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Abstracts tagged "Dendritic cells"

  • Abstract Number: 1404 • ACR Convergence 2020

    Investigating the Dermatomyositis Skin Inflammatory Infiltrate Using Image Mass Cytometry

    Jay Patel1, Spandana Maddukuri2, Yubin Li3, Christina Bax4 and Victoria Werth3, 1University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, 2University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Montville, NJ, 3University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 4University of Pennsylvania, Department of Dermatology, Philadelphia

    Background/Purpose: Dermatomyositis (DM) is a systemic autoimmune disease affecting the skin and muscles, among other organs. The inflammatory infiltrate in skin has not been fully…
  • Abstract Number: 1949 • ACR Convergence 2020

    CB2 Receptor Distribution and Effects of LenabasumTM in Dermatomyositis In Vitro

    Spandana Maddukuri1, Jay Patel2, Christina Bax3, Maria Wysocka3 and Victoria Werth4, 1University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Montville, NJ, 2University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, 3University of Pennsylvania, Department of Dermatology, Philadelphia, 4University of Pennsylvania and Corporal Michael J. Crescenz Veterans Administration Hospital, Philadelphia

    Background/Purpose: Dermatomyositis (DM) patients report poor quality of life due to disease activity and persistent itch. Lenabasum is an oral non-immunosuppressive, non-psychoactive cannabinoid type 2…
  • Abstract Number: 0067 • ACR Convergence 2020

    Functionally Mature CD1c+ Dendritic Cells Contribute to Synovial Inflammation in Rheumatoid Arthritis via STAT3

    Mary Canavan1, Viviana Marzaioli1, Vipul Bhargava2, Sunil Nagpal3, Phil Gallagher4, Conor Hurson5, Ronan Mullan6, Douglas Veale7 and Ursula Fearon1, 1Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, 2Janssen Research & Development, Springhouse, PA, 3Janssen Research & Development, Collegeville, PA, 4St Vincents University Hospital, UCD, Dublin, Ireland, 5St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, 6Adelaide and Meath Hospital, Dublin, Dublin, Ireland, 7EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland

    Background/Purpose: Myeloid Dendritic Cells (DC) are potent antigen presenting cells that can be subdivided into CD141+ and CD1c+ DC. We have previously reported an unacknowledged…
  • Abstract Number: 0075 • ACR Convergence 2020

    CD209+/CD14+ Dendritic Cells Characterization in Rheumatoid versus Psoriasis Arthritis Patients

    Viviana Marzaioli1, Achilleas Floudas2, Mary Canavan1, Siobhán Wade3, Kieran Murray4, Ronan Mullan5, Conor Hurson6, Douglas Veale7 and Ursula Fearon1, 1Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, 2Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Dublin, Ireland, 3Trinity College Dublin, Dublin, Ireland, 4Saint Vincent's University Hospital, Dublin 4, Dublin, Ireland, 5Adelaide and Meath Hospital, Dublin, Dublin, Ireland, 6St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, 7EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland

    Background/Purpose: Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells which are at the interface between innate and adaptive immunity. There are different…
  • Abstract Number: 0770 • ACR Convergence 2020

    Effect of Citrullination on the Processing and Presentation of Rheumatoid Arthritis Autoantigens

    Ashley Curran1, Jonathan Crawford1 and Erika Darrah1, 1Division of Rheumatology, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Citrullinated proteins are hallmark targets of the autoimmune response in rheumatoid arthritis (RA), but the mechanism by which immune tolerance is broken to these self-proteins…
  • Abstract Number: 0786 • ACR Convergence 2020

    A Combination of Dimensionality Reduction Techniques Reveals Novel HLA-DR+ ‘Candidate’ Antigen-Presenting Cell Subsets (cAPC) in Patients with Rheumatoid Arthritis (RA)

    Christian Geier1, Jon Giles1, Samantha Gaines2, Christopher Depender1, Joan Bathon1 and Robert Winchester1, 1Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 2Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York

    Background/Purpose: The presentation of MHC-peptide complexes to T lymphocytes via antigen-presenting cells (APC) is a crucial step in the initiation of immune responses. Dendritic cells…
  • Abstract Number: 58 • 2019 ACR/ARP Annual Meeting

    In Rheumatoid Arthritis (RA) Decreases in Conventional Dendritic Cell Lineages Are Associated with Adverse Measures of Myocardial Function and Expansions of Anomalous HLA-DR+ Myeloid Subsets

    Christian Geier1, Jon Giles 2, Gilad Gibor 3, Joan Bathon 2 and Robert Winchester 3, 1Columbia University, New York, NY, 2Division of Rheumatology, Columbia University, New York, NY, 3Columbia University, New York

    Background/Purpose: Dendritic cells (DC) are specialized antigen-presenting cells (APC) that have a central role in the initiation of immune responses. However, prior studies showed numeric decreases…
  • Abstract Number: 984 • 2019 ACR/ARP Annual Meeting

    Important Role of CD11c+ Cells in Inflammatory Arthritis

    Antonia Puchner1, Elisabeth Simader 1, Victoria Saferding 2, Gerhard Kroenke 3, Rene Pfeifle 4, Daniel Aletaha 1, Josef Smolen 1 and Stephan Blueml 1, 1Medical University of Vienna, Vienna, Austria, 2Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 3Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Austria, 4University Hospital Erlangen, Erlangen, Germany

    Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…
  • Abstract Number: 1064 • 2019 ACR/ARP Annual Meeting

    CD123+ Plasmacytoid Dendritic Cells from Systemic Sclerosis Patients Are Susceptible to the Cytotoxic Activity of Tagraxofusp, a CD123-Targeted Therapy

    Ross Lindsay1, Janice Chen 1, Robert Spiera 2, Jessica Gordon 2, Marie-Dominique Ah Kioon 3, Franck Barrat 3 and Christopher Brooks 1, 1Stemline Therapeutics, New York, 2Hospital for Special Surgery, New York, NY, 3HSS Research Institute, Hospital for Special Surgery, New York

    Background/Purpose: Tagraxofusp is a novel targeted therapy directed to the interleukin-3 receptor (CD123). Tagraxofusp is comprised of human IL-3 recombinantly fused to a truncated diphtheria…
  • Abstract Number: 97 • 2018 ACR/ARHP Annual Meeting

    Enhanced IFN-α Production By Plasmacytoid Dendritic Cells Is Associated with Increased Toll-like Receptor 7 Retention in the Lysosomes and Exosure to Type I IFN in Systemic Lupus Erythematosus

    Goh Murayama1, Asako Chiba2, Ayako Makiyama2, Ken Yamaji1, Naoto Tamura1 and Sachiko Miyake2, 1Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Immunology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Type I interferon(IFN) appears to contribute to the development of systemic lupus erythematosus (SLE). Overexpression of type I IFN regulated genes has been reported…
  • Abstract Number: 845 • 2018 ACR/ARHP Annual Meeting

    New Insights in Lupus Dermatitis: Differential Regulation and Roles of Tissue-Resident Dendritic Cell Subsets in the Pathogenesis of Autoimmune Skin Inflammation

    Ram R. Singh, Miguel-Angel Gutierrez, Peter Kim, Darshan Randhawa, Rachael Philips, Jennifer K. King and Anna Eriksson, Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA

    Background/Purpose: Acquired or self antigens in tissues are taken to lymphoid organs to elicit protective immunity or tolerance, respectively. This is accomplished by dendritic cells…
  • Abstract Number: 1018 • 2018 ACR/ARHP Annual Meeting

    Tofacitinib Impairs Monocyte-Derived Dendritic Cell Differentiation in Rheumatoid Arthritis and Psoriatic Arthritis.

    Viviana Marzaioli1, Mary Canavan1, Achilleas Floudas1, Siobhan C. Wade1, Candice Low2, Douglas J. Veale2 and Ursula Fearon1, 1Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 2Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland

    Background/Purpose: Tofacinitib (Pfizer) is an oral Janus kinase inhibitor, recently approved for the treatment of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Although its mechanism…
  • Abstract Number: 1022 • 2018 ACR/ARHP Annual Meeting

    TNF-α Regulates Plasmacytoid Dendritic Cells By Suppressing IFN-α Production and Enhancing Th1 and Th17 Cell Differentiation

    Antonios Psarras1,2,3, Agne Antanaviciute4, Ian Carr4, Miriam Wittmann1,2, Paul Emery1,5, George C Tsokos6 and Edward M Vital1,2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, 4Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom, 5Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 6Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: Human plasmacytoid dendritic cells (pDCs) play a vital role in modulating immune responses. pDCs can produce massive amounts of type I IFNs in response…
  • Abstract Number: 1023 • 2018 ACR/ARHP Annual Meeting

    Plasmacytoid Dendritic Cells That Infiltrate the Lungs Produce Profibrotic Cytokines and Chemokines in Bleomycin-Induced Model of Systemic Sclerosis

    Isela Valera1 and Ram R. Singh2, 1Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA, Los Angeles, CA, 2UCLA, Los Angeles, CA

    Background/Purpose: In bleomycin-induced model of systemic fibrosis and patients with systemic sclerosis, plasmacytoid DC (pDC) are unaffected or reduced systemically (spleen/peripheral blood) but they increase…
  • Abstract Number: 1111 • 2018 ACR/ARHP Annual Meeting

    CBS004, a Novel Monoclonal Antibody Against Bdca-2 Inhibits TLR-Induced Activation of Human pDC in Vitro and In Vivo. a Novel Therapeutic Target for Systemic Sclerosis

    Clarissa Corinaldesi1, Yasser M El-Sherbiny2, Gemma Migneco3, Rebecca Ross1, Steve Holmes4, Clive McKimmie5 and Francesco Del Galdo1, 1Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom, 3Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom, 4Capella Biosciences, LTD, London, United Kingdom, 5Virus Host Interactions Team, Section of Infection and Immunity, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Human plasmacytoid dendritic cells (pDCs) have been implicated in the pathogenesis of Systemic Sclerosis (SSc) through their ability to infiltrate the skin and secrete…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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