ACR Meeting Abstracts

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Abstracts tagged "Dendritic cells"

  • Abstract Number: 1022 • 2018 ACR/ARHP Annual Meeting

    TNF-α Regulates Plasmacytoid Dendritic Cells By Suppressing IFN-α Production and Enhancing Th1 and Th17 Cell Differentiation

    Antonios Psarras1,2,3, Agne Antanaviciute4, Ian Carr4, Miriam Wittmann1,2, Paul Emery1,5, George C Tsokos6 and Edward M Vital1,2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, 4Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom, 5Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 6Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: Human plasmacytoid dendritic cells (pDCs) play a vital role in modulating immune responses. pDCs can produce massive amounts of type I IFNs in response…
  • Abstract Number: 1023 • 2018 ACR/ARHP Annual Meeting

    Plasmacytoid Dendritic Cells That Infiltrate the Lungs Produce Profibrotic Cytokines and Chemokines in Bleomycin-Induced Model of Systemic Sclerosis

    Isela Valera1 and Ram R. Singh2, 1Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA, Los Angeles, CA, 2UCLA, Los Angeles, CA

    Background/Purpose: In bleomycin-induced model of systemic fibrosis and patients with systemic sclerosis, plasmacytoid DC (pDC) are unaffected or reduced systemically (spleen/peripheral blood) but they increase…
  • Abstract Number: 1111 • 2018 ACR/ARHP Annual Meeting

    CBS004, a Novel Monoclonal Antibody Against Bdca-2 Inhibits TLR-Induced Activation of Human pDC in Vitro and In Vivo. a Novel Therapeutic Target for Systemic Sclerosis

    Clarissa Corinaldesi1, Yasser M El-Sherbiny2, Gemma Migneco3, Rebecca Ross1, Steve Holmes4, Clive McKimmie5 and Francesco Del Galdo1, 1Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom, 3Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom, 4Capella Biosciences, LTD, London, United Kingdom, 5Virus Host Interactions Team, Section of Infection and Immunity, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Human plasmacytoid dendritic cells (pDCs) have been implicated in the pathogenesis of Systemic Sclerosis (SSc) through their ability to infiltrate the skin and secrete…
  • Abstract Number: 2082 • 2018 ACR/ARHP Annual Meeting

    ERAP1 Deficiency Partially Relieves HLA-B27-Induced ER Stress and IL-23 Expression, but Does Not Restore Dendritic Cell Function in Experimental Spondyloarthritis

    Tri Tran1, Vance Holt2, Tejpal Gill1, Joshua R. Bennett2, Joel Taurog3 and Robert Colbert4, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, 4National Institute of Arthritis and Musculuskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: Preliminary results suggest that endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) deficiency partially protects HLA-B27/human b2m transgenic (B27-Tg) rats from spondyloarthritis (SpA) as evidenced by…
  • Abstract Number: 2121 • 2018 ACR/ARHP Annual Meeting

    Serum High Type I Interferon Is Associated with Active Proliferative Lupus Nephritis in Lupus Patients Accompanied with High Interferon Signature Gene Expression and Plasmacytoid Dendritic Cell Infiltration in Lupus Nephritis Kidney

    Taro Iwamoto1, Jessica M. Dorschner2, Mark A. Jensen1, Shanmugapriya Selvaraj3, Danielle Vsetecka2, Shreyasee Amin2, Ashima Makol2, Floranne C. Ernste2, Thomas Osborn2, Kevin Moder2, Vaidehi R. Chowdhary2, Valeria Mezzano4, Peter M. Izmirly5, H. Michael Belmont5, Robert M. Clancy1, Jill P. Buyon1, Ming Wu3, Cynthia A. Loomis3 and Timothy B. Niewold1, 1Colton Center for Autoimmunity, New York University, New York, NY, 2Mayo Clinic College of Medicine, Rochester, MN, 3Department of Pathology, New York University, New York, NY, 4Division of Cardiology, New York University, New York, NY, 5Division of Rheumatology, New York University, New York, NY

    Background/Purpose: Despite recent advancements in immunosuppressive therapies, lupus nephritis (LN) remains one of the most severe organ manifestations in systemic lupus erythematosus (SLE). High type…
  • Abstract Number: 97 • 2018 ACR/ARHP Annual Meeting

    Enhanced IFN-α Production By Plasmacytoid Dendritic Cells Is Associated with Increased Toll-like Receptor 7 Retention in the Lysosomes and Exosure to Type I IFN in Systemic Lupus Erythematosus

    Goh Murayama1, Asako Chiba2, Ayako Makiyama2, Ken Yamaji1, Naoto Tamura1 and Sachiko Miyake2, 1Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Immunology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Type I interferon(IFN) appears to contribute to the development of systemic lupus erythematosus (SLE). Overexpression of type I IFN regulated genes has been reported…
  • Abstract Number: 845 • 2018 ACR/ARHP Annual Meeting

    New Insights in Lupus Dermatitis: Differential Regulation and Roles of Tissue-Resident Dendritic Cell Subsets in the Pathogenesis of Autoimmune Skin Inflammation

    Ram R. Singh, Miguel-Angel Gutierrez, Peter Kim, Darshan Randhawa, Rachael Philips, Jennifer K. King and Anna Eriksson, Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA

    Background/Purpose: Acquired or self antigens in tissues are taken to lymphoid organs to elicit protective immunity or tolerance, respectively. This is accomplished by dendritic cells…
  • Abstract Number: 1018 • 2018 ACR/ARHP Annual Meeting

    Tofacitinib Impairs Monocyte-Derived Dendritic Cell Differentiation in Rheumatoid Arthritis and Psoriatic Arthritis.

    Viviana Marzaioli1, Mary Canavan1, Achilleas Floudas1, Siobhan C. Wade1, Candice Low2, Douglas J. Veale2 and Ursula Fearon1, 1Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 2Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland

    Background/Purpose: Tofacinitib (Pfizer) is an oral Janus kinase inhibitor, recently approved for the treatment of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Although its mechanism…
  • Abstract Number: 4 • 2017 ACR/ARHP Annual Meeting

    Downregulation of microRNAs in Plasmacytoid Dendritic Cells Is Associated with a Type I Interferon Signature in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

    Lucas L. van den Hoogen1, Joel A.G. van Roon2,3, Ruth D.E. Fritsch-Stork4, Cornelis P.J. Bekker1, Aridaman Pandit1, Marzia Rossato5 and Timothy R.D.J. Radstake1, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 3Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: The most prominent alteration in the immune system of patients with SLE is a type I interferon (IFN) signature, which we recently also reported…
  • Abstract Number: 861 • 2017 ACR/ARHP Annual Meeting

    CD11b+Gr1dim tolerogenic Dendritic Cell-like Cells Suppress the Progression of Interstitial Lung Disease in SKG Mice

    Sho Sendo1, Jun Saegusa1, Hirotaka Yamada2, Yoshihide Ichise2, Ikuko Naka3, Yo Ueda2, Takaichi Okano2, Soshi Takahashi4, Kengo Akashi5, Akira Onishi6 and Akio Morinobu4, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 4Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 5Department of Rheumatology and Clinical Immnology, Kobe University Graduate School of Medicine, Kobe, Japan, 6Department for Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    CD11b+Gr1dim tolerogenic Dendritic Cell-like Cells Suppress the Progression of Interstitial Lung Disease in SKG Mice Background/Purpose: SKG mice develop interstitial lung disease (ILD) resembling rheumatoid arthritis-associated…
  • Abstract Number: 1064 • 2017 ACR/ARHP Annual Meeting

    Characterization of Human Tolerogenic Dendritic Cells Generated with Protein Kinase C Inhibitor and Induction from Patients with Autoimmune Diseases

    Hitoshi Hasegawa1, Takuya Matsumoto1, Endy Adnan2, Jun Ishizaki1, Koichiro Suemori1 and Masaki Yasukawa1, 1Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan, 2Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan

    Background/Purpose: Tolerogenic dendritic cells (tDCs) are a promising therapeutic tool for specific induction of immunological tolerance. Human tDCs can be generated ex vivo using various…
  • Abstract Number: 1338 • 2017 ACR/ARHP Annual Meeting

    Important Role of CD11c+ Dendtritic Cells in Inflammatory Arthritis

    Antonia Puchner1, Victoria Saferding1, Michael Bonelli2, Harald Leiss3, Gerhard Krönke4, René Pfeifle5, Josef S. Smolen6, Kurt Redlich7 and Stephan Blüml6, 1Medical University of Vienna, Austria, Vienna, Austria, 2Rheumatology, Medical University of Vienna, Vienna, Austria, 3Rheumatology, Medical University Vienna, Vienna, Austria, 4Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Austria, 5Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 6Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, 7Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…
  • Abstract Number: 1579 • 2017 ACR/ARHP Annual Meeting

    Monocyte-Derived Dendritic Cells (MDDCs) from Spondyloarthritis (SpA) Patients Exhbit a Coordinated Downregulation of the Cholesterol (chol) Biosynthesis Pathway That Relates to Lipid Overload

    Maxime Breban1, Clémence Desjardin2, Emmanuel Chaplais3, Alice Talpin3, Felicie Costantino4, Christophe Hue3, Aude Jobart-Malfait5, Benoit Maury6, Stanislas Grassin-Delyle3, Nelly Bonilla7, Ariane Leboime8, Roula Said Nahal9, Franck Letourneur7, Sébastien Jacques7, Anne Boland10, Jean-François Deleuze10, Gilles Chiocchia11 and Henri-Jean Garchon3,6,12, 1Rheumatology, Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, INSERM UMR1173, Boulogne-Billancourt, France, 2INSERM UMR1173, Montigny-le-Bretonneux, France, 3Inserm U1173, Montigny-le-Bretonneux, France, 4Hôpital Universitaire Ambroise Pare, Paris, France, 5INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, 6University of Versailles Saint-Quentin, Simone Veil school of Health Sciences, Montigny-le-Bretonneux, France, 7Institut Cochin, Inserm U1016, Paris, France, 8Ambroise Paré Hospital Division of Rheumatology, Assistance Publique des Hopitaux de Paris, Boulogne-Billancourt, France, 9Ambroise Paré Hospital, Boulogne-Billancourt, France, 10Centre National de Recherche en Génomique Humaine, Evry, France, 11Service d'Immunologie, Ambroise Paré Hospital, University of Versailles Saint-Quentin-en-Yvelines, Boulogne, France, Boulogne-Billancourt, France, 12Ambroise Paré Hospital Division of Genetics, AP-HP, Boulogne-Billancourt, France

    Background/Purpose: Gene expression studies are useful to investigate the pathogenesis of complex diseases. The critical role of antigen-presenting cells such as dendritic cells (DCs) being…
  • Abstract Number: 1656 • 2017 ACR/ARHP Annual Meeting

    Type I Interferon Drives the Dysregulation of Plasmacytoid and Myeloid Dendritic Cells in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

    Lucas L. van den Hoogen1, Aridaman Pandit1, Giovanni Palla2, Marzia Rossato3, Ruth D.E. Fritsch-Stork4, Joel A.G. van Roon5 and Timothy R.D.J. Radstake1, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Rheumatology and Clinical Immunology, Laboratory of Translational Medicine, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Dendritic cells (DC) are the sentinel cells of the immune system that potently activate T-cells, making them important players in the pathophysiology of systemic…
  • Abstract Number: 1948 • 2017 ACR/ARHP Annual Meeting

    TNF-α Overrides the Ability of RANK Ligand to Induce Osteoclast Differentiation of Classical Circulating Precursors

    Cecilia Ansalone1, Flavia Sunzini1, Caitlin Duncan1, Sabarinadh Chilaka1, Iain B. McInnes2 and Carl S. Goodyear3, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2University of Glasgow, Glasgow, United Kingdom, 3Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: TNF-α is well known to be involved in inflammatory-induced bone destruction. This is widely supported by clinical studies showing reduced bone pathology after anti-TNF-α…
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