Abstracts tagged "cytokines"

Abstract Number: 2712 • 2016 ACR/ARHP Annual Meeting
Inverse Correlation Between IL-10-Producing Bregs and IFN-Gamma-Producing NK Cells in Psoriatic Arthritis and Psoriasis
Athanasios Mavropoulos¹, Areti Varna¹, Christos Liaskos¹, Efterpi Zafiriou², Marianna Vlychou³, Christina Katsiari⁴, Dimitrios Bogdanos⁵ and Lazaros I. Sakkas⁶, ¹Department of Rheumatology, School of Health Sciences, University of Thessaly, Larissa, Greece, ²Dermatology, University of Thessaly, Larissa, Greece, ³Radiology, University of Thessaly, Larissa, Greece, ⁴Department of Rheumatology, University of Thessaly, Larrisa, Thessaly, Greece, ⁵Department of Rheumatology, University of Thessaly, Larissa, Greece, ⁶University, Athens, Greece
Background/Purpose: A recent study from our group has shown functional impairment and numerical decrease of transitional and memory IL-10-producing regulatory B cells (Bregs) in patients…
Abstract Number: 480 • 2016 ACR/ARHP Annual Meeting
Local Cryotherapy Down-Regulates Local and Systemic IL-6/IL-17 Pathway with No Effect on TNF-α in Adjuvant-Induced Arthritis
Xavier Guillot^1,2, Hélène Martin¹, Katy Maguin-Gaté¹, Stéphanie Py³, Céline Demougeot¹, Daniel Wendling⁴ and Nicolas Tordi⁵, ¹EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, ²EA 4267 FDE, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France, ³INSERM-CIC 1431, Besançon University Hospital, Besançon, France, Besançon, France, ⁴Rheumatology, Besançon university hospital, Besançon, France, ⁵EA 4267 FDE, FHU INCREASE,, Bourgogne Franche-Comté University, Besançon, France
Background/Purpose: Cryotherapy is widely and empirically used in an adjuvant and symptomatic setting in inflammatory rheumatic diseases, with a low level of evidence [1]. The aim…
Abstract Number: 1606 • 2016 ACR/ARHP Annual Meeting
Metrotexate Treatment Inmunomodulate the Abnormal Cytokine Expression Present in NaïVe Rheumatoid Arthritis Patients
Jorge Monserrat Sanz¹, Ana Maria Gómez Lahoz¹, Maria Dolores Sosa Reina¹, Cristina Bohórquez Heras², Atusa Movasat², Ana Pérez Gómez², Lucía Ruiz Gutiérrez², Ana Sánchez Atrio², Eduardo Cuende Quintana², M José León², David Diaz³, Fernando Albarrán Hernández² and Melchor Alvarez-Mon^2,3, ¹Medicine and Medical Specialities, Laboratory of Immune System Diseases, Department of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain, ²University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcalá de Henares, Madrid, Spain, ³Laboratory of Immune System Diseases, Department of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain
Background/Purpose: Methotrexate (MTX) is the most commonly used DMARD in rheumatoid arthritis (RA) patients. Since the first reports of the efficacy of low-dose MTX in…
Abstract Number: 2926 • 2016 ACR/ARHP Annual Meeting
Rorc Positive Th17, Th17/Th1, and Th17.1 Cells from the Blood of Treatment NaïVe RA Patients Differ in IL-17A but Are All Pathogenic When Co-Cultured with RA Synovial Fibroblasts
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar², Wendy Dankers³, Patrick Asmawidjaja², Anne-Marie Otten-Mus² and Erik Lubberts², ¹Room Nb-84, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Background/Purpose: T cells play a central role in the early stages of rheumatoid arthritis (RA). In this context, we have shown increased proportions of memory…
Abstract Number: 486 • 2016 ACR/ARHP Annual Meeting
IRF5 Promotes Arthritis but Restricts Virus Replication and Spread during Chikungunya Virus Infection
Jonathan Miner¹, Amber Smith², Raeann Shimak² and Michael Diamond³, ¹Internal Medicine / Rheumatology, Washington University in Saint Louis School of Medicine, Saint Louis, MO, ²Washington University in Saint Louis School of Medicine, Saint Louis, MO, ³Medicine / Infectious Diseases, Washington University in Saint Louis School of Medicine, Saint Louis, MO
Background/Purpose: Chikungunya virus (CHIKV) is an arthritogenic alphavirus that invades the joints and causes chronic arthritis in up to 60% of infected individuals. Over the…
Abstract Number: 1658 • 2016 ACR/ARHP Annual Meeting
Regulatory Role of the IL-9/IL-9R System on Pannus Formation in Psoriatic Arthritis
Siba P. Raychaudhuri^1,2 and Smriti K. Raychaudhuri³, ¹Davis, CA, ²Rheumatology, Univ of California, Davis & VAMC Sacramento, Davis, CA, ³Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA
Background/Purpose: Earlier we have reported that synovial tissues of psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are enriched with the Th9 cells along…
Abstract Number: 3006 • 2016 ACR/ARHP Annual Meeting
IFN-Gamma (IFNγ), IFNγ-Induced Chemokines and Other Biomarkers in Macrophage Activation Syndrome (MAS)
Claudia Bracaglia¹, Denise Pires Marafon², Ivan Caiello², Kathy de Graaf³, Florence Guilhot³, Walter Ferlin³, Sergio Davì⁴, Grant Schulert⁵, Angelo Ravelli⁴, Alexei Grom⁶, Robert Nelson³, Cristina de Min³ and Fabrizio De Benedetti¹, ¹Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy, Rome, Italy, ²Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Italy, ³NovImmune S.A., Geneva, Switzerland, ⁴Istituto Giannina Gaslini, Genoa, Italy, ⁵Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Evidence in animals and humans points to a pivotal role of IFNγ in primary HLH. We have recently generated data in an animal model…
Abstract Number: 583 • 2016 ACR/ARHP Annual Meeting
Associations of Serum Anti-Citrullinated Proteins and Cytokines with Radiographic Scores in African-American Rheumatoid Arthritis Patients
Dongmei Sun¹, William H Robinson², Xiangqin Cui³, Vincent A. Laufer⁴, Maria I. Danila⁵, Richard J. Reynolds⁶, Chander Raman⁷, Stephanie Ledbetter⁸, Alexander Szalai⁹ and S. Louis Bridges Jr.⁹, ¹Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸1825 University Blvd., University of Alabama at Birmingham, Birmingham, AL, ⁹Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Serum anti-citrullinated proteins (ACPA, including anti-CCP antibodies) and rheumatoid factor (RF) are critical diagnostic markers for RA, and are associated with more severe radiographic…
Abstract Number: 1824 • 2016 ACR/ARHP Annual Meeting
Mycophenolate Mofetil Use Associates with Unique Biologic Changes in B Cell and T Regulatory Cell Pathways in SLE Patients
Samantha Slight-Webb¹, Rufei Lu², Krista M. Bean¹, Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge⁵ and Judith A. James⁶, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: The management of systemic lupus erythematosus (SLE) is complicated by a heterogeneous clinical presentation. Currently, mycophenolate mofetil (MMF) is a commonly used medication to…
Abstract Number: 3107 • 2016 ACR/ARHP Annual Meeting
Switching from Anabolic to Catabolic Metabolism – a Novel Immunomodulatory Therapy in RA
Zhen Yang¹, Yi Shen¹, Eric L. Matteson², Ebru Hosgur¹, Jison Hong³, Jorg Goronzy⁴ and Cornelia M. Weyand¹, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Medicine/Immunology & Rheumatology, Stanford University, Palo Alto, CA, ⁴Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Inflammatory activity in RA relies on numerous anabolic processes; including cellular proliferation, cell trafficking, secretion of proinflammatory cytokines and release of antibodies. Lasting reversal…
Abstract Number: 633 • 2016 ACR/ARHP Annual Meeting
High Similarity Between Ex-Vivo Inhibited Cytokine Profiling By Golimumab and Adalimumab As a Putative Explanation for Inferior Treatment Response to Golimumab after Adalimumab Failure in Rheumatoid Arthritis
L. Tweehuysen¹, K. Schraa², M.G. Netea³, F.H.J. van den Hoogen^4,5, L.A.B. Joosten³ and A.A. den Broeder⁴, ¹Sint Maartenskliniek, Nijmegen, Netherlands, ²Internal Medicine, Radboudumc, Nijmegen, Netherlands, ³Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ⁴Department of Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ⁵Rheumatology, Radboudumc, Nijmegen, Netherlands
Background/Purpose: Better prediction of treatment response to biologics in rheumatoid arthritis (RA) would contribute to optimal individualized treatment. Clinical data suggest that the response of…
Abstract Number: 1862 • 2016 ACR/ARHP Annual Meeting
Modelling Healthy and Scleroderma Fibrotic Skin in Vitro: Mechanical Stress Alters Macrophage Cytokine Expression and Triggers Signalling Via the Mechano-Sensing Transcription Factor Myocardin-Related Transcription Factor-a
Angela Tam¹, Shiwen Xu¹, Henry Lopez¹, Korsa Khan², Bahja Ahmed Abdi³, Henrique Rosario⁴, Nikita Arumalla², Mark Gibson², Christopher Denton², David Abraham², Barbara D Smith⁵ and Richard J Stratton², ¹Division of Medicine, Centre for Rheumatology and Connective tissue disease, University College London, London, United Kingdom, ²Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ³Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁴Division of Medicine, Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Skin involvement is one of the most prominent clinical features in scleroderma. There is a marked contrast in mechanical stiffness between healthy forearm skin…
Abstract Number: 690 • 2016 ACR/ARHP Annual Meeting
Increase in Serum Leptin Levels Is Associated with Radiographic Progression of Male Patients with Ankylosing Spondylitis: A 2-Year Longitudinal Study
Seung-Geun Lee¹, Eun-Kyoung Park², Ji-Heh Park¹, Hee-Sang Tag³ and Geun-Tae Kim⁴, ¹Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, ⁴Kosin University College of Medicine, Busan, South Korea
Background/Purpose: The immunomodulatory effects of adipokines have been extensively studied in rheumatic diseases, there is a paucity of information regarding their effects on bone metabolism.…
Abstract Number: 1881 • 2016 ACR/ARHP Annual Meeting
Targeting Oncostatin M in the Target Tissue: Assessment of in-Vivo Affinity and Target Engagement of an Anti-OSM Monoclonal Antibody By Combining Blood and Skin Blister Fluid Data
Juliet Reid¹, Stefano Zamuner², Ken Edwards³, Sally Rumley⁴, Katherine Sully⁵, Maria Feeney⁶, Subramanya Kumar⁷, Disala Fernando⁷ and Nicolas Wisniacki¹, ¹ImmunoImflammation, GlaxoSmithKline, Stevenage, United Kingdom, ²Clinical Pharmacology, GlaxoSmithKline, Stevenage, United Kingdom, ³Statistics, GlaxoSmithKline, Stevenage, United Kingdom, ⁴Clinical Platforms and Sciences, GlaxoSmithKline, Stevenage, United Kingdom, ⁵Biopharm Translational Medicine, GlaxoSmithKline, Stevenage, United Kingdom, ⁶Biopharm Research, GlaxoSmithKline, Stevenage, United Kingdom, ⁷Clinical Unit Cambridge, GlaxoSmithKline, Cambridge, United Kingdom
Background/Purpose: Oncostatin M (OSM) is a pleiotropic member of the gp130/IL-6 cytokine family involved in pathological processes of fibrosis, inflammation and vasculopathy. Diffuse cutaneous systemic…
Abstract Number: 923 • 2016 ACR/ARHP Annual Meeting
Retinoic Acid Inhibits Expression of Interleukin 9 By Altering Enhancer Architecture
Daniella Schwartz¹, Francoise Meylan², Hong-Wei Sun³, Han-Yu Shih⁴, Kan Jiang⁴, Franziska Petermann⁴, Richard M. Siegel⁵, Arian Laurence⁶ and John J O'Shea⁷, ¹NIAMS - Rheumatology, National Institutes of Health, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴NIAMS, Rheumatology, National Institutes of Health, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ⁶University of Oxford, Oxford, United Kingdom, ⁷NIAMS NIH, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: Vitamin A and its major metabolite, retinoic acid (ATRA), modulate T cell function and fitness to shape immune responses. Vitamin A deficiency causes increased…

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