ACR Meeting Abstracts

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Abstracts tagged "dermatomyositis"

  • Abstract Number: 1007 • ACR Convergence 2021

    Vascular Deposition of Oxidized LDL Is Increased in Children with Untreated Juvenile Dermatomyositis

    Jacob Spitznagle1, Akadia Kacha-Ochana2, Joan Cook-Mills3, Amer Khojah2, Gabrielle Morgan4 and Lauren Pachman5, 1Hospital for Special Surgery, New York, NY, 2Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 3Indiana University School of Medicine, Departments of Pediatrics and Microbiology & Immunology, Indianapolis, IN, 4Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 5Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

    Background/Purpose: Juvenile dermatomyositis (JDM) is a systemic vasculopathy associated with metabolic derangements and possible increased risk for premature atherosclerosis. Oxidation of low-density lipoprotein (LDL) in…
  • Abstract Number: 0700 • ACR Convergence 2021

    Clinical Outcomes in Idiopathic Inflammatory Myositis Within the Military Health System: A 15 Year Retrospective Review

    David Mecham1, William Moore1 and Ian Ward2, 1Dwight D Eisenhower Army Medical Center, Fort Gordon, 2United States Army, Evans, GA

    Background/Purpose: The Idiopathic Inflammatory Myopathies (IIM) are often difficult to treat, require chronic steroid therapy, and can remain active despite multiple treatment regimens. The objective…
  • Abstract Number: 1026 • ACR Convergence 2021

    Factors Impacting Likelihood of Discontinuing Immunosuppression in Adult Dermatomyositis: A Single-Center Study

    Sung Kyung Cho1, Lorinda Chung2 and David Fiorentino3, 1University of Texas Southwestern, Dallas, TX, 2Stanford University, Palo Alto, CA, 3Stanford University, Redwood City, CA

    Background/Purpose: Dermatomyositis (DM) is a chronic idiopathic inflammatory myopathy with variable clinical course, but little is known regarding factors associated with remission of disease. We…
  • Abstract Number: 1061 • ACR Convergence 2020

    Daily Myositis Symptom Changes Collected via a Smartphone-Based App Are Associated with Flare Occurrence – Providing Evidence of Potential Digital Biomarkers

    Alexander Oldroyd1, Belay Yimer2, Max Little3, William Dixon2 and Hector Chinoy4, 1University of Manchester, Manchester, United Kingdom, 2Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester, United Kingdom, 3University of Birmingham, Birmingham, United Kingdom, 4The University of Manchester, Manchester, United Kingdom

    Background/Purpose: The concept of idiopathic inflammatory myopathy (IIM) flare is widely used, although no consensus definition exists. Studies have demonstrated the feasibility and utility of…
  • Abstract Number: 1639 • ACR Convergence 2020

    Preliminary Baseline Subject Demographics and Disease Characteristics in a Phase 3 Clinical Trial of the Safety and Efficacy of Lenabasum in Dermatomyositis (DETERMINE)

    Victoria Werth1, Chester Oddis2, David Fiorentino3, Nancy Dgetluck4, Quinn Dinh5, Michael Tillinger6, Barbara White5 and Ingrid Lundberg7, 1University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 2Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 3Department of Dermatology, Stanford University, Redwood City, CA, 4Corbus Pharmaceuticals, Inc., Norwood, MA, 5Corbus Pharmaceuticals, Norwood, MA, 6Corbus Pharmaceuticals Inc., Norwood, MA, 7Division of Rheumatology, Department of Medicine, Karolinska Institutet,, Stockholm, Sweden

    Background/Purpose: There is significant unmet need for new treatments to achieve disease control in dermatomyositis (DM), because of limited efficacy or toxicity of immunosuppressive agents…
  • Abstract Number: 1062 • ACR Convergence 2020

    Dermatomyositis: A Dermatology-Rheumatology Clinic Retrospective Analysis

    Burak Elkiran1, Mahroo Tajalli2, Terrence M. Vance3, Abrar A. Qureshi4 and Anthony M. Reginato5, 1Department of Medicine, Division of Rheumatology; Warren Alpert Medical School of Brown University, BOSTON, 2Department of Dermatology, Warren Alpert Medical School of Brown University, PROVIDENCE, 3Department of Epidemiology, Warren Alpert Medical School of Brown University, PROVIDENCE, 4Department of Dermatology, Warren Alpert Medical School of Brown University, BOSTON, 5Department of Medicine, Division of Rheumatology, Warren Alpert Medical School of Brown University, Boston, MA

    Background/Purpose: Dermatomyositis (DM) can be categorized into two major subtypes: clinically amyopathic dermatomyositis (CADM) and classic dermatomyositis (CDM). In this study, we aimed to identify characteristics…
  • Abstract Number: 1695 • ACR Convergence 2020

    Anti-Melanoma Differentiation Associated Protein 5 (MDA5) Positive Juvenile Dermatomyositis: Focus on the Lung

    David Moreno McNeill1, Miriah Gillispie-Taylor2, Kevin Baszis3, Edouard Sayad1, Manuel Silva Carmona1 and Tiphanie Vogel1, 1Baylor College of Medicine/Texas Children's Hospital, Houston, TX, 2Baylor College of Medicine, Houston, 3Washington Univ School of Medicine, St Louis, MO

    Background/Purpose: A subset of juvenile dermatomyositis (JDM), clinically amyopathic dermatomyositis (CADM), is uncommon and mainly described in adults. CADM is classically characterized by skin ulcerations,…
  • Abstract Number: 1063 • ACR Convergence 2020

    Spirulina Stimulates Inflammatory Cytokine Production Through the STING and TLR Pathways in Dermatomyositis in Vitro

    Christina Bax1, Yubin Li1, Spandana Maddukuri2, Adarsh Ravishankar3, Jay Patel3, Daisy Yan1, Josef Symon Concha1 and Victoria Werth1, 1University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 2University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Montville, NJ, 3University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia

    Background/Purpose: Spirulina, a popular herbal supplement, stimulates the immune system, as determined by in vitro and in vivo studies. Our recent epidemiologic data suggest that Spirulina…
  • Abstract Number: 1916 • ACR Convergence 2020

    KZR-616, a First-in-class Selective Inhibitor of the Immunoproteasome, Ameliorates Polymyositis in a Murine Model

    Marta Del Rio Oliva1, Michael Basler1, Darrin Bomba2, Diana Lam2, Jennifer Brandl2, Christopher Kirk2 and Marcus Groettrup1, 1University of Konstanz, Konstanz, Germany, 2Kezar Life Sciences, Inc, San Francisco, CA

    Background/Purpose: Polymyositis (PM) is a chronic autoimmune inflammatory myopathy affecting striated muscles and resulting in muscle weakness. PM is a rare disease, and there are…
  • Abstract Number: 1065 • ACR Convergence 2020

    Immunostimulatory Herbal Supplement Use Is More Common Among Patients with Dermatomyositis

    Adarsh Ravishankar1, Daisy Yan2, Christina Bax3, Josef Symon Concha2, Bridget Shields4, Lisa Pappas-Taffer4, Rui Feng5, Joyce Okawa4 and Victoria Werth2, 1University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, 2University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 3University of Pennsylvania, Department of Dermatology, Philadelphia, 4Department of Dermatology, University of Pennsylvania, Philadelphia, PA, 5University of Pennsylvania, Philadelphia

    Background/Purpose: The use of complementary and alternative medicine (CAM) is prevalent in dermatology. Certain CAMs, including Spirulina, Alfalfa, Chlorella, Echinacea, and Blue-Green Algae have been…
  • Abstract Number: 1949 • ACR Convergence 2020

    CB2 Receptor Distribution and Effects of LenabasumTM in Dermatomyositis In Vitro

    Spandana Maddukuri1, Jay Patel2, Christina Bax3, Maria Wysocka3 and Victoria Werth4, 1University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Montville, NJ, 2University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, 3University of Pennsylvania, Department of Dermatology, Philadelphia, 4University of Pennsylvania and Corporal Michael J. Crescenz Veterans Administration Hospital, Philadelphia

    Background/Purpose: Dermatomyositis (DM) patients report poor quality of life due to disease activity and persistent itch. Lenabasum is an oral non-immunosuppressive, non-psychoactive cannabinoid type 2…
  • Abstract Number: 1067 • ACR Convergence 2020

    Anti-Viral Proinflammatory Phenotype in Circulating Monocytes from Patients with Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Associated Interstitial Lung Disease

    Takahisa Gono1, Yuka Okazaki1 and Masataka Kuwana2, 1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 2Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Tokyo, Japan

    Background/Purpose: Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is associated with interstitial lung disease (ILD), which often represents rapidly progressive course and fatal outcomes. Circulating levels…
  • Abstract Number: 1988 • ACR Convergence 2020

    Skin Disease More Recalcitrant to Intervention Than Muscle Disease: A Long-Term Prospective Study of 184 Children with Juvenile Dermatomyositis

    Andi Wang1, Gabrielle Morgan2, Chiang-Ching Huang3, Amy Paller4 and Lauren Pachman5, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 3Joseph J. Zilber School of Public Health, Milwaukee, 4Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, 5Department of Pediatrics, Northwestern University Feinberg School of Medicine; The Ann and Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Rheumatology; The CureJM Center of Excellence in Juvenile Myositis Research and Care, The Stanley Manne Children's Research Center of Chicago, Lake Forest, IL

    Background/Purpose: Persistent skin manifestations, in particular calcinosis, contribute to significant morbidity in patients with JDM. The goal of this study was to compare the course…
  • Abstract Number: 1068 • ACR Convergence 2020

    Efficacy of Early Initiation of Plasma Exchange Therapy for a Patient with Anti-MDA5 Autoantibody-Positive Dermatomyositis Developing Refractory Rapidly Progressive Interstitial Lung Disease

    Noriko Sasaki1, Akira Ishii1, Keigo Shimura1, Azusa Kojima1, Mai Sugiyama2, Yuto Izumi1, Kazuki Hirano1, Sho Sasaki2, Takayoshi Kurabayashi1, Yuji Hosono2, Chiho Yamada2 and Shinji Sato2, 1Tokai University School of Medicine, Isehara, Kanagawa, Japan, 2Tokai University School of Medicine, Isehara, Japan

    Background/Purpose: Dermatomyositis (DM), and particularly the subtype clinically amyopathic DM (CADM), is often associated with fatal rapidly progressive interstitial lung disease (RP-ILD) when anti-melanoma differentiation-associated…
  • Abstract Number: 1990 • ACR Convergence 2020

    Janus Kinase (JAK) Inhibition with Baricitinib in Refractory Juvenile Dermatomyositis

    Hanna Kim1, Lylan Bergeron2, Samantha Dill2, Michelle O'Brien2, Laura Vian3, Minal Jain4, Manuk Manukyan2, Xiaobai Li5, Shajia Lu3, Wanxia L. Tsai3, Kalyani Mishra Thakur6, Yinghui Shi6, Massimo Gadina7, April Brundidge2, Michelle Millwood2, Lisa G. Rider8 and Robert Colbert2, 1Juvenile Myositis Pathogenesis and Therapeutics Unit / NIAMS / National Institutes of Health, Bethesda, MD, 2Pediatric Clinical Trials Unit and Office of Clinical Director, NIAMS, NIH, Bethesda, MD, 3Translational Immunology Section, NIAMS, NIH, Bethesda, MD, 4Rehabilitation Medicine Department, Physical Therapy Section, Clinical Research Center, NIH, Bethesda, MD, 5Biostatistics and Clinical Epidemiology Service, Clinical Center, NIH, Bethesda, MD, 6Office of Clinical Director, NIAMS, NIH, Bethesda, MD, 7National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, 8Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD

    Background/Purpose: Juvenile dermatomyositis (JDM) is a systemic autoimmune disease with a prominent interferon (IFN) signature. Treatment often requires prolonged high-dose steroids and other immunosuppressive medications.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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