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Abstracts tagged "Disease Activity"

  • Abstract Number: 126 • 2017 ACR/ARHP Annual Meeting

    Smoking Is Causally Associated with Disease Activity in Rheumatoid Arthritis

    Milena Gianfrancesco1, Laura Trupin2, Stephen Shiboski3, Mark van der Laan4, Jonathan Graf5, John B. Imboden Jr.6, Jinoos Yazdany2 and Gabriela Schmajuk7, 1Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 2Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, 3Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 4University of California, Berkeley, Berkeley, CA, 5Department of Medicine, Division of Rheumatology Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, 6Medicine, University of California, San Francisco, San Francisco, CA, 7San Francisco VA Medical Center, University of California San Francisco, San Francisco, CA

    Background/Purpose: The association between smoking and risk of rheumatoid arthritis (RA) has been well documented; however, the relationship between smoking and RA disease activity is…
  • Abstract Number: 655 • 2017 ACR/ARHP Annual Meeting

    Innate Lymphoid Cells – New Players in Psoriatic Arthritis

    Alina Soare1, Stefanie Weber2, Lisa Maul3, Ana Maria Gheorghiu4, Ismail Housni5, Arnd Kleyer6, Markus Luber2, Simon Rauber2, David Simon6, Juergen Rech6, Georg Schett6, Jörg Distler1 and Andreas Ramming7, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 4Carol Davila University of Medicine and Pharmacy,Internal Medicine and Rheumatology Department ,,Dr.I.Cantacuzino'' Clinical Hospital, Bucharest, Romania, 5Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, 6Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 7Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany

    Background/Purpose: Innate lymphoid cells (ILCs) produce disease-related cytokines including IL-17 and IL-22 and are therefore of substantial interest in PsA. Spreading the disease from the…
  • Abstract Number: 1086 • 2017 ACR/ARHP Annual Meeting

    Screening and Intervention of Depression in Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Rui Zhang1, Priya Prakash2, Amy Wasserman3, Kirk Sperber4 and Julia Ash5, 1Medicine -Rheumatology, New York Medical College / Westchester Medical Center, valhalla, NY, 2Rheumatology, NYMC /WMC, VALHALLA, NY, 3Medicine - Rheumatology, New York Medical College / Westchester Medical Center, VALHALLA, NY, 4New York Medical College / Westchester Medical Center, Valhalla, NY, 5Medicine -Rheumatology, New York Medical College / Westchester Medical Center, Valhalla, NY

    Background/Purpose: Depression is common and associated with worse outcomes among patients with RA and SLE. Our study assessed depression using Patient Help Questionnaire (PHQ-9) and…
  • Abstract Number: 1501 • 2017 ACR/ARHP Annual Meeting

    Sexual Dysfunction and Vaginal Dryness Are Common in Female Patients with Early, Active Primary Sjogren’s Syndrome

    Jolien F. van Nimwegen, Greetje S. van Zuiden, Frans G.M. Kroese, Suzanne Arends and Hendrika Bootsma, Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose : The objective of this study was to evaluate the prevalence of sexual dysfunction and vaginal dryness in female patients with early, active primary…
  • Abstract Number: 1814 • 2017 ACR/ARHP Annual Meeting

    Time Trends over a Decade Show Earlier Intensified Medication Strategies and Improved Outcomes in Canadians with Early Inflammatory Arthritis

    Orit Schieir1, Marie-France Valois2, Susan J. Bartlett3,4, Carol A Hitchon5, Janet E. Pope6, Gilles Boire7, Boulos Haraoui8, Diane Tin9, Carter Thorne10, Edward C. Keystone11,12 and Vivian P. Bykerk13,14, 1Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, 2McGill University, Montreal, QC, Canada, 3Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, 4Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5University of Manitoba, Winnipeg, MB, Canada, 6Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, 7Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, 8Institute de Rheumatologie, Montreal, QC, Canada, 9The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 10University of Toronto, Newmarket, ON, Canada, 11University of Toronto, Toronto, ON, Canada, 12Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 13Mount Sinai Hospital, Toronto, ON, Canada, 14Divison of Rheumatology, Hospital for Special Surgery, New York, NY

     Background/Purpose: Treatment recommendations aim to improve outcomes in rheumatoid arthritis (RA) through early identification and a treat-to-target approach. We examined recent trends over the past…
  • Abstract Number: 2302 • 2017 ACR/ARHP Annual Meeting

    The Impact of JIA on Physician and Patient-Reported Outcomes over the First Five Years Following Diagnosis

    Stephanie Shoop-Worrall1, Suzanne M Verstappen2, Janet E. McDonagh3, Wendy Thomson4 and Kimme L. Hyrich4, 1The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, 2Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal and Dermatology Research, Faculty of Medicine, Biology and Health, United Kingdom, University of Manchester, Manchester, United Kingdom, 3Faculty of Medical and Human Sciences, Centre for MSK Research, Manchester, United Kingdom, 4National Institute of Health Research Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Information regarding longer-term outcomes in JIA largely pre-date the introduction of biologic therapies and have been cross-sectional. The aim of this analysis was to…
  • Abstract Number: 2532 • 2017 ACR/ARHP Annual Meeting

    The Relationship between the Degree of Skin Involvement and Joint Activity in Patients with Psa: Experience from the Corrona Registry

    Philip J Mease1, Carol J. Etzel2, Jeffrey Lisse3, April W Armstrong4, William J Huster3, Sabrina Rebello2, Rhiannon Dodge2, Talia M Muram3, Sarah Al Sawah3, Mwangi J Murage3, Jeffrey D Greenberg2 and William Malatestinic3, 1Department of Rheumatology, Swedish Medical Center and University of Washington, Seattle, WA, 2Corrona, LLC, Southborough, MA, 3Eli Lilly and Company, Indianapolis, IN, 4Keck School of Medicine, University of Southern California, Los Angeles, CA

    Background/Purpose:   Prior studies have shown an inconsistent relationship between skin and joint symptoms in patients with comorbid PsO and PsA1-3.  The objective of the…
  • Abstract Number: 2908 • 2017 ACR/ARHP Annual Meeting

    High Disease Activity Is a Predictor of Depression and Persistent Depression in Early Rheumatoid Arthritis: Results from a Rheumatoid Arthritis Cohort

    Raman Joshi1, Mohammad Movahedi2, Bindee Kuriya3, Emmanouil Rampakakis4, Angela Cesta2, Xiuying Li2, Sandra Couto2, John S. Sampalis5 and Claire Bombardier2, 1William Osler Health Centre-Brampton Civic Hospital, Brampton, ON, Canada, 2Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 3Sinai Health System, University of Toronto, Toronto, ON, Canada, 4JSS Medical Research, Montreal, QC, Canada, 5McGill University, Montreal, QC, Canada

    Background/Purpose: The prevalence of depression among individuals with rheumatoid arthritis (RA) may be as high as 40% but persistence of depression over time is relatively…
  • Abstract Number: 63 • 2017 Pediatric Rheumatology Symposium

    Performance of Disease Activity Measures in Pediatric Patients With Enthesitis-related Arthritis

    Rubén Burgos-Vargas1, Gerd Horneff2, Shirley M.L. Tse3, Pierre Quartier4, Kristina Unnebrink5 and Jaclyn K. Anderson6, 1Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, 2Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, 3The Hospital for Sick Children, Toronto, ON, Canada, 4Hopital Necker-Enfants Malades, Paris, France, 5AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 6AbbVie Inc., North Chicago, IL

    Background/Purpose: Enthesitis-related arthritis (ERA) is a category of juvenile idiopathic arthritis (JIA), with clinical features similar to those of adult spondyloarthritis (SpA). An unmet ERA…
  • Abstract Number: 101 • 2017 Pediatric Rheumatology Symposium

    Defining Active Features of Juvenile Localized Scleroderma

    Suzanne Li1, Xiaohu Li2, Elena Pope3, Katie G. Stewart4, Gloria Higgins5, C. Egla Rabinovich6, Kathleen O'Neil7, Kathleen Haines8, Ronald Laxer9, Marilynn Punaro10, Heidi Jacobe11, Knut Wittkowski12, Themba Nyirenda13, Ivan Foeldvari14 and Kathryn S. Torok15, 1Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, 2Mathematical Sciences, Stevens Institute of Technology, Hoboken, NJ, 3Dermatology, The Hospital for Sick Children, Toronto, ON, Canada, 4Pediatric Rheumatology, Texas Scottish Rite Hospital, Dallas, TX, 5Pediatrics, Nationwide Children's Hospital, Columbus, OH, 6Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 7Pediatrics, Indiana University, Indianapolis, IN, 8Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, 9Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 10Texas Scottish Rite Hospital for Children, Dallas, TX, 11Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, 12Rockefeller University, New York, NY, 13Hackensack University Medical Center, Hackensack, NJ, 14Kinder- und Jugenrheumatologie, Hamburger Zentrum Kinder-und Jugendrheumatologie, Hamburg, Germany, 15Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA

    Background/Purpose: Juvenile localized scleroderma (jLS) is the most common form of childhood scleroderma. Because of its chronicity and association with extracutaneous involvement, children are at…
  • Abstract Number: 5 • 2017 Pediatric Rheumatology Symposium

    Effects of Puberty on Systemic Lupus Erythematosus:  Results of a multi-center prospective longitudinal observational study in children entering puberty with SLE

    Kathleen O'Neil1, Hermine Brunner2, Andrew Zeft3, Anne Stevens4, Suzanne Li5, Tracey Wright6, Emily von Scheven7, B. Anne Eberhard8, C. Egla Rabinovich9 and Deborah M. Levy10, 1Pediatrics, Indiana University, Indianapolis, IN, 2Rheumatology, PRCSG, Cincinnati, OH, 3Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, 4University of Washington, Department of Pediatrics, Seattle, WA, 5Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health, Hackensack, NJ, 6Pediatrics/Rheumatology, University of TX Southwestern, Dallas, TX, 7Division of Rheumatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, 8Cohen Children's Medical Center of New York, New Hyde Park, NY, 9Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 10Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose:  Lupus often presents during puberty, and when it affects pre-pubertal children, disease activity is thought to increase at puberty. Sex hormones play some role…
  • Abstract Number: 499 • 2016 ACR/ARHP Annual Meeting

    High Levels of Mir-451a Differentiate Patients at Risk of Developing RA from Healthy Controls

    Klára Prajzlerová1, Veronika Hrušková2, Petra Hánová1, Heřman F Mann1, Karel Pavelka1, Jiří Vencovský3, Ladislav Šenolt1 and Mária Filková1, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, Faculty of Science, Charles University in Prague, Prague, Czech Republic, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose:  Individuals with clinically suspect arthralgia (CSA) with positivity of antibodies to citrullinated protein antigens (ACPA) have articular symptoms without clinical signs of arthritis. CSA…
  • Abstract Number: 704 • 2016 ACR/ARHP Annual Meeting

    Does Change in Disease Activity over One Year Result in Change in Health-Related Quality of Life in Early Axial Spondyloarthritis Patients?

    Miranda van Lunteren1, Zineb Ez-Zaitouni1, Pauline Bakker1, Hanne Dagfinrud2, Robert Landewé3, Maikel van Oosterhout4, Roberta Ramonda5, Floris van Gaalen1 and Désirée van der Heijde1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Rheumatology, Academic Medical Center, Amsterdam, Netherlands, 4Rheumatology, Groene Hart Ziekenhuis, Gouda, Netherlands, 5Rheumatology Unit, University of Padova, Padova, Italy

    Background/Purpose: In axial Spondyloarthritis (axSpA), treatment is targeted at reducing disease activity  with the aim of improving the health-related quality of life (HRQoL). Therefore, it…
  • Abstract Number: 1055 • 2016 ACR/ARHP Annual Meeting

    Physical Activity Behavior in Men with Inflammatory Arthritis: A Cross-Sectional Register Based Study of Physical Activity Correlates, Motivators, Barriers and Preferences

    Nanna Maria Hammer1, Julie Midtgaard2, Merete Lund Hetland3,4, Niels Steen Krogh5 and Bente Appel Esbensen1,6, 1Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, The DANBIO registry and Copenhagen Center for Arthritis Research, Glostrup, Denmark, 2Section of Social Medicine, University of Copenhagen, Copenhagen, Denmark, Department of Public Health, Copenhagen, Denmark, 3Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, 4Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 5Zitelab, Frederiksberg, Denmark, 6Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen Copenhagen, Denmark, Copenhagen, Denmark

    Background/Purpose: While physical activity (PA) has been recommended as a part of the non-pharmacological management of inflammatory arthritis (IA), previous research within this area has…
  • Abstract Number: 1437 • 2016 ACR/ARHP Annual Meeting

    Netrin-1 and Its Receptor Unc5b Are Novel Targets for the Treatment of Inflammatory Arthritis

    Aranzazu Mediero1, Tuere Wilder2, Bhama Ramkhelawon3, Kathryn Moore3 and Bruce Cronstein4, 1Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, 2Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 3Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, 4Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose:  Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation and destruction of joints. Netrin-1, a laminin-like matrix protein that acts as a…
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