ACR Meeting Abstracts

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Abstracts tagged "Epigenetics"

  • Abstract Number: 112 • 2023 Pediatric Rheumatology Symposium

    Adverse Childhood Experiences: Prevalence and Relationship to Disease in Childhood-onset Lupus

    Olivia Hendrikx1, Stephanie Fevrier1, Ibrahim Mohamed1, Chelsea DeCoste2, Paris Moaf1, Lawrence Ng1, Deborah Levy1, Linda Hiraki1, Alene Toulany1 and Andrea Knight1, 1The Hospital for Sick Children, Toronto, ON, Canada, 2IWK Health Centre, Halifax, NS, Canada

    Background/Purpose: Adverse Childhood Experiences (ACEs) measure traumatic experiences in childhood. ACEs are associated with epigenetic changes, are known to increase stress response and inflammation, and…
  • Abstract Number: 0397 • ACR Convergence 2022

    Aberrant Global DNA Methylation in Peripheral Blood Cell Subpopulations of Patients with Axial Spondyloarthritis

    ERIC TOUSSIROT1, Sebastien Pasquereau2, Charline Vauchy3, Daniel Wendling4, Jean Charles Balblanc5, caroline Laheurte6, Marc Puyraveau7 and Georges Herbein2, 1CHU de Besançon, Besançon, France, 2EA EPILAB, Besancon, Besançon, France, 3INSERM CIC-1431, Besancon, Besançon, France, 4CHU, University Teaching Hospital, Besançon, France, 5Rhumatologie, Hopital Nord Franche Comté, Trevenans, France, 6EFS Bourgogne Franche Comté, Biomonotoring Plateform, Besançon, France, 7INSERM CIC-1431 CHU, Besançon, France

    Background/Purpose: Axial spondyloarthritis (axSpA) corresponds to a group of chronic inflammatory diseases mainly affecting the axial skeleton. TNFa and IL-17A have been identified as key…
  • Abstract Number: 1173 • ACR Convergence 2022

    Single-cell Multi-omic Analysis of a 3D Skin-Like Tissue Model Provides Insights into Molecular and Cellular Drivers of Systemic Sclerosis

    Tamar Abel1, Noelle Kosarek2, Rezvan Parvizi3, Helen Jarnagin1, Mengqi Huang4, Avi Smith5, Michael Mariani1, Dillon Popovich6, Heetaek Yang7, Tammara Wood8, Jonathan Garlick9, Patricia Pioli7 and Michael Whitfield10, 1Dartmouth College, Lebanon, NH, 2Dartmouth Geisel School of Medicine, Lebanon, NH, 3Dartmouth, Lebanon, NH, 4University of Pittsburgh, Pittsburgh, PN, 5Tufts University, Boston, MA, 6Dartmouth College, West Lebanon, NH, 7Geisel School of Medicine at Dartmouth, Lebanon, NH, 8Dartmouth College, Hanover, NH, 9Tufts University School of Dental Medicine, Boston, MA, 10Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Systemic Sclerosis (SSc) currently lacks reliable in vitro models of skin fibrosis constructed from all human cells. We have developed a skin-like tissue model of systemic…
  • Abstract Number: 0531 • ACR Convergence 2022

    Development and Performance of a Diagnostic Precision Biomarker for Seronegative Rheumatoid Arthritis Based on DNA Methylation in Blood

    Espen Riskedal1, Karl Trygve Kalleberg1, Arne Søraas2, Maria Dahl Mjaavatten3, Grethe-Elisabeth Stenvik4, Joe Sexton4, Janis Neumann1, Cathrine Lund Hadley1, Guro Goll4, Silje Watterdal Syversen4, Håkon Bøås5, Jennifer Ruth Harris5, Astanand Jugessur5, Siri Lillegraven4 and Espen Haavardsholm4, 1Age Labs AS, Oslo, Oslo, Norway, 2Age Labs AS, Eiksmarka, Norway, 3Diakonhjemmet Hospital, Haslum, Norway, 4Diakonhjemmet Hospital, Oslo, Norway, 5Norwegian Institute of Public Health, Oslo, Norway

    Background/Purpose: Patients with seronegative rheumatoid arthritis (RA) exhibit no detectable antibodies, often resulting in delayed diagnosis and treatment initiation. A blood-based test, capable of detecting…
  • Abstract Number: 1175 • ACR Convergence 2022

    Epigenetic Regulation of MicroRNA-126 in Scleroderma Is Associated with Upregulation of DNA Methyltransferase-1, Repression of Endothelial Nitric Oxide Synthase Expression, and Enhanced Platelet Adhesion to Endothelial Cells

    Yongqing Wang and bashar Kahaleh, University of Toledo, Toledo, OH

    Background/Purpose: SSc vasculopathy is characterized by endothelial injury and deficient endothelial-dependent vasodilation leading to occlusive and proliferative vascular outcomes. Platelet activation and elevated circulating platelet…
  • Abstract Number: 0603 • ACR Convergence 2022

    Survivin-dependent Regulation of Bivalent Chromatin and Its Relevance for Adaptive Immunity

    Venkataragavan Chandrasekaran1, Nina Oparina2, Karin Andersson2, Malin Erlandsson2, Maria-Jose Garcia-Bonete3, Maja Jensen4, Gergely Katona5 and Maria Bokarewa6, 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden, 3Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden, 4Department of Chemistry and Molecular Biology, Gothenburg, Sweden, 5Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden, 6Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

    Background/Purpose: Bivalent chromatin (BvCR) is characterized by simultaneous binding of active and repressive modifications to the histone H3 proteins. Influencing expression of the genes, BvCR…
  • Abstract Number: 1621 • ACR Convergence 2022

    Genome-wide Association Study in African American Systemic Sclerosis Patients Identifies a Novel Target – Transforming Growth Factor-β3 (TGFβ3)

    Urvashi Kaundal1, Julia Hartman2, Emilee Stenson1, Sarah Safran1, Chloe Borden1, Mousumi Sahu1, Janet Wang1, Andrea Conte1, Ami Shah3, Maureen Mayes4, Ayo Doumatey5, Amy Bentley5, Daniel Shriner5, Robyn Domsic6, Thomas Medsger7, Paula Ramos8, Richard Silver8, Virginia Steen9, John Varga10, Vivien Hsu11, Lesley Ann Saketkoo12, Elena Schiopu13, Dinesh Khanna14, Jessica Gordon15, Lindsey Criswell16, Heather Gladue17, Chris Derk18, Elana Bernstein19, S. Louis Bridges, Jr.15, Victoria Shanmugam20, Lorinda Chung21, Suzanne Kafaja22, Reem Jan23, Marcin Trojanowski24, Avram Goldberg25, Benjamin Korman26, Settara Chandrasekharappa5, Yongbing Zhao27, Stephen Brooks27, Stefania Dell'Orso1, Adebowale Adeyemo5, Charles Rotimi5, Elaine Remmers5, Daniel Kastner5, Francesco Boin28, Rafael Casellas27, Fredrick Wigley29 and Pravitt Gourh30, 1National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Washington, DC, 3Johns Hopkins Rheumatology, Baltimore, MD, 4Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX, 5National Human Genome Research Institute, Bethesda, MD, 6University of Pittsburgh, Pittsburgh, PA, 7University of Pittsburgh School of Medicine, Pittsburgh, PA, 8Medical University of South Carolina, Charleston, SC, 9Georgetown University School of Medicine, Washington, DC, 10University of Michigan, Ann Arbor, MI, 11Rutgers-RWJ Medical School, South Plainfield, NJ, 12University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, 13Michigan Medicine, Ann Arbor, MI, 14Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI, 15Hospital for Special Surgery, New York, NY, 16National Human Genome Research Institute, NIH, Bethesda, MD, 17Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, 18University of Pennsylvania, Philadelphia, PA, 19Columbia University, New York, NY, 20George Washington University, Great Falls, VA, 21Stanford University, Stanford, CA, 22UCLA Department of Medicine, Division of Rheumatology, Los Angeles, CA, 23University of Chicago, Chicago, IL, 24Boston University School of Medicine, Boston, MA, 25NYU Langone Medical Center - NYU Hospital for Joint Diseases, Lake Success, NY, 26University of Rochester, Rochester, NY, 27National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 28Cedars-Sinai Medical Center, Los Angeles, CA, 29Johns Hopkins University, Baltimore, MD, 30National Institutes of Health, Bethesda, MD

    Background/Purpose: Transforming Growth Factor-β (TGFβ) isoforms play an important role in extracellular matrix biology. Increased TGFβ-regulated gene signature has been observed in lesional skin and…
  • Abstract Number: 0606 • ACR Convergence 2022

    Mechanism of Joint-Specific Homeobox D10 Regulation in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

    Hyeonjeong Lee1, Camilla Machado2, Deepa Hammaker3, Wei Wang4, David Boyle5 and Gary S. Firestein6, 1University of California San Diego, San Diego, CA, 2UCSD, San Diego, CA, 3UC San Diego, San Diego, CA, CA, 4University of California San Diego, San Diego, 5UCSD, La Jolla, CA, 6University of California, San Diego, San Diego, CA

    Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) have joint-specific epigenetic and transcriptome profiles. This is particularly notable for homeobox (HOX) genes, which contribute to joint…
  • Abstract Number: 1698 • ACR Convergence 2022

    LINE1 Reverse Transcriptase Inhibitors Abrogate Type 1 Interferon Responses

    Daniel Rios1, Nafeeza Hafeez1, Brian Desrosiers1, Shradha Rao1, Jess Floro1, Joelle Baddour1, Nisha Perez2, Greg Bisacchi2, Oliver Saunders2, Donna Romero1, Menachem Fromer2, Enrique Garcia-Rivera2, Wilson McKerrow2, Julie Behr2, Bryan Thornlow2, Dennis Zaller2, David Proia2 and Wenyan Miao2, 1Rome Therapeutics, Cambridge, MA, 2Rome Tx, Cambridge, MA

    Background/Purpose: Transposable elements (TEs) are mobile DNA elements that can replicate and move from one position to another within the host genome. Through co-evolution, TEs…
  • Abstract Number: 0607 • ACR Convergence 2022

    Cadherin 6 Regulates Rheumatoid Arthritis Fibroblasts-Like Synoviocyte Aggressiveness

    Camilla Machado1, Hyeonjeong Lee2, Sho Sendo3, Narayanan Perumal4, Wei Wang5, David Boyle5 and Gary S. Firestein6, 1UCSD, San Diego, CA, 2University of California San Diego, San Diego, CA, 3University California, San Diego (UCSD), La Jolla, CA, 4Eli Lilly Company, San Diego, 5University of California San Diego, San Diego, 6University of California, San Diego, San Diego, CA

    Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) display an aggressive behavior. Previous studies have implicated cadherins in FLS function in this phenotype, which are type…
  • Abstract Number: 1715 • ACR Convergence 2022

    Ezh2 Knockout in B Cells Impairs Plasmablast Differentiation and Ameliorates Lupus-like Disease in MRL/lpr Mice

    Xiaoqing Zheng1, Mikhail Dozmorov2, Colleen Strohlein1, Sheldon Bastacky1 and Amr Sawalha1, 1University of Pittsburgh, Pittsburgh, PA, 2Virginia Commonwealth University, Richmond, VA

    Background/Purpose: Enhancer of zeste homolog 2 (EZH2) has been shown to regulate early B cell development and the differentiation of antibody secreting cells (ASCs). We…
  • Abstract Number: 0643 • ACR Convergence 2022

    Subsetting SLE Patients Based on DNA Methylation at the Time of Disease Flare

    Mary Horton1, Joanne Nitithalm2, Kimberly Taylor3, Laura Trupin4, Patricia Katz5, Jinoos Yazdany6, Maria Dall'Era7, Lisa Barcellos8, Lindsey Criswell9 and Cristina M Lanata10, 1NIH/NHGRI, Oakland, CA, 2NIH/NHGRI, Bethesda, MD, 3University of Californi, San Francisco, San Francisco, CA, 4UC San Francisco, San Francisco, CA, 5UCSF, San Rafael, CA, 6UCSF, San Francisco, CA, 7University of California, Division of Rheumatology, San Francisco, CA, 8School of Public Health, UC Berkeley; National Human Genome Research Institute, National Institutes of Health, Berkeley, CA, 9National Human Genome Research Institute, NIH, Bethesda, MD, 10NIH/NHGRI, Washington, DC

    Background/Purpose: Current treatments for SLE do not adequately prevent disease progression. This lack of efficacy, in part, relates to the molecular heterogeneity of disease. The…
  • Abstract Number: 1726 • ACR Convergence 2022

    Impaired Dynamic X-Chromosome Inactivation Maintenance in T Lymphocytes Is a Feature of Spontaneous Lupus in Female Mice and Is Exacerbated in Female-Biased Disease Models

    Nikhil Jiwrajka1, Natalie Toothacre2, Zachary Beethem2, Sarah Sting2, Katherine Forsyth2, Amanda Driscoll2, William Stohl3 and Montserrat Anguera2, 1Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 2Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 3University of Southern California, Los Angeles, CA

    Background/Purpose: SLE is highly female-biased, yet the molecular origins of this bias remain unclear. The X chromosome contains many immune-related genes, suggesting that X-linked epigenetic…
  • Abstract Number: 0923 • ACR Convergence 2022

    Identification of Cell-Specific DNA Methylation Changes Associated with MTX Treatment Response in Rheumatoid Arthritis

    Cameron Adams1, Nisha Nair2, Hong Quach1, Diana Quach1, Joanne Nititham3, Mary Nakamura4, Jonathan Graf5, Lindsey Criswell6 and Lisa Barcellos7, 1University of California, Berkeley, Berkeley, CA, 2The University of Manchester, Manchester, United Kingdom, 3National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 4UCSF/SFVAHCS, San Francisco, CA, 5Ucsf, San Francisco, CA, 6National Human Genome Research Institute, NIH, Bethesda, MD, 7School of Public Health, UC Berkeley; National Human Genome Research Institute, National Institutes of Health, Berkeley, CA

    Background/Purpose: MTX is the recommended first treatment for rheumatoid arthritis (RA); however, only ~40% respond adequately to MTX. Significant joint damage can occur in the…
  • Abstract Number: 1727 • ACR Convergence 2022

    BATF Represses BIM Expression to Sustain the T Cell Anergy Program

    Philip Titcombe, Milagros Silva-Morales, Na Zhang and Daniel Mueller, University of Minnesota, Minneapolis, MN

    Background/Purpose: T cell tolerance is essential for preventing autoimmune diseases and resolving inflammation. To maintain tolerance, CD4+ T cells recognizing self-antigens in the periphery can…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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