Abstracts tagged "Disease Activity and systemic lupus erythematosus (SLE)"

Abstract Number: 1673 • 2018 ACR/ARHP Annual Meeting
Validation and Evaluation of the Spanish Version of the Systemic LUPUS Activity Questionnaire in an Argentine Population
Cecilia Catoggio¹, Alejandro Martinez Muñoz², María Alejandra Medina³, Rafael Chaparro del Moral⁴, Diana Silvia Klajn⁵, Maximiliano Machado Escobar⁶, Luciana Gonzalez Lucero⁷, Sebastian Muñoz⁸, María Victoria Collado⁹, Graciela N Gómez¹⁰, Judith Sarano¹⁰, Marina Scolnik¹¹, Josefina Marin¹², Julia Romero¹³, Juan Carlos Barreira¹³, María Marta Zalazar¹⁴, Oscar Rillo⁴, Silvia Beatriz Papasidero⁴ and Cecilia N. Pisoni¹⁵, ¹Rheumatology and Immunology, Rheumatology and Immunology, CEMIC, Buenos Aires, Argentina, ²Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, San Miguel- Buenos Aires, Argentina, ³Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ⁴Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, CABA, Argentina, ⁵Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ⁶Rheumatology, Rheumatology Unit, Hospital Padilla, Tucumán, Tucuman, Argentina, ⁷Hospital Angel C. Padilla, Tucuman, Argentina, ⁸Rheumatology Unit, Hospital “Dr. Juan A. Fernández”, CABA, Argentina, ⁹Rheumatology, Instituto de Investigaciones Medicas Alfredo Lanari, Buenos Aires, Argentina, ¹⁰Rheumatology Unit, Instituto de Investigaciones Medicas Alfredo Lanari, Buenos Aires, Argentina, ¹¹Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina, ¹²Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ¹³Rheumatology Unit, Hospital Británico, Buenos Aires, Buenos Aires, Argentina, ¹⁴Rheumatology Section, Hospital General de Agudos Dr. Ignacio Pirovano, Buenos Aires, Argentina, ¹⁵Internal Medicine, CEMIC, Rheumatology and Immunology, CEMIC, Buenos Aires, Argentina
Background/Purpose: disease activity in Systemic Lupus Erythematosus (SLE) leads to damage, comorbidities and increased overall mortality. Frequent assessment is needed to adapt patients’ management. The…
Abstract Number: 2644 • 2018 ACR/ARHP Annual Meeting
Identifying Response for the Systemic Lupus Erythematosus Disease Activity Glucocorticoid Index (SLEDAI-2KG)
Zahi Touma¹, Dafna D Gladman², Jiandong Su¹, Nicole Anderson³ and Murray Urowitz², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) Glucocorticoid Index (SLEDAI-2KG) is a valid index able to measure disease activity while accounting for glucocorticoid (GC)…
Abstract Number: 889 • 2017 ACR/ARHP Annual Meeting
Attainment of Low Disease Activity By Patients with Systemic Lupus Erythematosus Starting with High Disease Activity in a 24-Week, Randomized, Placebo-Controlled, Phase IIb Study of Atacicept (ADDRESS II)
Eric F Morand¹, Joan T. Merrill², Amy H. Kao³, Cristina Vazquez-Mateo³, Stephen Wax⁴, Peter Chang⁴, Kishore Pudota³ and David A. Isenberg⁵, ¹Monash University, Melbourne, Australia, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁴EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, ⁵Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Low disease activity (LDA) in lupus patients is increasingly a goal of treatment. For instance, Lupus Low Disease Activity State (LLDAS) attainment is associated…
Abstract Number: 1603 • 2017 ACR/ARHP Annual Meeting
Lupus Low Disease Activity State: Can We Relax the Definition and Still Achieve Low Risk of SLE-Related Damage?
Michelle Petri¹, Daniel Goldman² and Laurence S Magder³, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Lupus low disease activity state (LLDAS) is a systemic lupus erythematosus (SLE) outcome measure that combines low disease activity and a 7.5 mg limit…
Abstract Number: 1604 • 2017 ACR/ARHP Annual Meeting
Validation of Remission and Lupus Low Disease Activity State As Predictors of Organ Damage in SLE
Michelle Petri¹, Daniel Goldman² and Laurence S Magder^3,4, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Epidemiology and Public Health, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Outcome measures that combine control of SLE activity and prednisone reduction are clinically relevant. A clinical goal in SLE is to reduce risk of…
Abstract Number: 1605 • 2017 ACR/ARHP Annual Meeting
Lupus Low Disease Activity State Protects Against Most Subtypes of Organ Damage in SLE
Michelle Petri¹, Daniel Goldman² and Laurence S Magder³, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: In SLE the most common types of organ damage are osteoporotic fractures and cataracts. Other types of organ damage, such as end stage renal…
Abstract Number: 1647 • 2017 ACR/ARHP Annual Meeting
A Lupus Low Disease Activity State Is Associated with Reduced Flare, Lower Organ Damage Accrual, and Better Quality of Life in Patients with Systemic Lupus Erythematosus
Ji-Hyoun Kang¹, Kyung-Eun Lee², Dong-Jin Park¹ and Shin-Seok Lee¹, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), ²Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South)
Background/Purpose: To identify the potential predictors of a lupus low disease activity state (LLDAS), and the relationship between LLDAS and disease flare, organ damage, and…
Abstract Number: 1793 • 2016 ACR/ARHP Annual Meeting
Visceral Adiposity Assessed By DXA in Juvenile-Onset Systemic Lupus Erythematosus: A Correlation with Damage Index and Disease Duration
Juliane Paupitz¹, Glauce Lima¹, Nadia E Aikawa¹, Liliam Takayama¹, Luciana Seguro², Eloisa Bonfa³ and Rosa M R Pereira⁴, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology Divison, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ⁴Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil
Background/Purpose: Young woman with lupus (SLE) are at increased risk of early atherosclerosis leading to cardiovascular disease in adult life and consequently higher morbidity and…
Abstract Number: 1815 • 2016 ACR/ARHP Annual Meeting
Frequency and Predictors of Attaining the Lupus Low Disease Activity State (LLDAS) in a Multinational SLE Cohort from the Asia Pacific
Vera Golder¹, Rangi Kandane-Rathnayake², Alberta Y. Hoi³, Molla Huq⁴, Worawit Louthrenoo⁵, Yuan An⁶, Zhanguo Li⁶, Shue Fen Luo⁷, Sargunan Sockalingam⁸, Chak Sing Lau⁹, Alfred Lee¹⁰, Mo Yin Mok¹⁰, Aisha Lateef¹¹, Kate Franklyn³, Susan Morton¹², Sandra V. Navarra¹³, Leonid Zamora¹³, Yeong-Jian Wu⁷, Laniyati Hamijoyo¹⁴, Madelynn Chan¹⁵, Sean O'Neill¹⁶, Fiona Goldblatt¹⁷, Eric F Morand³, Mandana Nikpour¹⁸ and Asia Pacific Lupus Collaboration, ¹Southern Clinical School, Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ²Rheumatology, Monash University, Melbourne, Australia, ³Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ⁴Department of Medicine (Rheumatology), Melbourne University, Melbourne, Australia, ⁵Division of Rheumatology, Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand, ⁶Peking University People's Hospital, Beijing, China, ⁷Chang Gung University, Taoyuan County, Taiwan, ⁸University of Malaya, Kuala Lumpur, Malaysia, ⁹Univ Dept of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ¹⁰Queen Mary Hospital, Hong Kong, Hong Kong, ¹¹Medicine/Rheumatology, National University Health System, Singapore, Singapore, ¹²Monash Health, Melbourne, Australia, ¹³Rheumatology, University of Santo Tomas Hospital, Manila, Philippines, ¹⁴University of Padjadjaran, Bandung, Indonesia, ¹⁵Tan Tock Seng Hospital, Singapore, Singapore, ¹⁶University of New South Wales, Sydney, Australia, ¹⁷Royal Adelaide Hospital, Adelaide, Australia, ¹⁸Melbourne University, Melbourne, Australia
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic heterogeneous disease with considerable burden from disease activity and damage. A novel clinical treatment target in the…
Abstract Number: 790 • 2016 ACR/ARHP Annual Meeting
Assessment of the Construct Validity of the Lupus Low Disease Activity State (LLDAS) – an Expert Opinion Case Study
Vera Golder¹, Molla Huq², Kate Franklyn³, Alicia Calderone⁴, Aisha Lateef⁵, Chak Sing Lau⁶, Sandra V. Navarra⁷, Timothy Godfrey^4,8, Shereen Oon⁴, Alberta Y. Hoi³, Eric F Morand³, Mandana Nikpour⁹ and Asia Pacific Lupus Collaboration, ¹Southern Clinical School, Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ²Department of Medicine (Rheumatology), Melbourne University, Melbourne, Australia, ³Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ⁴St. Vincent’s Hospital, Melbourne, Australia, ⁵Medicine/Rheumatology, National University Health System, Singapore, Singapore, ⁶Univ Dept of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ⁷Rheumatology, University of Santo Tomas Hospital, Manila, Philippines, ⁸63 Sutton Street, St. Vincent’s Hospital, Melbourne, Australia, ⁹Melbourne University, Melbourne, Australia
Background/Purpose: Systemic lupus erythematosus (SLE) has historically lacked clear treat-to-target definitions. The recently reported Lupus Low Disease Activity State (LLDAS) definition, combining disease activity and…
Abstract Number: 795 • 2016 ACR/ARHP Annual Meeting
Low Disease Activity in Systemic Lupus Erythematosus: An Achievable Goal?
Chiara Tani¹, Roberta Vagelli¹, Chiara Stagnaro², Linda Carli^3,4, Viola Signorini⁵ and Marta Mosca¹, ¹Clinical and Experimental Medicine, University of Pisa, Rheumatology Unit, Pisa, Italy, ²Department of Clinical and Experimental Medicine, University of Pisa, Rheumatology Unit, Pisa, Italy, ³GenOMec PhD, University of Siena, Italy, ⁴Clinical and Experimental Medicine, Rheumatology Unit, Pisa, Italy, ⁵Rheumatology Unit, Pisa, Italy
Background/Purpose: To date, there is no generally accepted definition for remission in SLE, thus a possible goal in the treat-to-target strategy might be low disease…
Abstract Number: 1051 • 2016 ACR/ARHP Annual Meeting
Determining the Minimal Clinically Important Difference for Improvement for Systemic Lupus Erythematosus Disease Activity Index-2000 Responder Index-50 (S2K RI-50)
Zahi Touma¹, Dafna D Gladman², Dorcas Beaton³, Jiandong Su⁴ and Murray Urowitz¹, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³Mobility Program Clinical Research Unit, St Michael's Hospital, Toronto, ON, Canada, ⁴Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Systemic Lupus Erythematosus Disease Activity Index-2000 Responder Index-50 (S2K RI-50) is a reliable and valid index able to measure ≥ 50% improvement in disease…
Abstract Number: 1787 • 2016 ACR/ARHP Annual Meeting
Increased Heart Rate Variability Reflects Improvement in Clinical Status of Patients with Systemic Lupus Erythematosus
Aikaterini Thanou¹, Stavros Stavrakis², John W. Dyer², Stan Kamp³, Judith A. James⁴ and Joan T. Merrill³, ¹Arthritis and Clinical Immunology Reseach Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Decreased heart rate variability (HRV) is a sign of potentially serious cardiac morbidity and is known to reflect autonomic dysfunction and inflammatory dysregulation (1).…
Abstract Number: 765 • 2015 ACR/ARHP Annual Meeting
Clinical Improvements in Systemic Lupus Erthematosus Are Correlated to Cellular and Soluble Biomarkers in Classical Complement Pathway
Chaim Putterman¹, Jill P. Buyon², Richard Furie³, Rosalind Ramsey-Goldman⁴, Kenneth Kalunian⁵, John Conklin⁶, Tyler O'Malley⁷, Derren Barken⁸ and Thierry Dervieux⁷, ¹Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ²NYU School of Medicine, New York, NY, ³NSLIJHS, Lake Success, NM, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵UCSD School of Medicine, La Jolla, CA, ⁶1261 Liberty Way Suite C, Exagen Diagnostics, Vista, CA, ⁷Research and Development, Exagen Diagnostics, Vista, CA, ⁸Exagen Diagnostics, Vista, CA
Background/Purpose : There is a need to identify biomarkers that track disease response in systemic lupus erythematosus (SLE). The value of various biomarkers in monitoring…
Abstract Number: 766 • 2015 ACR/ARHP Annual Meeting
Clinical and Immunological Characteristics of 150 Systemic Lupus Erythematosus Patients in Urban Jamaica
Keisha Maloney¹, Trevor Ferguson² and Karel De Ceulaer³, ¹Department of Medicine,, University of the West Indies, Kingston 7, Jamaica, ²Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies, Kingston 7, Jamaica, ³Internal Medicine, University of the West Indies, Kgn 7, Jamaica
Background/Purpose: Epidemiological studies in systemic lupus erythematosus (SLE) have been reported in the literature in many countries and ethnic groups. Although SLE in Jamaica has…

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