ACR Meeting Abstracts

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Abstracts tagged "DNA Methylation"

  • Abstract Number: 0521 • ACR Convergence 2021

    Genome-Wide DNA Methylation and Gene Expression Signatures in Classical Monocytes from African Ancestry Patients with Systemic Sclerosis

    Sarah Smith1, Peter Allen2, Robert Wilson1, Jena Wirth1, DeAnna Baker Frost1, Gary Gilkeson1, Melissa Cunningham1, Devin Absher3 and Paula Ramos1, 1Medical University of South Carolina, Charleston, SC, 2University of Alabama at Birmingham, Birmingham, AL, 3HudsonAlpha Institute for Biotechnology, Huntsville, AL

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects individuals of African ancestry (AA). Despite this, AA…
  • Abstract Number: 1470 • ACR Convergence 2021

    Cartilage Epigenetic Changes Induced by Microbial DNA Amplified from Human OA Samples

    Vladislav Izda1, Christopher Dunn2, Cassandra Sturdy1, Jake Martin1, Cassandra Velasco2, Paul Jacob3 and Matlock Jeffries1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Oklahoma Joint Reconstruction Institute, Oklahoma City, OK

    Background/Purpose: Strong links between epigenetic changes, particularly alterations in DNA methylation, have been linked with the onset and progression of knee osteoarthritis (OA); however, the…
  • Abstract Number: 1483 • ACR Convergence 2021

    Down-regulation of Hematopoietic Progenitor Kinase 1 by Aberrant Epigenetic Alterations in T Follicular Helper Cells Accounts for Excessive Immunity in Systemic Lupus Erythematosus

    Qing Zhang1, Huilin Zhang2 and Yuming Xie1, 1Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China (People's Republic), 2Clinical Nursing Teaching and Research Section, Second Xiangya Hospital, Central South University, Changsha, China (People's Republic)

    Background/Purpose: Recently, T follicular helper cells (Tfh cells) have been discovered to be the main CD4+ T cells assisting B cells to produce antibody. Tfh…
  • Abstract Number: 1789 • ACR Convergence 2021

    Prediction of Psoriatic Arthritis in Patients with Psoriasis Using DNA Methylation Profiles

    Omar Cruz Correa1, Remy Pollock1, Rohan Machhar2 and Dafna Gladman3, 1University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) poses an immense clinical burden with significantly increased morbidity and mortality risk compared to psoriasis alone. PsA may develop in 30%…
  • Abstract Number: 2738 • 2019 ACR/ARP Annual Meeting

    Differential Methylation of Peripheral Blood Adaptive Immune Cells in Individuals at High Risk for RA and with Early RA Compared with Controls Identifies Pathways Important in Transition to Arthritis

    Rizi Ai1, David Boyle 2, Deepa Hammaker 3, Kevin Deane 4, V. Michael Holers 5, Andre Matti 6, William Robinson 7, Jane Buckner 8, Navin Rao 9, Frédéric Baribaud 10, George Vratsanos 11, Sunil Nagpal 9, Wei Wang 2 and Gary Firestein 3, 1University of California San Diego, San Diego, 2University of California, San Diego, San Diego, CA, 3University of California, San Diego, San Diego, 4University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 5University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, 6UCSD, La Jolla, CA, 7Stanford University, Stanford, CA, 8Benaroya Research Institute, Seattle, WA, 9Janssen R&D, Spring House, PA, 10Janssen Research & Development, LLC, Spring House, PA, 11JNJ, Raritan, NJ

    Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing RA because of serum anti-citrullinated protein antibody…
  • Abstract Number: 1050 • 2019 ACR/ARP Annual Meeting

    Genome-Wide DNA Methylation Signatures in Classical Monocytes from African Ancestry Patients with Systemic Sclerosis

    Peter Allen1, Jena Wirth 2, Nathan Wilson 2, Jim Oates 3, Melissa Cunningham 2, Devin Absher 4 and Paula Ramos 2, 1University of Alabama at Birmingham, Birmingham, AL, 2Medical University of South Carolina, Charleston, 3Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, 4HudsonAlpha Institute for Biotechnology, Huntsville, AL

    Background/Purpose: Systemic sclerosis (SSc) is a rare, fibrotic autoimmune disorder characterized by cutaneous and visceral fibrosis, immune dysregulation, and vasculopathy. It disproportionately affects individuals of…
  • Abstract Number: 2041 • 2019 ACR/ARP Annual Meeting

    Epigenome-wide Association Study Reveals Differential DNA Methylation in Systemic Lupus Erythematosus Patients with a History of Ischemic Heart Disease

    Juliana Imgenberg-Kreuz1, Christopher Sjöwall 2, Martina Frodlund 2, Iva Gunnarsson 3, Elisabet Svenungsson 4 and Dag Leonard 1, 1Department of Medical Sciences, Section of Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, 2Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden, 3Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 4Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of ischemic heart disease (IHD). Altered methylation patterns have been reported both in SLE,…
  • Abstract Number: 2396 • 2019 ACR/ARP Annual Meeting

    DNA Methylation of the Dual Specificity Phosphatase 22 (DUSP22) Gene Promoter in Plasma and Medication Use in Rheumatoid Arthritis (RA)

    Lissette Delgado-Cruzata 1, Milena Rodriguez Alvarez 2, Abhimanyu Amarnani2, Edgardo Guzman 3, Alorah Bliese 1, Belen Albarracin 1, Carl Cirilli 1 and Shante Hinson 4, 1John Jay College, City University of New York, New York, 2SUNY Downstate Medical Center, Brooklyn, 3Lincoln Medical & Mental Mental Health Center, Brooklyn, 4Lincoln Medical & Mental Mental Health Center, New York

    Background/Purpose: The Dual Specificity Phosphatase 22 (DUSP22) gene expression has been shown to be regulated via DNA methylation of its promoter. In addition, aberrant DNA…
  • Abstract Number: 76 • 2018 ACR/ARHP Annual Meeting

    Whole Blood Targeted Bisulfite Pyrosequencing Identifies Differentially Methylated Regions within Major Histocompatibility Complex (MHC) of Patients with Rheumatoid Arthritis

    Vidyanand Anaparti1, Irene Smolik2, Prasoon Agarwal3, Neeloffer Mookherjee1 and Hani El-Gabalawy4, 1Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, 2Food and Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada, 3Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada, 4University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Human major histocompatibility complex (MHC) is strongly associated with rheumatoid arthritis (RA) pathogenesis. Epigenome-wide association study by Liu et al showed that differential DNA…
  • Abstract Number: 88 • 2018 ACR/ARHP Annual Meeting

    Lymphocyte DNA Methylation As a Mediator of Genetic Risk in Rheumatoid Arthritis

    Alex Clark1,2, Nisha Nair3, Andrew Skelton1,2, Amy Anderson1,2, Nishanthi Thalayasingam1,2, Najib Naamane1,2, Julie Diboll1,2, Jonathan Massey4, Stephen Eyre3,4, Anne Barton3,4, John Isaacs1,2, Louise Reynard5 and Arthur Pratt1,2, 1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 2NIHR, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 3Arthritis Research UK Centre for Genetics and Genomics and Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, 4NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom, 5Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

    Background/Purpose: Genome-wide association studies (GWAS) have to date identified over 100 genomic loci at which single nucleotide polymorphisms (SNPs) confer an increased risk of developing…
  • Abstract Number: 154 • 2018 ACR/ARHP Annual Meeting

    Epigenetic Editing of FOXP3 in Human T Cells Is Sufficient to Induce Overexpression and Create a Regulatory T Cell Phenotype in Vitro

    Christopher Dunn1, Cassandra Velasco1, Madison Andrews2, Alexander Rivas3 and Matlock A. Jeffries4, 1Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3University of Arkansas for Medical Sciences, Little Rock, AR, 4Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Defects in the number and function of naturally-occurring regulatory T cells (Tregs) have been identified in a variety of autoimmune diseases. The development of…
  • Abstract Number: 916 • 2018 ACR/ARHP Annual Meeting

    Integrative Analysis of Multi-Omics Data in an Ethnically Diverse Lupus Cohort Identifies Distinct Molecular Subtypes of SLE

    Cristina Lanata1, Ishan Paranjpe2, Joanne Nitiham3, Kimberly Taylor4, Brooke Rhead5, Milena Gianfrancesco6, Lisa Barcellos7, Louise Murphy8, Patricia Katz9, Laura Trupin6, Jinoos Yazdany2, Maria Dall'Era2, Marina Sirota10 and Lindsey A. Criswell9, 1Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 2University of California, San Francisco, San Francisco, CA, 3Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 4University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, 5University of California, Berkeley, Berkeley, CA, 6Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 7School of Public Health, UC Berkeley, Berkeley, CA, 8Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, 9University of California San Francisco, San Francisco, CA, 10Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Systemic Lupus Erythematous (SLE) is a chronic autoimmune disease with heterogeneous disease manifestations and outcomes. We aimed to define how molecular differences underlie this…
  • Abstract Number: 2061 • 2018 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Analysis in Ankylosing Spondylitis

    Patrick Coit1, Prashant Kaushik2, Liron Caplan3, Gail S. Kerr4, Jessica Walsh5, Maureen Dubreuil6, Andreas Reimold7 and Amr H Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Rheumatology/Medicine, Stratton VAMC, Albany, NY, 3Div of Rheumatology, Denver VA Medical Center and University of Colorado, Aurora, CO, 4Rheumatology, Washington DC VAMC and Georgetown and Howard University, Washington, DC, 5George E. Wahlen Veteran Affairs Medical Center & University of Utah, Salt Lake City, UT, 6Rheumatology, VA Boston Healthcare System & Boston University School of Medicine, Boston, MA, 7Rheumatology, Dallas VA Medical Center and University of Texas - Southwestern, Dallas, TX

    Background/Purpose: Ankylosing spondylitis is a chronic inflammatory disease characterized by inflammation of the sacroiliac joints and the spine leading to significant immobility. A subset of…
  • Abstract Number: 755 • 2017 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Pattern in Systemic Sclerosis Microvascular Endothelial Cells:  Identification of Epigenetically Affected Key Genes and Pathways

    Shadia Nada1, Ibtissam Gad2, Ali Alqahtani3, Ahmad Assaly2, Sadik Khuder4, Yongqing Wang5, Bashar Kahaleh1 and Nezam Altorok1, 1Medicine/Rheumatology, University of Toledo, Toledo, OH, 2University of Toledo, Toledo, OH, 3Internal Medicine, University of Toledo, Toledo, OH, 4Department of Medicine, University of Toledo, Toledo, OH, 5Medicine, University of Toledo, Toledo, OH

    Background/Purpose: The etiology of systemic sclerosis (SSc) is not clear, but there is evidence suggesting a critical role for epigenetic alterations in disease pathogenesis and…
  • Abstract Number: 1018 • 2017 ACR/ARHP Annual Meeting

    Comprehensive Identification of Differentially Methylated Regions Associated with Systemic Sclerosis in Dermal Fibroblasts from African-American Patients

    Paula S. Ramos1,2, Willian da Silveira3, E. Starr Hazard3, Ilia Atanelishvili4, Robert C. Wilson5, Jim C. Oates1, Galina S. Bogatkevich4 and Gary Hardiman1,2,3, 1Department of Medicine, Medical University of South Carolina, Charleston, SC, 2Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 3Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC, 4Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 5Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African-Americans are disproportionally affected by SSc, yet dramatically underrepresented in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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