Abstracts tagged "dermatomyositis"

Abstract Number: 0287 • ACR Convergence 2025
Comprehensive Profiling of Neutrophil Subsets Reveals Functional Signatures Linked to Vasculopathic Features in Patients with Inflammatory Myopathies
Daniel Alberto Carrillo-Vázquez¹, Beatriz Alcalá-Carmona¹, Jennifer Tiaré Balderas Miranda², Yatzil Reyna Juárez³, María José Ostos Prado¹, Samuel Govea-Peláez¹, Nancy R Mejía Domínguez⁴, Guillermo Juárez Vega⁴, Karina Santana-De Anda¹, Jiram Torres-Ruiz⁵ and Diana Gómez-Martín⁶, ¹Instituto Nacional De Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, Distrito Federal, Mexico, ²Universidad Nacional Autónoma de México, Coyoacán, Federal District, Mexico, ³Instituto Politècnico Nacional, Tultitlán de Mariano Escobedo, Mexico State, Mexico, ⁴Universidad Nacional Autónoma de México, Mexico City, Distrito Federal, Mexico, ⁵INCMNSZ, Ciudad de México, Mexico, ⁶INCMNSZ, Mexico city, Federal District, Mexico
Background/Purpose: Vasculopathic manifestations of idiopathic inflammatory myopathies (IIM) such as interstitial lung disease (ILD), calcinosis, skin ulcers, mechanic’s hands, are characterized by immune-mediated vascular damage.…
Abstract Number: 2668 • ACR Convergence 2025
CD14⁺ Myeloid Cells Mediate UVB Photosensitivity in Autoimmune Skin Disease via a Spatially Resolved Inflammatory Circuit
Nazgol Haddadi¹, Khashayar Afshari¹, Yuqing Wang¹, Carolina S. Lopes¹, Chee-Huat L. Eng², Nuria Martinez-Gutierrez¹, Leah Whiteman¹, Kevin Wei³, Kirsten Frieda², Stefania Gallucci¹, Misha Rosenbach⁴, Ruth Ann Vleugels⁵, John E. Harris¹, Manuel Garber¹ and Mehdi Rashighi¹, ¹UMass Chan Medical School, Worcester, MA, ²Spatial Genomics, Inc., Pasadena, CA, ³Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Brigham and Women's Hospital, Chestnut Hill, MA
Background/Purpose: Inflammatory skin diseases vary widely in symptoms and causes. While ultraviolet (UV) light helps treat some like vitiligo and psoriasis, in conditions like cutaneous…
Abstract Number: 1967 • ACR Convergence 2025
Developing an Algorithm to Quantify Dermatomyositis-Associated Calcinosis Using Infrared Imaging
Saahil Sachdeva¹, Briana Cervantes², Lisa Rider³ and Adam Schiffenbauer⁴, ¹NIEHS/NIBIB/NIH, Danville, CA, ²Department of Emergency Medicine, Norfolk, VA, ³National Institute of Environmental Health Sciences/National Institutes of Health, Environmental Autoimmunity Group, Bethesda, MD, ⁴National Institute of Health/National Institute of Dental and Craniofacial Research, Bethesda, MD
Background/Purpose: Dermatomyositis (DM) is a rare autoimmune disease characterized by chronic muscle and skin inflammation. One potential complication of DM is calcinosis, the heterotopic calcification…
Abstract Number: 1202 • ACR Convergence 2025
High Prevalence of Asymptomatic Interstitial Lung Disease in Idiopathic Inflammatory Myopathies: Validation of ACR/CHEST Risk Factors in a Hong Kong Cohort
Ka Ki Yam¹, Lucas Tsz Ho Luk¹, Weng Nga Lao², Chiu Wai Shirley Chan³, Dennis Tin Ho Chan⁴, Billy Tin Lok Lai⁵, Roy Tsz Chung Ho⁶, Vivian Hoi Shan Tang⁷, Ho So⁸ and Iris Tang⁹, ¹Department of Medicine & Geriatrics, Hong Kong, Hong Kong, ²Department of Medicine & Geriatrics, Kwong Wah Hospital, Hong Kong, Hong Kong, ³Division of Rheumatology and Clinial Immunology, Department of Medicine, the University of Hong Kong, Hong Kong, Hong Kong, China, ⁴Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong, ⁵Department of Medicine, Tseung Kwan O Hospital, Hong Kong, Hong Kong, ⁶Department of Medicine, Queen Elizabeth Hospital, Hong Kong, Hong Kong, ⁷Department of Medicine, North District Hospital, Hong Kong, Hong Kong, ⁸Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁹Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Interstitial lung disease (ILD) is a common and severe complication of idiopathic inflammatory myopathies (IIM), adversely impacting clinical outcomes. While the ACR/CHEST guideline recommends…
Abstract Number: 0286 • ACR Convergence 2025
Anifrolumab For Treatment Of Refractory Juvenile Dermatomyositis In Adult Patients
Connor Buechler¹ and David Pearson², ¹University of Minnesota, Mendota Heights, MN, ²Department of Dermatology, University of Minnesota, Minneapolis, MN
Background/Purpose: Juvenile dermatomyositis (JDM) is an autoimmune connective tissue disorder with a chronic, relapsing course that can persist into adulthood. Current therapies exhibit widely variable…
Abstract Number: 2558 • ACR Convergence 2025
Impact of Social Determinants of Health on Patient Perceptions of Home Infusion Therapy in the Treatment of Rheumatologic Conditions
Leslie Myers¹, Elizabeth Neal², Edward O'Bryan¹, Michele Way³ and Timothy Walton¹, ¹CSI Pharmacy, Nash, ²CSI Pharmacy, Nash, TX, ³CSI Pharmacy, Olathe, KS
Background/Purpose: Home infusion therapy is an established alternative site of care for patients requiring administration of infusion medications through a needle or catheter. Supported by…
Abstract Number: 1956 • ACR Convergence 2025
68Ga-FAPI-04 and 18F-FDG PET/ CT in MDA5 dermatomyositis-associated interstitial lung disease: a single-center, pilot study
Jia Li¹, Weijun Wei², Lianghua Li², Wenwen Xu³, Jianjun Liu² and Shuang Ye⁴, ¹Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (People's Republic), ²Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai ²⁰⁰²¹⁷, China., Shanghai, China (People's Republic), ³Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai ²⁰⁰²¹⁷, China., Shanghai, China (People's Republic), ⁴Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai, Shanghai, China (People's Republic)
Background/Purpose: Interstitial lung disease (ILD) is the leading cause of death in MDA5 dermatomyositis (MDA5-DM). Fibrosis and inflammation are pivotal drivers in the pathogenesis of…
Abstract Number: 1200 • ACR Convergence 2025
Mortality in Idiopathic Inflammatory Myopathy in the Toulouse cohort (MIIRTALITY)
Aurore Larrauffie¹, Chloé Bost¹, Marie Faruch¹, Claire Barrier¹, Jérémy Zordan¹, Marie Guille¹, Grégoire Prevot¹, Thomas Villeneuve¹, Morgane Mourguet¹, Laurent Alric¹, Laurent Sailler¹, Martin Michaud¹, Sébastien De Almeida Chaves¹ and Grégory Pugnet², ¹CHU Toulouse, Toulouse, France, ²CHU Toulouse Rangueil Service de Medecine Interne et Immunologie Clinique, Toulouse, France
Background/Purpose: Idiopathic Inflammatory Myopathies (IIM) are a group of heterogeneous connective tissue diseases including dermatomyositis (DM), polymyositis (PM), anti-synthetase syndromes (ASS), immune-mediated necrotizing myopathies (NM),…
Abstract Number: 0285 • ACR Convergence 2025
Delayed-Onset Myopathy in Dermatomyositis: A Retrospective Cohort Study
Connor Buechler¹, Nawang Singhe², Lindsey Wanberg², Cody Rasner², Joseph McGrath², Karen Baker-James², Rebecca Freese² and David Pearson³, ¹University of Minnesota, Mendota Heights, MN, ²University of Minnesota, Minneapolis, MN, ³Department of Dermatology, University of Minnesota, Minneapolis, MN
Background/Purpose: Amyopathic dermatomyositis (ADM) is a subset of DM in which cutaneous findings occur without muscle disease for >6 months after diagnosis. However, there is…
Abstract Number: 2158 • ACR Convergence 2025
Evaluating Nailfold Capillary Changes as Indicators of Disease Activity in Juvenile Dermatomyositis
Zilan Zheng¹, Laila Metni², Susan Kim³ and Jessica Neely⁴, ¹University of California, San Francisco, San Francisco, CA, ²University of California, Berkeley, Berkeley, CA, ³UCSF Benioff Children's Hospital, San Francisco, CA, ⁴UCSF, San Francisco, CA
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare pediatric autoimmune myopathy characterized by skin and muscle inflammation, resulting in microvascular changes that can be visualized in…
Abstract Number: 1889 • ACR Convergence 2025
Navigating Diagnostic Challenges: Insights into the Patient Journey and Delays in Diagnosing Dermatomyositis from a Real-world Survey in the United States and Europe
Esther Yi¹, Jason Xenakis¹, Chris Blazos², Jade Garratt-Wheeldon², James Piercy², Peter Anderson² and Rohit Aggarwal³, ¹Pfizer Inc., New York, United States of America, New York, ²Adelphi Real World, Bollington, United Kingdom, Bollington, United Kingdom, ³University of Pittsburgh, Rheumatology and Clinical Immunology, Pittsburgh, United States of America, Pittsburgh, PA
Background/Purpose: Idiopathic inflammatory myopathies (IIMs) are a heterogenous group of rare autoimmune inflammatory rheumatic diseases, including dermatomyositis (DM).Methods: Data were drawn from the Adelphi Real…
Abstract Number: 1194 • ACR Convergence 2025
Risk of Calcinosis with Proton Pump Inhibitor Use in Adult Dermatomyositis and Systemic Sclerosis
Antonia Valenzuela¹, Nicolás González², José Rojas³, Martin Fuentes³, Srijana Davuluri⁴, Brian Lee⁵, David Fiorentino⁶ and Lorinda Chung⁴, ¹Pontificia Universidad Catolica de Chile, Santiago, Chile, ²Pontificia Universidad Católica de Chile, Santiago de Chile, Chile, ³Pontificia Universidad Católica de Chile, Santiago de Chile, Chile, ⁴Stanford University, Stanford, CA, ⁵Stanford University, Stanford, ⁶Department of Dermatology, Stanford University Medical Center, Stanford, CA
Background/Purpose: Calcinosis is a painful, debilitating manifestation in connective tissue diseases. Recent findings suggest a link between proton pump inhibitor (PPI) use and calcinosis in…
Abstract Number: 0284 • ACR Convergence 2025
Glucocorticoid Tapering and Relapse Risk in Anti-ARS Antibody-Positive Myositis: A Retrospective Study in a Single-Center Cohort Treated with Immunosuppressants
Ayaka Inoue¹, Takashi Yamane², Noriaki Yasuda³ and Takahisa Ohnishi¹, ¹Kakogawa Central City Hospital, Kakogawa, Japan., kakogawa-cho, kakogawa city, Hyogo, Japan, ²Kakogawa Central City Hospital, Kobe, Hyogo, Japan, ³Kakogawa Central City Hospital, Kakogawa, Japan
Background/Purpose: Anti–synthetase syndrome is generally responsive to glucocorticoid (GC) therapy, though relapse frequently complicates tapering. Prolonged GC use is associated with adverse events and decreased…
Abstract Number: 2148 • ACR Convergence 2025
Initial MRI Findings as Predictors of Disease Phenotype in Juvenile Dermatomyositis: A Comparative Study of Myositis Specific Antibodies NXP2-Positive and Myositis Specific Antibody-Negative Patients in a Large Tertiary Hospital
Juan Torres Sanchez¹, Pritish Bawa², Andrea Ramirez¹, MaiLan Nguyen³, Amit Thakral⁴, Xiaofan Huang¹, J Herman Kan² and Marietta De Guzman¹, ¹Baylor College of Medicine, Houston, TX, ²Texas Childrens Hospital, Houston, TX, ³Baylor College of Medicine, Austin, TX, ⁴Texas Children’s Hospital, Houston, TX
Background/Purpose: Juvenile dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy of childhood, characterized by proximal muscle weakness and distinctive cutaneous findings. Magnetic resonance imaging…
Abstract Number: 1857 • ACR Convergence 2025
Role of autoantigen-specific reactivity in the pathogenesis of murine interstitial lung disease model with anti-MDA5 antibody mouse model
Atsubumi Ogawa¹, Ran Nakashima², Tsuneyasu Yoshida³, Keisuke Hirobe¹, Yasuhiro Nohda¹, Tsuneo Sasai¹, Mirei Shirakashi², Ryosuke Hiwa¹, Hideaki Tsuji¹, Shuji Akizuki², Hajime Yoshifuji², Kosaku Murakami⁴, Norimichi Nomura⁵, Atsuyasu Sato⁶, Motomu Hashimoto⁷ and Akio Morinobu⁸, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, ³Division of Clinical Immunology and Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁴Division of Clinical Immunology and Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, ⁵Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁶Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁷Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Sakyo-ku, Japan, ⁸Kyoto University, Kyoto, Kyoto, Japan
Background/Purpose: Anti-Melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5-DM) is often complicated by rapidly progressive interstitial lung disease (RP-ILD) and has a poor prognosis. Although there has…

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