Abstracts tagged "Epigenetics"

Abstract Number: 1925 • 2017 ACR/ARHP Annual Meeting
TGFβ Promotes Fibrosis By MYST1-Dependent Epigenetic Regulation of Autophagy
Ariella Zehender¹, Neng-Yu Lin², Adrian Stefanica³, Chih-Wei Chen⁴, Alina Soare⁵, Thomas Wohlfahrt⁶, Simon Rauber⁶, Christina Bergmann⁷, Andreas Ramming⁸, Oliver Distler⁹, Georg Schett¹⁰ and Jörg Distler⁵, ¹1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ²Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³1Department of Internal Medicine 3 – Rheumatology and Immunology, University of Erlangen, Erlangen, Germany, ⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ⁵Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁶Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁷Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁸Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹⁰Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Autophagy (Atg) is catabolic process allowing cells to degrade unnecessary or dysfunctional cellular organelles. Aberrant activation of Atg has been implicated into the pathogenesis…
Abstract Number: 2654 • 2017 ACR/ARHP Annual Meeting
Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus
Juliana Imgenberg-Kreuz^1,2, Jonas Carlsson Almlöf¹, Dag Leonard³, Gunnel Nordmark², Maija-Leena Eloranta³, Leonid Padyukov⁴, Iva Gunnarsson⁴, Elisabet Svenungsson⁴, Christopher Sjöwall⁵, Lars Rönnblom², Ann-Christine Syvänen¹ and Johanna K Sandling^1,2, ¹Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ³Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ⁴Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁵Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping University, Linköping, Sweden, Linköping, Sweden
Background/Purpose: DNA methylation has emerged as an important contributing factor in the pathogenesis of systemic lupus erythematosus (SLE). SLE typically requires continuous treatment to control…
Abstract Number: 2829 • 2017 ACR/ARHP Annual Meeting
Complete Epigenetic Landscape of Rheumatoid Arthritis Fibroblast-like Synoviocytes Reveals Unanticipated Critical Pathogenic Pathways
Rizi Ai¹, Teresina Laragione², Deepa Hammaker³, David L. Boyle⁴, Andre ‎ Wildberg⁵, Keisuke Maeshima³, Emmanuele Palescandolo⁶, Vinod Krishna⁶, Bryan Linggi⁷, David Pocalyko⁸, John W. Whitaker⁹, Percio S. Gulko², Wei Wang¹⁰ and Gary S. Firestein¹¹, ¹UC San Diego, La Jolla, CA, ²Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ³Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ⁴University of California San Diego, La Jolla, CA, ⁵Chemistry and Biochemistry, UNIVERSITY OF CALIFORNIA SAN DIEGO, LA JOLLA, CA, ⁶Janssen Pharmaceuticals, Spring House, PA, ⁷janssen Pharmaceuticals, Spring House, PA, ⁸Janssen Research, Spring House, PA, ⁹Janssen Pharmaceuticals, La Jolla, CA, ¹⁰Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ¹¹Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: Epigenetics participates in the pathogenesis of rheumatoid arthritis (RA). Epigenetic marks, gene expression and DNA polymorphisms have been investigated but the analyses are limited…
Abstract Number: 66 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Profiling of OA PBMCs Reveals Slowed Epigenetic Aging Among Rapid Radiographic Progressors: Data from the Osteoarthritis Initiative (OAI)
Alexander Rivas¹, Madison Andrews² and Matlock A. Jeffries³, ¹Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Department of Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Extensive evidence has correlated epigenetic alterations in articular tissues with both the presence and progression of human osteoarthritis. A recent study demonstrated that accelerated…
Abstract Number: 178 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Study in Lupus in an Admixed Mexican Population
Maria Teruel¹, Patrick Coit², Mikhail Dozmorov³, Mario Cardiel⁴, Ignacio Garcia-De La Torre⁵, Marco A Maradiaga-Ceceña Sr.⁶, José Francisco Moctezuma⁷, Maria Teresa Tusié-Luna⁸, Marta Alarcón-Riquelme^9,10 and Amr H Sawalha², ¹GENYO, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, ⁴Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, ⁵Immunology & Rheumatology, Centro de Est. de Invest. Bas. y Clin., S.C., Guadalajara, JAL, Mexico, ⁶Hospital General de Culiacán, Culiacán, Mexico, ⁷Servicio de Reumatología, Hospital General de Mexico, Ciudad de Mexico, Mexico, ⁸Medicina Genómica y Toxicología Ambiental, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico, ⁹Uppsala University, Uppsala, Sweden, ¹⁰Centro de Genomica e Investigación Oncológica, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain
Background/Purpose: Our knowledge about the pivotal role DNA methylation plays in the pathogenesis of SLE has significantly increased in the last few years. However, we…
Abstract Number: 184 • 2017 ACR/ARHP Annual Meeting
An Epigenome-Guided Approach to Causal Variant Discovery in Autoimmune Disease
Richard C. Pelikan¹, Jennifer A. Kelly², Yao Fu², Caleb Lareau³, Graham B. Wiley¹, Stuart Glenn¹, Martin Aryee^3,4, Courtney Montgomery⁵ and Patrick Gaffney², ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Department of Biostatistics, Harvard T.H. Chan School of Public Health, Charlestown, MA, ⁴Department of Pathology, Harvard Medical School, Boston, MA, ⁵Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Genome-wide association studies have identified thousands of genetic associations with complex human diseases and traits. However, establishing the truly causal regions of risk haplotypes…
Abstract Number: 753 • 2017 ACR/ARHP Annual Meeting
The Histone Demethylase Jumonji Domain-Containing Protein 3 (JMJD3) As Central Mediator of Fibroblast Activation
Christina Bergmann¹, Amelie Brandt¹, Clara Dees², Yun Zhang³, Chih-Wei Chen⁴, Tatjana Mallano⁵, Thomas Wohlfahrt⁶, Ruifang Liang⁷, Rosebeth Kagwiria¹, Aline Bozec⁸, Ralf Rieker⁹, David Abraham¹⁰, Andreas Ramming¹¹, Oliver Distler¹², Georg Schett¹³ and Jörg Distler¹⁴, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ⁵Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁶Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁸Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ⁹Department of Pathology, University Clinic Erlangen, Erlangen, Germany, ¹⁰Centre for Rheumatology and Connective Tissue, UCL School of Life and Medical Sciences, London, London, United Kingdom, ¹¹Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ¹²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹³Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ¹⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
Background/Purpose: Epigenetic modifications are key drivers of chronic fibroblast activation. Trimethylation of histone 3 at lysine residue K27 (H3K27me3) is a repressive modification, that is…
Abstract Number: 755 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Pattern in Systemic Sclerosis Microvascular Endothelial Cells: Identification of Epigenetically Affected Key Genes and Pathways
Shadia Nada¹, Ibtissam Gad², Ali Alqahtani³, Ahmad Assaly², Sadik Khuder⁴, Yongqing Wang⁵, Bashar Kahaleh¹ and Nezam Altorok¹, ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²University of Toledo, Toledo, OH, ³Internal Medicine, University of Toledo, Toledo, OH, ⁴Department of Medicine, University of Toledo, Toledo, OH, ⁵Medicine, University of Toledo, Toledo, OH
Background/Purpose: The etiology of systemic sclerosis (SSc) is not clear, but there is evidence suggesting a critical role for epigenetic alterations in disease pathogenesis and…
Abstract Number: 137 • 2017 Pediatric Rheumatology Symposium
Chromatin Landscapes and Genetic Risk For Juvenile Idiopathic Arthritis
James Jarvis¹, Lisha Zhu², Lai Ping Wong³, Tao Liu⁴, Kaiyu Jiang³ and Yanmin Chen³, ¹Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Department of Biochemistry, University at Buffalo, Buffalo, NY
Background/Purpose: The transcriptomes of peripheral blood cells in children with juvenile idiopathic arthritis (JIA) show distinct transcriptional aberrations that suggest impairment of transcriptional regulation. To…
Abstract Number: 647 • 2016 ACR/ARHP Annual Meeting
Genomic and Epigenetic Bioinformatics Demonstrate Dual TNF-α and IL17A Target Engagement By ABT-122, and Suggest Mainly TNF-α–Mediated Relative Target Contribution to Drug Response in MTX-IR Rheumatoid Arthritis Patients
Robert W. Georgantas III¹, Melanie Ruzek², Justin Wade Davis¹, Feng Hong¹, Elizabeth Asque¹, Kenneth Idler¹, Heikki T. Mansikka¹, Benoit Guerette¹ and Jeffrey F. Waring¹, ¹AbbVie Inc., North Chicago, IL, ²Immunology Discovery, AbbVie, Worcester, MA
Background/Purpose: ABT-122 is a dual variable domain (DVD-Ig) biologic which inhibits TNF-α and IL17A. In a 12-wk phase 2 study (NCT02141997) in MTX-IR patients (pts)…
Abstract Number: 1093 • 2016 ACR/ARHP Annual Meeting
DNA Methylation Defines Joint Specific Differences in Synovial Fibroblasts from OA and RA Patients
Emmanuel Karouzakis¹, Mojca Frank Bertoncelj², Kerstin Klein¹, Christoph Kolling³, Renate E. Gay¹, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Schulthess Clinic, Zurich, Switzerland
Background/Purpose: Recent studies revealed epigenetic changes in DNA methylation associated with rheumatoid arthritis (RA) synovial fibroblasts (SF). In addition, we have shown that SF exhibit…
Abstract Number: 1566 • 2016 ACR/ARHP Annual Meeting
Histone Lysine Methylation and STAT3 Differentially Regulate Constitutive and IL-6-Induced MMPs Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts
Yasuto Araki^1,2, Takuma Tsuzuki Wada^2,3, Yoshimi Aizaki^1,2, Kazuhiro Yokota¹, Hiroshi Kajiyama¹, Yu Funakubo Asanuma¹, Kojiro Sato¹, Hiromi Oda⁴ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan, ³Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma, Japan, ⁴Orthopedic Surgery, Faculty of Medicine, Saitama Medical Univeristy, Morohongo Moroyama, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes progressive joint destruction. In spite of the modern medications, including biologic reagents, it…
Abstract Number: 1665 • 2016 ACR/ARHP Annual Meeting
Validation of Germ Line Epigenetic Variants Associated with Psoriatic Disease
Remy Pollock¹, Laila Zaman¹, Vinod Chandran² and Dafna D Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Heritable epigenetic phenomena may play a role in the parent-of-origin effect observed in psoriasis and psoriatic arthritis (PsA). A previous epigenome-wide association study (EWAS)…
Abstract Number: 1825 • 2016 ACR/ARHP Annual Meeting
the Non-Coding Genome and the Genetics of Systemic Lupus
Joyce Hui-Yuen¹, Lisha Zhu², Lai Ping Wong³, Kaiyu Jiang⁴, Yanmin Chen⁴, Tao Liu⁵ and James Jarvis⁶, ¹North Shore-Long Island Jewish Health System, Lake Success, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Pediatrics, The University at Buffalo, Buffalo, NY, ⁵Department of Biochemistry, University at Buffalo, Buffalo, NY, ⁶Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-system, complex disease believed to be triggered by gene-environment interactions. While we have made considerable progress in investigation…
Abstract Number: 2033 • 2016 ACR/ARHP Annual Meeting
A Multi-Dimensional Genomic Map for Polyarticular Juvenile Idiopathic Arthritis
James Jarvis¹, Lisha Zhu², Kaiyu Jiang³, Michael Buck², Yanmin Chen³, Halima Moncrieffe⁴, Laura Brungs⁴, Tao Liu⁵ and Ting Wang⁶, ¹Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Department of Biochemistry, University at Buffalo, Buffalo, NY, ⁶Genetics, Washington University School of Medicine, St. Louis, MO
Background/Purpose: Polyarticular juvenile idiopathic arthritis (JIA) is a complex trait characterized by gene-environment interactions. While we are beginning to identify multiple genomic regions associated with…

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