Abstracts tagged "Disease Activity"

Abstract Number: 3192 • 2016 ACR/ARHP Annual Meeting
Influence of Temperature and Humidity on Disease Activity in Rheumatoid Arthritis
Peter Mandl¹, Farideh Alasti¹, Rainer Kaltenberger², Thomas Krennert², Gabriela Supp¹, Uriel Landesmann¹, Josef S. Smolen³ and Daniel Aletaha⁴, ¹Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria, ²Central Institute for Meteorology and Geodynamics, Vienna, Austria, ³Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria
Background/Purpose: To evaluate whether meteorological parameters influence pain and disease activity in patients with rheumatoid arthritis (RA). Methods: We assessed correlations between individual meteorological variables…
Abstract Number: 272 • 2016 ACR/ARHP Annual Meeting
Interferon Chemokine Score and Other Cytokine Measures Predict Changes in Disease Activity in Patients with Juvenile and Adult Dermatomyositis
Cynthia S. Crowson¹, Jeannette M. Olazagasti Lourido², Molly S. Hein³, Richard S. Pendegraft⁴, Michael A. Strausbauch⁵, Timothy B. Niewold⁶, Floranne C. Ernste⁷, Theresa L. Wampler Muskardin³, Erik J. Peterson⁸, Emily C. Gillespie⁹ and Ann M Reed¹⁰, ¹Health Sciences Research, Mayo Clinic, Rochester, MN, ²University of Puerto Rico, San Juan, Puerto Rico, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Biomedical Statistics and informatics, Rochester, MN, ⁵Surgical Research, Mayo Clinic, Rochester, MN, ⁶Rheumatology and Immunology, Mayo Clinic, Rochester, MN, ⁷Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁸Center for Immunology/Department of Medicine, University of Minnesota, Minneapolis, MN, ⁹Medicine, University of Minnesota, Minneapolis, MN, ¹⁰Rheumatology, Duke University, Durham, NC
Background/Purpose: Methods: Multiplexed immunoassays (Meso Scale Discovery) enabled simultaneous measurement of IFN-regulated chemokines and other pro- and anti-inflammatory cytokines specific to differentiation of specific…
Abstract Number: 556 • 2016 ACR/ARHP Annual Meeting
Higher Multi Biomarker Disease Activity Scores Foreshadow Greater Longitudinal Improvement in RA Disease Activity
Jeffrey Curtis¹, Leslie Harrold², Joel Kremer³ and J. Lynn Palmer⁴, ¹Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²U Massachusetts, Worcester, MA, ³Albany Medical Center, Albany, NY, ⁴Corrona Research Foundation, Albany, NY
Background/Purpose: Biomarkers in patients with rheumatoid arthritis (RA) have the attractive potential to help select patients that have a greater burden of disease activity and…
Abstract Number: 902 • 2016 ACR/ARHP Annual Meeting
High Disease Activity Scores and Leptin Levels in Takayasu Patients with Overweight and Obesity
Gokce Kenar¹, Handan Yarkan², Berrin Zengin¹, Gerçek Can², Merih Birlik¹, Nurullah Akkoc¹ and Fatos Onen¹, ¹Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ²Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey
Background/Purpose: We aimed to determine the prevalence of overweight, obesity and metabolic syndrome (MetS) and leptin levels in patients with Takayasu arteritis (TA) and their…
Abstract Number: 1375 • 2016 ACR/ARHP Annual Meeting
A Five Year Study of 102 Children with Juvenile Myositis: Disease Course and Outcomes
Lauren M. Pachman^1,2,3, Megan L. Curran⁴, Gabrielle A. Morgan^5,6, Maria C. Amoruso^1,7, Ira N. Targoff^8,9 and Chiang-Ching Huang¹⁰, ¹Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ²Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Rheumatology/Immunology, Ann & Robert H. Lurie Children's Hosptial of Chicago, Chicago, IL, ⁴Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Cure JM Program of Excellence in Myositis Research, Chicago, IL, ⁶Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁷Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹University of Oklahoma, Oklahoma City, OK, ¹⁰Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI
Background/Purpose: Children with juvenile myositis (JM) have a variable disease course, in part associated with myositis specific/associated antibodies (MSA). Time to off medications has not…
Abstract Number: 1553 • 2016 ACR/ARHP Annual Meeting
Declining Flare Rates in the First Five Years of RA Disease, but Not after
Shafay Raheel¹, Cynthia S. Crowson², Eric L. Matteson¹ and Elena Myasoedova¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Flare or episodic worsening of disease activity is an important aspect of the disease experience for patients with rheumatoid arthritis (RA). Improving trends towards…
Abstract Number: 1903 • 2016 ACR/ARHP Annual Meeting
Determining Disease Course in Localized Scleroderma: A Prospective Cohort Study
Jack O'Brien¹ and Heidi Jacobe², ¹Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA, Dallas, TX, ²Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Localized scleroderma (LS) is characterized by skin sclerosis, producing devastating impairment in those affected. It was previously thought to “burn out” within 5 years,…
Abstract Number: 2470 • 2016 ACR/ARHP Annual Meeting
Treat to Target: Theoretical Agreement Vs Daily Applicability
Leonardo Romeiro¹, Dalton Torigoe², Claiton Brenol³, Roberto Ranza⁴, Lícia M. H. Mota⁵, Manoel Bertolo⁶, Max Freitas⁷, José Tupinambá⁸, Ivanio Pereira⁹, Lucila Fronza¹⁰ and Ieda Maria Magalhães Laurindo¹¹, ¹Rheumatology, UNESA, Rio de Janeiro, Rio de Janeiro, Brazil, ²Faculdade de Medicina da Santa Casa de Misericordia, São Paulo, Brazil, ³Rua Cabral, 764 – Apto 302, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ⁴Reumatologia, Reumatologia, Universidade Federal de Uberlandia, Uberlandia, Brazil, ⁵Hospital Universitário de Brasília - UnB, Brasília, Brazil, ⁶INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil, ⁷Pathology, Federal University of Ceara, Fortaleza, Brazil, ⁸Universidade Federal do Piaui, Teresina, Brazil, ⁹Rheumatology, Universidade do Sul de Santa Catarina, Florianopolis, Brazil, ¹⁰CETI - Centro de Estudos em Terapias Inovadoras, Curitiba, Brazil, ¹¹Internal Medicine - Rheumatology, Faculdade de Medicina da Universidade Nove de Julho, São Paulo, Brazil
Background/Purpose: Treat to target (T2T) strategy has been widely recognized as effective and leading to better outcomes. There have been no questions regarding its theoretical…
Abstract Number: 2713 • 2016 ACR/ARHP Annual Meeting
Differentially Expressed Microrna As Candidate Biomarker for Disease Activity in Ankylosing Spondylitis
Marina N. Magrey¹, Abdul Haseeb² and Tariq M Haqqi², ¹Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Differentially Expressed MicroRNA as candidate Biomarker for Disease Activity in Ankylosing Spondylitis Background/Purpose: MicroRNAs (miRNAs) have evolved as a novel class of biomarkers We proposed…
Abstract Number: 2860 • 2016 ACR/ARHP Annual Meeting
Exercise Significantly Improves Cardiorespiratory Fitness and Reduces Disease-Related Fatigue without Adverse Effects on Disease Activity in Systemic Lupus Erythematosus: a Systematic Review with Meta-Analysis
Tom O'Dwyer¹, Laura Durcan² and Fiona Wilson³, ¹Physiotherapy, Trinity College Dublin, Dublin, Ireland, ²University of Washington, Seattle, WA, ³Physiotherapy, Trinity College, Dublin, Ireland
Background/Purpose: Systemic lupus erythematous (SLE) associates with accelerated mortality, frequently attributable to cardiovascular (CV) causes, which is not fully explained by traditional CV risk factors.…
Abstract Number: 3196 • 2016 ACR/ARHP Annual Meeting
A Natural Language Processing System Can Capture Rheumatoid Arthritis Disease Activity Measures in US Veterans Across Multiple Sites
Grant W. Cannon¹, Shobhit Mehortra², Brett South², Ted R Mikuls³, Andreas M. Reimold⁴ and Brian C Sauer², ¹Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ²Salt Lake City VA and University of Utah, Salt Lake City, UT, ³Omaha VA and University of Nebraska Medical Center, Omaha, NE, USA, Omaha, NE, ⁴Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX
Background/Purpose: The retrieval of rheumatoid arthritis (RA) disease activity measures recorded in an electronic medical record through natural language processing (NLP) would significantly aid…
Abstract Number: 279 • 2016 ACR/ARHP Annual Meeting
Increased Heat Shock Protein 90 in Muscle Tissue and Plasma in Idiopathic Inflammatory Myopathies Correlates with Disease Activity and Skeletal Muscle Involvement
Hana Storkanova¹, Olga Krystufkova¹, Martin Klein², Herman F Mann¹, Lucia Vernerova¹, Maja Spiritovic^1,3, Josef Zámecník⁴, Karel Pavelka², Ladislav Senolt¹, Jiří Vencovský¹ and Michal Tomcik¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ³Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, ⁴Department of Pathology and Molecular Medicine, 2nd Medical School and University Hospital Motol, Charles University, Prague, Czech Republic
Background/Purpose: Heat shock proteins (Hsps) are chaperones playing important roles in skeletal muscle physiology, adaptation to exercise or stress, and activation of inflammatory cells. The…
Abstract Number: 559 • 2016 ACR/ARHP Annual Meeting
Comparison of Multi-Dimensional Health Assessment Questionnaire (MD-HAQ)-Based and Patient-Reported Outcomes Measurement Information System (PROMIS) 29-Based Routine Assessment of Patient Index 3 (RAPID3) for Assessing Rheumatoid Arthritis Disease Activity
Yong Gil Hwang¹, Juan (June) Feng², Heather Eng², Jason Lyons², Anthony Fabio² and Larry W. Moreland¹, ¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, PA
Background/Purpose: Patient-reported outcomes measurement information system (PROMIS) 29 is recommended by the National Institute of Health (NIH) consensus panel as the preferred battery of…
Abstract Number: 941 • 2016 ACR/ARHP Annual Meeting
An International, Multi-Specialty Validation Study of the IgG4-Related Disease Responder Index
Zachary Wallace¹, Arezou Khosroshahi², Mollie Carruthers³, Campochiaro Corrado⁴, Hyon K. Choi⁵, Emma Culver⁶, Frank Cortazar⁷, Mikael Ebbo⁸, Ana Fernandes⁹, Luca Frulloni¹⁰, Omer Karadag¹¹, Shigeyuki Kawa¹², Mitsuhiro Kawano¹³, MH Kim¹⁴, Marco Lanzillotta¹⁵, Shoko Matsui¹⁶, Cory Perugino¹⁷, Kazuichi Okazaki¹⁸, Philip Hart¹⁹, Jay H. Ryu²⁰, Takako Saeki²¹, Nicolas Schleinitz²², Paula Tanasa²³, Hisanori Umehara²⁴, George Webster²⁵, Wen Zhang²⁶ and John H. Stone²⁷, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Medicine, Emory University School of Medicine, Atlanta, GA, ³Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁴San Raffaele Scientific Institute, Milan, Italy, ⁵Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁶Translational Gastroenterology Unit and NDM Oxford University, Translational Gastroenterology Unit and NDM Oxford University, John Radcliffe Hospital/Oxford University, Oxford, United Kingdom, ⁷Department of Nephrology, Massachusetts General Hospital, Boston, MA, ⁸Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, ⁹Rheumatology Unit, Massachusetts General Hospital, Boston, MA, ¹⁰Gastroenterology, University of Verona, Verona, Italy, ¹¹Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ¹²Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan, ¹³Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan, ¹⁴University of Ulsan College of Medicine, Seoul, Korea, The Republic of, ¹⁵Vita-Salute San Raffaele University, Milan, Italy, ¹⁶University of Toyama, Toyama, Japan, ¹⁷Rheumatology, Massachusetts General Hospital, Boston, MA, ¹⁸Department of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan, ¹⁹Ohio State University Wexner Medical Center, Columbus, OH, ²⁰Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, ²¹Nagaoka Red Cross Hospital, Niigata, Japan, ²²La Timone University Hospital, Marseille, France, ²³Rheumatology, Emory University, Atlanta, GA, ²⁴Kyoto University, Kyoto, Japan, ²⁵University College Hospital, London, United Kingdom, ²⁶Rheuamtology, Peking Union Medical College Hospital, Beijing, China, ²⁷Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is an immune-mediated condition responsible for fibro-inflammatory lesions that can affect nearly any organ and lead to irreversible damage. To evaluate…
Abstract Number: 1376 • 2016 ACR/ARHP Annual Meeting
In Juvenile Dermatomyositis, Organ Damage Is Comparable after Median 13.5 and 21.5 Years Follow-up Time, Despite Sustained Disease Activity
Kristin Schjander Berntsen¹, Berit Flatø^1,2, Ivar Sjaastad^2,3 and Helga Sanner^1,4, ¹Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ²Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ³Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway, Oslo, Norway, ⁴Norwegian National Advisory Unit on Rheumatic Diseases in Children and Adolescents, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway
Background/Purpose: All previous studies of disease outcome in juvenile dermatomyositis (JDM) patients have been based on retrospective data or cross sectional examination. We aimed to…

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