ACR Meeting Abstracts

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Abstracts tagged "Diagnostic Tests"

  • Abstract Number: 1859 • 2018 ACR/ARHP Annual Meeting

    The Prognostic Value of Autoantibody Isotypes for Predicting Therapeutic Responses to Methotrexate in Patients with Rheumatoid Arthritis

    Daniela Sieghart1, Alexander Platzer2, Farideh Alasti2, Paul Studenic3, Maresa Grundhuber4, Sascha Swiniarski4, Stephan Blüml2, Helmuth Haslacher5, Josef S. Smolen6 and Günter Steiner1, 1Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Austria, Vienna, Austria, 2Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria, 3Division of Rheumatology, Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Thermo Fisher Scientific, Freiburg, Germany, Freiburg, Germany, 5Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria, 6Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) are the most specific diagnostic markers of rheumatoid arthritis (RA). Lately we showed that the determination…
  • Abstract Number: 2184 • 2018 ACR/ARHP Annual Meeting

    An Economic Evaluation on the Impact of Earlier Systemic Lupus Erythematosus (SLE) Diagnosis Using Complement C4d Activation Products in a Multivariate Assay Panel (MAP)

    Ann E. Clarke1, Tom Goss2, Andrew Piscitello3, Tarun Chandra3, Tyler O'Malley4, Thierry Dervieux4 and Tami Powell5, 1Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 2Health Economics Outcomes Research, Boston Healthcare, Boston, MA, 3EmpiriQA LLC, Long Grove, IL, 4Exagen Diagnostics, Inc., Vista, CA, 5Corporate Payer Strategy & Reimbursement, Exagen Diagnostics, Inc., vista, CA

    Background/Purpose: Diagnosis (dx) of systemic lupus erythematosus (SLE) is made via a combination of clinical and laboratory examinations; the sensitivity and specificity (S&S) of standard…
  • Abstract Number: 2402 • 2018 ACR/ARHP Annual Meeting

    Acoustic Emissions Generated By the Temporomandibular Joint of Patients with Juvenile Idiopathic Arthritis and Their Implication on Patient Assessment and Screening: A Pilot Study

    Daniel Whittingslow1,2, Hyeon Ki Jeong3, Talia Gergely4, Lori Ponder4, Sampath Prahalad5, Omer Inan3 and Shelly Abramowicz6, 1Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 2Emory University School of Medicine, Atlanta, GA, 3Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 4Emory University, Atlanta, GA, 5Pediatrics, Emory University, Atlanta, GA, 6Surgery, Emory University/Children's Healthcare of Atlanta, Atlanta, GA

    Background/Purpose: The temperomandibular joint (TMJ) is one of the most commonly affected joints in juvenile idiopathic arthritis (JIA) (up to 45% of cases). There is a discrepancy between…
  • Abstract Number: 2833 • 2018 ACR/ARHP Annual Meeting

    Complement Activation Is a Feature of Diseases in the Lupus Spectrum

    Rosalind Ramsey-Goldman1, Roberta Alexander2, Elena Massarotti3, Daniel J. Wallace4, Sonali Narain5, Cristina Arriens6, Christopher E. Collins7, Amit Saxena8, Chaim Putterman9, Kenneth C. Kalunian10, Armida Sace2, Rowena Lafon2, Tyler O'Malley2, JoAnne Ligayon2, Claudia Ibarra2, John Conklin2, Thierry Dervieux2 and Arthur Weinstein7, 1FSM, Northwestern University, Chicago, IL, 2Exagen Diagnostics, Inc., Vista, CA, 3Brigham and Women's Hospital, Boston, MA, 4Cedars-Sinai Medical Center, Los Angeles, CA, 5Northwell Health, Great Neck, NY, 6Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 7Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC, 8NYU Langone Health, New York, NY, 9Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, 10Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: We showed previously that complement activation - cell-bound complement activation products (CB-CAPS) or multi-analyte assay panel (MAP) - is a sensitive and specific biomarker…
  • Abstract Number: 172 • 2017 ACR/ARHP Annual Meeting

    Optimizing Precision Medicine By Using Genetics to Assign Diagnostic Prior Probabilities to Patients with Synovitis

    Rachel Knevel1,2,3,4, Chikashi Terao5,6,7, Jing Cui1,8, Kamil Slowikowski2,9,10, TWJ Huizinga3, Elizabeth Karlson11 and Soumya Raychaudhuri1,2,12,13, 1Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Bosten, MA, 5Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 6Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan, 7Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 8Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 9Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, 10Division of Genetics, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, 11Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 12Department of Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 13Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: As the cost of genome-wide genotyping plummets, and biobanking efforts integrating medical records and genetics are rapidly expanding, many patients will have genotyping available…
  • Abstract Number: 441 • 2017 ACR/ARHP Annual Meeting

    Social Media Based, Direct-to-Patient Study Designed for Development of “from Home” Testing for Rheumatoid Arthritis Patients Is Feasible and Engaged Individuals with Distinct Clinical Characteristics

    Kristen Warren1, Olga Derbeneva1, Francisco Flores1, Michelle Frits2, James Healy1, Christine Iannaccone3, Omar Khalid1, Krishna Morampudi1, Nancy Shadick4, Michael Weinblatt4, Hemani Wijesuriya1 and Robert Terbrueggen1, 1DxTerity, Rancho Dominguez, CA, 2Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 4Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose:   Physicians equipped with low cost, patient-administered, “from home” genomic tests for monitoring disease activity and therapy response could revolutionize treatment for rheumatoid arthritis…
  • Abstract Number: 581 • 2017 ACR/ARHP Annual Meeting

    Diagnostic Value of Anti-CD74 Antibodies in Early Axial Spondyloarthritis: Data from the Spondyloarthritis Caught Early (SPACE) Cohort

    Janneke de Winter1, Marleen van de Sande1, Niklas Thomas Baerlecken2, Inger Berg3, Roberta Ramonda4, Désirée van der Heijde5, Floris van Gaalen6, Torsten Witte7 and Dominique Baeten1,8, 1Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 2Rheumatology, Private Practice, Cologne, Germany, 3Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 6Leiden University Medical Center, Leiden, Netherlands, 7Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, 8UCB Pharma, Slough, United Kingdom

    Background/Purpose: Anti-CD74 IgG antibodies are reported to be elevated in serum of patients with axial spondyloarthritis (axSpA). This study aimed to assess the diagnostic value…
  • Abstract Number: 695 • 2017 ACR/ARHP Annual Meeting

    Development of a Multimarker Model for the Detection of Systemic Lupus Erythematosus Based on New and Traditional Autoantibodies

    Petra Budde1, Hans-Dieter Zucht1, Johannes Schulte-Pelkum1, Daniel Wirtz1, Torsten Witte2, Matthias Schneider3 and Peter Schulz-Knappe1, 1Protagen AG, Dortmund, Germany, 2Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, 3Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

    Background/Purpose:  Given the heterogeneity of clinical presentations, the diagnosis of Systemic Lupus Erythematosus (SLE) can be challenging, in particular in those patients presenting with early…
  • Abstract Number: 707 • 2017 ACR/ARHP Annual Meeting

    Distinctive Features of Positive Anti-Cell Antibody Tests on HEp-2 Cells (HEp-2-ANA) in Patients with Non-Autoimmune Diseases

    Renan Agustinelli1, Sílvia H. Rodrigues2, Mônica Prado3, Henrique Mariz4 and Luis Eduardo C. Andrade5,6, 1Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, São Paulo, Brazil, 2Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil, 3Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, 4Internal Medicine Department, Hospital das Clínicas - Universidade Federal de Pernambuco, Recife, Brazil, 5Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil, 6Immunology Division, Fleury Medicine and Health, São Paulo, Brazil

    Background/Purpose: The indirect immunofluorescence (IIF) test for anti-cell or antinuclear (ANA) antibodies on HEp-2 cells (HEp-2-ANA) is considered the gold standard method for ANA detection.…
  • Abstract Number: 1023 • 2017 ACR/ARHP Annual Meeting

    The Autoimmune Discovery Ichip Distinguishes Healthy Individuals (HC) from Those with SLE, Rheumatoid Arthritis (RA), Scleroderma (SSc), Sjogren’s Syndrome (SS), and the Anti-Phospholipid Syndrome (APS)

    Chaim Putterman1, Armando Gabrielli2, Alexandra Balbir-Gurman3, Pennina Safer4, Keren Jakobi-Brook4, Rachel Sorek4, Ilana Gluzman4, Steve Wallace5 and Irun R. Cohen4,6, 1Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, 2Istituto di Clinica Medica dell'Università di Ancona, Ancona, Italy, Ancona, Italy, 3Rheumatology Unit, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Haifa, Israel, 4ImmunArray Ltd., Rehovot, Israel, Rehovot, Israel, 5ImmunArray Inc., VA, USA, Richmond, VA, 6Weizmann Institute of Science, Rehovot, Israel, Rehovot, Israel

    Background/Purpose: Current serological tests are not sufficiently accurate in differentiating between HC and those with autoimmune rheumatic diseases. We developed the iCHIP antigen microarray to…
  • Abstract Number: 1096 • 2017 ACR/ARHP Annual Meeting

    Clinical Significance of RNP Antibodies in Diagnosis of Systemic Autoimmune Rheumatic Disease When Detected By Multiplex Immunoassay

    Heather Bukiri1, Amish Dave2, Erin Bauer2, Vivian Stone2, Chris Chong3 and Punam Verma4, 1Graduate Medical Education, Virginia Mason Medical Center, Seattle, WA, 2Rheumatology, Virginia Mason Medical Center, Seattle, WA, 3Virginia Mason Medical Center, Seattle, WA, 4Microbiology/Immunology General Lab, Virginia Mason Medical Center, Seattle, WA

    Background/Purpose: A large multicenter healthcare system recently adopted multiplex immunoassay as an initial screen for antinuclear antibody (ANA) with confirmatory reflex testing by immunofluorescence antibody…
  • Abstract Number: 1266 • 2017 ACR/ARHP Annual Meeting

    Geographic Variation in Use of Echocardiography at Diagnosis and Detection of Acute Cardiac Disease in Youth with Systemic Lupus Erythematosus

    Joyce C. Chang1, Andrea M. Knight2, Laura M. Mercer-Rosa3, Rui Xiao4 and Pamela F. Weiss5, 1Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2Division of Rheumatology, Center for Pediatric Clinical Effectiveness & PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, 3Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, 4Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Child-onset systemic lupus erythematosus (SLE) is a chronic autoimmune condition with a high risk of organ damage. There are no guidelines on the use…
  • Abstract Number: 1368 • 2017 ACR/ARHP Annual Meeting

    Small RNA Sequencing Identifies Plasma microRNA Panel for Rheumatoid Arthritis Diagnosis

    Michelle J. Ormseth1, Joseph F. Solus2, Quanhu Sheng2, Yan Guo2, Fei Ye2, Ryan Allen2, Kasey Vickers2 and C Michael Stein2, 1Medicine, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose:  Small noncoding RNAs (sRNAs), such as microRNAs (miRNAs), are regulators of biological processes and serve as important biomarkers of disease. Most previous plasma sRNA…
  • Abstract Number: 1371 • 2017 ACR/ARHP Annual Meeting

    Development of an Adjusted Multi-Biomarker Disease Activity (MBDA) Score for Rheumatoid Arthritis (RA) That Accounts for Age, Sex and Adiposity, with Subsequent Evaluation of Ability to Predict Risk for Radiographic Damage

    Jeffrey R. Curtis1, Darl D. Flake II2, Michael Weinblatt3, Nancy A. Shadick4, Mikkel Østergaard5, Merete Lund Hetland6, Cecilie Heegaard Brahe6, Yong Gil Hwang7, Daniel E. Furst8, Vibeke Strand9, Carol J. Etzel10, Dimitrios A. Pappas11, Xingbin Wang12, Ching Chang Hwang13, Eric H. Sasso12, Alexander Gutin2, Elena Hitraya12 and Jerry S. Lanchbury2, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Myriad Genetics Inc., Salt Lake City, UT, 3Brigham and Women’s Hospital, Boston, MA, 4Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, 6Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 7Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 8David Geffen School of Medicine at UCLA, Los Angeles, CA, 9Stanford University, Palo Alto, CA, 10Departments of Epidemiology and Biostatistics, University of Texas School of Public Health, Houston, TX, 11Columbia University, New York, NY, 12Crescendo Bioscience Inc., South San Francisco, CA, 13Biostatistics, Crescendo Bioscience Inc., South San Francisco, CA

    Background/Purpose: The MBDA score, based on 12 serum proteins, is a validated tool for assessing disease activity in RA patients. MBDA biomarkers may be influenced…
  • Abstract Number: 1865 • 2017 ACR/ARHP Annual Meeting

    Novel Approach to Arthritis Surveillance Suggests a Much Higher Prevalence of Arthritis Among US Adults Than Previous Estimate

    S. Reza Jafarzadeh and David T. Felson, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Current national estimates of arthritis prevalence in the United States rely on a single survey question about doctor-diagnosed arthritis from the National Health Interview…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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