Abstracts tagged "Epigenetics"

Abstract Number: 2697 • 2013 ACR/ARHP Annual Meeting
Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis
Tibor A. Rauch¹, Beata Tryniszewska¹, Andras Vida¹, Timea Ocsko¹, Sandor Szanto², Holly L. Rosenzweig³, Matthew A. Brown⁴, Gethin P Thomas⁵, Katalin Mikecz¹ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, University of Debrecen, Debrecen, Hungary, ³Oregon Health & Science University, Portland, OR, ⁴Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ⁵Translational Reserch Institute, University of Queensland Diamantina Institute, Woolloongabba, Australia
Background/Purpose: Ankylosing spondylitis (AS) is the prototypic spondyloarthritis and affects approximately 0.2-0.5% of the human population. It is estimated that genetic risk factors contribute >90%…
Abstract Number: 2519 • 2013 ACR/ARHP Annual Meeting
A Systemic Lupus Erythematosus (SLE) Diagnostic Test Based On DNA Methylation Signatures From Peripheral Blood Mononuclear Cells
David W. Anderson¹, Robert Shoemaker², Kurt Krummel³, Zachary Hornby⁴ and Jonathan E. Lim¹, ¹Research and Development, IGNYTA, Inc., San Diego, CA, ²Bioinformatics, IGNYTA, Inc., San Diego, CA, ³Research and Development-Assay Development, IGNYTA, Inc., San Diego, CA, ⁴Business Development, IGNYTA, Inc., San Diego, CA
Background/Purpose: The heterogeneous nature of SLE and a lack of reliable biomarkers make SLE a challenge to classify in patients. A differential diagnosis of SLE…
Abstract Number: 2424 • 2013 ACR/ARHP Annual Meeting
Investigation Of The Role Of Histone Deacetylases In Rheumatoid Arthritis Synovial Fibroblasts
Sarah Hawtree¹, Munitta Muthana¹, Sarah Aynsley¹, J. Mark Wilkinson² and Anthony G. Wilson³, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom, ³Infection & Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS).…
Abstract Number: 2399 • 2013 ACR/ARHP Annual Meeting
Altered Histone Methylation Is Associated With IL-6 Dependent Matrix Metalloproteinases Gene Transcriptional Activation In Rheumatoid Arthritis Synovial Fibroblasts
Yasuto Araki^1,2, Takuma Tsuzuki Wada^1,2, Kojiro Sato¹, Kazuhiro Yokota¹, Fumihiko Miyoshi¹, Yu F. Asanuma³, Yuji Akiyama¹ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan, ³Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which causes progressive joint destruction. In spite of the modern medications including biologic reagents, it…
Abstract Number: 1896 • 2013 ACR/ARHP Annual Meeting
Arthritis Associated Sequence Alterations Within a Genetic Susceptibility Region Of Mouse Chromosome 3; A Genomic Region Which Is Syntenic With a Prominent Non-MHC Locus In Rheumatoid Arthritis
Andras Vida¹, Timea Besenyei², Beata Tryniszewska¹, Timea Ocsko¹, Zoltan Szekanecz³, Tibor A. Rauch¹, Katalin Mikecz¹ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Department of Rheumatology, University of Debrecen, Debrecen, Hungary, ³Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that results in inflammatory destruction of synovial joints in affected patients. The involvement of genetic and epigenetic…
Abstract Number: 1850 • 2013 ACR/ARHP Annual Meeting
The Bromodomain Protein Inhibitor I-BET151 Suppresses Inflammatory and Matrix Degrading Properties Of Rheumatoid Arthritis Synovial Fibroblasts
Kerstin Klein¹, Renate E. Gay², Christoph Kolling³, Lih-Ling Lin⁴, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ³Schultess Clinic, Zurich, Switzerland, ⁴Inflammation and Remodeling Research Unit, Pfizer, Cambridge, MA
Background/Purpose: Bromodomain proteins (BRD) contain conserved acetyl-lysine binding domains that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks.…
Abstract Number: 1707 • 2013 ACR/ARHP Annual Meeting
Biological Insights From Genetics Of Rheumatoid Arthritis Contribute To Drug Discovery
Yukinori Okada^1,2,3, Di Wu^2,4,5,6, Chikashi Terao^7,8, Katsunori Ikari⁹, Yuta Kochi¹⁰, Koichiro Ohmura¹¹, Akari Suzuki¹⁰, Hisashi Yamanaka⁹, Joshua C. Denny¹², Jeffrey D. Greenberg¹³, Robert R. Graham¹⁴, Matthew A. Brown¹⁵, Sang-Cheol Bae¹⁶, Jane Worthington¹⁷, Leonid Padyukov¹⁸, Lars Klareskog¹⁹, Peter K. Gregersen²⁰, Peter M. Visscher^21,22, Katherine A. Siminovitch^23,24 and Robert M. Plenge²⁵, ¹Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Broad Institute, Cambridge, MA, ⁴Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ⁵Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, ⁶Department of Statistics, Harvard University, Cambridge, MA, ⁷Center for Genomic Medicine, Kyoto University, Kyoto, Japan, ⁸Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ¹⁰Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ¹¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ¹²Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, ¹³Rheumatology, NYU Hospital for Joint Diseases, New York, NY, ¹⁴ITGR Human Genetics, Genentech, Inc., South San Francisco, CA, ¹⁵Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ¹⁶Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ¹⁷Arthritis Research UK Epidemiology Unit, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ¹⁸Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ¹⁹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²⁰Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²¹The University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia, ²²Queensland Brain Institute, The University of Queensland, St Lucia, Brisbane, Australia, ²³Mount Sinai Hospital, Toronto, ON, Canada, ²⁴University of Toronto, Toronto, ON, Canada, ²⁵Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological datasets to provide…
Abstract Number: 1625 • 2013 ACR/ARHP Annual Meeting
Prolactin-Induced Interferon Regulatory Factor 1 Activation and Histone H4 Hyperacetylation In Monomac-6 Cells Correlating With Changes Seen In Monocytes From Systemic Lupus Erythematosus Patients
Yiu Tak Leung¹, Lihua Shi², Kelly Maurer², Li Song², Michelle Petri³ and Kate Sullivan⁴, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Epigenetic changes have been described in systemic lupus erythematosus (SLE) and offer a potential explanation for the chronicity of disease and missing heritability. Therapies…
Abstract Number: 1492 • 2013 ACR/ARHP Annual Meeting
Histone Deacetylase 1 But Not 2 Is Highly Expressed In The Lymphocyte Foci In The Labial Glands Of Patients With Sjogren’s Syndrome
Juan Guo and Wei Zhou, Department of Rheumatology and Immunology, Peking University First Hospital, Beijing, China
Background/Purpose: Sjogren’s syndrome (SS) is an autoimmune disease with abnormally infiltrating lymphocytes in exocrine glands expressing Th1 cytokines and increased incidence of lymphoma. Histone deacetylases…
Abstract Number: 2872 • 2013 ACR/ARHP Annual Meeting
Long Noncoding RNA Nron Regulates The Cytoplasmic-Nuclear Shuttling and Activity Of NFAT5 In Rheumatoid Arthritis Synovial Fibroblast
Kunihiko Umekita¹, Michelle Trenkmann¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴, Steffen Gay¹ and Mojca Frank Bertoncelj⁵, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Schultess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) are critical regulators of gene expression and of major biological processes, such as cell migration, proliferation and invasion. The lncRNA…
Abstract Number: 1496 • 2013 ACR/ARHP Annual Meeting
DNA Methylation In Six Cell and Tissue Types In Sjögren’s Syndrome Reveals Distinct Patterns Across Samples and Clustering Based On Disease Status
Alice Baker¹, Diana Quach¹, Hong L. Quach¹, Emon Elboudwarej¹, Lisa F. Barcellos¹ and Lindsey A. Criswell², ¹Epidemiology, University of California, Berkeley, Berkeley, CA, ²Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA
Background/Purpose: Sjögren’s Syndrome (SS) is a chronic, multisystem autoimmune disease characterized by progressive destruction of the exocrine glands, with subsequent mucosal and conjunctival dryness. Increasing…
Abstract Number: 2876 • 2013 ACR/ARHP Annual Meeting
Key Rheumatoid Arthritis-Associated Pathogenic Pathways Revealed By Integrative Analysis Of RA Omics Datasets
John Whitaker¹, Wei Wang² and Gary S. Firestein³, ¹Chemistry, UCSD School of Medicine, La Jolla, CA, ²Chemistry, UCSD, La Jolla, CA, ³Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Genome-wide analysis of RA has independently evaluated DNA sequence variation, differential RNA expression, and differential DNA methylation. Each approach alone implicates promising pathways…
Abstract Number: 1426 • 2013 ACR/ARHP Annual Meeting
Inhibition Of Spermidine/Spermine N1-Acetyltransferase Activity – a New Therapeutical Concept In Rheumatoid Arthritis
Emmanuel Karouzakis¹, Astrid Jungel¹, Beat A. Michel², Renate E. Gay³, Steffen Gay¹ and Michel Neidhart⁴, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Spermine/spermidine N1-acetyltransferase (SSAT1) and polyamine modulating factor 1 (PMF1) are increased in rheumatoid arthritis synovial fibroblasts (RASF). Since PMF1 regulates the expression of SSAT1,…
Abstract Number: 2736 • 2013 ACR/ARHP Annual Meeting
High Density Microarray Analysis Identifies Novel Differentially Expressed Long Noncoding RNAs In Rheumatoid Arthritis Synovial Fibroblasts
Mojca Frank Bertoncelj¹, Michelle Trenkmann¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴ and Steffen Gay¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Schultess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) have emerged as key regulators of gene expression. Recently, several new susceptibility loci were identified for rheumatoid arthritis (RA), mapping…
Abstract Number: 1380 • 2013 ACR/ARHP Annual Meeting
Histone Modifications In The Interluekin-6 Gene Promoter Region Of Rheumatoid Arthritis Synovial Fibroblasts
Takuma Tsuzuki Wada^1,2, Yasuto Araki^1,2, Kazuhiro Yokota¹, Fumihiko Miyoshi¹, Kojiro Sato¹ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: , Rheumatoid arthritis (RA) is a disease of unknown origin, which develops continuous inflammation and progressive joint destruction resulting from an autoimmune response mainly…

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