Abstracts tagged "Diagnostic Tests"

Abstract Number: 2944 • 2015 ACR/ARHP Annual Meeting
Presepsin (sCD14 subtype) Concentration Is Elevated and Reflects Disease Activity in Systemic Lupus Erythematous Patients
Kohei Tsujimoto¹, Masaaki Fujita², Yutaka Shinkawa², Iku Shirasugi¹, Masashi Taniguchi¹, Saori Hatachi³ and Masato Yagita⁴, ¹Department of Clinical Immunology and Rheumatology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan, ²Department of Clinical Immunology and Rheumatology C, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan, ³Department of Rheumatology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan, ⁴Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan
Background/Purpose: Presepsin (sCD14 subtype) has recently been identified as a novel biomarker for predicting sepsis. Because presepsin is produced as a consequence of cellular phagocytosis,…
Abstract Number: 776 • 2015 ACR/ARHP Annual Meeting
Sensitivity of Antinuclear Antibody By Immunofluorescence Testing for Detection of Anti-Ro/SSA Antibodies
Ivan Alcantara-Arreola¹, Nina Tello-Winniczuk² and Alejandro Diaz-Borjon³, ¹Hospital Angeles Lomas, Huixquilucan, Mexico, ²Division of Internal Medicine / Rheumatology, Hospital Angeles Lomas, Huixquilucan, Mexico, ³Med/Div of Rheumatology, Hospital Angeles Lomas, Huixquilucan, Mexico
Background/Purpose: A positive ANA test is a diagnostic criterion for several rheumatic diseases, although it may appear in other autoimmune disorders and healthy individuals. An…
Abstract Number: 2961 • 2015 ACR/ARHP Annual Meeting
Reliability and Validity of the Total Joint Count and Swollen Joint Count in Early Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Veronica J. Berrocal², Gandikota Girish³, Meng Zhang⁴, Chris Hatzis¹, Shervin Assassi⁵, Elana J. Bernstein⁶, Robyn T. Domsic⁷, Faye N. Hant⁸, Monique E. Hinchcliff⁹, Elena Schiopu¹⁰, Virginia D. Steen¹¹, Tracy M. Frech¹² and Dinesh Khanna¹³, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Div of Rheumatology, University of Michigan, Ann Arbor, MI, ³Radiology, University of Michigan, Ann Arbor, MI, ⁴Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁶Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁷Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁸Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁹Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ¹⁰University of Michigan, Ann Arbor, MI, ¹¹Rheumatology, Georgetown University Medical Center, Washington, DC, ¹²Div of Rheumatology, University of Utah, Salt Lake City, UT, ¹³Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Arthropathy and tendinopathy in Systemic Sclerosis (SSc) contribute to disability and are associated with disease progression. Clinical trials in SSc sometimes include the tender…
Abstract Number: 777 • 2015 ACR/ARHP Annual Meeting
SLE-KeyTM Rule-out Test to Assess Lupus in Anti-Nuclear Antibody Positive Subjects Using the Immunarray iCHIP®
D. Scott Batty¹, I.R. Cohen², Chaim Putterman³, Nicole Jordan⁴, Keren Jakobi⁵, Rachel Sorek⁵, Yakov Blumenstein⁵, Pennina Safer⁵ and David Pisetsky⁶, ¹ImmunArray Inc., Richmond, VA, ²Weizmann Institute of Science, Rehovot, Israel, ³Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁴Montefiore Medical Center, New York, NY, ⁵ImmunArray LTD, Rehovot, Israel, ⁶Duke University Medical Center and Durham VAMC, Durham, NC
Background/Purpose: SLE is associated with a broad spectrum of autoantibodies, but currently there is no single serologic test to diagnose SLE definitively. Diagnosis is thus…
Abstract Number: 3127 • 2015 ACR/ARHP Annual Meeting
Serologic Diagnosis of Human Neuropsychiatric Lupus Using the Immunarray ICHIP®
Chaim Putterman¹, D. Scott Batty², I.R. Cohen³, Nicole Jordan⁴, Debbie Rybak¹, Tamar Rubinstein¹, Keren Jakobi⁵, Rachel Sorek⁵, Anat Reiner-Benaim⁵, Yakov Blumenstein⁵ and Pennina Safer⁵, ¹Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ²ImmunArray Inc., Richmond, VA, ³Weizmann Institute of Science, Rehovot, Israel, ⁴Montefiore Medical Center, New York, NY, ⁵ImmunArray LTD, Rehovot, Israel
Background/Purpose: Peripheral neurologic syndromes and central nervous system (CNS) manifestations are recognized as primary disease manifestations in systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) involves…
Abstract Number: 1095 • 2015 ACR/ARHP Annual Meeting
Identification of Carbamylated Alpha-1-Anti-Trypsin (A1AT) As an Antigenic Target of Anti-Carp Antibodies in Patients with Rheumatoid Arthritis
Marije K. Verheul¹, Alvin Yea², Andrea Seaman², Robert A. Cordfunke³, Jan W. Drijfhout⁴, George M. Janssen⁴, Arnoud de Ru³, Peter A. van Veelen⁴, René E. M. Toes⁵, Michael Mahler² and Leendert A. Trouw¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Inova Diagnostics, San Diego, CA, ³IHB, Leiden University Medical Center, Leiden, Netherlands, ⁴Immunohematology and Bloodbank, Leiden University Medical Center, Leiden, Netherlands, ⁵Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Antibodies targeting carbamylated proteins (anti-CarP) were recently identified in serum samples from patients with rheumatoid arthritis (RA). The presence of anti-CarP antibodies was associated…
Abstract Number: 1354 • 2015 ACR/ARHP Annual Meeting
Whipple’s Disease: The Diagnostic Utility of Synovial Fluid Tropheryma Whipplei Polymerase Chain Reaction
Zoran Kvrgic¹, Kelly Cawcutt², Robin Patel³, Abinash Virk², Clement J. Michet Jr.⁴, Eric L. Matteson⁵ and Tim Bongartz¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Infectious Diseases, Mayo Clinic, Rochester, MN, ³Medicine, Mayo Clinic, Rochester, MN, ⁴Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Department of Internal Medicine and Department of Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Inflammatory arthritis is a common, non-specific symptom of Whipple’s disease. Recovery of the organism by conventional culture is often unsuccessful. Synovial fluid polymerase chain…
Abstract Number: 1714 • 2015 ACR/ARHP Annual Meeting
Young Patients with Back Pain and Maximally 1 Spa Feature: Is It Useful to Test HLA-B27 or Image the Sacroiliac Joints?
Pauline Bakker¹, Zineb Ez-Zaitouni², Miranda van Lunteren², Manouk de Hooge³, Rosaline van den Berg⁴, Inger Jorid Berg⁵, Robert B. M. Landewé⁶, Maikel van Oosterhout⁷, Roberta Ramonda⁸, Monique Reijnierse⁹, Floris van Gaalen¹ and Désirée van der Heijde¹⁰, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Centre, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Rheumatology, University Hospital Maastricht, Maastricht, Netherlands, ⁷Rheumatology, GHZ Hospital, Gouda, Netherlands, ⁸Cattedra, Voc Rheumatology, University of Padua, Padova, Italy, ⁹Radiology, Leiden University Medical Center, Leiden, Netherlands, ¹⁰University Hospital, Maastricht, Netherlands
Background/Purpose: Axial SpondyloArthritis (axSpA) is a heterogeneous disease. The likelihood of diagnosis varies depending upon the specific findings that are present. However, it is debated…
Abstract Number: 1916 • 2015 ACR/ARHP Annual Meeting
Validation of Novel Biomarker Candidates for Systemic Sclerosis
Johannes Schulte-Pelkum¹, Petra Budde¹, Hans-Dieter Zucht¹, Daniel Wirtz¹, Peter Schulz-Knappe¹, Oliver Distler², Suzana Jordan³, Nicolas Hunzelmann⁴, Matthias Schneider⁵ and Britta Maurer², ¹Protagen AG, Dortmund, Germany, ²Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Dermatology, University of Cologne, Cologne, Germany, ⁵Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease that manifests as progressive fibrosis of the skin and internal organs. SSc is associated with the…
Abstract Number: 2065 • 2015 ACR/ARHP Annual Meeting
Verification of Novel Soluble Biomarkers That Differentiate Patients with Psoriatic Arthritis from Those with Psoriasis without Psoriatic Arthritis
Vinod Chandran¹, Daniela Cretu^2,3, Lisa Gao⁴, Kun Liang⁴, Antoninus Soosaipillai³ and Eleftherios Diamandis^2,3,5, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ³Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada, ⁴Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁵Department of Clinical Biochemistry, University Health Network, Toronto, ON, Canada
Background/Purpose: There is a high prevalence of undiagnosed psoriatic arthritis (PsA) in psoriasis patients. Therefore identifying soluble biomarkers for PsA will help in screening psoriasis…
Abstract Number: 2190 • 2015 ACR/ARHP Annual Meeting
Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Core Laboratory Validation Exercise: Comparison of Enzyme-Linked Immunosorbant Assay (ELISA) and Chemiluminescence Immunoassay (CIA)
Maria Laura Bertolaccini¹, Danieli Andrade², Gabriella Lakos³, Rohan Willis⁴, Vittorio Pengo⁵, Alessandra Banzato⁶, Hannah Cohen⁷, Steven Krilis⁸, Doruk Erkan⁹ and on behalf of APS ACTION, ¹Lupus Unit, Rayne Institute, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, St Thomas' Hospital, London, United Kingdom, ²Rheumatology, University of São Paulo, São Paulo, Brazil, ³INOVA Diagnostics, Inc., San Diego, CA, ⁴Department of Internal Medicine, Antiphospholipid Standardization Laboratory, Division of Rheumatology, Galveston, TX, ⁵Clinical Cardiology, Department of Cardiac Thoracic and Vascular Sciences, University of Padova, Padova, Italy, ⁶Department of Cardiac Thoracic and Vascular Sciences, Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy, ⁷Hematology., University College London, LOndon, United Kingdom, ⁸Immunology, Allergy, and Infectious Diseases, St George Hospital, Kogarah NSW, Australia, ⁹Rheumatology, Barbara Volcker Center for Women and Rheumatic Diseases: Hospital for Special Surgery, New York, NY
Background/Purpose: APS ACTION International Clinical Database and Repository was created to study the natural course of disease over 10 years in persistently aPL-positive patients with/without…
Abstract Number: 2231 • 2015 ACR/ARHP Annual Meeting
Vitamin D Deficiency States Can be Actively Prevented. Results from a Cross-Sectional Study of over 3000 Patients with Rheumatic Diseases
Elena Nikiphorou¹, Pekka Hannonen¹, Paula Väre¹, Arto Kokko², Tuomas Rannio^3,4 and Tuulikki Sokka-Isler⁴, ¹Jyvaskyla Central Hospital, Jyvaskyla, Finland, ²Jyvaskyla Central Hospital, Jyväskylä, Finland, ³Kuopio University Hospital, Kuopio, Finland, ⁴Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland
Background/Purpose: Vitamin D (D25) deficiency has been an ongoing matter of concern, especially in countries at northern latitudes. The effects of D25 deficiency in patients…
Abstract Number: 2598 • 2015 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap Levels Measured By Cell Free Nucleosome ELISA in Serum Are Highly Specific and Sensitive for Rheumatoid Arthritis
Paul Hasler¹, Stavros Giaglis¹, Ulrich A. Walker², Erik Deman¹, Christoph Hemmeler¹, Christina Ryser¹, Samuel Kretzschmar¹, Guenther Schaefer³, Juliane Franz¹ and Sinuhe Hahn⁴, ¹Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ²Rheumatology, University Hospital, Basel, Basel, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, ⁴Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland
Background/Purpose: Rheumatoid factor (RF) or anti-citrullinated peptide antibody (ACPA) detection have limited clinical utility for the diagnosis of rheumatoid arthritis (RA), as the specificity and…
Abstract Number: 2614 • 2015 ACR/ARHP Annual Meeting
Single Academic Center Experience with 14-3-3 Eta in the Evaluation of Inflammatory Arthritis
Lance Feller¹, Paul Tuttle IV², Austin M. Dalrymple³, Srikanth Bathula⁴, Katherine Temprano⁵, Reema H. Syed⁶, Rama Bandlamudi⁷, Kathryn Coulson⁸, Peri Pepmueller⁹ and Terry Moore¹⁰, ¹Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO, ²Saint Louis University, Saint Louis, MO, ³Pediatric Rheumatology, St. Louis University, St. Louis, MO, ⁴Rheumatology, Saint Louis University, Saint Louis, MO, ⁵Medicine/Rheumatology, Saint Louis University, St. Louis, MO, ⁶IM-Rheumatology, Saint Louis University, St. Louis, MO, ⁷Internal Medicine/Rheumatology, St. Louis Univ Health Sciences, St. Louis, MO, ⁸Rheumatology/ 213A, St. Louis University, St. Louis, MO, ⁹Rheumatology, Saint Louis University, St. Louis, MO, ¹⁰Division of Rheumatology and Pediatric Rheumatology, Saint Louis University School of Medicine, St Louis, MO
Background/Purpose: 14-3-3 proteins are chaperonins found in all eukaryotic cells. There are multiple isoforms which are thought to be involved in intracellular signaling and transcription…
Abstract Number: 101 • 2015 ACR/ARHP Annual Meeting
New Technologies for Typing Self-Identifying Antigens Encoded By HLA Genes Provide Cost-Effective Alternatives to Identifying B27 Allele Status in Rheumatoid Arthritis Subjects
Kimberly Robasky¹, Jatinder Kaur², Jennifer Sims¹, Melissa Howard¹, Eric Earley¹ and Eric Lai², ¹EA|Quintiles, Durham, NC, ²Takeda Pharmaceuticals International, Inc., Deerfield, IL
Background/Purpose: Human leukocyte antigen (HLA) genes code for proteins that allow the immune system to distinguish self from foreign cells. These genes have important indications…

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