Abstracts tagged "cytokines"

Abstract Number: 466 • 2017 ACR/ARHP Annual Meeting
Plasma Cytokines at Diagnosis May Predict Non-Response to Methotrexate in Patients with Early Rheumatoid Arthritis
Martin Pelletier¹, Paul R. Fortin^1,2, Marie-Pier Longchamps¹, Geneviève Parent¹, Hadrien Benk-Fortin¹, Anne-Sophie Julien³, Nathalie Amiable¹, Emmanuelle Rollet-Labelle¹, Laetitia Michou², Louis Bessette² and Philippe A. Tessier¹, ¹Infectious Diseases and Immunity Research Division, CHU de Québec-Université Laval Research Center, Québec, QC, Canada, ²Division of Rheumatology, Department of Medicine, CHU de Québec-Université Laval, Québec, QC, Canada, ³Clinical Research Platform, CHU de Québec-Université Laval Research Center, Québec, QC, Canada
Background/Purpose: Methotrexate (MTX) is the first line treatment for patients with rheumatoid arthritis (RA). For over 30% of patients, MTX fails to diminish DAS28 score…
Abstract Number: 1793 • 2017 ACR/ARHP Annual Meeting
Interleukin-17 Is Not a Determinant for the Pro- or Anti-Inflammatory Character of Interleukin-22 in Experimental Arthritis
Debbie M. Roeleveld¹, Loreto Parga Vidal², Monique M. Helsen², Birgitte Walgreen³, Bianka Marklein⁴, Karl Skriner⁵, Martin Hegen⁶, Peter L. van Lent², Fons A.J. van de Loo², Wim B. van den Berg², Peter M. van der Kraan² and Marije I. Koenders², ¹Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Experimental, Radboud university medical center, Nijmegen, Netherlands, ⁴Humboldt University and Free University, Berlin, Germany, ⁵Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, ⁶Inflammation and Immunology Research Unit, Pfizer, Cambridge, MA
Background/Purpose: High interleukin-22 (IL-22) levels are detected in serum and synovial fluid of rheumatoid arthritis (RA) patients and have been shown to positively correlate with…
Abstract Number: 2794 • 2017 ACR/ARHP Annual Meeting
Apolipoprotein B Binds to Enolase-1 and Aggravates Inflammation in Rheumatoid Arthritis
Joo Youn Lee¹, Min Jueng Kang¹, Ji Yong Choi², Ji Soo Park³, Jin Kyun Park^1,2, Eun Young Lee⁴, Eun Bong Lee⁵, Thomas Pap⁶, Eugene Yi¹ and Yeong Wook Song^1,2, ¹Department of Molecular medicine and biopharmaceutical science, Seoul National University, seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, Korea, Republic of (South), ³Department of Molecular medicine and biopharmaceutical science, Seoul National University, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University, seoul, Korea, Republic of (South), ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and joint destruction. Monocytes and synovial macrophages are key players in…
Abstract Number: 565 • 2017 ACR/ARHP Annual Meeting
Fatigue in Primary Sjögren’s Syndrome (pSS) Is Associated with Lower Levels of Proinflammatory Cytokines: A Validation Study
Kristen Davies¹, Kamran Mirza¹, Jessica Tarn², Nadia Howard Tripp³, Robert J. Moots⁴, Nagui Gendi⁵, Michele Bombardieri⁶, Costantino Pitzalis⁶, Nurhan Sutcliffe⁶, Simon Bowman⁷, Neil J. McHugh⁸, John McLaren⁹, Devesh Mewar¹⁰, David Coady¹¹, Kirsten MacKay¹², Susan Knight¹³, Monica Gupta¹⁴, Marian Regan¹⁵, Cathy Lawson¹⁶, Jacqueline Andrews¹⁷, Peter Lanyon¹⁸, Mohammed Akil¹⁹, Elizabeth Price²⁰, Annie Cooper²¹, Frances Hall²², Theodoros Dimitroulas²³, Gavin Clunie²⁴, Saravanan Vadivelu²⁵, Ian Giles²⁶, Bhaskar Dasgupta²⁷, Steve Young-Min²⁸, Dennis Lendrem^29,30 and Wan-Fai Ng^2,31, ¹Institute of Cellular Medicine, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, ²Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, ³Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-upon-Tyne, United Kingdom, ⁴University of Liverpool, Liverpool, UK, Liverpool, United Kingdom, ⁵Basildon and Thurrock University Hospital, Basildon, UK, Basildon, United Kingdom, ⁶Barts Health NHS Trust & Barts and the London School of Medicine & Dentistry, London, UK, London, United Kingdom, ⁷Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, Birmingham, United Kingdom, ⁸Royal National Hospital for Rheumatic Diseases, Bath, UK, Bath, United Kingdom, ⁹NHS Fife, Kirkcaldy, UK, Kirkcaldy, United Kingdom, ¹⁰Royal Liverpool University Hospital, Liverpool, UK, Liverpool, United Kingdom, ¹¹Sunderland Royal Hospital, Sunderland, UK, Sunderland, United Kingdom, ¹²Torbay Hospital, Torquay, UK, Torquay, United Kingdom, ¹³Macclesfield General Hospital, Macclesfield, UK, macclesfield, United Kingdom, ¹⁴Gartnavel General Hospital, Glasgow, UK, Glasgow, United Kingdom, ¹⁵Royal Derby Hospital, Derby, UK, Derby, United Kingdom, ¹⁶Harrogate District Hospital, Harrogate, UK, Harrogate, United Kingdom, ¹⁷Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom, ¹⁸Nottingham University Hospitals NHS Trust, Nottingham, UK, Nottingham, United Kingdom, ¹⁹Royal Hallamshire Hospital, Sheffield, UK, Sheffield, United Kingdom, ²⁰Great Western Hospital, Swindon, UK, Swindon, United Kingdom, ²¹Royal Hampshire County Hospital, Winchester, UK, Winchester, United Kingdom, ²²Addenbrooke’s Hospital, Cambridge, UK, Cambridge, United Kingdom, ²³Dudley Group of Hospitals NHS Foundation Trust, Dudley, UK, Dudley, United Kingdom, ²⁴Ipswich Hospital NHS Trust, Ipswich, UK, Ipswich, United Kingdom, ²⁵Queen Elizabeth Hospital, Gateshead, UK, Gateshead, United Kingdom, ²⁶Centre for Rheumatology, University College London, Centre for Rheumatology, University College London, UK, London, United Kingdom, ²⁷Rheumatology, Southend University Hospital NHS Foundation Trust, Southend, UK, Westcliff-on-Sea, United Kingdom, ²⁸Queen Alexander Hospital, Portsmouth, UK, Portsmouth, United Kingdom, ²⁹Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle, United Kingdom, ³⁰Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-upon-Tyne, United Kingdom, ³¹Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune rheumatic disease causing various symptoms including dryness, fatigue and pain. Previous work by our group has…
Abstract Number: 1794 • 2017 ACR/ARHP Annual Meeting
Overexpression of Interleuk-22 Induces Expression of the Negative Immune-Regulator SOCS3 and Potently Reduces Collagen-Induced Arthritis in Mice
Debbie M. Roeleveld¹, Monique M. Helsen², Birgitte Walgreen³, Elly Vitters², Fons A.J. van de Loo², Peter L. van Lent², Wim B. van den Berg², Peter M. van der Kraan² and Marije I. Koenders², ¹Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Experimental, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: High interleukin-22 (IL-22) levels are detected in serum and synovial fluid of rheumatoid arthritis (RA) patients and have been shown to positively correlate with…
Abstract Number: 2801 • 2017 ACR/ARHP Annual Meeting
Effects of Anti-IL17 Blockade with Secukinumab on Systemic and Local Immune Responses: A Mechanism-of-Action Study in Peripheral Spondyloarthritis
Leonieke van Mens¹, Marleen van de Sande², Silvia Menegatti³, Iris Blijdorp¹, Jet de Jong², Inka Fluri⁴, Talia Latuhihin¹, Arno van Kuijk⁵, Nataliya Yeremenko⁴ and Dominique Baeten¹, ¹AMC, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Immunology, Immunoregulation Unit, Institut Pasteur, Paris, France, ⁴Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, ⁵Reade, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands
Background/Purpose: IL-17A blockade is an effective therapy for AS and PsA, the prototypical forms of spondyloarthritis(SpA). How IL-17A blockade affects the systemic and local immune…
Abstract Number: 652 • 2017 ACR/ARHP Annual Meeting
Investigating the Role of Mechanical Stress in Spondyloarthritis Pathogenesis
Breanna Nguyen¹, Robert Colbert² and Gerlinde Layh-Schmitt¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD
Background/Purpose: Mechanotransduction is a cell’s ability to translate mechanical stimuli into biochemical signals and has been implicated in signaling pathways involving differentiation and proliferation. Mechanical…
Abstract Number: 1844 • 2017 ACR/ARHP Annual Meeting
Circulating Cytokine Profiles Reflect ANCA Specificity in Patients with ANCA-Associated Vasculitis
Alvise Berti¹, Roscoe Warner², Kent Johnson³, Divi Cornec⁴, Darrell Schroder⁵, Brian Kabat⁵, Peter A. Merkel⁶, Carol A. Langford⁷, Gary S. Hoffman⁸, Cees G.M. Kallenberg⁹, Philip Seo¹⁰, Robert F. Spiera¹¹, Eugene St. Clair¹², John H. Stone¹³, Ulrich Specks¹⁴ and Paul A. Monach¹⁵, ¹Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, ²University of Michigan Medical School, Ann Arbor,, MI, ³University of Michigan Medical School, Ann Arbor, MI, ⁴Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁵Mayo Clinic, Rochester, MN, ⁶Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ⁷Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁸Rheumatology, Cleveland Clinic, Cleveland, OH, ⁹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ¹⁰Medicine, Johns Hopkins University, Baltimore, MD, ¹¹Rheumatology, Hospital for Special Surgery, New York, NY, ¹²Department of Medicine, Duke University Medical Center, Durham, NC, ¹³Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ¹⁴Mayo Clinic College of Medicine, Rochester, MN, ¹⁵Boston University School of Medicine, Boston, MA
Background/Purpose: To evaluate serum cytokine and chemokine profiles in patients with ANCA-associated vasculitis (AAV) classified by ANCA specificity (proteinase 3 (PR3)-ANCA versus myeloperoxidase (MPO)-ANCA) or…
Abstract Number: 658 • 2017 ACR/ARHP Annual Meeting
Functionally Active MAIT Cells in Psoriatic Arthritis: A New Member of the IL-23/IL-17 Cytokine Network
Siba P. Raychaudhuri¹ and Smriti K. Raychaudhuri², ¹Rheumatology Section, Sacramento Veterans Affairs Medical Center, Sacramento, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA
Background/Purpose: The mucosal-associated invariant T (MAIT) cells recently have been implicated in autoimmune diseases. Murine model experiments also suggest that MAIT cells are capable…
Abstract Number: 1936 • 2017 ACR/ARHP Annual Meeting
Bimekizumab Blocks T Cell-Mediated Osteogenic Differentiation of Periosteal Stem Cells: Coupling Pathological Bone Formation to IL-17A and IL-17F Signaling
Mittal Shah^1,2, Ash Maroof¹, Rawiya Al-Hosni², Panagiotis Gikas³, Neil Gozzard¹, Stevan Shaw¹ and Scott Roberts^1,2, ¹UCB Pharma, Slough, United Kingdom, ²University College London, London, United Kingdom, ³The Royal National Orthopaedic Hospital, London, United Kingdom
Background/Purpose: Structural tissue damage, as a result of pathological bone formation, is a major cause of disability in spondyloarthritis (SpA). A paucity of in vitro…
Abstract Number: 758 • 2017 ACR/ARHP Annual Meeting
Identification of Biomarkers Predictive of Pulmonary Arterial Hypertension in Systemic Sclerosis
Kathleen D. Kolstad¹, Tyson Holmes², Yael Rosenberg-Hasson², Andrew Sweatt³, Roham T. Zamanian⁴, Shufeng Li⁵, Virginia D. Steen⁶, Paul J. Utz⁷ and Lorinda Chung⁸, ¹Rheumatology, Stanford University Medical Center, Stanford, CA, ²Stanford University Medical Center, Stanford, CA, ³Medicine, Division of Pulmonary and Critical Care, Stanford University Medical Center, Stanford, CA, ⁴Stanford University Medical Center, Palo Alto, CA, ⁵Dermatology, Stanford University School of Medicine, Stanford, CA, ⁶Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ⁷Medicine, Stanford University School of Medicine, Stanford, CA, ⁸Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular abnormalities, immune system dysregulation, and fibrosis. Pulmonary arterial hypertension (PAH) affects approximately 10% of…
Abstract Number: 2132 • 2017 ACR/ARHP Annual Meeting
Angiogenesis and VEGF-Expressing Cells Are Identified Predominantly in the Fascia Rather Than the Muscle in the Early Phase of Dermatomyositis
Ken Yoshida^1,2, Haruyasu Ito¹, Kazuhiro Furuya¹, Taro Ukichi¹, Kentaro Noda¹ and Daitaro Kurosaka¹, ¹Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, ²Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Background/Purpose: We previously showed that fasciitis is a frequent manifestation of the disease in dermatomyositis (DM) but not in polymyositis (PM) and that DM-associated fasciitis…
Abstract Number: 960 • 2017 ACR/ARHP Annual Meeting
ADAM-17 Is Expressed on Rheumatoid Arthritis Synovial Fibroblasts and Mediates Monocyte Migration and Adhesion
Sho Ishii, Takeo Isozaki, Airi Nishimi, Shinichiro Nishimi, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: A disintegrin and metalloproteinase 17 (ADAM-17), also known as tumor necrosis factor-α converting enzyme (TACE), have been reported to be involved in a number…
Abstract Number: 2135 • 2017 ACR/ARHP Annual Meeting
ADAM-17 Is Expressed in the Inflammatory Myopathy, and Is Involved with Interstitial Lung Disease
Airi Nishimi, Takeo Isozaki, Shinichiro Nishimi, Sho Ishii, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: A disintegrin and metalloprotesase (ADAM) family is protease that is thought to have an important role in tissue destruction and inflammatory reaction. ADAMs are…
Abstract Number: 962 • 2017 ACR/ARHP Annual Meeting
Role of Syndecans in Cytokine Mediated Inflammation in Rheumatoid Arthritis Synovial Fibroblasts
Solomon Agere¹, Nahid Akhtar¹, David Fox² and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Department of Medicine [Division of Rheumatology], University of Michigan Medical System, Ann Arbor, MI
Background/Purpose: Syndecans (SDCs) are type-I transmembrane proteoglycans that prominently interact with heparan sulfate, extracellular matrix (ECM) components and glycoproteins. The present study was carried out…

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