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Abstracts tagged "dermatomyositis"

  • Abstract Number: 2147 • 2017 ACR/ARHP Annual Meeting

    Dysphagia in Inflammatory Myositis: A Study of the Structural and Physiologic Changes Resulting in Disordered Swallowing

    Alba Azola1, Tae Chung2, Rachel Mulheren2, Genevieve Mckeon2, Lisa Christopher-Stine3 and Jeffrey Palmer2, 1Physical Medicine and Rehabilitation, Johns Hopkins University, Lutherville, MD, 2Johns Hopkins University, Baltimore, MD, 3Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: The prevalence of dysphagia in patients with inflammatory myopathies has been reported to be as high as 60% (1). Aspiration pneumonia is one of…
  • Abstract Number: 2151 • 2017 ACR/ARHP Annual Meeting

    The Predictive Risk Factors for Opportunistic Infection during Treatment for Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease

    Yumiko Sugiyama1,2, Ryusuke Yoshimi1,2, Maasa Tamura2,3, Naoki Hamada1,2, Hideto Nagai1,2, Naomi Tsuchida1,4, Yosuke Kunishita1,2, Yutaro Soejima1,2, Daiga Kishimoto1,2, Reikou Kamiyama1,2, Kaoru Minegishi1,5, Yohei Kirino1,2, Shigeru Ohno1,6 and Hideaki Nakajima2, 1Y-CURD Study Group, Yokohama, Japan, 2Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 3Y-CURD Study Group, Yokohma, Japan, 4Department of Hematology and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 5Rheumatic Disease Center, Yokohama City University Medical Center, Yokohama, Japan, 6Center for Rheumatic Disease, Yokohama City University Medical Center, Yokohama, Japan

    Background/Purpose: Although concomitant infectious diseases are the predominant causes of death in patients with polymyositis (PM)/dermatomyositis (DM)-associated interstitial lung disease (ILD), intensive immunosuppressive treatment are…
  • Abstract Number: 2158 • 2017 ACR/ARHP Annual Meeting

    HLA-DRB1*04:03/*04:06 As the Genetic Susceptibility to Dermatomyositis Positive for Anti-Transcriptional Intermediary Factor 1-γ Antibody in Japanese Population

    Yukie Yamaguchi1, Masataka Kuwana2, Miwa Kanaoka1, Tomoya Watanabe1, Naoko Okiyama3, Takahisa Gono2, Masanari Kodera4, Takeshi Kambara5, Yasuhito Hamaguchi6, Mariko Seishima7, Kazuhiko Takehara6, Manabu Fujimoto3 and Michiko Aihara1, 1Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 3Department of Dermatology, University of Tsukuba, Tsukuba, Japan, 4Department of Dermatology, Japan Community Health care Organization Chukyo Hospital, Nagoya, Japan, 5Department of Dermatology, Yokohama City University Medical Center, Yokohama, Japan, 6Department of Dermatology, Kanazawa University, Kanazawa, Japan, 7Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan

    Background/Purpose: Dermatomyositis (DM) is characterized by inflammation of the skin and skeletal muscle, and is occasionally complicated by interstitial lung disease or concomitant malignancy. It…
  • Abstract Number: 2159 • 2017 ACR/ARHP Annual Meeting

    Dermatomyositis Acute Onset/Flares Following Ingestion of Isalean® Herbal Supplement: Clinical and Immunostimulatory Findings

    Majid Zeidi1,2, Peter B Chansky1,2 and Victoria P Werth3,4, 1Department of Dermatology, Corporal Michael J. Crescenz VAMC, PHILADELPHIA, PA, 2Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 3University of Pennsylvania and the VA Medical Center, Philadelphia, PA, 4Department of Dermatology, Corporal Michael J. Crescenz VAMC, Philadelphia, PA

    Background/Purpose : The use of complementary and alternative medicine (CAM) has gained popularity in the United States over the last few decades. Herbal supplements have…
  • Abstract Number: 2164 • 2017 ACR/ARHP Annual Meeting

    Prognostic Factors in Polymyositis/ Dermatomyositis Patients with Anti-Synthetase Antibodies

    Masashi Taniguchi1, Ran Nakashima1, Nobuo Kuramoto1, Kosaku Murakami1, Motomu Hashimoto2, Hajime Yoshifuji1, Masao Tanaka2, Koichiro Ohmura1 and Tsuneyo Mimori1, 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Background/Purpose: Anti-aminoacyl-tRNA synthetase antibodies (Abs), which mainly consists of anti-Jo1, PL-7, PL-12, EJ, OJ and KS, are the most common myositis-specific autoantibodies (MSAs). It has…
  • Abstract Number: 2165 • 2017 ACR/ARHP Annual Meeting

    Easily Obtainable Myositis Autoantibody Panel Predictive Factors

    Jason Weiner1, Ryan Jessee2, Amanda M. Eudy3, Robert T. Keenan4, Michael Datto5 and Lisa Criscione-Schreiber6, 1Department of Medicine, Division of Rheumatology and Immunology, Duke University Medical Center, Durham, NC, 2Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC, 3Duke University Medical Center, Chapel Hill, NC, 4Rheumatology, NYU-HJD, New York, NY, 5Department of Pathology, Duke University, Durham, NC, 6Internal Medicine, Duke University Medical Center, Durham, NC

    Background/Purpose: Myositis autoantibodies have diagnostic, therapeutic and prognostic implications, but their utility in clinical practice is unclear.  We aimed to describe our institutionÕs ordering practices…
  • Abstract Number: 2169 • 2017 ACR/ARHP Annual Meeting

    A Two-Center Experience with Rituximab in Patients with Primary Idiopathic Myositis and Overlap Myositis: A Retrospective Observational Study

    Kimberly A. Rehberg1, Morgan M. Brown2, Anna K. Shmagel1, Elie Gertner3 and Jerry A. Molitor1, 1Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, 2HealthPartners Institute, St. Paul, MN, 3Section of Rheumatology, Regions Hospital, St. Paul, MN

    Background/Purpose: Recent studies have suggested the possible benefit of the anti-CD20 agent Rituximab (RTX) in autoimmune myositis (AIM). As AIM is a rare and heterogeneous…
  • Abstract Number: 28 • 2017 Pediatric Rheumatology Symposium

    Dyslipidemia in Juvenile Dermatomyositis

    Arya Kadakia1, Amer Khojah2, Gabrielle A. Morgan3,4, Megan L. Curran5, Irwin Benuck6, Chinag-Ching Huang1, Dong Xu7 and Lauren M. Pachman8,9, 1Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 2Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 3Cure JM Program of Excellence in Myositis Research, Chicago, IL, 4Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 5Pediatric Rheumatology, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, 6Division of Cardiology, Northwestern University Feinberg School of Medicine, Department of Pediatrics, Chicago, IL, 7Program of Excellence in Cure-Juvenile Myositis (JM) Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 8Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 9Rheumatology/Immunology, Ann & Robert H. Lurie Children's Hosptial of Chicago, Chicago, IL

    Background/Purpose: Juvenile Dermatomyositis (JDM) is a multisystem pediatric autoimmune disease characterized by chronic inflammation of muscle and skin. Premature atherosclerosis is an important cause of…
  • Abstract Number: 275 • 2016 ACR/ARHP Annual Meeting

    In Vitro Activation of Type I Interferon Pathway Reproduces the Characteristics Damages Observed in Dermatomyositis Patients

    Leandro Ladislau1,2,3, Xavier Suárez-Calvet1,4, Claudia Benjamin3, Ségolène Toquet1, Benjamin Terrier5, Flore Rozenberg6, Vincent Mouly1, Gillian Butler Browne7, Werner Stenzel8, Olivier Benveniste9 and Yves Allenbach10, 1Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS_974, CNRS FRE 3617, Center of Research in Myology., Paris, France, 2Programa de Ciências Biomédicas, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 3Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 4Neuromuscular Diseases Unit, Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona and Institut de Recerca Sant Pau., Barcelona, Spain, 5Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 6Departement de Virologie, Hôpital Cochin, Paris Descartes Universités, Paris, France, 7Sorbonne Universités UPMC Univ Paris 06, Myology research center, INSERM UMRS974, CNRS FRE3617, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, 8Charité-Universitätsmedizin Berlin, Berlin, Germany, 9Pitié-Salpêtrière University Hospital, Paris, France, 10Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France

    Background/Purpose: The type I interferons (IFN-I) including IFN-a, and IFN-b are key cytokines involved in innate immune response to viral infection. Almost all cells can…
  • Abstract Number: 285 • 2016 ACR/ARHP Annual Meeting

    Antibodies to Small Ubiquitin-like Modifier Activating Enzyme: Frequency and Characteristics of Antibody-Positive Patients in an Unselected Cohort

    Anne Tebo1, Troy Jaskowski2 and Lisa Peterson1, 1Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, UT, 2ARUP Laboratories, Salt Lake City, UT

    Background/Purpose:  Antibodies to small ubiquitin-like modifier activating enzyme (SAE) are associated with diagnosis of dermatomyositis (DM). The aims of this study were to establish the…
  • Abstract Number: 286 • 2016 ACR/ARHP Annual Meeting

    Clinical Significance and Prognostic Value of Neutrophil to Lymphocyte Ratio in Patients with Dermatomyositis

    Jaehyung Hur1, Dong Jin Go2, Sang Wan Chung3, You Jung Ha3, Eun Ha Kang1, Jin Kyun Park4, Eun Young Lee2, Eun Bong Lee2, Yeong Wook Song4 and Yun Jong Lee5, 1Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea

    Background/Purpose:  Recent studies have suggested that neutrophil to lymphocyte ratio (NLR) could be an emerging predictive marker of disease activity or mortality in patients with…
  • Abstract Number: 1187 • 2016 ACR/ARHP Annual Meeting

    Ultraviolet Radiation Exposures Are Associated with Dermatomyositis in a National Myositis Registry

    Christine G. Parks1, Jesse Wilkerson2, Kathryn M. Rose2, Abdullah Faiq3, Payam Noroozi Farhadi3, Craig S. Long4, Nastaran Bayat3, Hermine I. Brunner5, Bob Goldberg6, John McGrath2, Frederick W. Miller3 and Lisa G. Rider3, 1Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Durham, NC, 2Social and Scientific Systems, Inc., Durham, NC, 3Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD, 4NOAA/National Weather Service, National Centers for Environmental Prediction Climate Prediction Center, College Park, MD, 5Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6The Myositis Association, Alexandria, VA

    Background/Purpose:  Previous studies suggest exposure to ultraviolet (UV) radiation may be a risk factor for dermatomyositis (DM) and autoantibody phenotypes, based on differences in prevalence…
  • Abstract Number: 1237 • 2016 ACR/ARHP Annual Meeting

    The Economic Burden of Dermatomyositis and Polymyositis in the US

    J. Bradford Rice1, Alan White1, Philip Galebach1, Andrea Lopez1, Patricia Schepman2, Breanna Popelar3, Michael Philbin4 and Elaine Boing2, 1Analysis Group, Inc., Boston, MA, 2Affiliated with Mallinckrodt Pharmaceuticals at the time this study was conducted, Hazelwood, MO, 3Xcenda, L.L.C., Palm Harbor, FL, 4Mallinckrodt Pharmaceuticals, Hazelwood, MO

    Background/Purpose: Dermatomyositis and polymyositis (DM/PM) are inflammatory myopathies that can lead to persistent muscle weakness and disability. Although significant healthcare resource utilization (HCRU) and work…
  • Abstract Number: 1290 • 2016 ACR/ARHP Annual Meeting

    The Usefulness of Volumetric Parameters of FDG PET/CT for Reflecting Disease Activity in Polymyositis/Dermatomyositis Patients

    Atsushi Kondo1, Hiroaki Dobashi1, Tomohiro Kameda1, Miharu Izumikawa1, Shusaku Nakashima1, Hiromi Shimada1, Hiroki Ozaki1, Risa Wakiya1, Yuka Yamamoto2, Yoshihiro Nishiyama3 and Norimitsu Kadowaki1, 1Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan, 2Radiology, Kagawa University, Kagawa, Japan, 3Department of Radiology, Faculty of Medicine,Kagawa University, Kagawa University, Kita-gun, Japan

    Background/Purpose:  Polymyositis/dermatomyositis (PM/DM) are systemic inflammatory disorders predominantly affecting skeletal muscles and skin respectively. Although muscle biopsy is the most important to the diagnosis of…
  • Abstract Number: 1368 • 2016 ACR/ARHP Annual Meeting

    Clinical Course of Juvenile Dermatomyositis Presenting As Skin Predominant Disease

    Edward J. Oberle1,2, Dominic O. Co3,4, Yvonne Chiu3,4, Michelle Bayer4,5, Adam Huber6, Hatice Ezgi Baris7 and Susan Kim8, 1Pediatric Rheumatology, Nationwide Children's Hospital, Columbus, OH, 2Pediatrics, Ohio State University, Columbus, OH, 3Pediatrics, Medical College of Wisconsin, Milwaukee, WI, 4Children's Hospital of Wisconsin, Milwaukee, WI, 5Dermatology, Medical College of Wisconsin, Milwaukee, WI, 6Pediatric rheumatology, IWK Health Centre, Halifax, NS, Canada, 7Boston Children's Hospital, Boston, MA, 8Division of Immunology, Boston Children's Hospital, Boston, MA

    Background/Purpose:  Juvenile dermatomyositis (JDM) is a chronic inflammatory disorder of the skin and striated muscle. A subset of patients can present with rash only, labeled…
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