ACR Meeting Abstracts

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Abstracts tagged "DNA"

  • Abstract Number: 888 • 2019 ACR/ARP Annual Meeting

    Mitochondrial DNA Impact on Joint Degeneration Process Using DMM OA and Spontaneous Aging Conplastic Mice Models

    Morena Scotece1, Ignacio Rego-Pérez 2, Ana Victoria Lechuga-Vieco 3, María Concepción Jiménez Gómez 3, Purificación Filgueira-Fernández 4, José Antonio Enriquez 3 and Francisco J. Blanco 2, 1Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, 2Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 3Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Madrid, Spain, 4Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Galicia, Spain

    Background/Purpose: Accumulated data indicated that osteoarthritis has a strong genetic component with a prevalent role of mitochondria and mtDNA variations. In the present work, we…
  • Abstract Number: 1661 • 2019 ACR/ARP Annual Meeting

    Circulating Cell Free DNA Released from Eosinophils Is a Practical Biomarker in Patients with Eosinophilic Granulomatosis with Polyangiitis

    Teppei Hashimoto1, Yuichi Yokoyama 2, Tetsuya Furukawa 3, Takahiro Yoshikawa 3, Naoto Azuma 2, Kohsuke Yoshida 4, Akira Hashiramoto 4 and Kiyoshi Matsui 3, 1Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Hyogo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan, 3Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan, 4Kobe University Graduate School of Health Sciences, Kobe, Hyogo, Japan

    Background/Purpose: Fragmented cell-free DNA (cfDNA) is released into blood circulation as results of damage or death of peripheral blood cells as well as organ tissues,…
  • Abstract Number: 90 • 2018 ACR/ARHP Annual Meeting

    Deoxyribonuclease 1-like-3 Digests Self-DNA from Dead Cells and Prevents Autoimmunity

    Shoichiro Inokuchi1, Hiroki Mitoma2, Shotaro Kawano2, Masahiro Ayano2, Yasutaka Kimoto3, Mitsuteru Akahoshi2, Yojiro Arinobu2, Koichi Akashi2, Takahiko Horiuchi4 and Hiroaki Niro5, 1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, 2Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 3Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, 4Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 5Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    Background/Purpose: Deoxyribonuclease 1-like-3 (DNase1L3) belongs to Deoxyribonuclease 1(DNase1) family. This nuclease originally identified as one of apoptosis- and necrosis-related endonucleases that fragmentates intranucleosomal DNA. Unlike…
  • Abstract Number: 829 • 2018 ACR/ARHP Annual Meeting

    DNA Damage and Repair in Patients with Cryoglobulinemic Vasculitis Treated with Direct Anti-HCV Drugs

    Mohamed Tharwat Hegazy1, Walaa Allam2, Mohamed A Hussein1, Naguib Zoheir3, Luca Quartuccio4, Patrice Cacoub5, Wahid Doss6, Mona I. Ellawindi7, Mary Fawzy1, Loïc Guillevin8, Ahmed El Ray9, Maissa El Said El Raziky10,11, Magdy El Serafy6, Sherif El Khamisy2,12 and Gaafar Ragab1, 1Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt, Cairo, Egypt, 2Center for Genomics, Zewail City of Science and Technology, Giza, Egypt, Giza, Egypt, 3Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, Cairo, Egypt, 4Rheumatology Clinic, Academic Hospital S. M. della Misericordia, Medical Area Department, University of Udine, Italy, Udine, Italy, 5Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, Paris, France, 6Tropical Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt, Cairo, Egypt, 7Community Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt, Cairo, Egypt, 8Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 9Theodor Bilharz Research Institute, Cairo, Egypt, Cairo, Egypt, 10Fatimid Cairo hospital, Cairo, Egypt, Cairo, Egypt, 11Tropical Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt, cairo, Egypt, 12Krebs Institute, University of Sheffield, Sheffield, S10 2TN, UK, Sheffield, United Kingdom

    DNA Damage and Repair in Patients with Cryoglobulinemic Vasculitis Treated with Direct Anti-HCV Drugs Background/Purpose: Direct Acting Antiviral (DAA) agents were shown to be effective…
  • Abstract Number: 1084 • 2018 ACR/ARHP Annual Meeting

    Dysfunction of the DNASE1L3 Pathway and Antigen Accumulation in Lupus Nephritis

    Johannes Hartl1, Robert M. Clancy1, Peter M. Izmirly2, H. Michael Belmont1, Nicole Kaiden3, Nicole Bornkamp3, Vanja Sisirak1, Benjamin Sally1, Jill P. Buyon1 and Boris Reizis1, 1NYU School of Medicine, New York, NY, 2Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 3Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: DNASE1L3 is a unique secreted DNase that is capable of degrading DNA complexed with proteins and/or encapsulated in membranes, such as chromatin within microparticles…
  • Abstract Number: 1090 • 2018 ACR/ARHP Annual Meeting

    Cell-Free Mitochondrial DNA As a Novel Biomarker in Systemic Lupus Erythematosus

    Bhargavi Duvvuri1, Richard Moore1 and Christian Lood2, 1Division of Rheumatology, University of Washington, Seattle, WA, 2Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: We recently described a fundamental role for mitochondrial (mt)-mediated inflammation in systemic lupus erythematosus (SLE). Briefly, mtROS promoted formation of neutrophil extracellular traps (NETs),…
  • Abstract Number: 1136 • 2018 ACR/ARHP Annual Meeting

    Association of Mitochondrial DNA Haplotypes with Symptomatic Hand and Thumb Based Osteoarthritis and Hand OA Progression

    Charles Eaton1, Mary Roberts2, Jeffrey B. Driban3, Ida Kristin Haugen4, Lena Franziska Schaefer5, Bing Lu6, Rebecca D. Jackson7, Marc C. Hochberg8, C. Kent Kwoh9, Francisco J Blanco10 and Timothy E. McAlindon11, 1Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, 2Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, 3Rheumatology, Tufts Medical Center, BOSTON, MA, 4Diakonhjemmet Hospital, Oslo, Norway, 5Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, 6Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 7Ohio State University, Columbus, OH, 8School of Medicine, University of Maryland, Baltimore, MD, 9Medicine, Division of Rheumatology, University of Arizona School of Medicine, University of Arizona Arthritis Center, Tucson, AZ, 10Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 11Division of Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: Hand osteoarthritis (OA) can be a painful, disabling condition, with an increased prevalence in women, the elderly, and has a strong genetic component (hereditability…
  • Abstract Number: 2119 • 2018 ACR/ARHP Annual Meeting

    Association of the Variant Form of rs17408553 at Human Leukocyte Antigen-C Supports Evidence That Hypo-Responsive Natural Killer Cells Adversely Influence the Course of Nephritis

    Robert M. Clancy1, H. Michael Belmont1, Peter M. Izmirly2, Nicole Bornkamp3, Sarah Miller4, Matthew Poulin4, Liying Yan4, Jill P. Buyon1 and Ellen M. Ginzler5, 1NYU School of Medicine, New York, NY, 2Rheumatology, NYU School of Medicine, New York, NY, 3Medicine, NYU School of Medicine, New York, NY, 4EpigenDx, Hopkinton, MA, 5Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY

    Background/Purpose: In subjects with lupus nephritis (LN), tissue injury due to local immune activation involving persistently activated macrophages in the renal parenchyma is limited by…
  • Abstract Number: 2981 • 2018 ACR/ARHP Annual Meeting

    Mitochondrial Extrusion and Autoimmunity in Juvenile Dermatomyositis

    Christian Lood1, Bhargavi Duvvuri2, Richard Moore2, Gabrielle A. Morgan3, Marisa Klein-Gitelman4, Megan L. Curran5 and Lauren M. Pachman6, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Division of Rheumatology, University of Washington, Seattle, WA, 3Cure JM Program of Excellence in Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 4Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 5Section of Rheumatology, Children's Hospital of Colorado, Denver, CO, 6Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL

    Background/Purpose: We recently made the fundamental observation that mitochondrial extrusion is instrumental in mediating inflammation, autoimmunity and organ damage in lupus. Mitochondrial stress and mitochondrial…
  • Abstract Number: 577 • 2016 ACR/ARHP Annual Meeting

    TCZ Modulates the Production of Ccfdna Derived from RA Synovial Cells

    Naonori Hashimoto1, Kohsuke Yoshida1, Teppei Hashimoto2, Ayako Nakai1, Kenta Kaneshiro1, Kohjin Suzuki1, Yoshiko Kawasaki2, Nao Shibanuma3, Natsuko Nakagawa4, Yoshitada Sakai5 and Akira Hashiramoto6, 1Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, 2Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, 3Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, 4Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, 5Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 6Department of Biophysics, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan

    Background/Purpose:   DNA is fragmented and released into blood circulation as a circulating cell-free DNA (ccfDNA) because of damage or death of cells. Although the…
  • Abstract Number: 2075 • 2016 ACR/ARHP Annual Meeting

    No Detection of Varicella-Zoster Virus in Temporal Arteries of Patients with Giant Cell Arteritis

    Francesco Muratore1, Stefania Croci2, Ione Tamagnini3, Alessandro Zerbini2, Salvatore Bellafiore4, Lucia Belloni5, Luigi Boiardi6, Alessandra Bisagni7, Maria Parmeggiani8, Alberto Cavazza9 and Carlo Salvarani1, 1Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 2Clinical Immunology, Allergy and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 3Pathology Unit, Department of Oncology, Arsicpedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 4Pathology Unit, Department of Oncology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 5Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 6Rheumatology Unit, Arcispedale S.Maria Nuova, IRCCS, Reggio Emilia, Italy, 7Pathology Unit, Department of Oncology, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 8. Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 9Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy

    Background/Purpose: Recent studies found an high prevalence of varicella-zoster virus (VZV) infection in temporal arteries (TAs) from both temporal artery biopsy (TAB)-positive and TAB-negative giant…
  • Abstract Number: 202 • 2015 ACR/ARHP Annual Meeting

    Bone Accrual in the Dnase II-Deficient Model of Autoimmunity Requires Sting, As Well As Hematopoietic and Stromal Elements

    Rebecca Baum1, Shruti Sharma1, Ann Marshak-Rothstein1, Katherine A. Fitzgerald1 and Ellen M. Gravallese2, 1Medicine, University of Massachusetts Medical School, Worcester, MA, 2Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: We have previously identified a role for cytosolic DNA sensors in bone by analyzing mice that develop inflammatory polyarthritis and trabecular bone accrual in…
  • Abstract Number: 3006 • 2015 ACR/ARHP Annual Meeting

    Cell-Free Circulating DNA in Systemic Sclerosis: Increased Levels and Global Cytosine Hypomethylation

    Shadia Nada1, Omar Oraibi2, Farouk Abu Alhana2, Nawaf Almeshal2, Yongqing Wang2, Nezam Altorok3 and Bashar Kahaleh4, 1Internal Medicine, Divison of Rheumatology, The University of Toledo, Toledo, OH, 2The University of Toledo, Toledo, OH, 3Internal Medicine, Division of Rheumatology, The University of Toledo, Toledo, OH, 4Medicine/Rheumatology, The University of Toledo, Toledo, OH

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction, vascular injury, and activation of fibroblasts leading to organ fibrosis. The precise etiology…
  • Abstract Number: 1794 • 2014 ACR/ARHP Annual Meeting

    The Sting Pathway Regulates Bone Remodeling in a Model of Autoimmune Disease

    Rebecca Baum1, Jason M. Organ2, David B. Burr3, Ann Marshak-Rothstein4, Katherine A. Fitzgerald5 and Ellen M. Gravallese6, 1Cell Biology, University of Massachusetts Medical School, Worcester, MA, 2Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, 3Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, 4Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, 5Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, 6Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA

    Background/Purpose: Cytosolic DNA sensors detect viral and bacterial DNA, inducing inflammatory cytokines and type I IFNs via the adaptor stimulator of interferon genes (STING) to…
  • Abstract Number: 1814 • 2014 ACR/ARHP Annual Meeting

    RNA-Containing Immune Complexes Shift Human Neutrophils from Phagocytosing Cells to Efficient Releasers of Oxidized DNA in a Process Requiring Crosstalk Between Toll-like Receptors and Fc Gamma Receptor IIa

    Christian Lood1, Xizhang Sun2, Lena Tanaka2, Andrew Oberst3, Jeffrey Ledbetter2 and Keith B. Elkon2, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Division of Rheumatology, University of Washington, Seattle, WA, 3Department of Immunology, University of Washington, Seattle, WA

    Background/Purpose Neutrophil extracellular traps (NETs), the extrusion of chromatin to capture microbes, has recently emerged as a possible mechanism that may increase the autoantigenic burden…
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