Abstracts tagged "Disease Activity"

Abstract Number: 1545 • 2016 ACR/ARHP Annual Meeting
Vitamin D Insufficiency in Patients with Rheumatoid Arthritis and Healthy Controls and Correlation Between Vitamin D Levels and Disease Activity and Disability in RA Patients
Bhupendra Vaishnav^1,2, Bhowmik Meghnathi^1,3, Abhishek Patil¹, Sundeep Upadhyaya¹, S J Gupta¹ and Rohini Handa¹, ¹Rheumatology, Indraprastha Apollo Hospitals, New Delhi, India, ²Rheumatology, Rajiv Gandhi Superspeciality Hospital, Delhi, India, ³Rheumatology B, Groupe Hospitalier Cochin-Saint Vincent de Paul, Paris, France
Background/Purpose: Lower serum vitamin D levels have been shown to be associated with various autoimmune disorders including Rheumatoid Arthritis (RA). We undertook this study to…
Abstract Number: 1823 • 2016 ACR/ARHP Annual Meeting
African American and European American SLE Patients with Variable Disease Activity Reveal Distinct Differences in CD4+ T Cell and Monocyte Pathways
Samantha Slight-Webb¹, Rufei Lu², Krista M. Bean¹, Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge⁵ and Judith A. James⁶, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder with both genetic and environmental contributions to disease etiology. Patients with different ancestral backgrounds have different…
Abstract Number: 2466 • 2016 ACR/ARHP Annual Meeting
Remission According to RAPID3 (routine assessment of patient index data 3) in Patients with Rheumatoid Arthritis: A Cross-Sectional 3 Center Study from Routine Care
Isabel Castrejón¹, Martin J. Bergman², Kathryn Gibson^3,4, Yusuf Yazici⁵, Joel Block⁶ and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Rheumatology, Taylor Hospital, Ridley Park, PA, ³Liverpool Hospital, Sydney, Sydney, Australia, ⁴Ingham Research Institute, Liverpool, Australia, ⁵Division of Rheumatology, NYU Hospital for Joint Diseases, New York, NY, ⁶Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Remission rates in patients with rheumatoid arthritis (RA) according to RAPID3 (routine assessment of patient index data) are reported at 25% in France1 and…
Abstract Number: 2675 • 2016 ACR/ARHP Annual Meeting
Essdai, Clinessdai and DAS Scoring at Diagnosis of Primary Sjogren Syndrome: Association with the Development of Hematologic and Solid Neoplasias in 1301 Patients
Soledad Retamozo^1,2, Belchin Kostov³, Guadalupe Fraile⁴, Daniel Caravia-Durán⁵, Brenda Maure⁶, Francisco Javier Rascón⁷, Mónica Zamora⁸, Arnau Casanovas⁹, Miguel Lopez-Dupla¹⁰, Mar Ripoll¹¹, Blanca Pinilla¹², Eva Fonseca¹³, Miriam Akasbi¹⁴, Gloria De la Red¹⁵, Miguel-Angel Duarte-Millán¹⁶, Patricia Fanlo Mateo¹⁷, Pablo Guisado¹⁸, Roberto Pérez-Alvarez¹⁹, Sandra Rodríguez-Rodríguez²⁰, César Morcillo²¹, Iratxe Jiménez-Heredia²², Alberto Gato²³, Jordi Gratacós¹, Isabel Sánchez-Berná¹, Manuel Ramos-Casals^24,25, Pilar Brito-Zerón^1,26 and SS Registry GEAS-SEMI, ¹Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, ²Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Argentina, Córdoba, Argentina, ³Primary Care Research Group, IDIBAPS, ABS Les Corts, CAPSE, Barcelona, Barcelona, Spain, ⁴Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain, Madrid, Spain, ⁵Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain, ⁶Department of Internal Medicine, Complejo Hospitalario Universitario, Vigo, Vigo, Spain, ⁷Department of Internal Medicine, Hospital Son Espases, Palma de Mallorca, Palma de Mallorca, Spain, ⁸Department of Internal Medicine, Hospital Virgen de las Nieves, Granada, Granada, Spain, ⁹Department of Internal Medicine, Hospital Parc Taulí, Sabadell, Sadabell, Spain, ¹⁰Department of Internal Medicine, Hospital Joan XXIII, Tarragona, Tarragona, Spain, ¹¹Department of Internal Medicine, Hospital Infanta Sofía, Madrid, Madrid, Spain, ¹²Department of Internal Medicine, Hospital Gregorio Marañón, Madrid, Madrid, Spain, ¹³Department of Internal Medicine, Hospital de Cabueñes, Gijón, Gijón, Spain, ¹⁴Department of Internal Medicine, Hospital Infanta Leonor, Madrid, Madrid, Spain, ¹⁵Department of Internal Medicine, Hospital Esperit Sant, Badalona, Badalona, Spain, ¹⁶Department of Internal Medicine, Hospital de Fuenlabrada, Fuenlabrada, Spain, ¹⁷Department of Internal Medicine, Hospital Virgen del Camino, Pamplona, Spain, ¹⁸Department of Internal Medicine, Complejo Hospitalario Ruber Juan Bravo, Madrid, Madrid, Spain, ¹⁹Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Vigo, Spain, ²⁰Department of Internal Medicine, Hospital de Salamanca, Salamanca, Salamanca, Spain, ²¹Department of Medicine, Hospital CIMA-Sanitas, Barcelona, Barcelona, Spain, ²²Department of Internal Medicine, Hospital de Sagunto, Valencia, Valencia, Spain, ²³Department of Internal Medicine, Complejo Hospitalario Albacete, Albacete, Albacete, Spain, ²⁴Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, ²⁵Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain, ²⁶Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain
Background/Purpose: To score systemic activity at diagnosis of primary Sjogren syndrome (pSS) using the European systemic activity indexes ESSDAI, clinESSDAI and DAS in order to…
Abstract Number: 2833 • 2016 ACR/ARHP Annual Meeting
Low Plasma Concentrations of Apolipoprotein M Correlate to Disease Activity and Endothelial Dysfunction in SLE
Helena Tydén¹, Christian Lood², Andreas Jönsen³, Birgitta Gullstrand⁴, Bjorn Dahlback⁵ and Anders A. Bengtsson³, ¹Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ²Department of Clinical Sciences, Section of Rheumatology, Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, ³Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, ⁴Department of Clinical Sciences, Division of Rheumatology, Lund University, Lund, Sweden, ⁵Department of Translational Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital Malmö, Malmö, Sweden
Background/Purpose: Human apoM is a 25kDa apolipoprotein present in 5% of HDL particles in plasma. In mouse models, apoM is antiatherogenic and vasculoprotective and…
Abstract Number: 3186 • 2016 ACR/ARHP Annual Meeting
Determinants of Patient-Physician Discordance in Global Assessment in Psoriatic Arthritis and Levels of Discordance According to Disease Activity: A Multicenter European Study
Carole Desthieux¹, Benjamin Granger², Andra Rodica Balanescu³, P Balint⁴, Jürgen Braun⁵, Juan Canete⁶, Turid Heiberg⁷, Philip S. Helliwell⁸, Umut Kalyoncu⁹, Tore K Kvien¹⁰, Uta Kiltz⁵, Dora Niedermayer¹¹, Kati Otsa¹², Rossana Scrivo¹³, Josef Smolen¹⁴, Tanja A. Stamm¹⁵, Douglas J. Veale¹⁶, Kurt de Vlam¹⁷, Maarten de Wit¹⁸ and Laure Gossec¹, ¹Rheumatology, Pitié Salpêtrière Hospital, Paris, France, ²Biostatistics, Pitié Salpêtrière Hospital, Paris, France, ³Department of Internal Medicine and Rheumatology “Sf. Maria” Hospital, Bucharest, Romania, ⁴Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ⁵Rheumazentrum Ruhrgebiet, Herne, Germany, ⁶Rheumatology, Hospital Clínic and IDIBAPS, Barcelona, Spain, ⁷Oslo University Hospital, Oslo, Norway, ⁸NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁹Hacettepe University, Ankara, Turkey, ¹⁰Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ¹¹PsAID taskforce, EULAR, Zurich, Switzerland, ¹²Rheumatology, Tallinn Central Hospital, Tallinn, EE, ¹³Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, ¹⁴Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ¹⁵Internal Medicine III, Vienna Medical University, Vienna, Austria, ¹⁶Consultant Rheumatologist, Centre for Arthritis and Rheumatic Disease, St. Vincent’s University Hospital and University College Dublin, Dublin 4, Ireland, ¹⁷Katholieke Universiteit Leuven, Leuven, Belgium, ¹⁸Medical Humanities, VU Medical Centre, Amsterdam, Netherlands
Background/Purpose: In the management of chronic diseases, recommendations insist on the need to work in partnership with the patient. Patient-physician discordance in global assessment of…
Abstract Number: 185 • 2016 ACR/ARHP Annual Meeting
The Interferon Gene Signature Is Increased in Early DMARD Naive Rheumatoid Arthritis and Predicts a Poorer Response to Initial Therapy
Faye A H Cooles¹, Amy E. Anderson¹, Dennis W Lendrem¹, Julie Norris¹, Arthur G. Pratt¹, Catharien M U Hilkens² and John D Isaacs³, ¹Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom, ³Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom
Background/Purpose: Type 1 interferons, such as interferon-α, are of increasing interest in autoimmunity due to their pleiotropic effects on the immune system. Approximately 20-30% of…
Abstract Number: 551 • 2016 ACR/ARHP Annual Meeting
Changes in Diverse Disease Activity Measures Are Highly Correlated Following the Initiation of Most Treatment Modalities in the Management of Longstanding Rheumatoid Arthritis
Craig Wiesenhutter, Coeur d'Alene Arthritis Clinic, Coeur D Alene, ID; University of Washington School of Family Medicine, Seattle, ID
Background/Purpose: Treating rheumatoid arthritis (RA) patients to target (T2T) has been shown to result in better outcomes in patients with relatively recent onset RA. The…
Abstract Number: 899 • 2016 ACR/ARHP Annual Meeting
Disparities in Disease Characteristics, Treatment Pattern and Comorbidities in 1,858 Patients with Polymyalgia Rheumatica, Giant Cell Arteritis or Both Diseases
Dörte Huscher¹, Katinka Albrecht¹, Frank Buttgereit², Martin Aringer³, Guido Hoese⁴, Wolfgang Ochs⁵, Katja Thiele¹ and Angela Zink^1,2, ¹Epidemiology, German Rheumatism Research Centre, Berlin, Germany, ²Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ³Medicine III, University Medical Center and Faculty of Medicine at the TU Dresden, Dresden, Germany, ⁴Rheumatologische Fachpraxis Stadthagen, Stadthagen, Germany, ⁵Internistisch-rheumatologische Praxisgemeinschaft Bayreuth, Bayreuth, Germany
Background/Purpose: Methods: Conclusion:
Abstract Number: 1374 • 2016 ACR/ARHP Annual Meeting
Predictors of Changes in Disease Activity Among Children with Juvenile Dermatomyositis
Cynthia S. Crowson¹, Jeannette M. Olazagasti Lourido², Timothy B. Niewold³, Ann M Reed⁴ and CARRA Investigators, ¹Health Sciences Research, Mayo Clinic, Rochester, MN, ²University of Puerto Rico, San Juan, Puerto Rico, ³Rheumatology and Immunology, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Duke University, Durham, NC
Background/Purpose: Determinants of changes in disease activity among patients with juvenile dermatomyositis (JDM) are unknown. Our objective was to develop scores to predict changes in…
Abstract Number: 1548 • 2016 ACR/ARHP Annual Meeting
Correlates of Fatigue in People Living with Rheumatoid Arthritis
Jet Veldhuijzen van Zanten^1,2, Sally Fenton^3,4, Peter Rouse⁵, George Metsios^3,6, Ahmad Osailan^1,2, Chen-an Yu², Nikos Ntoumanis⁷, Joan Duda⁴ and George Kitas^1,2, ¹Department of Rheumatology, Dudley Group NHS Foundation Trust, Dudley, United Kingdom, ²School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom, ³Department of Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, ⁴School of Sport, Exercise and Rehabilitation, University of Birmingham, Birmingham, United Kingdom, ⁵Department for Health, University of Bath, Bath, United Kingdom, ⁶Department of Physical Activity Exercise and Health, University of Wolverhampton, Walsall, United Kingdom, ⁷School of Psychology & Speech Pathology, Curtin University, Perth, Australia
Background/Purpose: Fatigue is a frequently mentioned symptom by people living with rheumatoid arthritis (RA). However, little research has explored the associations between fatigue and other…
Abstract Number: 1831 • 2016 ACR/ARHP Annual Meeting
A Novel Graph Theoretic Approach Applied to Modular Repertoire Analysis Identifies a Dual Molecular Progression in Adult SLE Patients, with Distinct Interferon and Neutrophil Transcription Patterns
Ilya Korsunski¹, Noémie Jourde-Chiche^2,3, Peter K. Gregersen¹, Damien Chaussabel⁴, Laurent Chiche⁵ and Naomi I Maria⁶, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France, ³Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, ⁴Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, ⁵internal medicine, Hopital Europeen, Marseille, France, ⁶Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Gene expression studies support a pivotal role for type I interferon (IFN) in SLE. Previous work using a modular repertoire analysis based on co-clustered…
Abstract Number: 2468 • 2016 ACR/ARHP Annual Meeting
Assessment of the American-English Version of the French FLARE in Rheumatoid Arthritis
Nashla Barroso¹, Thasia G Woodworth², Francis Guillemin³, Daniel E. Furst⁴, Jenny Brook⁵, Suzanne Kafaja⁶, David Elashoff⁵, Bruno Fautrel⁷ and Veena Ranganath⁸, ¹Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Leading Edge Clinical Research, Stuart, FL, ³CHRU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, ⁴David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁵Medicine, David Geffen School of Medicine, Los Angeles, CA, ⁶Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁷Rheumatology, Pitié Salpêtrière Hospital, Paris, France, ⁸Cumberland Valley Rheumatology, P.C., Chambersburg, PA
Background/Purpose: Due to the lack of consensus of the definition of a rheumatoid arthritis (RA) flare, the French “FLARE” (FLare Assessment in RA) instrument was…
Abstract Number: 2705 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Autophagy Genes and Their Association with Spinal Damage in Patients with Ankylosing Spondylitis
Min-Chan Park¹, Hye Won Kim², Jason Jungsik Song¹ and Yong-Beom Park¹, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: However, a role of autophagy in ankylosing spondylitis has not been clearly elucidated and the association of autophagy-related gene expression levels with inflammatory or…
Abstract Number: 2847 • 2016 ACR/ARHP Annual Meeting
Antibodies to Double Stranded DNA: Combined Standard ELISA and High-Salt ELISA Assays for the Detection of SLE Disease Activity
Laura Durcan, Jenna Thomason, Daniel Kuo and Mark H. Wener, University of Washington, Seattle, WA
Background/Purpose: Serological markers in systemic lupus erythematosus (SLE) are crucial objective measures included in disease activity indices. Antibodies to double stranded DNA (anti-dsDNA) are included…

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