Date: Monday, November 6, 2017
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: To identify the potential predictors of a lupus low disease activity state (LLDAS), and the relationship between LLDAS and disease flare, organ damage, and quality of life in Korean patients with systemic lupus erythematosus (SLE).
Methods: The study followed 181 SLE patients from a single center for three years. LLDAS was defined as follows: (1) SLE Disease Activity Index (SLEDAI)-2K ≤ 4, with no activity in major organ systems; (2) no new lupus disease activity compared with the previous assessment; (3) SLEDAI Physician Global Assessment ≤ 1; (4) a current prednisolone (or equivalent) dose ≤ 7.5 mg daily; and (5) well-tolerated standard maintenance doses of immunosuppressive drugs. We assessed data annually and divided 4 groups according to the number of LLDAS; LLDAS =0, 1, 2, and 3. Univariate and multivariate analyses were performed to identify predictors of LLDAS.
Results: Of the 181 patients, 16.0% attained LLDAS on three consecutive years. Each group shows as follows; no LLDAS (n=30), LLDAS = 1 (n=60), LLDAS = 2 (n=62), and LLDAS = 3 (n=29). The patients who had higher number of LLDAS had shorter duration of symptoms, lower anti-histone antibody positivity, lower cumulative prescribed dose of prednisolone at baseline, lower mean PGA, lower mean SLEDAI, lower mean Mental Component Summary in SF-36, lower change in SLICC/ACR damage index, and a lower frequency of flare. In the multivariate analysis, LLDAS was significantly associated with lower mean PGA (OR = 0.671, 95% CI: 0.112–0.989, p = 0.019) and a reduced risk of flare after adjusting for confounders (OR = 0.012, 95% CI: 0.001–0.448, p = 0.017).
Conclusion: Attaining LLDAS was associated with an improved outcome, as represented by a decreased rate of disease flare, lower organ damage accrual, and better quality of life in Korean patients with SLE.
To cite this abstract in AMA style:Kang JH, Lee KE, Park DJ, Lee SS. A Lupus Low Disease Activity State Is Associated with Reduced Flare, Lower Organ Damage Accrual, and Better Quality of Life in Patients with Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/a-lupus-low-disease-activity-state-is-associated-with-reduced-flare-lower-organ-damage-accrual-and-better-quality-of-life-in-patients-with-systemic-lupus-erythematosus/. Accessed May 28, 2020.
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