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Abstracts tagged "Disease Activity"

  • Abstract Number: 2158 • ACR Convergence 2025

    Evaluating Nailfold Capillary Changes as Indicators of Disease Activity in Juvenile Dermatomyositis

    Zilan Zheng1, Laila Metni2, Susan Kim3 and Jessica Neely4, 1University of California, San Francisco, San Francisco, CA, 2University of California, Berkeley, Berkeley, CA, 3UCSF Benioff Children's Hospital, San Francisco, CA, 4UCSF, San Francisco, CA

    Background/Purpose: Juvenile dermatomyositis (JDM) is a rare pediatric autoimmune myopathy characterized by skin and muscle inflammation, resulting in microvascular changes that can be visualized in…
  • Abstract Number: 1608 • ACR Convergence 2025

    Efficacy of Anti-IL-5/R Therapies on Specific Disease Manifestations of Eosinophilic Granulomatosis with Polyangiitis

    Peter Merkel1, Arnaud Bourdin2, Bernhard Hellmich3, Nader Khalidi4, David Jackson5, David Jayne6, Parameswaran Nair7, Christian Pagnoux8, Ulrich Specks9, Benjamin Terrier10, Lena Börjesson Sjö11, Priya Jain12, Aadarsh Lal13, Sofia Necander14, Claire Walton15 and Michael Wechsler16, 1University of Pennsylvania, Philadelphia, PA, 2Department of Respiratory Diseases, Montpellier University Hospitals, Arnaud de Villeneuve Hospital, Montpellier, France, 3Klinik für Innere Medizin, Rheumatologie, Pneumologie, Nephrologie und Diabetologie, Medius Kliniken, Akademisches Lehrkrankenhaus der Universität Tübingen, Kirchheim unter Teck, Germany, 4Department of Medicine, McMaster University and St. Joseph’s Healthcare, Hamilton, Canada, 5Guy’s Severe Asthma Centre, Guy's and St Thomas’ NHS Trust, London, and School of Immunology and Microbial Sciences, King's College London, London, United Kingdom, 6University of Cambridge, Cambridge, United Kingdom, 7Department of Medicine, McMaster University and St. Joseph’s Healthcare, Hamilton, ON, Canada, 8Mount Sinai Hospital, University Health Network, Toronto, and Canadian Vasculitis Research Network (CanVasc), Toronto, ON, Canada, 9Mayo Clinic, Rochester, MN, 10Cochin Hospital, Paris, France, 11Late-stage Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca,, Gothenburg, Sweden, 12BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom, 13Respiratory & Immunology, AstraZeneca, Bengaluru, Karnataka, India, 14Late-stage Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 15Late-Stage Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, 16Department of Medicine, National Jewish Health, Denver

    Background/Purpose: Results from the 1-year double-blind period and first year of the open-label extension (OLE) of the MANDARA trial (NCT04157348) demonstrated that over 60% of…
  • Abstract Number: 1421 • ACR Convergence 2025

    Impact of Psoriatic Arthritis Disease Activity and Fatigue on Subjective Cognitive Decline (“Brainfog”)

    Lily Mikolajczak1, Helena Kuhn1, Leslie Harrold2 and George Reed3, 1Kuchnir Dermatology and Dermatologic Surgery, Milford, MA, 2CorEvitas, Northborough, MA, 3University of Massachusetts Chan Medical School, Worcester, MA

    Background/Purpose: Patients with psoriatic arthritis often report having brain fog, describing symptoms such as forgetfulness, difficulty thinking and memory issues. It has been hypothesized that…
  • Abstract Number: 1219 • ACR Convergence 2025

    Anti-Ro52 Antibody Identifies Patients with More Severe Lung disease among Patients with Idiopathic Inflammatory Myopathy

    Vasiliki Syrmou1, Ioannis Alexiou2, Christos Liaskos3, Eleni Patrikiou3, THEODORA SIMOPOULOU4, Christina Katsiari5 and Dimitrios Bogdanos6, 1University General Hospital of Larisa, University of Thessaly, Faculty of Medicine, Larisa, Greece, 2University General Hospital of Larisa, Larissa, Greece, 3University of Thessaly, Faculty of Medicine, Larisa, Greece, 4University Hospital of Larissa, Greece, Larissa, Greece, 5University General Hospital of Larisa, University of Thessaly Faculty of Medicine, Larisa, Greece, 6Professor, Larissa, Greece

    Background/Purpose: Anti-Ro52 antibodies are commonly detected in idiopathic inflammatory myopathies (IIMs), yet their clinical significance remains incompletely defined. There is evidence that it coexists with…
  • Abstract Number: 0608 • ACR Convergence 2025

    Strong Correlation Between SLEDAI and SLE-DAS in the Spanish Population: Assessment of Discordant Patients

    Elena Heras Recuero1, Antia Garcia Fernandez2, Cristina Gomez-Moreno3, Ivan Ferraz Amaro4, Javier Llorca5 and Miguel A. González-Gay6, 1Hospital Fundacion Jimenez Dias, Madrid, Spain, 2Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, 3Fundacion Jiménez Díaz School of Nursing, Madrid, Autonomous University Madrid, Madrid, Spain, 4Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 5CIBER Epidemiología y Salud Pública (CIBERESP) and Department of Medical and Surgical Sciences, University of Cantabria, Santander, Spain, 6Department of Rheumatology and Joint and Bone Research Unit, Hospital Universitario Fundación Jiménez Díaz, and Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Madrid, Spain, and Medicine and Psychiatry Department, University of Cantabria, Santander, Spain

    Background/Purpose: Assessing disease activity in systemic lupus erythematosus (SLE) is essential for effective treatment. SLEDAI-2K uses dichotomous items, while SLE-DAS incorporates both dichotomous and continuous…
  • Abstract Number: 0491 • ACR Convergence 2025

    Association of Short Chain Fatty Acids and Diet with Disease Activity and Methotrexate Response in New Onset Rheumatoid Arthritis: A Proof of Principle Study

    Kaci French1, Luz Alvarado2, Rebecca Haberman3 and Rebecca Blank3, 1NYU Langone, New York, NY, 2NYU Langone, New York, 3NYU Langone Health, New York, NY

    Background/Purpose: Diet, the gut microbiome, and gut microbial metabolites have been implicated in rheumatoid arthritis (RA) development and modulation. Seafood based-omega-3 fatty acids modulate inflammatory…
  • Abstract Number: 0385 • ACR Convergence 2025

    Musculoskeletal Ultrasound Enhances Patient Insight and Clinical Decisions: A Multi-Center Study

    Simran Nimal1, Meridith Balbach2, Aslam Fawad1, Midori Nishio3 and Erin Chew2, 1Mayo Clinic Arizona, Scottsdale, AZ, 2Vanderbilt University, Nashville, TN, 3John Muir Specialty Medical Group, Lafayette, CA

    Background/Purpose: Musculoskeletal ultrasound (MSKUS) is a valuable tool for early detection and management of inflammatory arthritis.(1) Although integrated into rheumatology guidelines, training programs, and classification…
  • Abstract Number: 2683 • ACR Convergence 2025

    Association of Genetic Risk for Pain Intensity with Longitudinal Disease Activity in Rheumatoid Arthritis

    Stevie Barry1, Katie McMenamin2, Austin Wheeler3, Bryant England3, Grant Cannon4, Brian Sauer5, Gary Kunkel6, Katherine Wysham7, Beth Wallace8, Andreas Reimold9, Gail Kerr10, Isaac Smith11, John Richards12, Iris Lee13, Rui Xiao1, Sylvanus Toikumo14, Henry Kranzler14, Rachel Kember14, Scott Damrauer14, Michael Levin14, Michael George1, Ted Mikuls3, Joshua Baker1 and Thomas Riley1, 1University of Pennsylvania, Philadelphia, PA, 2Boston Medical Center, Boston, MA, 3University of Nebraska Medical Center, Omaha, NE, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5Salt Lake City VA/University of Utah, Salt Lake City, UT, 6University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 7VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 8Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, 9Dallas VA Medical Center, Dallas, TX, 10Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 11Duke University Hospital, Durham, NC, 12Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, 13Washington University in St Louis, Saint Louis, MO, 14University of Pennsylvania / Corporal Michael J. Crescenz VAMC, Philadelphia, PA

    Background/Purpose: Guidelines recommend the use of composite scores to evaluate disease activity in RA and inform a treat-to-target approach. It is recognised that patient-reported components…
  • Abstract Number: 2349 • ACR Convergence 2025

    Classification of “Difficult-to-Manage Axial Spondyloarthritis”: A Real-World Cohort Study Evaluating the ASAS 2024 Criteria Over Time

    Gözde Sevgi Kart bayram1, Muhammed Çağrı Akdemir2, Mustafa Ekici3, Gizem Ayan4, Büşra Fırlatan Yazgan1, Erdinç Ünaldı3, Buğu Bulat1, Ali Aytuğ Kuştaş3, Ali Akdoğan5, Omer Karadağ5, Şule Apraş Bilgen1, Ali İhsan Ertenli1, Sedat Kiraz3, Umut Kalyoncu1 and Levent Kılıç1, 1Division of Rheumatology, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey, Ankara, Turkey, 2Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey, Ankara, Turkey, 3Division of Rheumatology, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey, Ankara, Ankara, Turkey, 4Ankara Research and Training Hospital, Ankara, Turkey, 5Division of Rheumatology, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey, Ankara

    Background/Purpose: The concept of difficult-to-manage axial spondyloarthritis (D2M-axSpA)[1], may vary over time. Transitions between D2M and non-D2M classifications throughout the disease course remain unclear. This…
  • Abstract Number: 2148 • ACR Convergence 2025

    Initial MRI Findings as Predictors of Disease Phenotype in Juvenile Dermatomyositis: A Comparative Study of Myositis Specific Antibodies NXP2-Positive and Myositis Specific Antibody-Negative Patients in a Large Tertiary Hospital

    Juan Torres Sanchez1, Pritish Bawa2, Andrea Ramirez1, MaiLan Nguyen3, Amit Thakral4, Xiaofan Huang1, J Herman Kan2 and Marietta De Guzman1, 1Baylor College of Medicine, Houston, TX, 2Texas Childrens Hospital, Houston, TX, 3Baylor College of Medicine, Austin, TX, 4Texas Children’s Hospital, Houston, TX

    Background/Purpose: Juvenile dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy of childhood, characterized by proximal muscle weakness and distinctive cutaneous findings. Magnetic resonance imaging…
  • Abstract Number: 1566 • ACR Convergence 2025

    Factors Associated with Patient and Physician Global Assessments in Early Systemic Sclerosis

    Ellen Romich1, Alexis Ogdie2, Peter Merkel3, Alisa Stephens Shields3, Jessica Alvey4, Shervin Assassi5, Elana Bernstein6, Sonali Bracken7, Flavia Castelino8, Lorinda Chung9, Luke Evnin10, Tracy Frech11, Jessica Gordon12, Faye Hant13, Monica Harding14, Laura Hummers15, Dinesh Khanna16, Kimberly Lakin12, Dorota Lebiedz-Odrobina14, Yiming Luo6, Ashima Makol17, Maureen Mayes18, Zsuzsanna McMahan19, Jerry Molitor20, Duncan Moore21, Carrie Richardson22, Ami Shah15, Ankoor Shah23, Brian Skaug24, Virginia Steen25, John VanBuren14, Elizabeth Volkmann26, Carleigh Zahn16 and Nora Sandorfi3, 1University of Pennsylvania, Media, PA, 2Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, 3University of Pennsylvania, Philadelphia, PA, 4Utah Data Coordinating Center, University of Utah, Salt Lake City, UT, 5Division of Rheumatology, UTHealth Houston, Houston, Texas, USA, Houston, TX, 6Columbia University, New York, NY, 7Duke University Medical Center, Durham, NC, USA, Apex, NC, 8Massachusetts General Hospital, Boston, MA, 9Stanford University, Stanford, CA, 10Scleroderma Research Foundation, San Francisco, CA, 11Vanderbilt University Medical Center, Nashville, TN, 12Hospital for Special Surgery, New York, NY, 13Medical University of South Carolina, Charleston, SC, 14University of Utah, Salt Lake City, UT, 15Johns Hopkins Rheumatology, Baltimore, MD, 16University of Michigan, Ann Arbor, MI, 17Mayo Clinic, Rochester, MN, 18UT Health Houston Division of Rheumatology, Houston, TX, 19UT Health Houston, Houston, TX, 20University of Minnesota, Minneapolis, MN, 21Northwestern Memorial Hospital, Chicago, IL, 22Northwestern University, Chicago, IL, 23Duke University, Durham, NC, 24UTHealth Houston Division of Rheumatology, Houston, TX, 25Georgetown University School of Medicine, Washington, DC, 26Division of Rheumatology, Department of Medicine, University of California, David Geffen School of Medicine, Los Angeles, CA, USA, Los Angeles, CA

    Background/Purpose: Global assessments by patients and physicians provide unique but complementary perspectives of disease severity. This study aimed to determine the clinical and patient-reported factors…
  • Abstract Number: 1411 • ACR Convergence 2025

    Defining Minimal Disease Activity (MDA) in Psoriatic Arthritis (PsA) with the inclusion of Psoriatic Arthritis Impact of Disease (PsAID) scores rather than Health Assessment Questionnaire (HAQ)

    Conor Coyle1, Sarah Yazji2, Sruthi Murthy3, Philip Helliwell4, Andra Balanescu5, Juan Cañete6, Emmanuelle Dernis7, Uta Kiltz8, Ying Ying Leung9, Ana-Maria Orbai10, PENELOPE PALOMINOS11, Josef Smolen12, Maarten de Wit13, Laure Gossec14 and Laura Coates15, 1Oxford University Hospitals, Reading, United Kingdom, 2South Texas Health System GME Consortium, Texas A&M College of Medicine, Texas, USA, College Station, TX, 3Oxford University Hospitals NHS Foundation Trust, Oxford, UK, Oxford, United Kingdom, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK, Leeds, United Kingdom, 5UNIVERSITY OF MEDICINE AND PHARMACY CAROL DAVILA, Bucharest, Romania, 6Rheumatology Department, Hospital Clínic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, 7Rheumatology Department, Le Mans Central Hospital, Le Mans, France, LE MANS, France, 8Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 9Rheumatology Department, Singapore General Hospital, Singapore, Singapore, Singapore, Singapore, 10Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 11Hospital Lifeplus Litoral Norte,  Xangri-lá, Brazil, Porto Alegre, Rio Grande do Sul, Brazil, 12Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 13Patient Research Partner, Stichting Tools, Amsterdam, Netherlands, 14Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France, 15Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom

    Background/Purpose: Treat to target management is recommended in psoriatic arthritis (PsA) to improve disease control and patient quality of life. Minimal disease activity (MDA) criteria…
  • Abstract Number: 1218 • ACR Convergence 2025

    Social Determinants Shape Health Outcomes in Idiopathic Inflammatory Myopathies: Insights from Lived Experience of 1,252 Patients

    Tsvetelina Velikova1, Kostadin Kostadinov2, Emilia Naseva3, Tamar Rubinstein4, Manali Sarkar5, Lavanya Mangla6, Joanna Makowska7, Raphael Micheroli8, Leandro ferreryra9, Linda Kobert10, Ioannis Parodis11, Elena Nikiphorou12, Samuel Shinjo13, Carlo Vinicio Caballero Uribe14, Vincenzo Venerito15, Vikas Agarwal16 and Latika Gupta17, 1Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria, 2Department of Social Medicine and Public Health, Faculty of Public Health, Medical University, Plovdiv; Health and Quality of Life in a Green and Sustainable Environment Research Group, Strategic Research and Innovation Program for the Development of MU- Plovdiv, Medical University of Plovdiv, Environmental Health Division, Research Institute at Medical University of Plovdiv, Medical University of Plovdiv,, Plovdiv, Bulgaria, 3Faculty of Public Health, Medical University of Sofia, 15 Acad. Ivan Evstratiev Geshov, 1606 Sofia; Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria, 4Albert Einstein College of Medicine, White Plains, NY, 5Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Maharashtra, India., Mumbai, Maharashtra, India, 6Maulana Azad Medical College, 2-Bahadurshah Zafar Marg, New Delhi, New Delhi, India, 7Department of Rheumatology, Medical University of Lodz, Lodz, Poland, 8University Hospital Zurich, Zurich, Switzerland, 9HIBA, CABA, Ciudad Autonoma de Buenos Aires, Argentina, 10The Myositis Association, Columbia, MD, 11Karolinska Institutet and Karolinska University Hospital, Department of Medicine Solna, Division of Rheumatology, Stockholm, Sweden, 12King's College London, London, United Kingdom, 13Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, Brazil, 14Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombi, Barranquilla, Colombia, 15Univeristy of Bari "Aldo Moro", Italy, Bari, Bari, Italy, 16Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, 17School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham; Royal Wolverhampton NHS Trust; Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester; Francis Crick Institute, London, Birmingham, UK, United Kingdom

    Background/Purpose: The impact of social determinants of health (SDoH)—including socioeconomic status, social support, and geographic context—on disease outcomes in idiopathic inflammatory myopathies (IIM) remains underexplored.…
  • Abstract Number: 0552 • ACR Convergence 2025

    Radiographic Sacroiliitis Progression in Psoriatic Arthritis

    Virginia Carrizo Abarza1, Pankti Mehta2, Fadi Kharouf3, Shangyi Gao4, Dafna D. Gladman5, Vinod Chandran6 and Denis Poddubnyy7, 1Toronto Western Hospital - University of Toronto, Toronto, ON, Canada, 2University of Toronto, Gladman Krembil Psoriatic Arthritis Research Program, Toronto, ON, Canada, 3University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, 4Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada, Toronto, ON, Canada, 5Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, 6University of Toronto, Toronto, ON, Canada, 7Division of Rheumatology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada, and Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Department of Epidemiology, German Rheumatism Research Centre, Berlin, Germany

    Background/Purpose: Radiographic sacroiliitis is an important indicator of axial involvement psoriatic arthritis (PsA), but only little is known about factors associated with progression of sacroiliitis.…
  • Abstract Number: 0488 • ACR Convergence 2025

    Early and Sustained Improvements in Disease Activity and Patient-Reported Outcomes in Patients Treated with Filgotinib for Rheumatoid Arthritis: Up to 2-Year Interim Real-World Data From FILOSOPHY and PARROTFISH

    Jérôme Avouac1, Neil Betteridge2, Karen Bevers3, Gerd Burmester4, Roberto Caporali5, Ouafia Bouzid6, Thomas Debray6, Carole Van der Donckt6, James Galloway7, Susana Romero-Yuste8 and Patrick Verschueren9, 1Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France, 2Neil Betteridge Associates, London, United Kingdom, 3Sint Maartenskliniek, Nijmegen, Netherlands, 4Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 5University of Milan and ASST Gaetano Pini-CTO, Milano, Italy, 6Alfasigma S.p.A., Bologna, Italy, 7King's College London, London, United Kingdom, 8University Hospital Complex of Pontevedra, Pontevedra, Spain, 9Rheumatology, University Hospital Leuven and Skeletal Biology and Engineering Research Centre, KU Leuven, Leuven, Belgium

    Background/Purpose: FILOSOPHY (NCT04871919) and PARROTFISH (NCT05323591) are ongoing, prospective, observational Phase 4 studies of filgotinib in patients (pts) with rheumatoid arthritis (RA) in Europe. In…
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Embargo Policy

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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