Abstracts tagged "Epigenetics"

Abstract Number: 3256 • 2015 ACR/ARHP Annual Meeting
Epigenetic Chromosome Conformations Predict MTX Responsiveness in Early Rheumatoid Arthritis Patients
Claudio Carini¹, Aroul Ramadass², Philip Jordan², Ewan Hunter², Alexandre Akoulitchev², Iain. B. McInnes³, Carl. S. Goodyear³ and Scottish Early Rheumatoid Arthritis Inception Cohort Investigators, ¹35 Cambridgepark Drive, Pfizer, Cambridge, MA, ²Oxford Biodynamics, Oxford, United Kingdom, ³Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: In early rheumatoid arthritis (RA), it is not possible to predict response to first line DMARDs (e.g. methotrexate (MTX)) and as such treatment decisions…
Abstract Number: 95 • 2015 ACR/ARHP Annual Meeting
Validation of Differential Methylation in Paternally Versus Maternally Transmitted Psoriatic Disease
Remy Pollock¹, Darren O'Reilly², Amanda Dohey², Dianne Codner², Vinod Chandran³, Dafna Gladman³ and Proton Rahman⁴, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Several studies have demonstrated excessive paternal transmission of psoriasis and psoriatic arthritis (PsA). This phenomenon is thought to be mediated by genomic imprinting. We…
Abstract Number: 804 • 2015 ACR/ARHP Annual Meeting
Prolactin Induces Interferon Regulatory Factor 1 Activation and Histone H4 Hyperacetylation in Primary Monocytes Comparable to Changes Seen in Monocytes from Systemic Lupus Erythematosus Patients
Yiu Tak Leung¹, Kathleen E. Sullivan², Kelly Maurer³, Li Song⁴ and Lihua Shi³, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: : Epigenetic changes have been described in systemic lupus erythematosus (SLE) and offer a potential explanation for the chronicity of disease. We previously found…
Abstract Number: 2448 • 2014 ACR/ARHP Annual Meeting
DNA Methylation Analysis of Lymph Node Stromal Cells of Rheumatoid Arthritis Patients
Emmanuel Karouzakis¹, Caroline Ospelt¹, Janine Hähnlein², Renate E. Gay³, Paul Peter Tak⁴, Danielle Marie Gerlag⁵, Michel Neidhart¹, Steffen Gay¹ and Lisa G.M. van Baarsen², ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁴University of Cambridge,Cambridge and GlaxoSmithKline, Stevenage, United Kingdom, ⁵GSK,Clinical Unit Cambridge,R&D Projects Clinical Platforms & Sciences, Cambridge, United Kingdom
Background/Purpose Lymph node stromal cells (LNSC) build the scaffold that enables migration and interaction of lymphocytes in the lymph node. More recently, it has been…
Abstract Number: 1889 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis (RA)-Associated Risk Allele LBH Alters the Function of a Differentially Methylated LBH Enhancer
Deepa Hammaker¹, Gary S. Firestein², Wei Wang³, John W. Whitaker⁴ and Anna-Karin Ekwall⁵, ¹Medicine, University of California San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, ³Chemistry, UCSD, La Jolla, CA, ⁴860 island ave, UCSD, San Diego, CA, ⁵Medicine, UC San Diego, La Jolla, CA
Background/Purpose Recent data suggest that epigenetics, including DNA methylation, contributes to imprinting RA fibroblast-like synoviocytes (FLS) and alters their behavior. To understand how RA-associated risk…
Abstract Number: 1887 • 2014 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis of Twin Pairs Discordant for Systemic Sclerosis Reveals Distinct Signatures in Blood and Dermal Fibroblasts
Paula S. Ramos¹, Rick Jordan², James Lyons-Weiler², Thomas A. Medsger Jr.³ and Carol A. Feghali-Bostwick⁴, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, ³Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose Systemic sclerosis (SSc) is a chronic, multisystem, autoimmune inflammatory disease with genetic and non-genetic contributions to risk. The etiology of SSc, including the reasons…
Abstract Number: 1728 • 2014 ACR/ARHP Annual Meeting
Bromodomain Inhibitor JQ1 Modulates Collagen Processing and Ameliorates Bleomycin Induced Dermal Fibrosis in Mice
Sarah Trinder¹, Mary Tarriela², Adrian Gilbane¹, Robert Good³, Xu Shi-Wen⁴, David Abraham⁵ and Alan M. Holmes⁶, ¹Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, ³Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, ⁵Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁶Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is a complex pro-inflammatory scarring disease, characterised by elevated deposition of extracellular matrix (ECM) proteins, in particular collagen type I. The…
Abstract Number: 1132 • 2014 ACR/ARHP Annual Meeting
A Novel Epigenetic Mark, Histone H1 Fucosylation, Orchestrates Macrophage Differentiation and Plasticity By Remodeling the Enhancer Landscape in Rheumatoid Arthritis
Jun Li¹, Keith Giles², Parastoo Azadi³, Mayumi Ishihara³, PingAr Yang¹, Qi Wu¹, Bao Luo¹, David M. Spalding⁴, James A Mobley⁵, S. Louis Bridges Jr.^6,7, Hui-Chen Hsu¹ and John D. Mountz^1,8, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Stem cell Institute, Birmingham, AL, ³University of Georgia, Complex Carbohydrate Research Center, Athens, GA, ⁴University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, ⁵University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸Birmingham VA Medical Center, Birmingham, AL
Background/Purpose There is an imbalance of inflammatory M1 vs. anti-inflammatory M2 macrophages (MΦs) in rheumatoid arthritis (RA). The epigenetic codes underlying this M1 dominating pathogenesis…
Abstract Number: 1128 • 2014 ACR/ARHP Annual Meeting
Regulation of PIWIL4 By Histone Modifications in Rheumatoid Arthritis
Lenka Pleštilová¹, Niharika Gaur¹, Mária Filková², Borbala Aradi-Vegh¹, Ladislav Senolt³, Adrian Ciurea¹, Renate E. Gay⁴, Jiri Vencovsky³, Michel Neidhart⁵, Steffen Gay⁵ and Astrid Juengel¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ³Institute of Rheumatology and Clinic of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose Analog to miRNAs that bind to argonaute proteins to suppress gene expression, a new group of non-coding RNAs piwi-interacting RNAs (piRNAs, 26-31 nt) build…
Abstract Number: 1124 • 2014 ACR/ARHP Annual Meeting
Genome-Wide Profiling of DNA from Cartilage Reveals Regions Differently Methylated in Osteoarthritis Patients
Guangju Zhai¹, Ming Liu², Yuhua Zhang¹, Patricia E. Harper¹, Erfan Aref-Eshghi², Glynn Martin³, Andrew Furey³, Roger Green¹, Guang Sun⁴ and Proton Rahman⁵, ¹Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²Discipline of Genetics, Memorial University, St. John's, NF, Canada, ³Department of Surgery, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁵Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Osteoarthritis (OA) represents the most common form of arthritis and has substantial clinical and economic impact. Evidence supports that DNA methylation plays a significant…
Abstract Number: 1033 • 2014 ACR/ARHP Annual Meeting
Stat3 Promotes IL-10 Expression in SLE T Cells through Trans-activation and Chromatin Remodeling
Christian Hedrich¹, Thomas Rauen², Sokratis Apostolidis³, Alexandros P. Grammatikos⁴, Noe Rodriguez Rodriguez⁴, Christina Ioannidis³, Vasileios C. Kyttaris⁴, José C. Crispin⁴ and George C. Tsokos⁵, ¹Children's Hospital, Dresden, Germany, ²Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ³Medicine, Rheumatology, BIDMC, Boston, MA, ⁴Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-10 is an immune-regulatory cytokine that is expressed by a wide range of cells and tissues. It plays a central role in the regulation…
Abstract Number: 939 • 2014 ACR/ARHP Annual Meeting
Prenatal Methyl-Rich Diet Decreases Inflammation in Collagen Induced Arthritis
Sanjay Garg¹, Dipak R. Patel² and Raymond Yung³, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Internal Med-Univ Michigan, University of Michigan, Ann Arbor, MI
Background/Purpose: Early-life nutrition can have a profound effect on late-life disease development. Most current studies focus on macro-nutrition (calorie, carbohydrate, fat, and protein), and much…
Abstract Number: 881 • 2014 ACR/ARHP Annual Meeting
DNA Methylation Analysis of the Temporal Artery Microenvironment Reveals a Robust T Cell Signature and Suggests a Role for TNF-α in Giant Cell Arteritis
Patrick S. Coit¹, Lindsey B. De Lott², Bin Nan³, Victor M. Elner⁴ and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, University of Michigan, Ann Arbor, MI, ⁴Department of Ophthalmology and Visual Sciences & Department of Pathology, University of Michigan, Ann Arbor, MI
Background/Purpose: Giant cell arteritis (GCA) is a systemic large vessel vasculitis of unknown etiology. A hallmark of GCA is the presence of granulomatous inflammation of…
Abstract Number: 624 • 2014 ACR/ARHP Annual Meeting
Genome-Wide Methylome Investigation Reveals New Candidate Genes Associated with Arthritis Mutilans
Vinod Chandran¹, Darren O'Reilly², Amir Haddad¹, Yuhua Zhang³, Guangju Zhai³, Dianne Codner², Arane Thavaneswaran⁴, Proton Rahman^5,6 and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵Rheumatology, St. Claires Mercy Hospital, St. Johns, NF, Canada, ⁶Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose Arthritis mutilans is a severe form of psoriatic arthritis (PsA). Why some patients develop this rapidly progressive destructive disease remains unclear. We hypothesized that…
Abstract Number: 2919 • 2014 ACR/ARHP Annual Meeting
The Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Is Regulated By TGFß and PDGF and Modulates Cell Growth in Fibroblast-like Synoviocytes
Anna-Karin Ekwall¹, Deepa Hammaker², John W. Whitaker³, William Bugbee⁴, Wei Wang⁵ and Gary S. Firestein⁶, ¹Medicine, UC San Diego, La Jolla, CA, ²Medicine, University of California San Diego, La Jolla, CA, ³860 island ave, UCSD, San Diego, CA, ⁴Orthopaedics, Scripps Clinic, La Jolla, CA, ⁵Chemistry, UCSD, La Jolla, CA, ⁶Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display an aggressive phenotype, such as increased cytokine production and cell growth. Currently no therapeutics specifically target FLS. To this…

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