Abstracts tagged "Disease Activity"

Abstract Number: 1365 • 2017 ACR/ARHP Annual Meeting
Correlation of the Multi-Biomarker Disease Activity Score with Composite Rheumatoid Arthritis Disease Activity Measures: A Systematic Review and Meta-Analysis
Tate Johnson¹, Kyle A. Register², Cynthia Schmidt³, James R. O'Dell⁴, Ted R. Mikuls⁵, Kaleb Michaud¹ and Bryant R. England⁶, ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, ³McGoogan Library of Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁶Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: The regular assessment of disease activity is necessary to implement a treat-to-target management approach in RA. The Multi-Biomarker Disease Activity (MBDA) Score is a…
Abstract Number: 1629 • 2017 ACR/ARHP Annual Meeting
Disease Activity Is an Independent Predictor of Leukopenia in a Large International SLE Cohort
Rangi Kandane-Rathnayake¹, Vera Golder², Worawit Louthrenoo³, Sargunan Sockalingam⁴, Aisha Lateef⁵, Yuan An⁶, Leonid Zamora⁷, Yeong-Jian Wu⁸, Shue-Fen Luo⁹, Madelynn Chan¹⁰, Fiona Goldblatt¹¹, Chak Sing Lau¹², Zhan-Guo Li¹³, Sandra V. Navarra⁷, Mandana Nikpour¹⁴, Eric F Morand¹⁵ and Alberta Y. Hoi², ¹Rheumatology, Monash University, Melbourne, Australia, ²Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ³Division of Rheumatology, Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand, ⁴University of Malaya, Kuala Lumpur, Malaysia, ⁵Medicine, Division of Rheumatology, National University Hospital of Singapore, Singapore, Singapore, ⁶Peking University People's Hospital, Beijing, China, ⁷Rheumatology, University of Santo Tomas Hospital, Manila, Philippines, ⁸Chang Gung University, Taoyuan County, Taiwan, ⁹Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ¹⁰Tan Tock Seng Hospital, Singapore, Singapore, ¹¹Flinders University, Adelaide, Australia, ¹²Univ Dept of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ¹³Peking University International Hospital, Beijing, China, ¹⁴Melbourne University, Melbourne, Australia, ¹⁵Monash University, Melbourne, Australia
Background/Purpose: Leukopenia is commonly seen in SLE, but its predictors are not well understood, as it can be a result of disease activity or bone…
Abstract Number: 2143 • 2017 ACR/ARHP Annual Meeting
Circulating Endothelial Cells and Endothelial Activation Markers As Disease Activity Measures in Idiopathic Inflammatory Myopathies
Takayuki Kishi¹, Jonathan Chipman¹, Maryalice Stetler-Stevenson², Khanh Nghiem³, Melvina Evereklian¹, Margaret E. Rick³, Frederick W Miller¹ and Lisa G Rider¹, ¹Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ²Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, ³Coagulation Laboratory, Clinical Center, National Institutes of Health, Bethesda, MD
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases with chronic muscle inflammation and microvasculopathy of muscle and skin capillaries. Circulating endothelial cells (CECs),…
Abstract Number: 2506 • 2017 ACR/ARHP Annual Meeting
In Ankylosing Spondylitis/Axial Spondyloarthritis Smoking Is Associated with a Dose Related Elevation in CRP, Worse Disease Activity and Worse Quality of Life over One Year
Simon Stebbings¹, Mary Wallace², Andrew A. Harrison³, Nicola Dalbeth⁴, Douglas White⁵, Lisa K. Stamp⁶, Daniel Ching⁷ and John Highton⁸, ¹Dunedin Hospital, Department of Rheumatology, Dunedin, New Zealand, ²Surgical Sciences, University of Otago, Dunedin, New Zealand, ³Department of Medicine, University of Otago Wellington, Wellington, New Zealand, ⁴University of Auckland, Auckland, New Zealand, ⁵Department of Rheumatology, Waikato Clinical School, Hamilton, New Zealand, ⁶University of Otago, Christchurch, New Zealand, ⁷Timaru Medical Specialists Ltd, Timaru, New Zealand, ⁸Dept of Medicine, Univ of Otago Med Sch, Dunedin, New Zealand
Background/Purpose: Analysis of data from several cohort studies of patients with ankylosing spondylitis (AS) /axial spondyloarthritis (AxSpA) have confirmed earlier suggestions that current smokers have…
Abstract Number: 2859 • 2017 ACR/ARHP Annual Meeting
Development of New Juvenile Arthritis Disease Activity Score Cut-Offs for Oligoarthritis and RF-Negative Polyarthritis from a Large Multinational Cohort of Children with Juvenile Idiopathic Arthritis
Alessandro Consolaro^1,2, Pieter Van Dijkhuizen¹, Graciela Espada³, Boriana Varbanova⁴, Sheila Oliveira⁵, Paivi Miettunen⁴, Gaëlle Chédeville⁵, Michaël Hofer⁵, Pavla Dolezalová⁵, Ivan Foeldvari⁵, Gerd Horneff⁵, Anne Estmann⁵, Chris Pruunsild⁵, Rosa Merino⁵, Inmaculada Calvo Penades⁵, Pablo Mesa del Castillo⁵, Pekka Lahdenne⁵, Maka Ioseliani⁵, Maria Trachana⁵, Olga Vougiouka⁵, Miroslav Harjacek⁵, Ilonka Orban⁵, Tamás Constantin⁵, Nahid Shafaie⁵, Violeta Vladislava Panaviene⁵, Marite Rygg⁵, Elzbieta Smolewska⁵, Jose Antonio Melo Gomes⁵, Jelena Vojinovic⁵, Ekaterina Alexeeva⁵, Tadej Avcin⁵, Veronika Vargova⁵, Nuray Aktay Ayaz⁶, Ozgur Kasapcopur⁵, Yaryna Boyko⁵, Sarah Ringold⁵, Mariangela Rinaldi⁵, Marco Garrone⁵, Nicolino Ruperto⁷ and Angelo Ravelli^8,9, ¹Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, ²University of Genova, GENOA, Italy, ³Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genova, Italy, ⁴Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, GENOA, Italy, ⁵Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy, ⁶Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Gernoa, Italy, ⁷Istituto Giannina Gaslini, Genoa, Italy, ⁸University of Genova, IRCCS Istituto Giannina Gaslini, Genova, Italy, ⁹University of Genova, Genova, Italy
Background/Purpose: The measurement of the level of disease activity plays a pivotal role in the care of patients with juvenile idiopathic arthritis (JIA). To serve…
Abstract Number: 470 • 2017 ACR/ARHP Annual Meeting
Clinical Response to the First Biologic in Rheumatoid Arthritis Patients with Moderate Disease in a Real World Clinical Cohort
Xiuying Li, Angela Cesta, Mohammad Movahedi and Claire Bombardier, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: While most randomized trials assess the effectiveness of biologic DMARDs (bDMARDs) in rheumatoid arthritis (RA) patients with high disease activity, in the real world…
Abstract Number: 999 • 2017 ACR/ARHP Annual Meeting
Association between Smoking with Spinal Level of Stiffness and Functional Limitation in Patients with Axial Spondyloarthritis: Results from the Spanish Atlas
Marco Garrido-Cumbrera¹, Victoria Navarro-Compán², Jorge Chacon-Garcia¹, Jordi Gratacos-Masmitja³, David Galvez-Ruiz¹, Eduardo Collantes Estevez⁴, Pedro Zarco⁵ and Olta Brace¹, ¹Universidad de Sevilla, Seville, Spain, ²Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ³Rheumatology, Hospital Parc Taulí, Sabadell - Barcelona, Spain, ⁴Universidad de Cordoba, Cordova, Spain, ⁵H Fundación Alcorcón, Alcorcón, Spain
Background/Purpose: Smoking has been associated with greater disease activity and radiographic progression in patients with Axial Spondyloarthritis (ax-SpA). In addition, radiographic damage has been linked…
Abstract Number: 1388 • 2017 ACR/ARHP Annual Meeting
Fatigue Is Strongly Associated with the Patient Global Assessment and May Affect Disease Severity and Clinical Remission in Patients with Rheumatoid Arthritis: A Cross-Sectional Study from IORRA, a Large Observational Cohort of Japanese Rheumatoid Arthritis Patients
Naoki Sugimoto¹, Eiichi Tanaka¹, Eisuke Inoue^1,2, Kumiko Saka¹, Eri Sugano¹, Naohiro Sugitani¹, Moeko Ochiai¹, Yoko Shimizu¹, Rei Yamaguchi¹, Katsunori Ikari¹, Ayako Nakajima¹, Atsuo Taniguchi¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Division of Medical Informatics, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: Fatigue is a common complaint in patients with rheumatoid arthritis (RA)1. However, its impact on disease activity and clinical remission in patients with RA…
Abstract Number: 1634 • 2017 ACR/ARHP Annual Meeting
Body Mass Index and Disease Activity in Systemic Lupus Erythematosus- a Paradoxical Relationship?
George Stojan¹, Wei Fu² and Michelle Petri³, ¹Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD
Background/Purpose: Obesity is more common in patients with SLE compared to the general population. The prevalence of obesity among SLE patients is between 28 and…
Abstract Number: 2153 • 2017 ACR/ARHP Annual Meeting
Decreased Lean Body Mass and Bone Mineral Density but Increased Body Fat in Myositis Patients Are Associated with Disease Duration, Inflammatory Status, Skeletal Muscle Involvement and Physical Activity
Sabina Oreska¹, Maja Spiritovic^1,2, Petr Cesak², Ondrej Marecek², Hana Storkanova¹, Katerina Kubinova¹, Martin Klein¹, Lucia Vernerova¹, Olga Ruzickova¹, Radim Becvar¹, Karel Pavelka¹, Ladislav Senolt¹, Herman F Mann¹, Jiri Vencovsky¹ and Michal Tomcik¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are characterized by inflammation and atrophy of skeletal muscles, pulmonary and articular involvement, which limit the mobility/self-sufficiency of patients, and…
Abstract Number: 2508 • 2017 ACR/ARHP Annual Meeting
Obese Axial Spondyloarthropathy Patients Have Worse Disease Outcomes
Gillian Fitzgerald¹, Phil Gallagher², Catherine Sullivan³, Killian O Rourke⁴, Claire Sheehy⁵, Frances Stafford⁶, Carmel Silke⁷, Muhammad Haroon⁸, Ronan Mullan⁹, Sandy Fraser¹⁰, Grainne Murphy¹¹, Shawn Chavrimootoo¹², Oliver FitzGerald¹³ and Finbar O' Shea¹, ¹Rheumatology, St James's Hospital, Dublin 8, Ireland, ²St. Vincent's University Hospital, Department of Rheumatology, Dublin, Ireland, ³Rheumatology, UCHG Ireland, Galway, Ireland, ⁴Rheumatology, Midlands Regional Hospital, Tullamore, Co Offaly, Ireland, ⁵Rheumatology, University Hospital Waterford, Waterford, Ireland, ⁶Rheumatology, Blackrock Clinic, Co Dublin, Ireland, ⁷Rheumatology, Sligo University Hospital, Sligo, Ireland, ⁸Rheumatology, Kerry General Hospital, Co Kerry, Ireland, ⁹Department of Rheumatology, Tallaght Hospital, TCD, Dublin 24, Ireland, ¹⁰Department of Rheumatology, University Hospitals Limerick, Ireland, Limerick, Ireland, ¹¹Rheumatology, Cork University Hospital, Cork, Ireland, ¹²Rheumatology, Our Lady's Hospital, Co Meath, Ireland, ¹³St. Vincent's University Hospital, Department of Rheumatology. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
Background/Purpose: Obesity is a worldwide public health concern, due to its association with morbidity and mortality. Existing literature looking at obesity in axial spondyloarthropathy (axSpA)…
Abstract Number: 2862 • 2017 ACR/ARHP Annual Meeting
Diverse Disease Activity Measures Demonstrate That the Routine Assessment of Patient Index Data with 3 Measures (Rapid-3) Assesses Only Non Inflammatory Components of Disease and Should Not be Utilized in a Treat to Target Strategy in Rheumatoid Arthritis
Craig Wiesenhutter, Coeur d'Alene Arthritis Clinic, Coeur D Alene, ID
Background/Purpose: Treating Rheumatoid Arthritis (RA) patients to target (T2T) has been shown to result in better outcomes in patients with RA. Surrogate measures of disease…
Abstract Number: 471 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients Resistant to Biologic Therapy, Are They Different?
Adeeba Al-Herz¹, Aqeel Ghanem², Khulood Saleh³, Adel Al-Awadhi⁴, Waleed Al-Kandari³, Eman Hasan⁵, Mohammad Hussain⁵, Ibrahim Nahar², Fatemah Abutiban⁶, Ahmad Alenizi⁶, Yaser Ali², Ali Aldei¹, Hebah Alhajeri², Sawsan Hayat², Ahmad Khadrawy³, Ammad Fazal³, Khaled Mokaddem¹, Agaz Zaman², Ghada Mazloum², Youssef Bartella¹, Sally Hamed¹, Ramia Alsouk⁶ and Ahmed Al-Saber⁷, ¹Rheumatology, Al-Amiri Hospital, Kuwait city, Kuwait, ²Rheumatology, Mubarak Al-Kabeer Hospital, Hawally, Kuwait, ³Rheumatology, Farwania Hospital, Farwania, Kuwait, ⁴Faculty of Medicine, Kuwait, Kuwait, ⁵Al-Amiri Hospital, Kuwait city, Kuwait, ⁶Rheumatology, Jahra Hospital, Jahra, Kuwait, ⁷Department of Mathematics, Kuwait Technical College, Kuwait city, Kuwait
Background/Purpose: Patients with rheumatoid arthritis (RA) may fail to respond to biologic therapy. We study patients who are resistant to different classes of biologic agents…
Abstract Number: 1039 • 2017 ACR/ARHP Annual Meeting
Influences for Therapeutic Changes in Rheumatoid Arthritis Patients from the Veterans Affairs Rheumatology Arthritis Registry Who Have Moderate to High Disease Activity
Brian Sauer¹, Jacob R. Stever¹, Chia-Chen Teng, MS¹, Neil Accortt², David Collier² and Grant Cannon¹, ¹Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ²Amgen Inc., Thousand Oaks, CA
Background/Purpose: Current guidelines encourage the measurement of rheumatoid arthritis (RA) disease activity to achieve a low disease state (treat-to-target). Many RA patients with documented moderate…
Abstract Number: 1390 • 2017 ACR/ARHP Annual Meeting
Agreement between the DAS28-ESR and the DAS28-CRP and Factors Related to the Discrepancies between Disease Activity Levels According to These 2 Scores in Patients with Early Rheumatoid Arthritis
Cécile Gaujoux-Viala¹, Mohamed Belkacemi², Alain Cantagrel³, Bruno Fautrel⁴ and Bernard Combe⁵, ¹Rheumatology, Nîmes University Hospital and EA2415 Montpellier University, Nîmes, France, ²EA2415 Montpellier University, Montpellier, France, ³Rheumatology, Toulouse University Hospital and Toulouse University, Toulouse, France, ⁴UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ⁵Rheumatology, CHU Lapeyronie and Montpellier University, Montpellier, France
Background/Purpose: DAS28 is often used as a treatment decision tool in patients with rheumatoid arthritis (RA) in the daily clinic. Although different versions of DAS28…

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