Abstracts tagged "Disease Activity"

Abstract Number: 2457 • 2018 ACR/ARHP Annual Meeting
Association between Biologic Dmards and Weight Change in Patients with Inflammatory Arthritis
Britney Jones¹, Imran Hassan², Walter P. Maksymowych³ and Elaine Yacyshyn⁴, ¹University of Alberta, Edmonton, AB, Canada, ²EPICORE Centre, University of Alberta, Edmonton, AB, Canada, ³CaRE Arthritis, Edmonton, AB, Canada, ⁴Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Inflammatory arthritis (IA) is a chronic disorder that encompasses rheumatoid and psoriatic arthritis. Rheumatoid cachexia is defined as elevated HDL, increased adiposity, and loss…
Abstract Number: 2643 • 2018 ACR/ARHP Annual Meeting
Sledai-2K Responder Index-50 Is Effective in Demonstrating Partial Response in a Phase 2, Randomized Placebo-Controlled Study of Ustekinumab in Patients with Active Systemic Lupus Erythematosus
Zahi Touma¹, Murray Urowitz², Dafna D Gladman², Carrie Wagner³, Bei Zhou³, Robert Gordon³, Benjamin Hsu³, Marc Chevrier³ and Shawn Rose³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Krembil Research Institute, U of Toronto, Toronto, ON, Canada, ³Janssen Research & Development, LLC, Spring House, PA
Background/Purpose: Ustekinumab (UST), a monoclonal antibody that targets the shared p40 subunit of the cytokines IL-12 & IL-23, is being investigated in patients (pts) w/…
Abstract Number: 2951 • 2018 ACR/ARHP Annual Meeting
Ustekinumab Treatment Response in SLE Is Associated with Changes in Type II but Not Type I Interferons
Jarrat Jordan¹, Kristen Sweet², Matteo Cesaroni¹, Keying Ma², Carol Franks², Loqmane Seridi², Jessica Schreiter³, Robert Gordon², Peter E. Lipsky⁴, Shawn Rose², Frédéric Baribaud², Matthew Loza² and Kim Campbell², ¹Janssen Research and Development, LLC., Spring House, PA, ²Janssen Research & Development, LLC, Spring House, PA, ³Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ⁴AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: We previously reported that treatment with ustekinumab (UST), an anti-IL-12/23 p40 neutralizing monoclonal antibody, improved global and organ-specific measures of disease activity in a…
Abstract Number: 322 • 2018 ACR/ARHP Annual Meeting
Swollen Joint Count Vs. RAPID3: Why a Discrepancy in Remission State?
Gary Craig¹ and Keith Knapp², ¹Discus Analytics LLC., Spokane, WA, ²Discus Analytics LLC, Spokane, WA
Background/Purpose: RA patients (pts) often have multiple comorbidities, and with multiple disease activity (DA) metrics available selecting an appropriate metric is vital. It remains an…
Abstract Number: 592 • 2018 ACR/ARHP Annual Meeting
Improved Response to Etanercept Is Associated with Serum Vitamin D Levels in Rheumatoid Arthritis
W Dankers¹, Pascal HP de Jong², S Heil³, S van den Berg³, A Weel⁴, JMW Hazes⁵, E Colin⁶ and Erik Lubberts⁷, ¹Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, ³Clinincal Chemistry, Erasmus MC, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus MC, Rotterdam, Netherlands, ⁵Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ⁶ZGT Almelo, Deventer, Netherlands, ⁷Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: Although treatment of rheumatoid arthritis (RA) has significantly improved during the past decades, many patients do not adequately respond or become resistant to current…
Abstract Number: 1385 • 2018 ACR/ARHP Annual Meeting
Subjective Well-Being Among Rheumatoid Arthritis Patients
Goichi Kageyama^1,2, Akira Onishi³, Yo Ueda³, Kengo Akashi³, Sho Sendo³, Jun Saegusa³ and Akio Morinobu², ¹Department of Rheumatology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan, ²Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Subjective well-being (SWB) is a psychological construct that is synonymous with happiness. Many variables including age, sex, income, employment, and marital status are related…
Abstract Number: 1617 • 2018 ACR/ARHP Annual Meeting
Influence of Disease Activity in the Physical Activity of Psoriatic Arthritis Patients
M. Vanesa Hernandez-Hernandez¹, Hiurma Sanchez-Perez², Esmeralda Delgado-Frías¹, Iván Ferraz-Amaro³ and Federico Díaz-González⁴, ¹Rheumatology Division, Hospital Universitario de Canarias, La Laguna, Spain, ²Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, La Laguna, Spain, ³Rheumatology Division, Hospital Insular de Gran Canaria, La Laguna, Spain, ⁴University of La Laguna, Hospital Universitario de Canarias, La Laguna, Spain
Background/Purpose: It is generally assumed that patients with chronic arthritis conditions tend to exercise less than what is currently recommended. Although several evidences support this…
Abstract Number: 1854 • 2018 ACR/ARHP Annual Meeting
SLE Flares during and after Pregnancy Are Mild and Occur at Similar Rates
Julia Davis-Porada¹, Sam Stern², Marta M. Guerra³, Carl Laskin^4,5, Michelle Petri⁶, Michael Lockshin⁷, Lisa R Sammaritano^8,9, David Branch^10,11, Allen D. Sawitzke¹², Joan T. Merrill^13,14, Jill P. Buyon¹⁵, Mimi Kim¹⁶ and Jane E. Salmon^8,9, ¹Research, Hospital for Special Surgery, New York, NY, ²Albert Einstein College of Medicine, New York, NY, ³Department of Medicine and Program in Inflammation and Autoimmunity, Hospital for Special Surgery, New York, NY, ⁴Mount Sinai Hospital Toronto, Toronto, ON, Canada, ⁵Trio Fertility, Toronto, ON, Canada, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Barbara Volcker Center, Hospital for Special Surgery, New York, NY, ⁸Hospital for Special Surgery, New York, NY, ⁹Weill Cornell Medicine, New York, NY, ¹⁰Intermountain Healthcare, Salt Lake City, UT, ¹¹Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT, ¹²Rheumatology, University of Utah Health Sciences Center, Salt Lake City, UT, ¹³University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Medicine, New York University School of Medicine, New York, NY, ¹⁶Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionally affects women of childbearing age. Low disease activity for 6 months prior to conception leads to the best outcomes;…
Abstract Number: 2466 • 2018 ACR/ARHP Annual Meeting
Prolonged Delay in Presentation to Rheumatologists for Hispanic Patients with Rheumatoid Arthritis Contributes to Later Diagnosis and Treatment
Mariam Riad¹, Daniel Dunham², Jacquelin R. Chua¹, Theodore Pincus¹, Najia Shakoor¹, Sobia Hassan¹, Joel A. Block¹ and Isabel Castrejón¹, ¹Division of Rheumatology, Rush University Medical Center, Chicago, IL, ²Division of Internal Medicine, Rush University Medical Center, Chicago, IL
Background/Purpose: Disparities in the initiation of disease modifying anti-rheumatic drugs (DMARDs) in ethnic minorities have been described in rheumatoid arthritis (RA) patients in the US…
Abstract Number: 2651 • 2018 ACR/ARHP Annual Meeting
Patients Characteristics and Patters of Treatment in Refractory Systemic Lupus Erythematosus Patients in the Pre-Biologic Period: Data from a Multiethnic, Multinational Latin American Lupus Cohort
Guillermo J. Pons-Estel^1,2, Marina Scolnik³, Enrique R Soriano³, Guillermina Harvey⁴, Rosana Quintana^5,6, Mercedes Garcia⁷, Verónica Saurit⁸, Cristina Drenkard⁹, Guillermo Berbotto¹⁰, Emilia Sato¹¹, Lilian Costallat¹², Eloisa Bonfa¹³, Eduardo Ferreira Borba¹⁴, Joao C. Tavares Brenol¹⁵, Nilzio A. da Silva¹⁶, Andre Cavalcanti¹⁷, Antonio Iglesias-Gamarra¹⁸, Marlene Guibert-Toledano¹⁹, Gil A. Reyes¹⁹, Loreto Massardo²⁰, Oscar Neira²¹, Mario H Cardiel²², Leonor Barile²³, Mary Carmen Amigo²⁴, Luis H. Silveira²⁵, Ignacio Garcia de la Torre²⁶, Rosa Maria Serrano⁶, Eduardo Acevedo-Vasquez²⁷, Manuel Ugarte-Gil²⁷, Ines Segami²⁸, Viviana Gervasoni⁵, Silvana Conti⁵, Rosa Chacón-Díaz²⁹, Maria H Esteva-Spinetti³⁰ and Bernardo A Pons-Estel⁶, ¹Rheumatology, Hospital Provincial de Rosario, Rosario, Argentina, ²Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario. Argentina, Rosario, Argentina, ³Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina, ⁴Escuela de Estadística, Universidad Nacional de Rosario, Rosario, Argentina, ⁵Hospital Provincial de Rosario, Rosario, Argentina, ⁶Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Rosario, Argentina, ⁷Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, ⁸Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, ⁹Medicine/Rheumatology, Emory University, Atlanta, GA, ¹⁰Sanatorio Británico, Rosario, Argentina, ¹¹Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ¹²Universidade Estadual da Campinas, Campinas, Brazil, ¹³Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ¹⁴Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ¹⁵Hospital da Clinicas da Porto Alegre, Porto Alegre, Brazil, ¹⁶Universidade Federal de Goiás, Goiânia, Brazil, ¹⁷Novartis, Sao Paulo, Brazil, ¹⁸Clinical Development, Nordic Bioscience, Herlev, Denmark, ¹⁹Centro de Investigaciones Médico-Quirúrgicas (CIMEQ), Havana, Cuba, ²⁰GLADEL, Santiago, Chile, ²¹Rheumatology Section., Hospital del Salvador, Universidad de Chile., Santiago, Chile, ²²Centro de Investigación Clínica de Morelia, Morelia, Mexico, ²³Hospital Ángeles del Pedregal, Mexico, Mexico, ²⁴Rheumatology, Centro Medico ABC, Mexico, Mexico, ²⁵Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, ²⁶Hospital General de Occidente, Guadalajara, Mexico, ²⁷Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²⁸Hospital Edgardo Rebagliati Martins. EsSalud, Lima, Peru, ²⁹Servicio de Reumatología, Hospital Universitario de Caracas, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela, ³⁰Hospital Central de San Cristóbal, San Cristóbal, Venezuela, San Cristóbal, Venezuela (Bolivarian Republic of)
Background/Purpose: Over the last few years, the importance of treating patients with systemic lupus erythematosus (SLE) towards achieving Remission or Low Disease Activity State has…
Abstract Number: 2963 • 2018 ACR/ARHP Annual Meeting
Improving Clinically Inactive Disease in Patients with Juvenile Idiopathic Arthritis- a Quaternary Center Experience
Cagri Yildirim-Toruner¹, Ohoud AlAhmed², Fatima Barbar-Smiley³, Karla Jones³, Melanie Kohlheim⁴, Stephanie Lemle⁵, Darby MacDonald², Evan Mulvihill⁶, Edward Oberle², Aliese Sarkissian², Vidya Sivaraman⁷, Bethanne Thomas², Kelly Wise⁸ and Stacy P. Ardoin¹, ¹Division of Rheumatology, Nationwide Children’s Hospital, Columbus, OH, ²Pediatric Rheumatology, Nationwide Children's Hospital, Columbus, OH, ³Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁴Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, OH, ⁵Nationwide Children's Hospital, Columbus, OH, ⁶Pediatrics and Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁷Division of Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁸Specialty Pharmacy/Rheumatology, Nationwide Children's Hospital, Columbus, OH
Background/Purpose: Juvenile idiopathic arthritis (JIA), the most common pediatric rheumatologic diagnosis, influences many aspects of a child’s life. Although there is no known cure, disease…
Abstract Number: 323 • 2018 ACR/ARHP Annual Meeting
Impact of Gains in Rheumatoid Arthritis Disease Activity Documentation on Outcomes over Time
Jing Li¹, Julie Gandrup¹, Laura Trupin¹, Zara Izadi², Jinoos Yazdany¹ and Gabriela Schmajuk³, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ³San Francisco VA Medical Center, San Francisco, CA
Background/Purpose: Despite significant interest in using health information technology (IT) to improve processes of care such as documentation of disease activity in RA, few studies…
Abstract Number: 597 • 2018 ACR/ARHP Annual Meeting
Characteristics of Patients and Predictors of Composite Disease Activity Scores for Switching to Monotherapy Vs Continuing TNF Inhibitor and Methotrexate Combination Therapy in RA: A Retrospective Analysis of the Brigham and Women’s Rheumatoid Arthritis Sequential Study Registry
Nancy A. Shadick¹, Michael E Weinblatt¹, Christine K Iannaccone², Michelle Frits³, Tigwa Davis⁴, Christopher Young⁴, David H. Collier⁵, Mahdi Gharaibeh⁵ and Bradley S. Stolshek⁶, ¹Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Health Analytics, LLC, Columbia, MD, ⁵Amgen Inc., Thousand Oaks, CA, ⁶Amgen, Inc., Thousand Oaks, CA
Background/Purpose: Biologics in combination with methotrexate (MTX) are being incorporated earlier in rheumatoid arthritis (RA) therapy to prevent long-term damage and maintain patient function. While…
Abstract Number: 1396 • 2018 ACR/ARHP Annual Meeting
Factors Associated with Specific Quality of Life Evolution in SLE Patients: A French Prospective Longitudinal Multicenter Study
Hervé Devilliers¹, Marie Corneloup², Francois Maurier³, Denis Wahl^4,5, Geraldine Muller⁶, Olivier Aumaître⁷, Pascal Sève⁸, Gilles Blaison⁹, Jean-Loup Pennaforte¹⁰, Thierry Martin¹¹, Nadine Magy¹², Sabine Berthier¹³, Laurent Arnaud¹⁴, Abderrahmane Bourredjem¹⁵ and Zahir Amoura¹⁶, ¹Service de Médecine Interne et Maladies Systémiques, CHU de Dijon, Dijon, France, ²Clinical epidemiology, Clinical investigation center, INSERM CIC-EC 1432, Dijon University Hospital, 21000 Dijon, France, ³Médecine interne, Hôpitaux Privés de Metz, Metz, France, ⁴CHU de Nancy, Vascular Medicine Division and Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases, Nancy, F-54000, France; Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France, Nancy, France, ⁵CHU de Nancy, Vascular Medicine Division and Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases; and UMR_S U1116 Research Unit, Nancy, France, ⁶Department of Internal Medicine and Systemic Diseases, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, ⁷CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, ⁸Internal medicine, Internal medicine department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France, ⁹Internal medicine departement, Colmar Hospital, Colmar, France, ¹⁰Internal Medicine, Internal medicine departement, CHU de Reims, Reims, France, ¹¹Cnrs UPR9021, Department of Clinical Immunology and Internal Medicine, Strasbourg University Hospital, IBMC CNRS UPR9021, Strasbourg, France, ¹²Internal Medecine, CHRU Besançon, Besancon, France, ¹³Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ¹⁴Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ¹⁵Clinical investigation center, INSERM CIC-EC 1432, Dijon University Hospital, Dijon, France, ¹⁶Université Pierre et Marie Curie, Paris, France
Background/Purpose: To analyze variables associated with evolution of disease-specific health related quality of life (HRQoL) in systemic lupus erythematosus (SLE) patients. Methods: We conducted a…
Abstract Number: 1619 • 2018 ACR/ARHP Annual Meeting
Patterns and Outcomes on As Patients Disease Activity Using Smart System of Disease Management (SSDM): Analysis of T2T Pattern Shift and the Correlation between Disease Activity and Mental Health
Jing Xue¹, Hui Song², Jing Yang³, Zhenchun Zhang⁴, Chun Li⁵, Hongbin Li⁶, Zhenbiao Wu⁷, Hua Wei⁸, Jianlin Huang⁹, Hongzhi Wang¹⁰, Yasong Li¹¹, Xiaohan Wang¹², Henglian Wu¹³, Miaojia Zhang¹⁴, Yuhua Jia¹⁵, Hui Xiao¹⁵, Fei Xiao¹⁵ and Huaxiang Wu¹⁶, ¹88 Jiefang Road, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, ²Department of Rheumatology, Beijing Jishuitan Hospital, Beijing, China, ³Department of rheumatology, Central Hospital of MianYang, Sichuan, Mian Yang, China, ⁴People's Hospital of Linyi, Shandong, Linyi, China, ⁵Peking University People's Hospital, Beijing, China, ⁶The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, ⁷The First Affiliated Hospital of The Fourth Military Medical University, Xi'an, China, ⁸Northern Jiangsu People's Hospital, Yangzhou, China, ⁹Department of rheumatology, The Sixth Hospital Affiliated to Sun yat-sen University, Guangzhou, China, ¹⁰The First Hospital of Jiaxing, Jiaxing, China, ¹¹Department of Rheumatology and Immunology, Zhejiang Provincal People's Hospital, Hangzhou, China, ¹²Department of Rheumatology and Immunology, Anyang district hospital, Anyang, China, ¹³Dongguan Donghua Hospital, Dongguan, China, ¹⁴Department of Rheumatology and Immunology, Jiangsu Province Hospital, Nanjing, China, ¹⁵Shanghai Gothic Internet Technology Co., Ltd., Shanghai, China, ¹⁶The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Background/Purpose: Ankylosing Spondylitis Disease Activity Score (ASDAS) was adopted to evaluate the degree of disease activity and the inflammatory response in AS patients. ASDAS score…

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