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Abstracts tagged "DNA Methylation"

  • Abstract Number: 1050 • 2019 ACR/ARP Annual Meeting

    Genome-Wide DNA Methylation Signatures in Classical Monocytes from African Ancestry Patients with Systemic Sclerosis

    Peter Allen1, Jena Wirth 2, Nathan Wilson 2, Jim Oates 3, Melissa Cunningham 2, Devin Absher 4 and Paula Ramos 2, 1University of Alabama at Birmingham, Birmingham, AL, 2Medical University of South Carolina, Charleston, 3Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, 4HudsonAlpha Institute for Biotechnology, Huntsville, AL

    Background/Purpose: Systemic sclerosis (SSc) is a rare, fibrotic autoimmune disorder characterized by cutaneous and visceral fibrosis, immune dysregulation, and vasculopathy. It disproportionately affects individuals of…
  • Abstract Number: 2041 • 2019 ACR/ARP Annual Meeting

    Epigenome-wide Association Study Reveals Differential DNA Methylation in Systemic Lupus Erythematosus Patients with a History of Ischemic Heart Disease

    Juliana Imgenberg-Kreuz1, Christopher Sjöwall 2, Martina Frodlund 2, Iva Gunnarsson 3, Elisabet Svenungsson 4 and Dag Leonard 1, 1Department of Medical Sciences, Section of Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, 2Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden, 3Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 4Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of ischemic heart disease (IHD). Altered methylation patterns have been reported both in SLE,…
  • Abstract Number: 2396 • 2019 ACR/ARP Annual Meeting

    DNA Methylation of the Dual Specificity Phosphatase 22 (DUSP22) Gene Promoter in Plasma and Medication Use in Rheumatoid Arthritis (RA)

    Lissette Delgado-Cruzata 1, Milena Rodriguez Alvarez 2, Abhimanyu Amarnani2, Edgardo Guzman 3, Alorah Bliese 1, Belen Albarracin 1, Carl Cirilli 1 and Shante Hinson 4, 1John Jay College, City University of New York, New York, 2SUNY Downstate Medical Center, Brooklyn, 3Lincoln Medical & Mental Mental Health Center, Brooklyn, 4Lincoln Medical & Mental Mental Health Center, New York

    Background/Purpose: The Dual Specificity Phosphatase 22 (DUSP22) gene expression has been shown to be regulated via DNA methylation of its promoter. In addition, aberrant DNA…
  • Abstract Number: 2738 • 2019 ACR/ARP Annual Meeting

    Differential Methylation of Peripheral Blood Adaptive Immune Cells in Individuals at High Risk for RA and with Early RA Compared with Controls Identifies Pathways Important in Transition to Arthritis

    Rizi Ai1, David Boyle 2, Deepa Hammaker 3, Kevin Deane 4, V. Michael Holers 5, Andre Matti 6, William Robinson 7, Jane Buckner 8, Navin Rao 9, Frédéric Baribaud 10, George Vratsanos 11, Sunil Nagpal 9, Wei Wang 2 and Gary Firestein 3, 1University of California San Diego, San Diego, 2University of California, San Diego, San Diego, CA, 3University of California, San Diego, San Diego, 4University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 5University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, 6UCSD, La Jolla, CA, 7Stanford University, Stanford, CA, 8Benaroya Research Institute, Seattle, WA, 9Janssen R&D, Spring House, PA, 10Janssen Research & Development, LLC, Spring House, PA, 11JNJ, Raritan, NJ

    Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing RA because of serum anti-citrullinated protein antibody…
  • Abstract Number: 76 • 2018 ACR/ARHP Annual Meeting

    Whole Blood Targeted Bisulfite Pyrosequencing Identifies Differentially Methylated Regions within Major Histocompatibility Complex (MHC) of Patients with Rheumatoid Arthritis

    Vidyanand Anaparti1, Irene Smolik2, Prasoon Agarwal3, Neeloffer Mookherjee1 and Hani El-Gabalawy4, 1Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, 2Food and Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada, 3Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada, 4University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Human major histocompatibility complex (MHC) is strongly associated with rheumatoid arthritis (RA) pathogenesis. Epigenome-wide association study by Liu et al showed that differential DNA…
  • Abstract Number: 88 • 2018 ACR/ARHP Annual Meeting

    Lymphocyte DNA Methylation As a Mediator of Genetic Risk in Rheumatoid Arthritis

    Alex Clark1,2, Nisha Nair3, Andrew Skelton1,2, Amy Anderson1,2, Nishanthi Thalayasingam1,2, Najib Naamane1,2, Julie Diboll1,2, Jonathan Massey4, Stephen Eyre3,4, Anne Barton3,4, John Isaacs1,2, Louise Reynard5 and Arthur Pratt1,2, 1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 2NIHR, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 3Arthritis Research UK Centre for Genetics and Genomics and Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, 4NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom, 5Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

    Background/Purpose: Genome-wide association studies (GWAS) have to date identified over 100 genomic loci at which single nucleotide polymorphisms (SNPs) confer an increased risk of developing…
  • Abstract Number: 154 • 2018 ACR/ARHP Annual Meeting

    Epigenetic Editing of FOXP3 in Human T Cells Is Sufficient to Induce Overexpression and Create a Regulatory T Cell Phenotype in Vitro

    Christopher Dunn1, Cassandra Velasco1, Madison Andrews2, Alexander Rivas3 and Matlock A. Jeffries4, 1Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3University of Arkansas for Medical Sciences, Little Rock, AR, 4Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Defects in the number and function of naturally-occurring regulatory T cells (Tregs) have been identified in a variety of autoimmune diseases. The development of…
  • Abstract Number: 916 • 2018 ACR/ARHP Annual Meeting

    Integrative Analysis of Multi-Omics Data in an Ethnically Diverse Lupus Cohort Identifies Distinct Molecular Subtypes of SLE

    Cristina Lanata1, Ishan Paranjpe2, Joanne Nitiham3, Kimberly Taylor4, Brooke Rhead5, Milena Gianfrancesco6, Lisa Barcellos7, Louise Murphy8, Patricia Katz9, Laura Trupin6, Jinoos Yazdany2, Maria Dall'Era2, Marina Sirota10 and Lindsey A. Criswell9, 1Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 2University of California, San Francisco, San Francisco, CA, 3Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 4University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, 5University of California, Berkeley, Berkeley, CA, 6Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 7School of Public Health, UC Berkeley, Berkeley, CA, 8Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, 9University of California San Francisco, San Francisco, CA, 10Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Systemic Lupus Erythematous (SLE) is a chronic autoimmune disease with heterogeneous disease manifestations and outcomes. We aimed to define how molecular differences underlie this…
  • Abstract Number: 2061 • 2018 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Analysis in Ankylosing Spondylitis

    Patrick Coit1, Prashant Kaushik2, Liron Caplan3, Gail S. Kerr4, Jessica Walsh5, Maureen Dubreuil6, Andreas Reimold7 and Amr H Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Rheumatology/Medicine, Stratton VAMC, Albany, NY, 3Div of Rheumatology, Denver VA Medical Center and University of Colorado, Aurora, CO, 4Rheumatology, Washington DC VAMC and Georgetown and Howard University, Washington, DC, 5George E. Wahlen Veteran Affairs Medical Center & University of Utah, Salt Lake City, UT, 6Rheumatology, VA Boston Healthcare System & Boston University School of Medicine, Boston, MA, 7Rheumatology, Dallas VA Medical Center and University of Texas - Southwestern, Dallas, TX

    Background/Purpose: Ankylosing spondylitis is a chronic inflammatory disease characterized by inflammation of the sacroiliac joints and the spine leading to significant immobility. A subset of…
  • Abstract Number: 755 • 2017 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Pattern in Systemic Sclerosis Microvascular Endothelial Cells:  Identification of Epigenetically Affected Key Genes and Pathways

    Shadia Nada1, Ibtissam Gad2, Ali Alqahtani3, Ahmad Assaly2, Sadik Khuder4, Yongqing Wang5, Bashar Kahaleh1 and Nezam Altorok1, 1Medicine/Rheumatology, University of Toledo, Toledo, OH, 2University of Toledo, Toledo, OH, 3Internal Medicine, University of Toledo, Toledo, OH, 4Department of Medicine, University of Toledo, Toledo, OH, 5Medicine, University of Toledo, Toledo, OH

    Background/Purpose: The etiology of systemic sclerosis (SSc) is not clear, but there is evidence suggesting a critical role for epigenetic alterations in disease pathogenesis and…
  • Abstract Number: 1018 • 2017 ACR/ARHP Annual Meeting

    Comprehensive Identification of Differentially Methylated Regions Associated with Systemic Sclerosis in Dermal Fibroblasts from African-American Patients

    Paula S. Ramos1,2, Willian da Silveira3, E. Starr Hazard3, Ilia Atanelishvili4, Robert C. Wilson5, Jim C. Oates1, Galina S. Bogatkevich4 and Gary Hardiman1,2,3, 1Department of Medicine, Medical University of South Carolina, Charleston, SC, 2Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 3Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC, 4Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 5Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African-Americans are disproportionally affected by SSc, yet dramatically underrepresented in…
  • Abstract Number: 1727 • 2017 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Analysis in Systemic Sclerosis Reveals Hypomethylation of Interferon-Associated Genes in CD4+ and CD8+ T Cells

    Weilin Pu1, Weifeng Ding2, Lei Wang3, Shuai Jiang4, Wenzhen Tu3, Shicheng Guo5, Qingmei Liu6, Yanyun Ma4, Sidi Chen7, Wenyu Wu6, Xiaodong Zhou8, Maureen D. Mayes9, Shervin Assassi9, John D. Reveille9, Li Jin10 and Jiucun Wang10, 1State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, 2Medical Laboratory Center, Medical Laboratory Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China, Nantong, China, 3Division of Rheumatology, Division of Rheumatology, Shanghai TCM-integrated Hospital, Shanghai, China, Shanghai, China, 4Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, Shanghai, China, 5Department of Bioengineering, Department of Bioengineering, University of California at San Diego, CA, USA, San Diego, CA, 6Department of Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China, 7State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, 8Internal Medicine-Rheumatology, University of Texas McGovern Medical School, Houston, TX, 9University of Texas McGovern Medical School, Houston, TX, 10State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China

    Background/Purpose: Systemic sclerosis (SSc) is a complex systemic autoimmune disease caused by complicated interaction between genetic, epigenetic and environmental risk factors. Evidence showed epigenetic modifications,…
  • Abstract Number: 1791 • 2017 ACR/ARHP Annual Meeting

    TET1 Is an Important Transcriptional Activator of the Tnfa Locus in Macrophages

    Emmanuel Karouzakis1, Fangfang Sun2, Agnieszka Pajak1, Shuang Ye2, Steffen Gay1, Oliver Distler3 and Michel Neidhart1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 3Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Activated macrophages are found in the inflamed and hyperplastic synovial RA tissue. Macrophages are the main producers of high levels of pro-inflammatory cytokines such…
  • Abstract Number: 2654 • 2017 ACR/ARHP Annual Meeting

    Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus

    Juliana Imgenberg-Kreuz1,2, Jonas Carlsson Almlöf1, Dag Leonard3, Gunnel Nordmark2, Maija-Leena Eloranta3, Leonid Padyukov4, Iva Gunnarsson4, Elisabet Svenungsson4, Christopher Sjöwall5, Lars Rönnblom2, Ann-Christine Syvänen1 and Johanna K Sandling1,2, 1Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 2Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 3Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, 4Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 5Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping University, Linköping, Sweden, Linköping, Sweden

    Background/Purpose: DNA methylation has emerged as an important contributing factor in the pathogenesis of systemic lupus erythematosus (SLE). SLE typically requires continuous treatment to control…
  • Abstract Number: 74 • 2016 ACR/ARHP Annual Meeting

    Arthritis-Associated DNA Hypermethylation Provokes Increased Antibody Expression in Mouse Model of Rheumatoid Arthritis

    Daniel M. Tóth1, Timea Ocskó1, Adrienn Markovics1, Attila Balog2, Katalin Mikecz1, Tibor T. Glant1 and Tibor A. Rauch1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary

    Background/Purpose: Although a number of epigenetic alterations have been revealed in rheumatoid arthritis (RA), it remained an open question whether these epimutations play role in…
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