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Abstracts tagged "Disease Activity"

  • Abstract Number: 2493 • 2018 ACR/ARHP Annual Meeting

    Features of Disease Severity Associated with Patient Satisfaction with Biologic Treatment: Results from the Abatacept Best Care Real-World Study

    Boulos Haraoui1, Janet E. Pope2, Emmanouil Rampakakis3, Julie Vaillancourt3, Meryem Maoui4 and Louis Bessette5, 1Université de Montréal, Montreal, QC, Canada, 2St. Joseph’s Health Care, London, ON, Canada, 3JSS Medical Research, Montreal, QC, Canada, 4Bristol-Myers Squibb, Montreal, QC, Canada, 5Laval University, Québec, QC, Canada

    Background/Purpose: Patients satisfaction with their treatment is important for adherence to medications, particularly for chronic conditions such as rheumatoid arthritis (RA). The aim of this…
  • Abstract Number: 2860 • 2018 ACR/ARHP Annual Meeting

    Disease Activity and Its Measurement in Patients with RA across the U.S.: Data from the Rheumatology Informatics System for Effectiveness (RISE) Registry

    Gabriela Schmajuk1,2, Michael Evans3, Julia Kay1, Lisa Gale Suter4, Megan E. B. Clowse5, Esi Morgan6, Andreas Reimold7, Alex Limmani8, Tracy Johansson9, Lindsay Lewis9 and Jinoos Yazdany10, 1Medicine/Rheumatology, University of California - San Francisco, San Francisco, CA, 2San Francisco VA Medical Center, San Francisco, CA, 3University of California - San Francisco, San Francisco, CA, 4Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT, 5Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC, 6University of Cincinnati, Cincinnati, OH, 7Rheumatology, Dallas VA and Univ of TX Southwestern Med Ct, Dallas, TX, 8Arthritis Centers of Texas, Dallas, TX, 9Practice, Advocacy & Quality, American College of Rheumatology, Atlanta, GA, 10University of California, San Francisco, San Francisco, CA

    Background/Purpose: Although national quality measures promote the measurement of disease activity (DA) in RA, the burden of DA in a population-based sample of RA patients…
  • Abstract Number: 71 • 2018 ACR/ARHP Annual Meeting

    Association of Shared Epitope and Poor Prognostic Factors in RA

    Evo Alemao1, Joshua Bryson1, Christine K Iannaccone2, Michelle Frits2, Nancy A. Shadick3 and Michael Weinblatt2, 1Bristol-Myers Squibb, Princeton, NJ, 2Brigham and Women’s Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: There is a strong genetic association between RA and human leukocyte antigen (HLA) regions, particularly HLA-DRB1 alleles with the shared epitope (SE). SE alleles…
  • Abstract Number: 483 • 2018 ACR/ARHP Annual Meeting

    Correlation between Disease Activity and Hip Score in Patients with Rheumatoid Arthritis after Total Hip Arthroplasty

    Hiroki Wakabayashi1,2, Masahiro Hasegawa3 and Akihiro Sudo4,5, 1Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan, 2Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan, 3Mie University Graduate School of Medicine, Tsu, Japan, 4Department of Orthopaedic surgery, Mie University Graduate School of Medicine, Tsu-city, Japan, 5Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Japan

    Background/Purpose: The Disease Activity Score including 28 joints (DAS28), the Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI) were developed in…
  • Abstract Number: 884 • 2018 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Disease Activity Predicting Incident Clinically-Apparent Interstitial Lung Disease: A Prospective Cohort Study

    Jeffrey A. Sparks1, Tracy Doyle2, Jie Huang1, Beatrice Pan2, Elaine Fletcher2, Ritu Gill3, Hiroto Hatabu2, Mizuki Nishino4, David Murphy2, Taysir Mahmoud2, Christine K Iannaccone5, Michelle Frits2, Bing Lu6, Ivan O. Rosas7, Paul Dellaripa2, Michael E Weinblatt5, Elizabeth Karlson6 and Nancy A. Shadick2, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Beth-Israel Deaconess Medical Center, Boston, MA, 4Dana-Farber Cancer Institute, Boston, MA, 5Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 6Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 7BWH - Pulmonary, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Determining modifiable risk factors for interstitial lung disease (ILD) is crucial given its substantial morbidity/mortality. Treatment to target of remission/low disease activity improves articular…
  • Abstract Number: 1478 • 2018 ACR/ARHP Annual Meeting

    Factors Associated with Disability and Health-Related Quality of Life in Biologic-Treated Patients with Rheumatoid Arthritis in Persistent Moderate Disease Activity

    Ian C. Scott1,2, Julie Mount3, Jane Barry3 and Bruce Kirkham4, 1Research Institute for Primary Care & Health Sciences, Primary Care Sciences, Keele University, Keele, United Kingdom, 2Department for Rheumatology, Haywood Hospital, Stoke on Trent, United Kingdom, 3Eli Lilly and Company, Basingstoke, United Kingdom, 4Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom

    Background/Purpose: A treat-to target (T2T) strategy is recommended for the management of rheumatoid arthritis (RA), with the target being remission or at least low disease…
  • Abstract Number: 1693 • 2018 ACR/ARHP Annual Meeting

    Innate, Adaptive, and TNF-Superfamily Immune Pathways Inform a Lupus Disease Activity Immune Index That Characterizes Disease Activity in SLE

    Melissa E. Munroe1,2, Joel M. Guthridge1, Rufei Lu1,3, Joseph M. Kheir1, Bolanle Adebayo1, Susan R. Macwana1, Hua Chen1, Virginia C. Roberts1, Mohan Purushothaman2, Sanjiv Sharma2, Teresa Aberle1, Stan Kamp1, Cristina Arriens1, Eliza Chakravarty1, Katherine Thanou1, Joan T. Merrill1 and Judith A. James4,5, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Progentec Diagnostics, Inc., Oklahoma City, OK, 3Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease marked by immune dysregulation. A comprehensive but cost-effective tool to track relevant mediators of altered…
  • Abstract Number: 2151 • 2018 ACR/ARHP Annual Meeting

    The Impact of Obesity on SLE Disease Activity

    Phildrich Teh1, Bishoy Zakhary2, Arezoo Haghshenas3 and Vaneet K. Sandhu3, 1Internal Medicine, University of California, Riverside, Riverside, CA, 2Office of Research, Riverside University Health System, Moreno Valley, CA, 3Division of Rheumatology, Loma Linda University, Loma Linda, CA

    Background/Purpose: Obesity is associated with increased disease severity in multiple autoimmune conditions, likely via formation of pro-inflammatory adipokines [1]. However, the role of obesity in…
  • Abstract Number: 2505 • 2018 ACR/ARHP Annual Meeting

    Sociodemographic Factors Are Predictors of Poorer Clinical Outcome Trajectories in Early Rheumatoid Arthritis: Results from the Singapore Early Arthritis Cohort

    Yuhan Zou1, Peter P.M. Cheung2,3, Lay Kheng Teoh4 and Manjari Lahiri2,3, 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 2Division of Rheumatology, University Medicine Cluster, National University Hospital, Singapore, Singapore, Singapore, 3Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 4National University Hospital, Division of Rheumatology, University Medicine Cluster, Singapore, Singapore

    Background/Purpose: Variable outcomes in early rheumatoid arthritis (ERA) may be explained by heterogeneous latent disease activity trajectories, the predictors of which are not well defined.…
  • Abstract Number: 2870 • 2018 ACR/ARHP Annual Meeting

    Thresholds for Disease Activity Measures DAS28, CDAI, and RAPID3 Do Not Align with Clinical Practice Patterns of Rheumatoid Arthritis (RA) Disease Management Decisions

    Brian C. Sauer1, Chia-Chen Teng, MS1, Neil A. Accortt2, David H. Collier2, Tzu-Chieh Lin2 and Grant W. Cannon1, 1Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 2Amgen Inc., Thousand Oaks, CA

    Background/Purpose:   Treatment guidelines recommend using disease activity measures (DAMs) to guide RA therapy, but DAM use in real-world treatment decisions is not defined.  We…
  • Abstract Number: 92 • 2018 ACR/ARHP Annual Meeting

    Lupus Nephritis Serum Induces Neutrophil Chemotaxis Towards Glomerular Endothelial Cells in Vitro

    Dayvia Russell1, Margaret Markiewicz2, Xian Zhang2 and Jim C. Oates3, 1Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, 2Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 3Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC

    Title: Lupus Nephritis Serum Induces Neutrophil Chemotaxis towards Glomerular Endothelial Cells In Vitro Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with…
  • Abstract Number: 491 • 2018 ACR/ARHP Annual Meeting

    Cognitive Impairment Is Associated with Disease Activity in Patients with Rheumatoid Arthritis

    Wanruchada Katchamart1, Pongthorn Narongroeknawin2, Nattharadee Phutthinart3, Vararak Srinonprasert4, Weerasak Muangpaisan5 and Sumapa Chaiamnuay2, 1Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 2Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok, Thailand, 3Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University,, Bangkok, Thailand, 4Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 5Division of Geriatric Medicine, Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Bangkok, Thailand

    Background/Purpose: Intact cognitive function is important for executing several tasks on day-to-day basis in people with chronic diseases, including rheumatoid arthritis (RA). A number of…
  • Abstract Number: 906 • 2018 ACR/ARHP Annual Meeting

    Defining the Gut Microbiome in Patients with ANCA-Associated Vasculitis

    Catherine E. Najem1, Jung-Jin Lee2, Ceylan Tanes2, Antoine G. Sreih1, Rennie L. Rhee1, Abdallah Geara3, Hongzhe Li4, Kyle Bittinger2, James D. Lewis5 and Peter A. Merkel4,6, 1Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 3Division of Nephrology and Hypertension, University of Pennsylvania, Philadelphia, PA, 4Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, 5Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, 6Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose:Although a link between gut microbiome and autoimmune diseases has been suggested, there is a gap in the understanding of the gut microbiome in ANCA-associated…
  • Abstract Number: 1489 • 2018 ACR/ARHP Annual Meeting

    “Continuous Reduction” in Serum RF Titers Predicts Low Disease Activity and Good Therapeutic Response in RA Patients Treated with TNF Inhibitors, but Does Not Relate to Clinical Outcomes during ABT Treatment

    Takayoshi Owada1, Kazuhiro Kurasawa1, Yuta Takamura1, Tomoyuki Miyao1, Ayae Tanaka1, Ryutaro Yamazaki2, Satoko Arai1, Reika Maezawa1 and Masafumi Arima3, 1Rheumatology, Dokkyo Medical University, Mibu, Tochigi, Japan, 2Rheumatology, Dokkyo Medical University, Mibu, tochigi, Japan, 3Rheumatology, Dokkyo Medical University, mibu-gun, Tochigi, Japan

    Background/Purpose: Relative change of serum RF titer has been reported to correlate with those of RA disease activity. However, it is debatable whether serum RF…
  • Abstract Number: 1696 • 2018 ACR/ARHP Annual Meeting

    Impact of Hurricane Maria on a Cohort of Systemic Lupus Erythematosus Patients from Puerto Rico

    Luis M. Vilá1, Yaritza Berríos-López1, Carla Santiago-Burgos1, Lorena González-Sepúlveda2, Ileana Vázquez-Otero1 and Elizabeth Brown3, 1Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, 2Puerto Rico Clinical and Translational Research Consortium, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, 3Department of Pathology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: On September 20, 2017, Puerto Rico was devastated by Hurricane Maria causing severe damage to the Island infrastructure and essential services such as electricity,…
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