Abstract Number: 2743 • 2019 ACR/ARP Annual Meeting
Characterizing the Epigenomic Landscape of Psoriasis Patients Destined to Develop Psoriatic Arthritis
Background/Purpose: Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA), an inflammatory musculoskeletal disease, usually after psoriasis onset. A large proportion of individuals with PsA…Abstract Number: 816 • 2019 ACR/ARP Annual Meeting
The Long Non-coding RNA HOTAIR Regulates BMP2 and Wnt Pathways in Synovial Fibroblasts
Background/Purpose: Mechanisms involved in joint patterning of rheumatic diseases remain unknown. The long non-coding RNA HOTAIR is exclusively expressed in synovial fibroblasts (SF) from lower…Abstract Number: 1013 • 2019 ACR/ARP Annual Meeting
Effects of Anti-TNF on MiR Expression in Monocytes and CD4+ T-Lymphocytes in Spondyloarthritis
Background/Purpose: TNFα inhibitors are an effective treatment for many inflammatory diseases. However, their mechanism of action is more complicated than just blocking the targeted cytokine.…Abstract Number: 1058 • 2019 ACR/ARP Annual Meeting
Inhibition of Histone Readers Bromodomain and Extraterminal Domain Proteins Alleviates Scleroderma Fibrosis
Background/Purpose: Epigenetic regulation, including histone acetylation, plays an important role in scleroderma (SSc) fibrosis. The binding of the bromodomain and extra-terminal domain proteins (BRDs) to…Abstract Number: 88 • 2018 ACR/ARHP Annual Meeting
Lymphocyte DNA Methylation As a Mediator of Genetic Risk in Rheumatoid Arthritis
Background/Purpose: Genome-wide association studies (GWAS) have to date identified over 100 genomic loci at which single nucleotide polymorphisms (SNPs) confer an increased risk of developing…Abstract Number: 113 • 2018 ACR/ARHP Annual Meeting
Epigenetic Changes in Dermal Fibroblasts By Inhibition of DOT1L Affect Cell Proliferation and Cell Cycle, but Have No Direct Effects on Collagen Deposition in in Vitro and In Vivo models of Fibrosis
Background/Purpose: Fibrosis is a key feature of systemic sclerosis, a devastating disease that is not well understood. The role of epigenetic factors in the pathophysiology…Abstract Number: 116 • 2018 ACR/ARHP Annual Meeting
Identifying Matricellular Protein CYR61 As a Potential Anti-Fibrotic and Pro-Angiogenic Mediator in Scleroderma
Background/Purpose: Vascular abnormalities represent a fundamental event in the pathogenesis of scleroderma (SSc) in that endothelial cell (EC) damage triggers a self-fueling process ending in…Abstract Number: 921 • 2018 ACR/ARHP Annual Meeting
Multi-Omics Analysis Identifies a Gene Signature Associated with the Clinical Response to Anti-TNF Therapy in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is the most common inflammatory arthritis affecting up to 1% of the population. Tumor Necrosis Factor (TNF) inhibitors have significantly improved…Abstract Number: 1902 • 2018 ACR/ARHP Annual Meeting
Pathogenic and Therapeutic Modulation of Activating Epigenetic Memory at a Novel Enhancer for TGFβ2 in Systemic Sclerosis
Background/Purpose: Systemic Sclerosis (SSc) is an etiologically mysterious disease, in which adults acquire an inflammatory prodrome with progressive fibrosis of the skin and viscera. In…Abstract Number: 1959 • 2018 ACR/ARHP Annual Meeting
Stability of DNA Methylation Signature in Primary RA Synovial Fibroblasts Compared with Cultured Fibroblast-like Synoviocytes
Background/Purpose: Rheumatoid arthritis (RA) is an aggressive immune-mediated joint disease with synovial inflammation and joint destruction. Fibroblast-like synoviocytes (FLS) play a key role in mediating…Abstract Number: 1964 • 2018 ACR/ARHP Annual Meeting
Epigenetic Changes of Energy Metabolism-Related Genes in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Background/Purpose: Epigenetic changes contribute to the pathogenesis of rheumatoid arthritis (RA) and a comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS) has recently been described.…Abstract Number: 2011 • 2018 ACR/ARHP Annual Meeting
Juvenile Arthritis-Associated Single Nucleotide Polymorphisms Identified on Whole Genome Sequencing Show Enrichment within H3K9me3-Marked Regions
Background/Purpose: We have found extensive alterations in chromatin accessibility when the CD4+ T cells of children with active polyarticular juvenile idiopathic arthritis (JIA) are compared…Abstract Number: 2044 • 2018 ACR/ARHP Annual Meeting
Impaired microRNA Processing in Neutrophils from Rheumatoid Arthritis Patients Confers Their Pathogenic Profile. Modulation By Biological Therapies
Background/Purpose: Neutrophils are the most abundant cells in synovial fluid, having all the features of activated cells in rheumatoid arthritis (RA), including prolonged cell survival,…Abstract Number: 2053 • 2018 ACR/ARHP Annual Meeting
Global Mirna Expression and Transcriptomic Profiling of Monocytes from RA Patients
Background/Purpose: Infiltration of the synovium by mononuclear cells, including monocytes, is one of the main features of RA. Monocytes are the first immune cells which…Abstract Number: 2074 • 2018 ACR/ARHP Annual Meeting
Micrornas Deregulation in Monocytes and T CD4 Lymphocytes from Patients with Axial Spondyloarthritis
Background/Purpose: MicroRNAs have been shown to play a crucial role during innate or adaptive immune response. Deregulation of miRNAs has been described in several autoimmune…
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