ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "DMOAD"

  • Abstract Number: 1468 • ACR Convergence 2021

    Intra-articular (IA) Injection of Empty Large Multilamellar Vesicles Liposomes Reduces Cartilage Degeneration in Rat Osteoarthritis Model

    Alison Bendele1, Jacob Favret1, Gadi Sarfati2, Ronny Pinkus2 and Roni Wechsler2, 1Bolder BioPATH Inc., Boulder, CO, 2Moebius Medical LTD, Tel Aviv, Israel

    Background/Purpose: A suspension of empty large multilamellar vesicles (MLV) liposomes composed of dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC), is currently under clinical development for symptomatic knee…
  • Abstract Number: 1180 • 2019 ACR/ARP Annual Meeting

    Confirmation of Manual Cartilage Segmentation Findings by Automated Segmentation: Retrospective Analysis of MRI Images from a Sprifermin Phase II Study

    Alan Brett1, Michael A Bowes 1, Philip G Conaghan 2, Christoph Ladel 3, Jeffrey Kraines 4, Hans Guehring 3, Flavie Moreau 4 and Felix Eckstein 5, 1Imorphics, Manchester, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 3Merck KGaA, Darmstadt, Germany, 4EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 5Paracelsus Medical University, Salzburg, Austria

    Background/Purpose: Sprifermin is under investigation as a potential disease-modifying osteoarthritis drug (DMOAD). 2-yr results from the FORWARD study showed significant dose-dependent modification of cartilage thickness…
  • Abstract Number: 1325 • 2019 ACR/ARP Annual Meeting

    Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Male Japanese Subjects of the ADAMTS-5 Inhibitor S201086/GLPG1972, a Potential New Treatment in OA

    Agnès Lalande 1, Nadya Kuzniatsova-Mouchette 2, Florian Chassereau 1, Julia Geronimi 1, Staffan Larsson 3, Andre Struglics 3, Stefan Lohmander 3 and Maria Pueyo1, 1Institut de Recherches Internationales Servier, Suresnes, France, Suresnes, France, 2Institut de Recherches Internationales Servier, Suresnes, France, Suresnes, 3Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden, Lund, Sweden

    Background/Purpose: The disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) is a key enzyme in OA (Verma P, et al. J Cell Biochem 2011;112:3507-14). In preclinical models…
  • Abstract Number: 2761 • 2019 ACR/ARP Annual Meeting

    Cartilage Thickness Modification with Sprifermin in Knee Osteoarthritis Patients Translates into Symptomatic Improvement over Placebo in Patients at Risk of Further Structural and Symptomatic Progression: Post-Hoc Analysis of a Phase II Trial

    Hans Guehring1, Jeffrey Kraines 2, Flavie Moreau 2, Benjamin Daelken 1, Christoph Ladel 1, Wolfgang Wirth 3, Philip G Conaghan 4, Felix Eckstein 5 and Marc C. Hochberg 6, 1Merck KGaA, Darmstadt, Germany, 2EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 3Paracelsus Medical University, Salzbury, Austria, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 5Paracelsus Medical University, Salzburg, Austria, 6University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Results from the 5-year Phase II FORWARD study showed significant dose-dependent modification of total femorotibial joint (TFTJ) cartilage thickness change with sprifermin at 2…
  • Abstract Number: L03 • 2018 ACR/ARHP Annual Meeting

    Efficacy and Safety from a Phase 2b Trial of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor for the Treatment of Osteoarthritis of the Knee

    Yusuf Yazici1, Timothy E. McAlindon2, Allan Gibofsky3, Nancy Lane4, Christian Lattermann5, Nebojsa Skrepnik6, Christopher Swearingen1, Anita DiFrancesco1, Jeymi Tambiah1 and Marc Hochberg7, 1Samumed, LLC, San Diego, CA, 2Division of Rheumatology, Tufts Medical Center, Boston, MA, 3Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, 4Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Tucson Orthopaedic Institute, Tucson, AZ, 7University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: A previous Phase 2a study of SM04690, a small molecule, intra-articular (IA), Wnt pathway inhibitor, demonstrated positive effects on knee OA pain, physical function,…
  • Abstract Number: 1366 • 2018 ACR/ARHP Annual Meeting

    Assessment of Health-Related Quality of Life in a 52-Week, Phase 2, Randomized, Controlled Trial of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for Treatment of Knee Osteoarthritis

    Vibeke Strand1, Heli Ghandehari2, Christopher Swearingen2 and Jeyanesh Tambiah2, 1Stanford University School of Medicine, Palo Alto, CA, 2Samumed, LLC, San Diego, CA

    Background/Purpose: SM04690, a small molecule, intra-articular (IA) Wnt pathway inhibitor, is in development for knee OA treatment. A phase 2, 52-week, trial evaluated changes in…
  • Abstract Number: 429 • 2018 ACR/ARHP Annual Meeting

    The Potential Clinical Relevance of Imaging Biomarker Data from Short-Term Interventional Trials in Osteoarthritis: A Comparison of the Cathepsin K Inhibitor Miv-711 Phase 2a MRI Knee Joint Data and KL-Matched 5577 Knee Control Data from the Osteoarthritis Initiative

    Philip G. Conaghan1, Michael A Bowes2, Sarah R. Kingsbury1, Alan Brett2, Gwenael Guillard2, Åsa Jansson3, Cecilia Wadell3, Richard Bethell3 and John Öhd3, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, 2Imorphics Ltd, Manchester, United Kingdom, 3Medivir AB, Huddinge, Sweden

    Background/Purpose: New imaging biomarkers using supervised machine learning offer opportunities to demonstrate effects of potential DMOADs on joint structure in short, small trials based on…
  • Abstract Number: 436 • 2018 ACR/ARHP Annual Meeting

    Structural Effects of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: A Post-Hoc Analysis of Cartilage Morphology over the 2-Year Treatment-Period of a 5-Year Randomized, Placebo-Controlled, Phase II Study

    Ali Guermazi1, Jeffrey Kraines2, Aida Aydemir2, Stephen Wax3, Michel Crema4, Marc C. Hochberg5 and Frank Roemer1,6, 1Radiology, Boston University School of Medicine, Boston, MA, 2EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 3EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, 4Boston University School of Medicine, Boston, MA, 5University of Maryland School of Medicine, Baltimore, MD, 6Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Sprifermin, a recombinant human fibroblast growth factor 18, is currently being investigated as a potential disease-modifying OA drug. Sprifermin treatment leads to a dose-dependent…
  • Abstract Number: 1356 • 2018 ACR/ARHP Annual Meeting

    Increasing Oral Doses of GLPG1972 Administered Daily for 29 Days Show a Strong Target Engagement in Patients with Knee and/or Hip OA

    Henri Deckx1, Simon Hatch2, Martine Robberechts1, Sonia Dupont3, Julie Desrivot3, Hugh Coleman4, Staffan Larsson5, André Struglics5, Ellen van der Aar1 and Ann Fieuw1, 1Galapagos NV, Mechelen, Belgium, 2Galapagos NV, Boston, MA, 3Galapagos SASU, Romainville, France, 4CRU, Covance, Daytona Beach, FL, 5Clinical Sciences, Lund University, Lund, Sweden

    Background/Purpose: Osteoarthritis (OA) is characterized by structural changes of the joint, of which degradation of articular cartilage is one of the major signs1. The main…
  • Abstract Number: 1364 • 2018 ACR/ARHP Annual Meeting

    Treatment of Knee Osteoarthritis with SM04690 Improved WOMAC A1 “Pain on Walking” – Results from a 52-Week, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor

    Jeyanesh Tambiah1, Sarah Kennedy1, Heli Ghandehari1, Christopher Swearingen1 and Marc C. Hochberg2, 1Samumed, LLC, San Diego, CA, 2University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional limitation, and physical disability due to articular cartilage degradation and bone remodeling. Wnt signaling is involved…
  • Abstract Number: 1L • 2017 ACR/ARHP Annual Meeting

    Efficacy and Safety of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: Results of the 2-Year Primary Analysis from a 5-Year Randomised, Placebo-Controlled, Phase II Study

    Marc C. Hochberg1, Ali Guermazi2, Hans Guehring3, Aida Aydemir4, Stephen Wax5, Patricia Fleuranceau-Morel4, Asger Reinstrup Bihlet6, Inger Byrjalsen6, Jeppe Ragnar Andersen6 and Felix Eckstein7, 1University of Maryland School of Medicine, Baltimore, MD, 2Boston Imaging Core Lab, LLC, and Boston University School of Medicine, Boston, MA, 3Merck KGaA, Darmstadt, Germany, 4EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 5EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, 6Nordic Bioscience, Herlev, Denmark, 7Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria

    Background/Purpose: Sprifermin, a novel recombinant human fibroblast growth factor-18 is currently investigated as a potential disease-modifying osteoarthritis (OA) drug. Two-year primary data from a 5-year…
  • Abstract Number: 14L • 2017 ACR/ARHP Annual Meeting

    Miv-711, a Novel Cathepsin K Inhibitor Demonstrates Evidence of Osteoarthritis Structure Modification: Results from a 6 Month Randomized Double-Blind Placebo-Controlled Phase IIA Trial

    Philip G. Conaghan1, Michael A Bowes2, Sarah R. Kingsbury1, Alan Brett2, Gwenael Guillard2, Åsa Jansson3, Cecilia Wadell3, Richard Bethell3 and John Öhd3, 1University of Leeds, Leeds, United Kingdom, 2Imorphics Ltd, Manchester, United Kingdom, 3Medivir AB, Huddinge, Sweden

    Background/Purpose: The need for drugs that achieve structure modification in OA is imminent but their development has been burdened by the need for large, long…
  • Abstract Number: 1207 • 2017 ACR/ARHP Annual Meeting

    Clinical Relevance of Structural Measures in Knee Osteoarthritis: Baseline Values and Change from Baseline Discriminate Patients Subsequently Receiving Knee Replacement

    C. Kent Kwoh1, Hans Guehring2, Michael J Hannon3 and Aida Aydemir4, 1University of Arizona Arthritis Center, Tuscan, AZ, 2Merck KGaA, Darmstadt, Germany, 3Medicine, University of Pittsburgh, Pittsburgh, PA, 4EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA

    Background/Purpose: Structural measures of knee OA (KOA) progression include assessment of radiographic joint space width (JSW) and quantitative MRI (qMRI) measurement of cartilage thickness, both…
  • Abstract Number: 2183 • 2017 ACR/ARHP Annual Meeting

    Two-Year Changes in Knee Osteoarthritis Symptoms: Comparing Clinical Relevance of Patient-Reported Outcomes By Anchoring to Knee Replacement

    C. Kent Kwoh1, Hans Guehring2, Erin Ashbeck3, Michael J Hannon4 and Aida Aydemir5, 1University of Arizona Arthritis Center, Tuscan, AZ, 2Merck KGaA, Darmstadt, Germany, 3The University of Arizona Arthritis Center, Tucson, AZ, 4Medicine, University of Pittsburgh, Pittsburgh, PA, 5EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA

    Background/Purpose: Randomized controlled trials (RCTs) of interventions for knee OA (KOA) may include a patient-reported outcome (PRO) measure as a primary endpoint. Several measures of…
  • Abstract Number: 1151 • 2015 ACR/ARHP Annual Meeting

    The Proteomic Profile of Histological Samples Derived from a Surgical Mouse Model of Osteoarthritis Reveals an Unexpected Mode of Action for the Anti-Aggrecanase-2 Monoclonal Antibody CRB0017

    Gianfranco Caselli1, Riccardo Chiusaroli2, Michela Visintin3, Tiziana Piepoli2, Ornella Letari2, Adriana Grotti2, Marco Lanza2, Antonella De Palma4, Dario di Silvestre4, Pierluigi Mauri4 and Lucio Claudio Rovati2, 1Pharmacology & Toxicology, Rottapharm Biotech Srl, Monza, Italy, 2Rottapharm Biotech Srl, Monza, Italy, 3Rottapharm Biotech Srl, Trieste, Italy, 4Institute for Biomedical Technologies - CNR, Segrate, Italy

    Background/Purpose : CRB0017 is a novel therapeutic monoclonal antibody that recognizes the spacer domain of aggrecanase-2, a key enzyme in the degradation of extracellular matrix…
  • 1
  • 2
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology