ACR Meeting Abstracts

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Abstracts tagged "Diagnostic Tests"

  • Abstract Number: 683 • 2018 ACR/ARHP Annual Meeting

    Spanish Validation of the Gepard Questionnaire for the Detection of Psoriatic Arthritis in Argentinean Patients with Psoriasis

    María Victoria Martire1, María Paula Girard Bosch1, Santiago Scarafia2, Vanesa Laura Cosentino3, María Janina Tapia4, Eduardo Kerzberg3, Natalia Estrella5, Cristian Troitiño6, Josefina Marin7, Fernando Andres Sommerfleck8, Hernán Maldonado Ficco9, Erika Catay10, Mariana Benegas11 and Enrique R Soriano12, 1Rheumatology, Instituto Médico Platense, La Plata, Argentina, 2Rheumatology, Instituto de Asistencia Reumatológica Integral, Buenos Aires, Argentina, 3Ramos Mejía Hospital, Buenos Aires, Argentina, 4Reumatology, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina, 5Consultorio Privado, Buenos Aires, Argentina, 6Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, 7Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 8Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 9section of Rheumatology, Clinica Regional Del Sud, Rio Cuarto, Argentina, 10Consultorios Moreno, Formosa, Argentina, 11Rheumatology Section, Sanatorio Dr. Julio Méndez, Buenos Aires, Argentina, 12Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina

    Background/Purpose: Psoriatic Arthritis (PSA) is preceded by the presence of cutaneous psoriasis (PS) in approximately 80% of the cases. We consider relevant to have tools…
  • Abstract Number: 1229 • 2018 ACR/ARHP Annual Meeting

    Diagnosing Prosthetic Joint Infections in Patients with Inflammatory Arthritis

    Serene Z. Mirza1, Shawn Richardson2, Cynthia Kahlenberg2, Jason Blevins2, Michelle Demetres3, Lily Martin3, Jackie Szymonifka2, Peter K. Sculco4, Mark P. Figgie5 and Susan M. Goodman2, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Weill Cornell Medicine, New York, NY, 4Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 5Surgery, Hospital for Special Surgery, New York, NY

    Background/Purpose: Patients with inflammatory arthritis (IA) are at increased risk of prosthetic joint infections, yet differentiating between septic and aseptic failure is a  challenge in…
  • Abstract Number: 1441 • 2018 ACR/ARHP Annual Meeting

    Diagnostic Performances of Antibodies Against Carbamylated Proteins in US Based Populations with Rheumatoid Arthritis and Other Autoimmune Rheumatic Diseases

    Jing Shi1, Jay Milo2, Kelley Bradey1, Chelsea Bentow2, John Conklin1, Tyler O'Malley1, Armida Sace1, Rowena Lafon1, Duncan Poling1, Claudia Ibarra1, Michael Mahler2 and Thierry Dervieux1, 1Exagen Diagnostics, Inc., Vista, CA, 2Research and Development, Inova Diagnostics, San Diego, CA

    Background/Purpose: Recently, antibodies directed against carbamylated antigens (anti-CarP antibodies) were identified in rheumatoid arthritis (RA). Studies have established the predictive and prognostic value of this…
  • Abstract Number: 1482 • 2018 ACR/ARHP Annual Meeting

    Is 14.3.3η a Predictor of Development of Rheumatoid Arthritis in Patients with Early Undifferentiated Arthritis?

    Karen Marie Carlsen1, Nina Schmidt2, Anne Duer3, Kim Hørslev-Petersen4, Cecilie Heegaard Brahe5, Merete Lund Hetland2, Norma K Biln6, Michelle L Zaharik7, Bo Jannik Ejbjerg8, Lene Bak9, Michael Sejer Hansen10, Julia Sidenius Johansen11, Hanne Merete Lindegaard12, Jakob M. Møller13 and Mikkel Østergaard14, 1Center for Rheumatology and Spine Diseases,, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Hillerød, Denmark, Hillerød, Denmark, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, 3Department of Radiology, Rigshospitalet Glostrup, Denmark, Glostrup, Denmark, 4King Christian the Xth Hospital for Rheumatic Diseases, Denmark, Graasten, Denmark, 5Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, 6Augurex Life Sciences Corp, Vancouver, BC, Canada, 7Augurex Life Sciences Corp, Vancouver, DC, Canada, 8Rheumatology, Department of Rheumatology, Køge Hospital, Denmark, Køge, Denmark, 9Department of Radiology, Odense University Hospital, Denmark, Odense, Denmark, 10Reuma-Klinik Roskilde, Denmark, Roskilde, Denmark, 11Dept. of Oncology, Department of Oncology, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark, 12Dept. of Rheumatology, Department of Rheumatology, Odense University Hospital, Denmark, Odense, Denmark, 13Department of Radiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark, 14Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Copenhagen, Denmark

    Background/Purpose: Optimal management of rheumatoid arthritis (RA) requires early diagnosis and therefore sensitive methods for early identification of RA to prevent joint damage and disability.…
  • Abstract Number: 707 • 2017 ACR/ARHP Annual Meeting

    Distinctive Features of Positive Anti-Cell Antibody Tests on HEp-2 Cells (HEp-2-ANA) in Patients with Non-Autoimmune Diseases

    Renan Agustinelli1, Sílvia H. Rodrigues2, Mônica Prado3, Henrique Mariz4 and Luis Eduardo C. Andrade5,6, 1Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, São Paulo, Brazil, 2Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil, 3Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, 4Internal Medicine Department, Hospital das Clínicas - Universidade Federal de Pernambuco, Recife, Brazil, 5Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil, 6Immunology Division, Fleury Medicine and Health, São Paulo, Brazil

    Background/Purpose: The indirect immunofluorescence (IIF) test for anti-cell or antinuclear (ANA) antibodies on HEp-2 cells (HEp-2-ANA) is considered the gold standard method for ANA detection.…
  • Abstract Number: 1023 • 2017 ACR/ARHP Annual Meeting

    The Autoimmune Discovery Ichip Distinguishes Healthy Individuals (HC) from Those with SLE, Rheumatoid Arthritis (RA), Scleroderma (SSc), Sjogren’s Syndrome (SS), and the Anti-Phospholipid Syndrome (APS)

    Chaim Putterman1, Armando Gabrielli2, Alexandra Balbir-Gurman3, Pennina Safer4, Keren Jakobi-Brook4, Rachel Sorek4, Ilana Gluzman4, Steve Wallace5 and Irun R. Cohen4,6, 1Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, 2Istituto di Clinica Medica dell'Università di Ancona, Ancona, Italy, Ancona, Italy, 3Rheumatology Unit, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Haifa, Israel, 4ImmunArray Ltd., Rehovot, Israel, Rehovot, Israel, 5ImmunArray Inc., VA, USA, Richmond, VA, 6Weizmann Institute of Science, Rehovot, Israel, Rehovot, Israel

    Background/Purpose: Current serological tests are not sufficiently accurate in differentiating between HC and those with autoimmune rheumatic diseases. We developed the iCHIP antigen microarray to…
  • Abstract Number: 1096 • 2017 ACR/ARHP Annual Meeting

    Clinical Significance of RNP Antibodies in Diagnosis of Systemic Autoimmune Rheumatic Disease When Detected By Multiplex Immunoassay

    Heather Bukiri1, Amish Dave2, Erin Bauer2, Vivian Stone2, Chris Chong3 and Punam Verma4, 1Graduate Medical Education, Virginia Mason Medical Center, Seattle, WA, 2Rheumatology, Virginia Mason Medical Center, Seattle, WA, 3Virginia Mason Medical Center, Seattle, WA, 4Microbiology/Immunology General Lab, Virginia Mason Medical Center, Seattle, WA

    Background/Purpose: A large multicenter healthcare system recently adopted multiplex immunoassay as an initial screen for antinuclear antibody (ANA) with confirmatory reflex testing by immunofluorescence antibody…
  • Abstract Number: 1266 • 2017 ACR/ARHP Annual Meeting

    Geographic Variation in Use of Echocardiography at Diagnosis and Detection of Acute Cardiac Disease in Youth with Systemic Lupus Erythematosus

    Joyce C. Chang1, Andrea M. Knight2, Laura M. Mercer-Rosa3, Rui Xiao4 and Pamela F. Weiss5, 1Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2Division of Rheumatology, Center for Pediatric Clinical Effectiveness & PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, 3Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, 4Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Child-onset systemic lupus erythematosus (SLE) is a chronic autoimmune condition with a high risk of organ damage. There are no guidelines on the use…
  • Abstract Number: 1368 • 2017 ACR/ARHP Annual Meeting

    Small RNA Sequencing Identifies Plasma microRNA Panel for Rheumatoid Arthritis Diagnosis

    Michelle J. Ormseth1, Joseph F. Solus2, Quanhu Sheng2, Yan Guo2, Fei Ye2, Ryan Allen2, Kasey Vickers2 and C Michael Stein2, 1Medicine, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose:  Small noncoding RNAs (sRNAs), such as microRNAs (miRNAs), are regulators of biological processes and serve as important biomarkers of disease. Most previous plasma sRNA…
  • Abstract Number: 1371 • 2017 ACR/ARHP Annual Meeting

    Development of an Adjusted Multi-Biomarker Disease Activity (MBDA) Score for Rheumatoid Arthritis (RA) That Accounts for Age, Sex and Adiposity, with Subsequent Evaluation of Ability to Predict Risk for Radiographic Damage

    Jeffrey R. Curtis1, Darl D. Flake II2, Michael Weinblatt3, Nancy A. Shadick4, Mikkel Østergaard5, Merete Lund Hetland6, Cecilie Heegaard Brahe6, Yong Gil Hwang7, Daniel E. Furst8, Vibeke Strand9, Carol J. Etzel10, Dimitrios A. Pappas11, Xingbin Wang12, Ching Chang Hwang13, Eric H. Sasso12, Alexander Gutin2, Elena Hitraya12 and Jerry S. Lanchbury2, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Myriad Genetics Inc., Salt Lake City, UT, 3Brigham and Women’s Hospital, Boston, MA, 4Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, 6Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 7Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 8David Geffen School of Medicine at UCLA, Los Angeles, CA, 9Stanford University, Palo Alto, CA, 10Departments of Epidemiology and Biostatistics, University of Texas School of Public Health, Houston, TX, 11Columbia University, New York, NY, 12Crescendo Bioscience Inc., South San Francisco, CA, 13Biostatistics, Crescendo Bioscience Inc., South San Francisco, CA

    Background/Purpose: The MBDA score, based on 12 serum proteins, is a validated tool for assessing disease activity in RA patients. MBDA biomarkers may be influenced…
  • Abstract Number: 1865 • 2017 ACR/ARHP Annual Meeting

    Novel Approach to Arthritis Surveillance Suggests a Much Higher Prevalence of Arthritis Among US Adults Than Previous Estimate

    S. Reza Jafarzadeh and David T. Felson, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Current national estimates of arthritis prevalence in the United States rely on a single survey question about doctor-diagnosed arthritis from the National Health Interview…
  • Abstract Number: 1900 • 2017 ACR/ARHP Annual Meeting

    Effect of Age and Body Mass Index (BMI) on Multi-Biomarker Disease Activity (MBDA) Score in Patients with Rheumatoid Arthritis

    Kerri Ford1, David Chernoff1, Xingbin Wang1, Eric H. Sasso1, Carol J. Etzel2,3 and Dimitrios A. Pappas3,4, 1Crescendo Bioscience Inc., South San Francisco, CA, 2Departments of Epidemiology and Biostatistics, University of Texas School of Public Health, Houston, TX, 3Corrona, LLC, Southborough, MA, 4Columbia University, New York, NY

    Background/Purpose: We evaluated the associations between MBDA score and age and between MBDA score and BMI in patients with rheumatoid arthritis (RA). These relationships may…
  • Abstract Number: 1919 • 2017 ACR/ARHP Annual Meeting

    The SLE-Key Test Detects an SLE Serologic Signature That Persists over Time and Is Independent of Disease Activity

    Chaim Putterman1, Michelle Petri2, Roberto Caricchio3, Jim C. Oates4, Pennina Safer5, Keren Jakobi-Brook5, Rachel Sorek5, Ilana Gluzman5, Steve Wallace6 and Irun R. Cohen5,7, 1Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, 2Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, 3Temple Lupus Clinic, Temple University, Philadelphia, PA, USA, Philadelphia, PA, 4Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 5ImmunArray Ltd., Rehovot, Israel, Rehovot, Israel, 6ImmunArray Inc., VA, USA, Richmond, VA, 7Weizmann Institute of Science, Rehovot, Israel, Rehovot, Israel

    Background/Purpose: We have developed the iCHIP1,2 to profile repertoires of serum autoantibodies. The first iCHIP application was the SLE-key RuleOut test3,4 , to rule out…
  • Abstract Number: 2312 • 2017 ACR/ARHP Annual Meeting

    Prevalence of Serum 14-3-3η (eta) in Juvenile Idiopathic Arthritis

    Iris Reyhan1, Olga S. Zhukov2, Robert J. Lagier3, Robert Bridgforth4, Gary J Williams5, Joanna M. Popov2, Stanley J. Naides2 and Andreas Reiff6, 1Rheumatology, Children's Hospital of Los Angeles, Los Angeles, CA, 2Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, 3Research Support, Alameda, Quest Diagnostics Alameda, Alameda, CA, 4Quest Diagnostics Nichols Institute, clemente, CA, 5Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, 6Children’s Hospital of Los Angeles, Los Angeles, CA

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease. Currently, diagnosis is based on clinical assessment defined by the International League of…
  • Abstract Number: 2871 • 2017 ACR/ARHP Annual Meeting

    Anti-RA33 (hnRNP-A2/B1) Autoantibodies Are Associated with the Therapeutic Response to Methotrexate and Anti-TNF Treatment in Patients with Rheumatoid Arthritis

    Daniela Sieghart1, Paul Studenic1, Farideh Alasti2, Daniel Aletaha3, Josef S. Smolen1 and Günter Steiner2, 1Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, 2Rheumatology, Medical University of Vienna, Vienna, Austria, 3Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Besides the determination of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), anti-RA33 antibodies (which are directed to the nuclear antigen hnRNP-A2/B1) could be…
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