Abstracts tagged "Environmental factors"

Abstract Number: 482 • 2018 ACR/ARHP Annual Meeting
The Association of Short-Term Ultraviolet Radiation Exposure and Calcinosis in Juvenile Dermatomyositis in the Childhood Arthritis & Rheumatology Research Alliance Registry
Jessica Neely¹, Craig S. Long², Hugh Sturrock³ and Susan Kim⁴, ¹Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA, ²National Oceanic and Atmospheric Administration (NOAA)/Climate Prediction Center, College Park, MD, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴Pediatric Rheumatology, University of California, San francisco School of Medicine, San Francisco, CA
Background/Purpose: JDM is an autoimmune systemic vasculopathy characterized by myositis and skin rash. Some myositis specific antibodies (MSAs) are associated with clinical manifestations in JDM,…
Abstract Number: 1087 • 2018 ACR/ARHP Annual Meeting
Association between Cigarette Smoking and Systemic Lupus Erythematosus – a Bayesian Multivariate Meta-Analysis of Case-Control and Cohort Studies
Monica Hui Yan Chua¹, Irene Ai Ting Ng¹, Mike Wai-Leung Cheung² and Anselm Mak³, ¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ²Psychology, Faculty of Arts and Social Sciences, National University of Singapore, Singapore, Singapore, ³Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Background/Purpose: The association between cigarette smoking and the occurrence of SLE has been studied over the past two decades but results are conflicting. The global…
Abstract Number: 69 • 2018 ACR/ARHP Annual Meeting
Possible Association of Early Inflammatory Arthritis with Viral Outbreaks Such As Influenza: Time Series Analysis of the Canadian Early Inflammatory Arthritis Cohort
Fatima Kudaeva¹, Mark Speechley², Neil Klar², Orit Schieir³, Susan J. Bartlett⁴, Louis Bessette⁵, Gilles Boire⁶, Glen Hazlewood⁷, Carol A Hitchon⁸, Edward C. Keystone⁹, Diane Tin¹⁰, Carter Thorne¹¹, Vivian P. Bykerk¹² and Janet E. Pope¹³, ¹Department of Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁴Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, ⁵Division of Rheumatology, Department of Medicine, CHU de Québec-Université Laval, Québec, QC, Canada, ⁶Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁷Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB, Canada, ⁸University of Manitoba, Winnipeg, MB, Canada, ⁹University of Toronto and Mount Sinai Hospital, Toronto, ON, Canada, ¹⁰The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹¹University of Toronto, Newmarket, ON, Canada, ¹²Hospital for Special Surgery, New York, NY, ¹³Department of Medicine, University of Western Ontario, London, ON, Canada
Background/Purpose: Disease clustering suggests a possible environmental cause. Rheumatoid arthritis (RA) is an autoimmune disease that may be triggered by environmental factors such as viruses.…
Abstract Number: 89 • 2018 ACR/ARHP Annual Meeting
Anti-Nuclear Antibodies (ANA) and Air Pollution: Ultrafine Particles and Ozone
Sasha Bernatsky¹, Shouao Wang², May Y Choi³, Scott Weichenthal⁴, Marianne Hatzopoulou⁵, Marvin J. Fritzler⁶ and Audrey Smargiassi⁷, ¹Divisions of Rheumatology and Clinical Epidemiology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁴Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada, ⁵Civil and Mineral Engineering, University of Toronto, Toronto, ON, Canada, ⁶Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁷Public Health, Université de Montreal, Montreal, QC, Canada
Background/Purpose: Previous studies have suggested links between air pollution (particularly PM2.5) and serum antibodies related to rheumatic diseases. No one has yet examined anti-nuclear antibody…
Abstract Number: 119 • 2017 ACR/ARHP Annual Meeting
Occupational Exposure to Asbestos and Risk of Rheumatoid Arthritis
Anna Ilar¹, Per Gustavsson¹, Pernilla Wiebert¹, Camilla Bengtsson¹, Lars Klareskog² and Lars Alfredsson¹, ¹The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Due to the known association between silica dust and rheumatoid arthritis (RA), we wanted to study the association between RA and another silicate mineral;…
Abstract Number: 126 • 2017 ACR/ARHP Annual Meeting
Smoking Is Causally Associated with Disease Activity in Rheumatoid Arthritis
Milena Gianfrancesco¹, Laura Trupin², Stephen Shiboski³, Mark van der Laan⁴, Jonathan Graf⁵, John B. Imboden Jr.⁶, Jinoos Yazdany² and Gabriela Schmajuk⁷, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ³Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴University of California, Berkeley, Berkeley, CA, ⁵Department of Medicine, Division of Rheumatology Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, ⁶Medicine, University of California, San Francisco, San Francisco, CA, ⁷San Francisco VA Medical Center, University of California San Francisco, San Francisco, CA
Background/Purpose: The association between smoking and risk of rheumatoid arthritis (RA) has been well documented; however, the relationship between smoking and RA disease activity is…
Abstract Number: 132 • 2017 ACR/ARHP Annual Meeting
Occupational Physical Workload and Development of Anti-Collagen Type II Antibodies in Rheumatoid Arthritis Patients
Pingling Zeng¹, Lars Alfredsson², Lars Klareskog³, Mohammed Mullazehi⁴, Saedis Saevarsdottir⁵, Camilla Bengtsson⁶ and Johan Rönnelid⁷, ¹Institute of Environmental Medicine, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ²The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ³Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Department of Immunology, Genetics and Pathology,Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ⁵Karolinska Institute and Karonlinska University Hospital, Stockholm, Sweden, ⁶Inst of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden
Background/Purpose: We have previously observed an association between exposure to occupational physical workload (PW) and risk of developing rheumatoid arthritis (RA)[1].We posit that PW could…
Abstract Number: 914 • 2017 ACR/ARHP Annual Meeting
Occupational Exposure to Combustion Products and Risk of Developing Rheumatoid Arthritis
Anna Ilar¹, Pernilla Wiebert^1,2, Saedis Saevarsdottir³, Johan Askling^4,5, Per Gustavsson^1,2 and Lars Alfredsson^1,2, ¹The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Stockholm County Council, Centre for Occupational and Environmental Medicine, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁵Unit of Clinical Epidemiology, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Studies have suggested a potential association between traffic pollutants and rheumatoid arthritis (RA), but findings have been inconclusive. We therefore assessed the risk of…
Abstract Number: 915 • 2017 ACR/ARHP Annual Meeting
Pesticide Exposure and Risk of Systemic Lupus Erythematosus in an Urban Population of Predominantly African-American Women
Jessica Williams¹, Shun-Chiao Chang¹, Corine Sinnette¹, Susan Malspeis², Christine G. Parks³, Elizabeth Karlson¹, Patricia Fraser¹ and Karen H. Costenbader¹, ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Durham, NC
Background/Purpose: Several studies have reported an association between exposure to pesticides and the risk of systemic lupus erythematosus (SLE). However, this association has not yet…
Abstract Number: 988 • 2017 ACR/ARHP Annual Meeting
Association of Ultraviolet-B Radiation and Risk of SLE Among Women in the Nurses’ Health Studies
Medha Barbhaiya¹, Jaime Hart^2,3, Susan Malspeis⁴, Sara K. Tedeschi⁵, David J. Kreps⁵, Trang VoPham⁶, Jeffrey A. Sparks⁷, Elizabeth Karlson⁵, Francine Laden^2,3,8 and Karen H. Costenbader⁵, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, ³Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, ⁷Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁸Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
Background/Purpose: Ultraviolet-B radiation (UV-B) exposure may lead to worsened photosensitivity, rashes, and systemic flares among SLE patients. Although UV-B radiation damages keratinocytes and may result…
Abstract Number: 2140 • 2017 ACR/ARHP Annual Meeting
Infections and Medications Associated with Onset of Myositis in Myovision, a National Myositis Patient Registry
Lisa G Rider¹, Payam Noroozi Farhadi¹, Nastaran Bayat¹, Jesse Wilkerson², Abdullah Faiq¹, John McGrath², Hermine I. Brunner³, Bob Goldberg⁴ and Frederick W Miller¹, ¹Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ²Social and Scientific Systems, Inc., Durham, NC, ³Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴The Myositis Association, Alexandria, VA
Background/Purpose: Myositis is a rare systemic autoimmune disease with suspected environmental and genetic risk factors, but little is known about specific infections and medications that…
Abstract Number: 2825 • 2017 ACR/ARHP Annual Meeting
A Possible Environmental Origin for a Proportion of the Genetic Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus
John B. Harley¹, Xiaoting Chen¹, Mario Pujato², Daniel Miller¹, Avery Maddox¹, Carmy Forney³, Albert Magnusen³, Arthur Lynch¹, Kashish Chetal⁴, Masashi Yukawa⁵, Artem Barski⁶, Nathan Salomonis⁴, Kenneth Kaufman⁷, Leah C. Kottyan⁸ and Matthew Weirauch⁹, ¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Divisions of Allergy and Immunology and Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Divisions of Allergy and Immunology and Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁸Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Center for Autoimmune Genomics and Etiology (CAGE) and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Nearly 150 genetic loci are convincingly associated with lupus (SLE) or rheumatoid arthritis (RA) and underlie their incompletely understood mechanisms of pathogenesis. Since 90%…
Abstract Number: 488 • 2016 ACR/ARHP Annual Meeting
Exploring the Association Between Air Pollutant Exposure and Seropositivity in Rheumatoid Arthritis
Asha Mariam Alex^1,2, Gary A. Kunkel³, Jorge Flautero Arcos⁴, Richard Amdur⁵ and Gail S. Kerr⁶, ¹Rheumatology, Veterans Affairs Medical Center, Washington, DC, ²Rheumatology, Georgetown University Hospital, Washington, DC, ³Division of Rheumatology, George Wahlen VA Medical Center/University of Utah, Salt Lake City, UT, ⁴Rheumatology, Howard University Hospital, Washington, DC, ⁵Lead Biostatistician, Medical Faculty Associates Clinical Professor, Dept. of Surgery, George Washington University School of Medicine & Health Sciences, Washington, DC, ⁶Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC
Background/Purpose: The etiology of rheumatoid arthritis (RA) is multi-factorial, with expression of HLA-DRB1 shared epitope (SE), smoking and socioeconomic status (SES) exerting influence. Prior studies…
Abstract Number: 46 • 2015 ACR/ARHP Annual Meeting
Feasibility Study of Smartphone Data Collection for Cloudy with a Chance of Pain: Sustained Engagement for Daily Self-Reporting of Disease Severity in Rheumatoid Arthritis over Two Months
Samuel Reade¹, Jamie C Sergeant^2,3, Matthew Sperrin⁴, David M. Schultz⁵, Karen Spencer⁶, Caroline Sanders⁶ and William G Dixon⁷, ¹The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ⁴Institute of Population Health, Health e-Research Centre, The University of Manchester, Manchester, United Kingdom, ⁵Faculty of Engineering and Physical Sciences, School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, Manchester, United Kingdom, ⁶Institute of Population Health, Centre for Primary Care, The University of Manchester, Manchester, United Kingdom, ⁷Manchester Academic Health Sciences Centre, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Previous research has attempted to study the association between weather and joint pain. Inconclusive results may be due, in part, to infrequent measures of…
Abstract Number: 79 • 2015 ACR/ARHP Annual Meeting
Hypervigilence: Patients with Fibromyalgia Often Appear Very Sensitive to Environmental Stresses
Robert S. Katz¹, Kelli Davis², Lauren Kwan² and Jessica L. Polyak², ¹Rush University Medical Center, Chicago, IL, ²Rheumatology Associates S.C., Chicago, IL
Background/Purpose: We inquired about hypervigilence and hypersensitivity to various environmental stresses in patients with fibromyalgia and in rheumatic disease controls. Methods: 103 fibromyalgia patients with…

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