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Abstracts tagged "cytokines"

  • Abstract Number: 2156 • 2016 ACR/ARHP Annual Meeting

    IL-6 and TNF-α Modulate Expressions of Cell Cycle Regulators of Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Kenta Kaneshiro1, Teppei Hashimoto2, Kohsuke Yoshida1, Ayako Nakai1, Naonori Hashimoto1, Kohjin Suzuki1, Koto Uchida1, Yoshiko Kawasaki2, Natsuko Nakagawa3, Nao Shibanuma4, Yoshitada Sakai5 and Akira Hashiramoto6, 1Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, 2Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, 3Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, 4Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, 5Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 6Department of Biophysics, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan

    Background/Purpose:   Iinterleukin(IL)-6 and tumor necrosis factor(TNF)-α play important roles in the pathogenesis of RA, however, it remains unclear how they affect or modulate the…
  • Abstract Number: 1327 • 2016 ACR/ARHP Annual Meeting

    Patients with Chikungunya Fever Have Increased Serum Levels of Proinflamatory Cytokines 

    Andrea Dantas1, Claudia Marques2, Nara Cavalcanti1, Aline Ranzolin1, Laurindo Rocha Jr3, Carolina Andrade1, Paula Toche1, Mariana Luna4, Kamila Vilar5, Pablo Cardoso6, Michelly Pereira7, Moacyr Rêgo7, Angela Duarte8 and Maira Pitta6, 1Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brazil, 2Hospital das Clínicas, Universidade Federal de Pernambuco, Recife - PE, Brazil, 3Rheumatology, Instituto de Medicina Integral Professor Fernando Figueira - IMIP, Recife, Brazil, 4Universidade Federal de Pernambuco, Recife, Brazil, 5Departamento de bioquímica, Laboratório de Imunomodulação e Novas Abordagens Terapêuticas - UFPE, Recife, Brazil, 6Departamento de Bioquímica, Laboratório de Imunomodulação e Novas Abordagens Terapêuticas - UFPE, Recife, Brazil, 7Bioquimica, Laboratório de Imunomodulação e Novas Abordagens Terapêuticas - UFPE, Recife, Brazil, 8Av. Prof. Moraes Rego, s/n, Av. Prof. Moraes Rego, s/n, Recife, Brazil

    Background/Purpose:  Chikungunya fever (CHIK) is an arboviral disease characterized by sudden onset of fever and incapacitating polyarthralgia. Some patients develop chronic articular symptoms but the…
  • Abstract Number: 2259 • 2016 ACR/ARHP Annual Meeting

    Suppression of Monosodium Urate Crystal-Induced Cytokine Production Via Inhibition of Histone Deacetylases 1/2

    Maartje Cleophas1, Tania Crisan2, Charles Dinarello3, M.G. Netea2 and Leo .A.B. Joosten2, 1Department of Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 2Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 3Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO

    Background/Purpose: Acute gout is a highly common and painful form of inflammatory arthritis, occurring mainly in men above the age of 50. The recurring flares…
  • Abstract Number: 1458 • 2016 ACR/ARHP Annual Meeting

    Intraadrenal Dendritic Cells Inhibit Corticosterone Response during Collagen-Induced Arthritis – a Role for IL-1β and CXC Chemokines?

    Hubert Stangl, Christine Wolff, Martin Lesiak and Rainer Straub, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany

    Background/Purpose: In rheumatoid arthritis (RA) and collagen-induced arthritis (CIA) the phenomenon of a relative insufficiency of adrenal glands to produce an adequate amount of anti-inflammatory…
  • Abstract Number: 2284 • 2016 ACR/ARHP Annual Meeting

    Differential Effect of MSU-Crystal Induced Inflammation on Macrophage Polarization

    Rashid Ahmed1, Nicole Yang2, Changqi Sun3 and Anthony M. Reginato3, 1Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, 3Division of Rheumatology, Rhode Island Hosital/The Warren Alpert School of Medicine of Brown University, Providence, RI

    Background/Purpose:  Gouty arthritis is a common inflammatory joint disease that arises in response to the deposition of monosodium urate (MSU) crystals in soft joints, periarticular…
  • Abstract Number: 936 • 2015 ACR/ARHP Annual Meeting

    IL-1 Receptor Antagonist Maintains Intestinal Microbial Homeostasis to Prevent Overt Toll-like Receptor 4-Dependent Intestinal Th17 Differentiation and Autoimmune Arthritis

    Rebecca Rogier1, Tom Ederveen1, Jos Boekhorst2, Harm Wopereis3, Johan Garssen4, Peter van der Kraan5, Sacha van Hijum2, Marije Koenders6, Wim van den Berg6 and Shahla Abdollahi-Roodsaz7,8, 1Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, 2Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, 3Danone Research, Wageningen, Netherlands, 4Danone Nutricia Research, Utrecht, Netherlands, 5Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 6Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 7Medicine, NYU School of Medicine, New York, NY, 8Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Interleukin-1 (IL-1) plays a pivotal role in inflammation and immunity. Activation of IL-1 receptor is physiologically inhibited by the IL-1 receptor antagonist (IL-1Ra). Mice…
  • Abstract Number: 1757 • 2015 ACR/ARHP Annual Meeting

    Absence of Estrogen Receptor Alpha Is Protective Against Nephrotoxic Serum-Induced Nephritis

    Chelsea Corradetti1, Neelakshi Jog2, Michael Madaio3 and Roberto Caricchio4, 1Temple University, Philadelphia, PA, 2Rheumatology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Medicine, Medical College of Georgia, Augusta, GA, 4Medicine, Rheumatology, Temple University, Philadelphia, PA

    Background/Purpose: Glomerulonephritis (GN) is one of the most serious manifestations of systemic lupus erythematous (SLE). Lupus GN is characterized by severe inflammation and necrosis and…
  • Abstract Number: 1023 • 2015 ACR/ARHP Annual Meeting

    Tumor Necrosis Factor-a (TNF-a) and Interferon Gamma Inducible Protein-10 (IP-10) As Predictors of Active Disease Status in Localized Scleroderma

    Kathryn S. Torok1, Jonathan Yabes2, Qi Mi3, Christina Kelsey1 and Kelsey Magee4, 1Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA, 2Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 3Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, 4Pediatrics, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose:   Localized scleroderma has both inflammatory and fibrotic components contributing to its effect on the skin and underlying tissue.   The extent and duration of…
  • Abstract Number: 1924 • 2015 ACR/ARHP Annual Meeting

    Increased Stat1 and Stat 1 Phosphorylation in Patients with Systemic Sclerosis (SSc) 

    Martyna Skwarek, Julia Fantana, Babett Heschel, Martin Aringer and Christoph Kittel, Medicine III, University Medical Center and Faculty of Medicine at the TU Dresden, Dresden, Germany

    Background/Purpose: To analyze Stat1 and phosphorylated Stat1, the interleukin-6 (IL-6) receptor-Stat3 axis, and membrane bound tumor necrosis factor (mTNF) and TNF receptors 1 and 2…
  • Abstract Number: 1071 • 2015 ACR/ARHP Annual Meeting

    Single-Cell RNA Sequencing of Human Podocytes, Endothelial Cells, and Tubular Cells Identifies Markers and Gene Profiles Differentiating Class IV and Class V Renal Disease in Lupus Nephritis

    Evan Der1, Kemal Akat2, Robert Clancy3, Beatrice Goilav4, Anna R. Broder5, H. Michael Belmont6, Peter M. Izmirly7, Nicole Jordan8, Tao Wang9, James Pullman10, Daniel Schwartz10, Ming Wu11, Thomas Tuschl2, Jill P. Buyon3 and Chaim Putterman12, 1Albert Einstein College of Medicine, Bronx, NY, 2Rockefeller University, New York, NY, 3Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 4Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, 5Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 6Hosp for Joint Disease, New York, NY, 7Rheumatology, NYU School of Medicine, New York, NY, 8Montefiore Medical Center, New York, NY, 9Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, 10Pathology, Albert Einstein College of Medicine, Bronx, NY, 11Pathology, New York University School of Medicine, New York, NY, 12Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Currently, classification and treatment decisions in lupus nephritis (LN) are largely based on renal histology. Transcriptome analysis may accurately differentiate types of renal involvement,…
  • Abstract Number: 2076 • 2015 ACR/ARHP Annual Meeting

    Development of Lupus Nephritis: Preclinical Evaluation of Patients Who Subsequently Develop Systemic Lupus Erythematosus Demonstrate Elevation of Select Soluble Mediators Prior to and at Disease Classification in Patients with Nephritis

    Melissa E. Munroe1, Jourdan R. Anderson1, Julie M. Robertson1, Timothy B. Niewold2, George C. Tsokos3, Michael P. Keith4, Joan T. Merrill5, Jill P. Buyon6, John B. Harley7 and Judith A. James8, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 3Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4Walter Reed National Military Medical Center, Bethesda, MD, 5Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 7Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 8Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: SLE is a heterogeneous autoimmune disease marked by immune dysregulation and a spectrum of pathogenic autoantibodies. Why some patients have only moderate symptoms and…
  • Abstract Number: 1104 • 2015 ACR/ARHP Annual Meeting

    Mouse B Cells Require Glucose and Free Fatty Acids As Carbon Sources for Cytokine and Chemokine Secretion

    Doujiao Wu1, Dongyue Huang2, Edward Pearce1 and Alfred Kim2, 1Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, 2Rheumatology, Washington University School of Medicine, Saint Louis, MO

    Background/Purpose: B cells contribute to disease pathophysiology through several mechanisms, including cytokine and chemokine secretion. A wide variety of stimuli can activate B cells including…
  • Abstract Number: 2205 • 2015 ACR/ARHP Annual Meeting

    Inhibition of Dickkopf1 Dampens Anti Osteogenic Effect of Fibroblast-like Synoviocytes

    Eiji Sugiyama, Yusuke Yoshida and Satoshi Yamasaki, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose:   Fibroblast-Like Synoviocytes (FLS) play important roles in RA progression. Previous studies have revealed importance of FLS in osteoclast activation, however, the roles of…
  • Abstract Number: 1139 • 2015 ACR/ARHP Annual Meeting

    Differential Inflammatory Profile in Experimental Models of Arthritis

    Ana C. Ortiz1, Anne Crilly1, Lynette Dunning1, Carmen Huesa1, C. S. Goodyear2, John C. Lockhart1, William R. Ferrell2 and Iain B. McInnes2, 1Institute of Biomedical and Environmental Health Research, University of the West of Scotland, Paisley, United Kingdom, 2Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: While osteoarthritis (OA) in humans is characterized by cartilage degradation, osteophyte formation and joint remodeling, inflammation and synovitis are now recognized to contribute to…
  • Abstract Number: 2465 • 2015 ACR/ARHP Annual Meeting

    Cytokine Profile Comparison of Monogenic and Complex Conditions with Interferon-Regulated Gene Signatures in Chronic Atypical Neutrophilic Dermatosis with Lipodsytrophy and Elevated Temperature (CANDLE), SAVI, Aicardi-Goutieres Syndrome, JDM, and SLE

    Hanna Kim1, Yin Liu2, Adriana Almeida de Jesus1, Robert Wesley3, Yan Huang1, Gina A. Montealegre Sanchez1, Dawn C. Chapelle1, Wanxia L. Tsai4, Massimo G. Gadina4, Frederick W. Miller5, Sarfaraz Hasni6, Adeline Vanderver7, Lisa G Rider5 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, 2Scientific Review Branch, NIAMS, NIH, Bethesda, MD, 3Clinical Center, National Institutes of Health, Bethesda, MD, 4Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 5Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 7Pediatric Neurology, Children's National Medical Center, Washington, DC

    Background/Purpose: An Interferon (IFN) Regulated Gene Signature (IRS) was previously reported in patients with two complex autoimmune diseases, juvenile systemic lupus (JSLE)1  and juvenile dermatomyositis…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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