Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic heterogeneous disease with considerable burden from disease activity and damage. A novel clinical treatment target in the form of the Lupus Low Disease Activity State (LLDAS) has been recently reported (Franklyn et al, Ann Rheum Dis, 2015), with retrospective validation showing that time spent in LLDAS translated to reduced damage accrual. The objectives of this study were to describe the frequency and identify the predictors of attaining LLDAS in a large multinational cohort of patients with SLE.
Methods: Data were collected at the baseline visit of SLE patients enrolled in a longitudinal study in 12 centres across the Asia Pacific. Data were analysed cross-sectionally against the recently published definition of LLDAS, and the frequency and characteristics associated with LLDAS attainment were determined. Stepwise multivariable logistic regression was used to determine predictors of LLDAS.
Results: Of the 1846 patients assessed, criteria for LLDAS were met by 44%. Data revealed that patients with shorter disease duration were less likely to be in LLDAS (OR 0.31, 95% CI 0.19-0.49, p<0.001). Likewise, patients with a history of discoid rash (OR 0.66, 95% CI 0.49-0.89, p=0.006), renal disease (OR 0.60, 95% CI 0.48-0.75, p<0.001), or who had elevated double stranded DNA (OR 0.65, 95% CI 0.53-0.81, p<0.001) or hypocomplementaemia (OR 0.52, 95% CI 0.40-0.67, p<0.001) were less likely to be in LLDAS. When countries were compared, higher national social wealth (OR 1.57, 95% CI 1.25-1.98, p<0.001) as measured by the Gross Domestic Product per capita was positively associated with LLDAS.
Conclusion: In a large multinational SLE cohort, the lupus low disease activity state is observed in less than half of patients at a single point in time. Disease duration and phenotype, as well as national social wealth, are predictive of LLDAS.
To cite this abstract in AMA style:Golder V, Kandane-Rathnayake R, Hoi AY, Huq M, Louthrenoo W, An Y, Li Z, Luo SF, Sockalingam S, Lau CS, Lee A, Mok MY, Lateef A, Franklyn K, Morton S, Navarra SV, Zamora L, Wu YJ, Hamijoyo L, Chan M, O'Neill S, Goldblatt F, Morand EF, Nikpour M. Frequency and Predictors of Attaining the Lupus Low Disease Activity State (LLDAS) in a Multinational SLE Cohort from the Asia Pacific [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/frequency-and-predictors-of-attaining-the-lupus-low-disease-activity-state-lldas-in-a-multinational-sle-cohort-from-the-asia-pacific/. Accessed December 5, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/frequency-and-predictors-of-attaining-the-lupus-low-disease-activity-state-lldas-in-a-multinational-sle-cohort-from-the-asia-pacific/