Abstracts tagged "endothelial cells"

Abstract Number: 631 • 2013 ACR/ARHP Annual Meeting
Type I IFN Regulation Of IL-10 Is Detrimental To Endothelial Cell Differentiation and May Enhance Cardiovascular Risk In Systemic Lupus Erythematosus
J. Michelle Kahlenberg¹, Alyssa Cates², Victoria Holden³, Carolyne K. Smith⁴ and Mariana J. Kaplan⁵, ¹Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ³Pathology, University of Michigan, Ann Arbor, MI, ⁴Rheumatology and Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, ⁵Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a heterogeneous disease resulting in organ damage and an elevated risk of cardiovascular disease (CVD). Previous reports have suggested…
Abstract Number: 612 • 2013 ACR/ARHP Annual Meeting
Increased Expression Of Membrane Endothelial Protein C Receptor Associates With Poor Response In Lupus Nephritis Independent Of Chronicity Index
Barbara Mendez¹, Ming Wu², Dominick Santoriello², Laura Barisoni³, Peter M. Izmirly¹, Jill P. Buyon¹ and Robert M. Clancy⁴, ¹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Pathology, New York University School of Medicine, New York, NY, ³Pathology, University of Miami Hospital, Miami, FL, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: While a consensus is that a high chronicity index (CI) is associated with a greater risk for progression to renal failure in lupus nephritis…
Abstract Number: 381 • 2013 ACR/ARHP Annual Meeting
Coronary Endothelial Dysfunction Directly Measured By N13 Positron Emission Tomography (PET) Is Detected In Established Rheumatoid Arthritis (RA), But Not Early RA
OM Troum¹, OL Pimienta¹, B Hidalgo² and WA Hsueh³, ¹Keck School of Medicine, University of Southern California, Los Angeles, CA, ²Biostatistics, University of Alabama, Birmingham, AL, ³Medicine, Weill Cornell Medical College, Houston, TX
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular (CV) disease. The endothelium is a key regulator of vascular function. Subclinical CV disease and…
Abstract Number: 1443 • 2012 ACR/ARHP Annual Meeting
Caspase-1 Modulates Endothelial Dysfunction and Vascular Repair in Murine Lupus
J. Michelle Kahlenberg¹, Wenpu Zhao², Srilakshmi Yalavarthi² and Mariana J. Kaplan³, ¹Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Rheumatology, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Premature cardiovascular disease (CVD) represents a significant cause of morbidity and mortality in systemic lupus erythematosus (SLE). We recently proposed that type I interferon…
Abstract Number: 704 • 2012 ACR/ARHP Annual Meeting
Decreased Number of Endothelial Progenitor Cells in Systemic Sclerosis Patients with Early Disease
Fernando V. Andrigueti, Maria I. Arismendi, Pâmela C.C. Ebbing and Cristiane Kayser, Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Microangiopathy and endothelial dysfunction are present in early phases of Systemic sclerosis (SSc), resulting in decreased blood flow and tissue ischemia. Several mechanisms including…
Abstract Number: 667 • 2012 ACR/ARHP Annual Meeting
Interferon-Alpha Impairs the Survival and Function of Circulating Angiogenic Cells in Vitro: A Model of Failed Endothelial Repair in SLE
John A. Reynolds¹, David W. Ray², Terence O'Neill³, M. Yvonne Alexander⁴ and Ian N. Bruce⁵, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, ²Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁴Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Patients with Systemic Lupus Erythematosus have an increased risk of cardiovascular disease (CVD). No specific targeted therapies for CVD in lupus exist and there…
Abstract Number: 2454 • 2012 ACR/ARHP Annual Meeting
Expression of TLR5 Strongly Correlates with Levels of TNF-a and DAS28 in RA Monocytes and Ligation of TLR5 Induces Angiogenesis in RA
Nathan D. Chamberlain¹, Michael Volin², Olga M. Vila³, Shiva Arami⁴, Suncica Volkov⁵ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³University of Illinois at Chicago, Chicago, IL, ⁴Medicine - Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵Rheumatology/MC 733, University of Illinois at Chicago, Chicago, IL
Background/Purpose: This study was performed to determine whether expression of TLR5 is associated with Rheumatoid Arthritis (RA) disease activity as well as to examine the…
Abstract Number: 2295 • 2012 ACR/ARHP Annual Meeting
Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells in Vitro
Zhaodong Li¹, Peter J. Wermuth², Bryan Benn², Michael P. Lisanti³ and Sergio A. Jimenez², ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ³Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Recent studies demonstrated that the phenotypic transition of endothelial cells (EC) into activated mesenchymal cells, a process known an endothelial-to-mesenchymal transition (EndoMT), may be…
Abstract Number: 2297 • 2012 ACR/ARHP Annual Meeting
Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype
Bashar Kahaleh¹ and Yongqing Wang², ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: DNA methylation is one of the best-characterized epigenetic modifications that have been implicated in numerous biologic and pathologic processes. It is initiated by DNA…
Abstract Number: 1776 • 2012 ACR/ARHP Annual Meeting
Anti-SSA/Ro Mediated Injury to the Endothelium Via Urokinase Plasminogen Activator Receptor/Tgfbeta Activation: Implications in the Pathogenesis of Congenital Heart Block
Paraskevi Briasouli¹, Mark Halushka², Jill P. Buyon³ and Robert M. Clancy⁴, ¹Rheumatology, New York University Medical Center, New York, NY, ²Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: One mechanism by which anti-Ro antibodies are linked to the pathogenesis of (cardiac-NL) neonatal lupus is the increased urokinase plasminogen activator (uPA)/urokinase-type plasminogen activator receptor…
Abstract Number: 1599 • 2012 ACR/ARHP Annual Meeting
NF-Kb Inducing Kinase (NIK) Is a Key Regulator of Inflammation-Induced Angiogenesis
A.R. Noort¹, K.P.M. van Zoest¹, P. Koolwijk², D.V. Novack³, M.J. Siemerink⁴, P. P. Tak⁵ and S.W. Tas⁶, ¹Division of Clinical Immunology & Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Physiology, Institute for Cardiovascular Research (ICaR-VU) / VU University Medical Center, Amsterdam, Netherlands, ³Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, ⁴Department of Ophthalmology and Department of Cell Biology and Histology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁵Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands, ⁶Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: In rheumatoid arthritis (RA) synovial tissue (ST) angiogenesis can be observed already in the earliest phase of disease, which may be critical in the…
Abstract Number: 1491 • 2012 ACR/ARHP Annual Meeting
Systemic Sclerosis – Effects of Agonistic Autoantibodies Directed Against the Angiotensin Receptor Type 1 and the Endothelin Receptor Type A On Effector Cells
Jeannine Guenther¹, Angela Kill², Mike O. Becker³ and Gabriela Riemekasten⁴, ¹Rheumatology/Clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, Berlin, Germany, ²Rheumatology and clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ⁴Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany
Background/Purpose: Autoimmunity, vasculopathy and fibrosis are features of systemic sclerosis (SSc). The functional link between these three pathophysiological components is still missing. Research suggests an…
Abstract Number: 1493 • 2012 ACR/ARHP Annual Meeting
Transforming Growth Factor-β and Endothelin-1 Induce Endothelial-to-Mesenchymal Transition in Cultured Human Endothelial Cells
Stefano Soldano¹, Paola Montagna¹, Renata Brizzolara¹, Barbara Villaggio², Alberto Sulli³ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, Genova, Italy, ²Research Laboratory of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁴University of Genova, Genova, Italy
Background/Purpose: The endothelial/microvascular injury and the myofibroblast activation are crucial events that seem to contribute to the development of fibrosis in connective tissue diseases such…
Abstract Number: 1495 • 2012 ACR/ARHP Annual Meeting
Platelet Aggregability, Eicosanoid Biosynthesis and Oxidative Stress in Primary Raynaud’s Phenomenon and Systemic Sclerosis
John D. Pauling¹ and Neil McHugh², ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom
Background/Purpose: Increased platelet activation, endothelial dysfunction and oxidative stress are all thought to contribute to the pathogenesis of Raynaud’s phenomenon (RP), particularly in the context…

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