Abstracts tagged "Disease Activity"

Abstract Number: 2859 • 2017 ACR/ARHP Annual Meeting
Development of New Juvenile Arthritis Disease Activity Score Cut-Offs for Oligoarthritis and RF-Negative Polyarthritis from a Large Multinational Cohort of Children with Juvenile Idiopathic Arthritis
Alessandro Consolaro^1,2, Pieter Van Dijkhuizen¹, Graciela Espada³, Boriana Varbanova⁴, Sheila Oliveira⁵, Paivi Miettunen⁴, Gaëlle Chédeville⁵, Michaël Hofer⁵, Pavla Dolezalová⁵, Ivan Foeldvari⁵, Gerd Horneff⁵, Anne Estmann⁵, Chris Pruunsild⁵, Rosa Merino⁵, Inmaculada Calvo Penades⁵, Pablo Mesa del Castillo⁵, Pekka Lahdenne⁵, Maka Ioseliani⁵, Maria Trachana⁵, Olga Vougiouka⁵, Miroslav Harjacek⁵, Ilonka Orban⁵, Tamás Constantin⁵, Nahid Shafaie⁵, Violeta Vladislava Panaviene⁵, Marite Rygg⁵, Elzbieta Smolewska⁵, Jose Antonio Melo Gomes⁵, Jelena Vojinovic⁵, Ekaterina Alexeeva⁵, Tadej Avcin⁵, Veronika Vargova⁵, Nuray Aktay Ayaz⁶, Ozgur Kasapcopur⁵, Yaryna Boyko⁵, Sarah Ringold⁵, Mariangela Rinaldi⁵, Marco Garrone⁵, Nicolino Ruperto⁷ and Angelo Ravelli^8,9, ¹Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, ²University of Genova, GENOA, Italy, ³Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genova, Italy, ⁴Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, GENOA, Italy, ⁵Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy, ⁶Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Gernoa, Italy, ⁷Istituto Giannina Gaslini, Genoa, Italy, ⁸University of Genova, IRCCS Istituto Giannina Gaslini, Genova, Italy, ⁹University of Genova, Genova, Italy
Background/Purpose: The measurement of the level of disease activity plays a pivotal role in the care of patients with juvenile idiopathic arthritis (JIA). To serve…
Abstract Number: 470 • 2017 ACR/ARHP Annual Meeting
Clinical Response to the First Biologic in Rheumatoid Arthritis Patients with Moderate Disease in a Real World Clinical Cohort
Xiuying Li, Angela Cesta, Mohammad Movahedi and Claire Bombardier, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: While most randomized trials assess the effectiveness of biologic DMARDs (bDMARDs) in rheumatoid arthritis (RA) patients with high disease activity, in the real world…
Abstract Number: 999 • 2017 ACR/ARHP Annual Meeting
Association between Smoking with Spinal Level of Stiffness and Functional Limitation in Patients with Axial Spondyloarthritis: Results from the Spanish Atlas
Marco Garrido-Cumbrera¹, Victoria Navarro-Compán², Jorge Chacon-Garcia¹, Jordi Gratacos-Masmitja³, David Galvez-Ruiz¹, Eduardo Collantes Estevez⁴, Pedro Zarco⁵ and Olta Brace¹, ¹Universidad de Sevilla, Seville, Spain, ²Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ³Rheumatology, Hospital Parc Taulí, Sabadell - Barcelona, Spain, ⁴Universidad de Cordoba, Cordova, Spain, ⁵H Fundación Alcorcón, Alcorcón, Spain
Background/Purpose: Smoking has been associated with greater disease activity and radiographic progression in patients with Axial Spondyloarthritis (ax-SpA). In addition, radiographic damage has been linked…
Abstract Number: 1388 • 2017 ACR/ARHP Annual Meeting
Fatigue Is Strongly Associated with the Patient Global Assessment and May Affect Disease Severity and Clinical Remission in Patients with Rheumatoid Arthritis: A Cross-Sectional Study from IORRA, a Large Observational Cohort of Japanese Rheumatoid Arthritis Patients
Naoki Sugimoto¹, Eiichi Tanaka¹, Eisuke Inoue^1,2, Kumiko Saka¹, Eri Sugano¹, Naohiro Sugitani¹, Moeko Ochiai¹, Yoko Shimizu¹, Rei Yamaguchi¹, Katsunori Ikari¹, Ayako Nakajima¹, Atsuo Taniguchi¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Division of Medical Informatics, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: Fatigue is a common complaint in patients with rheumatoid arthritis (RA)1. However, its impact on disease activity and clinical remission in patients with RA…
Abstract Number: 1634 • 2017 ACR/ARHP Annual Meeting
Body Mass Index and Disease Activity in Systemic Lupus Erythematosus- a Paradoxical Relationship?
George Stojan¹, Wei Fu² and Michelle Petri³, ¹Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD
Background/Purpose: Obesity is more common in patients with SLE compared to the general population. The prevalence of obesity among SLE patients is between 28 and…
Abstract Number: 2153 • 2017 ACR/ARHP Annual Meeting
Decreased Lean Body Mass and Bone Mineral Density but Increased Body Fat in Myositis Patients Are Associated with Disease Duration, Inflammatory Status, Skeletal Muscle Involvement and Physical Activity
Sabina Oreska¹, Maja Spiritovic^1,2, Petr Cesak², Ondrej Marecek², Hana Storkanova¹, Katerina Kubinova¹, Martin Klein¹, Lucia Vernerova¹, Olga Ruzickova¹, Radim Becvar¹, Karel Pavelka¹, Ladislav Senolt¹, Herman F Mann¹, Jiri Vencovsky¹ and Michal Tomcik¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are characterized by inflammation and atrophy of skeletal muscles, pulmonary and articular involvement, which limit the mobility/self-sufficiency of patients, and…
Abstract Number: 2508 • 2017 ACR/ARHP Annual Meeting
Obese Axial Spondyloarthropathy Patients Have Worse Disease Outcomes
Gillian Fitzgerald¹, Phil Gallagher², Catherine Sullivan³, Killian O Rourke⁴, Claire Sheehy⁵, Frances Stafford⁶, Carmel Silke⁷, Muhammad Haroon⁸, Ronan Mullan⁹, Sandy Fraser¹⁰, Grainne Murphy¹¹, Shawn Chavrimootoo¹², Oliver FitzGerald¹³ and Finbar O' Shea¹, ¹Rheumatology, St James's Hospital, Dublin 8, Ireland, ²St. Vincent's University Hospital, Department of Rheumatology, Dublin, Ireland, ³Rheumatology, UCHG Ireland, Galway, Ireland, ⁴Rheumatology, Midlands Regional Hospital, Tullamore, Co Offaly, Ireland, ⁵Rheumatology, University Hospital Waterford, Waterford, Ireland, ⁶Rheumatology, Blackrock Clinic, Co Dublin, Ireland, ⁷Rheumatology, Sligo University Hospital, Sligo, Ireland, ⁸Rheumatology, Kerry General Hospital, Co Kerry, Ireland, ⁹Department of Rheumatology, Tallaght Hospital, TCD, Dublin 24, Ireland, ¹⁰Department of Rheumatology, University Hospitals Limerick, Ireland, Limerick, Ireland, ¹¹Rheumatology, Cork University Hospital, Cork, Ireland, ¹²Rheumatology, Our Lady's Hospital, Co Meath, Ireland, ¹³St. Vincent's University Hospital, Department of Rheumatology. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
Background/Purpose: Obesity is a worldwide public health concern, due to its association with morbidity and mortality. Existing literature looking at obesity in axial spondyloarthropathy (axSpA)…
Abstract Number: 2862 • 2017 ACR/ARHP Annual Meeting
Diverse Disease Activity Measures Demonstrate That the Routine Assessment of Patient Index Data with 3 Measures (Rapid-3) Assesses Only Non Inflammatory Components of Disease and Should Not be Utilized in a Treat to Target Strategy in Rheumatoid Arthritis
Craig Wiesenhutter, Coeur d'Alene Arthritis Clinic, Coeur D Alene, ID
Background/Purpose: Treating Rheumatoid Arthritis (RA) patients to target (T2T) has been shown to result in better outcomes in patients with RA. Surrogate measures of disease…
Abstract Number: 63 • 2017 Pediatric Rheumatology Symposium
Performance of Disease Activity Measures in Pediatric Patients With Enthesitis-related Arthritis
Rubén Burgos-Vargas¹, Gerd Horneff², Shirley M.L. Tse³, Pierre Quartier⁴, Kristina Unnebrink⁵ and Jaclyn K. Anderson⁶, ¹Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, ²Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, ³The Hospital for Sick Children, Toronto, ON, Canada, ⁴Hopital Necker-Enfants Malades, Paris, France, ⁵AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁶AbbVie Inc., North Chicago, IL
Background/Purpose: Enthesitis-related arthritis (ERA) is a category of juvenile idiopathic arthritis (JIA), with clinical features similar to those of adult spondyloarthritis (SpA). An unmet ERA…
Abstract Number: 101 • 2017 Pediatric Rheumatology Symposium
Defining Active Features of Juvenile Localized Scleroderma
Suzanne Li¹, Xiaohu Li², Elena Pope³, Katie G. Stewart⁴, Gloria Higgins⁵, C. Egla Rabinovich⁶, Kathleen O'Neil⁷, Kathleen Haines⁸, Ronald Laxer⁹, Marilynn Punaro¹⁰, Heidi Jacobe¹¹, Knut Wittkowski¹², Themba Nyirenda¹³, Ivan Foeldvari¹⁴ and Kathryn S. Torok¹⁵, ¹Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, ²Mathematical Sciences, Stevens Institute of Technology, Hoboken, NJ, ³Dermatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Pediatric Rheumatology, Texas Scottish Rite Hospital, Dallas, TX, ⁵Pediatrics, Nationwide Children's Hospital, Columbus, OH, ⁶Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ⁷Pediatrics, Indiana University, Indianapolis, IN, ⁸Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, ⁹Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁰Texas Scottish Rite Hospital for Children, Dallas, TX, ¹¹Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, ¹²Rockefeller University, New York, NY, ¹³Hackensack University Medical Center, Hackensack, NJ, ¹⁴Kinder- und Jugenrheumatologie, Hamburger Zentrum Kinder-und Jugendrheumatologie, Hamburg, Germany, ¹⁵Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA
Background/Purpose: Juvenile localized scleroderma (jLS) is the most common form of childhood scleroderma. Because of its chronicity and association with extracutaneous involvement, children are at…
Abstract Number: 5 • 2017 Pediatric Rheumatology Symposium
Effects of Puberty on Systemic Lupus Erythematosus: Results of a multi-center prospective longitudinal observational study in children entering puberty with SLE
Kathleen O'Neil¹, Hermine Brunner², Andrew Zeft³, Anne Stevens⁴, Suzanne Li⁵, Tracey Wright⁶, Emily von Scheven⁷, B. Anne Eberhard⁸, C. Egla Rabinovich⁹ and Deborah M. Levy¹⁰, ¹Pediatrics, Indiana University, Indianapolis, IN, ²Rheumatology, PRCSG, Cincinnati, OH, ³Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, ⁴University of Washington, Department of Pediatrics, Seattle, WA, ⁵Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, ⁶Pediatrics/Rheumatology, University of TX Southwestern, Dallas, TX, ⁷Division of Rheumatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, ⁸Cohen Children's Medical Center of New York, New Hyde Park, NY, ⁹Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ¹⁰Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Lupus often presents during puberty, and when it affects pre-pubertal children, disease activity is thought to increase at puberty. Sex hormones play some role…
Abstract Number: 382 • 2016 ACR/ARHP Annual Meeting
Tumor Necrosis Factor-α -308 a/G Gene Polymorphism in Children with Juvenile Idiopathic Arthritis: Relation to Disease Activity, Damage and Disability
Tamer Gheita¹, Iman El Gazzar², Hanan Fathy³, Abeer Nour El-Din⁴, Enas Abdel Rasheed⁵, Rasha Bassyouni⁶ and Sanaa Kenawy⁷, ¹Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Egypt, Cairo, Egypt, ²Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, ³Rheumatology, Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt, ⁴Pediatric Department, National Research Centre, Dokki, Egypt, Giza, Egypt, ⁵Clinical Pathology Department, National Research Centre, Dokki, Egypt, Giza, Egypt, ⁶Medical Microbiology and Immunology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt, ⁷Pharmacology, Pharmacology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood and an important cause of disability. Its cause remains unknown, but…
Abstract Number: 578 • 2016 ACR/ARHP Annual Meeting
Do Specific Anti-Citrullinated Antibodies Predict Different Phenotype of Rheumatoid Arthritis?
Mikael Brink¹, Monika Hansson², Linda Mathsson-Alm^3,4, Johan Rönnelid⁵, Karl Skriner⁶, Guy Serre⁷, Lars Klareskog² and Solbritt Rantapää-Dahlqvist¹, ¹Rheumatology, Umeå University, Umeå, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³ThermoFisher Scientific, Uppsala, Sweden, Uppsala, Sweden, ⁴Thermo Fisher Scientific, Uppsala, Sweden, ⁵Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁶Humboldt University of Berlin, Berlin, Germany, ⁷Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France
Background/Purpose: Antibodies against cyclic citrullinated peptides (anti-CCP) have been suggested to identify a more severe phenotype of rheumatoid arthritis. In this study we have analysed…
Abstract Number: 945 • 2016 ACR/ARHP Annual Meeting
When and Where Musculoskeletal Ultrasound Might Replace Magnetic Resonance in the Assessment of Patients with Juvenile Idiopathic Arthritis?
Stefano Lanni¹, Francesca Magnaguagno², Erica Ricci³, Angela Pistorio⁴, Cecilia Bava¹, Alberto Martini⁵ and Clara Malattia⁶, ¹Pediatria 2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, ²UO Radiologia, Istituto Giannina Gaslini, Genoa, Italy, ³Istituto G. Gaslini, Pediatria 2 -Reumatologia, genova, Italy, ⁴Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy, ⁵PRINTO-IRCCS, Genova, Italy, ⁶Pediatria2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: Magnetic resonance imaging (MRI) is the most attractive imaging modality for the investigation of patients with juvenile arthritis (JIA). Musculoskeletal ultrasound (MSUS) has intuitive…
Abstract Number: 1387 • 2016 ACR/ARHP Annual Meeting
Evaluation of Mild to Moderate SLE Flare in Patients with Childhood-Onset Disease
Malki Peskin¹, Dawn Wahezi^2,3, Chaim Putterman⁴, Tamar Rubinstein^5,6 and Nicole Jordan^4,7, ¹Pediatrics, Albert Einstein College of Medicine, Bronx, NY, ²Pediatric Rheumatology, The Children's Hospital at Montefiore, Bronx, NY, ³Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁵Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, ⁶Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁷Montefiore Medical Center, New York, NY
Background/Purpose: One aspect of childhood SLE lacking understanding is the prediction of disease flares. The objective of this study is to identify predictors of mild…

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