Abstracts tagged "cytokines"

Abstract Number: 2156 • 2016 ACR/ARHP Annual Meeting
IL-6 and TNF-α Modulate Expressions of Cell Cycle Regulators of Rheumatoid Arthritis Fibroblast-like Synoviocytes
Kenta Kaneshiro¹, Teppei Hashimoto², Kohsuke Yoshida¹, Ayako Nakai¹, Naonori Hashimoto¹, Kohjin Suzuki¹, Koto Uchida¹, Yoshiko Kawasaki², Natsuko Nakagawa³, Nao Shibanuma⁴, Yoshitada Sakai⁵ and Akira Hashiramoto⁶, ¹Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, ²Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, ³Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, ⁴Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁵Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Department of Biophysics, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan
Background/Purpose: Iinterleukin(IL)-6 and tumor necrosis factor(TNF)-α play important roles in the pathogenesis of RA, however, it remains unclear how they affect or modulate the…
Abstract Number: 1327 • 2016 ACR/ARHP Annual Meeting
Patients with Chikungunya Fever Have Increased Serum Levels of Proinflamatory Cytokines
Andrea Dantas¹, Claudia Marques², Nara Cavalcanti¹, Aline Ranzolin¹, Laurindo Rocha Jr³, Carolina Andrade¹, Paula Toche¹, Mariana Luna⁴, Kamila Vilar⁵, Pablo Cardoso⁶, Michelly Pereira⁷, Moacyr Rêgo⁷, Angela Duarte⁸ and Maira Pitta⁶, ¹Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brazil, ²Hospital das Clínicas, Universidade Federal de Pernambuco, Recife - PE, Brazil, ³Rheumatology, Instituto de Medicina Integral Professor Fernando Figueira - IMIP, Recife, Brazil, ⁴Universidade Federal de Pernambuco, Recife, Brazil, ⁵Departamento de bioquímica, Laboratório de Imunomodulação e Novas Abordagens Terapêuticas - UFPE, Recife, Brazil, ⁶Departamento de Bioquímica, Laboratório de Imunomodulação e Novas Abordagens Terapêuticas - UFPE, Recife, Brazil, ⁷Bioquimica, Laboratório de Imunomodulação e Novas Abordagens Terapêuticas - UFPE, Recife, Brazil, ⁸Av. Prof. Moraes Rego, s/n, Av. Prof. Moraes Rego, s/n, Recife, Brazil
Background/Purpose: Chikungunya fever (CHIK) is an arboviral disease characterized by sudden onset of fever and incapacitating polyarthralgia. Some patients develop chronic articular symptoms but the…
Abstract Number: 2259 • 2016 ACR/ARHP Annual Meeting
Suppression of Monosodium Urate Crystal-Induced Cytokine Production Via Inhibition of Histone Deacetylases 1/2
Maartje Cleophas¹, Tania Crisan², Charles Dinarello³, M.G. Netea² and Leo .A.B. Joosten², ¹Department of Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ³Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO
Background/Purpose: Acute gout is a highly common and painful form of inflammatory arthritis, occurring mainly in men above the age of 50. The recurring flares…
Abstract Number: 1458 • 2016 ACR/ARHP Annual Meeting
Intraadrenal Dendritic Cells Inhibit Corticosterone Response during Collagen-Induced Arthritis – a Role for IL-1β and CXC Chemokines?
Hubert Stangl, Christine Wolff, Martin Lesiak and Rainer Straub, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: In rheumatoid arthritis (RA) and collagen-induced arthritis (CIA) the phenomenon of a relative insufficiency of adrenal glands to produce an adequate amount of anti-inflammatory…
Abstract Number: 2284 • 2016 ACR/ARHP Annual Meeting
Differential Effect of MSU-Crystal Induced Inflammation on Macrophage Polarization
Rashid Ahmed¹, Nicole Yang², Changqi Sun³ and Anthony M. Reginato³, ¹Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ³Division of Rheumatology, Rhode Island Hosital/The Warren Alpert School of Medicine of Brown University, Providence, RI
Background/Purpose: Gouty arthritis is a common inflammatory joint disease that arises in response to the deposition of monosodium urate (MSU) crystals in soft joints, periarticular…
Abstract Number: 936 • 2015 ACR/ARHP Annual Meeting
IL-1 Receptor Antagonist Maintains Intestinal Microbial Homeostasis to Prevent Overt Toll-like Receptor 4-Dependent Intestinal Th17 Differentiation and Autoimmune Arthritis
Rebecca Rogier¹, Tom Ederveen¹, Jos Boekhorst², Harm Wopereis³, Johan Garssen⁴, Peter van der Kraan⁵, Sacha van Hijum², Marije Koenders⁶, Wim van den Berg⁶ and Shahla Abdollahi-Roodsaz^7,8, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ²Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, ³Danone Research, Wageningen, Netherlands, ⁴Danone Nutricia Research, Utrecht, Netherlands, ⁵Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁷Medicine, NYU School of Medicine, New York, NY, ⁸Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Interleukin-1 (IL-1) plays a pivotal role in inflammation and immunity. Activation of IL-1 receptor is physiologically inhibited by the IL-1 receptor antagonist (IL-1Ra). Mice…
Abstract Number: 1757 • 2015 ACR/ARHP Annual Meeting
Absence of Estrogen Receptor Alpha Is Protective Against Nephrotoxic Serum-Induced Nephritis
Chelsea Corradetti¹, Neelakshi Jog², Michael Madaio³ and Roberto Caricchio⁴, ¹Temple University, Philadelphia, PA, ²Rheumatology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Medicine, Medical College of Georgia, Augusta, GA, ⁴Medicine, Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Glomerulonephritis (GN) is one of the most serious manifestations of systemic lupus erythematous (SLE). Lupus GN is characterized by severe inflammation and necrosis and…
Abstract Number: 1023 • 2015 ACR/ARHP Annual Meeting
Tumor Necrosis Factor-a (TNF-a) and Interferon Gamma Inducible Protein-10 (IP-10) As Predictors of Active Disease Status in Localized Scleroderma
Kathryn S. Torok¹, Jonathan Yabes², Qi Mi³, Christina Kelsey¹ and Kelsey Magee⁴, ¹Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA, ²Department of Medicine, University of Pittsburgh, Pittsburgh, PA, ³Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, ⁴Pediatrics, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Localized scleroderma has both inflammatory and fibrotic components contributing to its effect on the skin and underlying tissue. The extent and duration of…
Abstract Number: 1924 • 2015 ACR/ARHP Annual Meeting
Increased Stat1 and Stat 1 Phosphorylation in Patients with Systemic Sclerosis (SSc)
Martyna Skwarek, Julia Fantana, Babett Heschel, Martin Aringer and Christoph Kittel, Medicine III, University Medical Center and Faculty of Medicine at the TU Dresden, Dresden, Germany
Background/Purpose: To analyze Stat1 and phosphorylated Stat1, the interleukin-6 (IL-6) receptor-Stat3 axis, and membrane bound tumor necrosis factor (mTNF) and TNF receptors 1 and 2…
Abstract Number: 1071 • 2015 ACR/ARHP Annual Meeting
Single-Cell RNA Sequencing of Human Podocytes, Endothelial Cells, and Tubular Cells Identifies Markers and Gene Profiles Differentiating Class IV and Class V Renal Disease in Lupus Nephritis
Evan Der¹, Kemal Akat², Robert Clancy³, Beatrice Goilav⁴, Anna R. Broder⁵, H. Michael Belmont⁶, Peter M. Izmirly⁷, Nicole Jordan⁸, Tao Wang⁹, James Pullman¹⁰, Daniel Schwartz¹⁰, Ming Wu¹¹, Thomas Tuschl², Jill P. Buyon³ and Chaim Putterman¹², ¹Albert Einstein College of Medicine, Bronx, NY, ²Rockefeller University, New York, NY, ³Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ⁵Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, ⁶Hosp for Joint Disease, New York, NY, ⁷Rheumatology, NYU School of Medicine, New York, NY, ⁸Montefiore Medical Center, New York, NY, ⁹Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, ¹⁰Pathology, Albert Einstein College of Medicine, Bronx, NY, ¹¹Pathology, New York University School of Medicine, New York, NY, ¹²Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Currently, classification and treatment decisions in lupus nephritis (LN) are largely based on renal histology. Transcriptome analysis may accurately differentiate types of renal involvement,…
Abstract Number: 2076 • 2015 ACR/ARHP Annual Meeting
Development of Lupus Nephritis: Preclinical Evaluation of Patients Who Subsequently Develop Systemic Lupus Erythematosus Demonstrate Elevation of Select Soluble Mediators Prior to and at Disease Classification in Patients with Nephritis
Melissa E. Munroe¹, Jourdan R. Anderson¹, Julie M. Robertson¹, Timothy B. Niewold², George C. Tsokos³, Michael P. Keith⁴, Joan T. Merrill⁵, Jill P. Buyon⁶, John B. Harley⁷ and Judith A. James⁸, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Walter Reed National Military Medical Center, Bethesda, MD, ⁵Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁷Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: SLE is a heterogeneous autoimmune disease marked by immune dysregulation and a spectrum of pathogenic autoantibodies. Why some patients have only moderate symptoms and…
Abstract Number: 1104 • 2015 ACR/ARHP Annual Meeting
Mouse B Cells Require Glucose and Free Fatty Acids As Carbon Sources for Cytokine and Chemokine Secretion
Doujiao Wu¹, Dongyue Huang², Edward Pearce¹ and Alfred Kim², ¹Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, ²Rheumatology, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: B cells contribute to disease pathophysiology through several mechanisms, including cytokine and chemokine secretion. A wide variety of stimuli can activate B cells including…
Abstract Number: 2205 • 2015 ACR/ARHP Annual Meeting
Inhibition of Dickkopf1 Dampens Anti Osteogenic Effect of Fibroblast-like Synoviocytes
Eiji Sugiyama, Yusuke Yoshida and Satoshi Yamasaki, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Fibroblast-Like Synoviocytes (FLS) play important roles in RA progression. Previous studies have revealed importance of FLS in osteoclast activation, however, the roles of…
Abstract Number: 1139 • 2015 ACR/ARHP Annual Meeting
Differential Inflammatory Profile in Experimental Models of Arthritis
Ana C. Ortiz¹, Anne Crilly¹, Lynette Dunning¹, Carmen Huesa¹, C. S. Goodyear², John C. Lockhart¹, William R. Ferrell² and Iain B. McInnes², ¹Institute of Biomedical and Environmental Health Research, University of the West of Scotland, Paisley, United Kingdom, ²Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: While osteoarthritis (OA) in humans is characterized by cartilage degradation, osteophyte formation and joint remodeling, inflammation and synovitis are now recognized to contribute to…
Abstract Number: 2465 • 2015 ACR/ARHP Annual Meeting
Cytokine Profile Comparison of Monogenic and Complex Conditions with Interferon-Regulated Gene Signatures in Chronic Atypical Neutrophilic Dermatosis with Lipodsytrophy and Elevated Temperature (CANDLE), SAVI, Aicardi-Goutieres Syndrome, JDM, and SLE
Hanna Kim¹, Yin Liu², Adriana Almeida de Jesus¹, Robert Wesley³, Yan Huang¹, Gina A. Montealegre Sanchez¹, Dawn C. Chapelle¹, Wanxia L. Tsai⁴, Massimo G. Gadina⁴, Frederick W. Miller⁵, Sarfaraz Hasni⁶, Adeline Vanderver⁷, Lisa G Rider⁵ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, ²Scientific Review Branch, NIAMS, NIH, Bethesda, MD, ³Clinical Center, National Institutes of Health, Bethesda, MD, ⁴Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁵Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁶National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁷Pediatric Neurology, Children's National Medical Center, Washington, DC
Background/Purpose: An Interferon (IFN) Regulated Gene Signature (IRS) was previously reported in patients with two complex autoimmune diseases, juvenile systemic lupus (JSLE)1 and juvenile dermatomyositis…

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