry, University at Buffalo, Buffalo, NY, ⁶Genetics, Washington University School of Medicine, St. Louis, MO
Background/Purpose: Polyarticular juvenile idiopathic arthritis (JIA) is a complex trait characterized by gene-environment interactions. While we are beginning to identify multiple genomic regions associated with…
Abstract Number: 2556 • 2016 ACR/ARHP Annual Meeting
Deficient Expression of the Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Induces S Phase Arrest in RA Fibroblast-like Synoviocytes (FLS)
Shinji Matsuda¹, Deepa Hammaker², Steven Dowdy³, David L. Boyle⁴ and Gary Firestein⁵, ¹Medicine, UC San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ³UC San Diego School of Medicine, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁵Medicine, UCSD, La Jolla, CA
Background/Purpose: LBH (Limb-bud and heart development) was recently identified as an RA risk gene that has abnormally methylated loci and a functional enhancer SNP in…
Abstract Number: 3119 • 2016 ACR/ARHP Annual Meeting
Complete Whole Genome Transcriptome, DNA Methylation, and Histone Mark Analysis of Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS) Reveals a Distinctive Epigenetic Landscape and Critical Pathogenic Pathways
Rizi Ai¹, Deepa Hammaker², David L. Boyle³, Andre ‎ Wildberg⁴, Keisuke Maeshima², Emmanuele Palescandolo⁵, Vinod Krishna⁵, Bryan Linggi⁶, Radu Dobrin⁵, John W. Whitaker⁷, Wei Wang⁸ and Gary Firestein⁹, ¹Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ³Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁴Chemistry and Biochemistry, UNIVERSITY OF CALIFORNIA SAN DIEGO, LA JOLLA, CA, ⁵Janssen Pharmaceuticals, Spring House, PA, ⁶janssen Pharmaceuticals, Spring House, PA, ⁷Janssen Pharmaceuticals, La Jolla, CA, ⁸Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁹Medicine, UCSD, La Jolla, CA
Background/Purpose: RA FLS display a unique aggressive phenotype with a distinctive DNA methylation profile that marks genes involved with cytokine signaling, cell recruitment, and matrix…
Abstract Number: 3120 • 2016 ACR/ARHP Annual Meeting
RA Net: A Systems Biology Approach to Identify Genes Regulating Pathogenic Pathways in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Wei Wang¹, RIchard Ainsworth², Richard Stein², Rizi Ai³ and Gary Firestein⁴, ¹Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ²UC San Diego, La Jolla, CA, ³Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁴Medicine, UCSD, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) remains a significant unmet need despite improved therapy. Defining the interlaced nature of gene regulation and disease pathogenesis using integrative systems…
Abstract Number: 647 • 2016 ACR/ARHP Annual Meeting
Genomic and Epigenetic Bioinformatics Demonstrate Dual TNF-α and IL17A Target Engagement By ABT-122, and Suggest Mainly TNF-α–Mediated Relative Target Contribution to Drug Response in MTX-IR Rheumatoid Arthritis Patients
Robert W. Georgantas III¹, Melanie Ruzek², Justin Wade Davis¹, Feng Hong¹, Elizabeth Asque¹, Kenneth Idler¹, Heikki T. Mansikka¹, Benoit Guerette¹ and Jeffrey F. Waring¹, ¹AbbVie Inc., North Chicago, IL, ²Immunology Discovery, AbbVie, Worcester, MA
Background/Purpose: ABT-122 is a dual variable domain (DVD-Ig) biologic which inhibits TNF-α and IL17A. In a 12-wk phase 2 study (NCT02141997) in MTX-IR patients (pts)…
Abstract Number: 1093 • 2016 ACR/ARHP Annual Meeting
DNA Methylation Defines Joint Specific Differences in Synovial Fibroblasts from OA and RA Patients
Emmanuel Karouzakis¹, Mojca Frank Bertoncelj², Kerstin Klein¹, Christoph Kolling³, Renate E. Gay¹, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Schulthess Clinic, Zurich, Switzerland
Background/Purpose: Recent studies revealed epigenetic changes in DNA methylation associated with rheumatoid arthritis (RA) synovial fibroblasts (SF). In addition, we have shown that SF exhibit…
Abstract Number: 1566 • 2016 ACR/ARHP Annual Meeting
Histone Lysine Methylation and STAT3 Differentially Regulate Constitutive and IL-6-Induced MMPs Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts
Yasuto Araki^1,2, Takuma Tsuzuki Wada^2,3, Yoshimi Aizaki^1,2, Kazuhiro Yokota¹, Hiroshi Kajiyama¹, Yu Funakubo Asanuma¹, Kojiro Sato¹, Hiromi Oda⁴ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan, ³Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma, Japan, ⁴Orthopedic Surgery, Faculty of Medicine, Saitama Medical Univeristy, Morohongo Moroyama, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes progressive joint destruction. In spite of the modern medications, including biologic reagents, it…
Abstract Number: 1130 • 2015 ACR/ARHP Annual Meeting
Global DNA Methylation Analysis of Osteoarthritic Subchondral Bone Reveals Significant Regional Variation and Similarity to Overlying Cartilage
Matlock A. Jeffries^1,2, Madison Andrews³, Mary Beth Humphrey¹, Judith A. James⁴ and Amr H. Sawalha⁵, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Association, Oklahoma City, OK, ³Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Univers, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is a leading cause of chronic disability affecting a majority of individuals over age 70. Outside of cartilage, little is known regarding…
Abstract Number: 1163 • 2015 ACR/ARHP Annual Meeting
Dynamic Regulation of Enhancers and Super-Enhancers in Rheumatoid Arthritis Synovial Finroblasts
Sung-Ho Park¹, Christopher Sohn¹, Konstantinos Loupasakis², Angela Lee³, Eugenia Giannopoulou¹, Lionel B. Ivashkiv³ and George D. Kalliolias¹, ¹Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, ³Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Enhancers are regulatory elements that modulate transcriptional rates of genes. Super-enhancers (SupE) are extremely large enhancers associated primarily with highly expressed genes that have…
Abstract Number: 1239 • 2015 ACR/ARHP Annual Meeting
Significant Impact of Microrna-Target Gene Networks on the Genetics of Rheumatoid Arthritis
Yukinori Okada^1,2 and Toshihiro Tanaka^3,4, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ³Bioresource Research Center, Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Background/Purpose: MicroRNA (miRNA), a short endogenous noncoding RNA, has a major role in the degradation and translational repression of a specific gene through its binding…
Abstract Number: 1242 • 2015 ACR/ARHP Annual Meeting
Germ Line DNA Methylation Profiling Provides Novel Insights into the Parent-of-Origin Effect in Psoriatic Disease
Remy Pollock¹, Darren O'Reilly², Proton Rahman³, Vinod Chandran⁴ and Dafna Gladman⁴, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Parent-of-origin effects refer to the differential risk or pathogenicity of a disease that depends on the sex of the disease-transmitting parent. Excessive paternal transmission…
Abstract Number: 1250 • 2015 ACR/ARHP Annual Meeting
DNA Methylation and Its Relation to Immunological Phenotypes in Peripheral Blood: A Study of Anti-CCP Antibody Positivity from a Population-Based Pool
Sasha Bernatsky¹, Xiaojian Shao², Marie-Michelle Simon², Marvin J. Fritzler³, Philip Awadalla^4,5, Marie Hudson⁶, Ines Colmegna⁷, Tony Kwan² and Tomi Pastinen², ¹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ²Department of Human Genetics, McGill University and Génome Québec Innovation Centre, Montreal, QC, Canada, ³Medicine, University of Calgary, Calgary, AB, Canada, ⁴Medicine, Université de Montreal, Montreal, QC, Canada, ⁵Ontario Institute for Cancer Research, Toronto, ON, Canada, ⁶McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁷Rheumatology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: DNA methylation represents an important potential mediator of environmental influences on autoimmunity, including rheumatoid arthritis (RA). Genome-wide methylation in the context of clinical phenotypes…

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