Abstracts tagged "cytokines"

Abstract Number: 919 • 2019 ACR/ARP Annual Meeting
Free Interlukin-18: A New Promising Biomarker for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome
Shima Yasin¹, Emiliana Rodriguez ², Thuy Do ³, Elizabeth Baker ¹, Sanjeev Dhakal ³, Scott Canna ⁴, Cem Gabay ⁵, Alexei A. Grom ³ and Grant Schulert ³, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, ²Rheumatology, Geneva University Hospitals and University of Geneva, Switzerland, Geneva, Swaziland, ³Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴UPMC Children's Hospital of Pittsburgh, Pittsburgh, ⁵Rheumatology, Geneva University Hospitals and University of Geneva, Switzerland, Geneva, Switzerland
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation, and is associated with high risk of macrophage activation syndrome (MAS).…
Abstract Number: 1062 • 2019 ACR/ARP Annual Meeting
Lymphocyte Subset Abnormalities in Early Diffuse Cutaneous Systemic Sclerosis
David Fox¹, Steven Lundy ², Michael Whitfield ³, Veronica Berrocal ⁴, Phillip Campbell ⁵, Stephanie Rasmussen ⁵, Ray Ohara ⁶, Alexander Stinson ⁶, Evan Wiewiora ⁷, Cathie Spino ⁷, Erica Bush ⁸, Daniel Furst ⁹, Shiv Pillai ¹⁰ and Dinesh Khanna ¹¹, ¹Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI, ²SystImmune, Inc., Redmond, WA, ³Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hannover, NH, ⁴Department of Biostatistics, School of Publich Health, University of Michigan, Ann Arbor, MI, ⁵Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁶Washington University, St. Louis, MO, ⁷Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, ⁸Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁹University of California, Los Angeles, CA, ¹⁰Ragon Institude of MGH, MIT and Harvard, Charlestown, MA, ¹¹Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor
Background/Purpose: A variety of abnormalities in lymphocyte surface markers and functional subsets have been described in patients with systemic sclerosis (SSc), but conflicting results abound,…
Abstract Number: 1536 • 2019 ACR/ARP Annual Meeting
A Novel MK2 Inhibitor for the Treatment of Ankylosing Spondylitis and Other Inflammatory Diseases
Francisco Ramírez-Valle¹, Mary Adams ¹, Lisa Beebe ², Jian Chen ¹, Claudio Chuaqui ¹, Jamie Connarn ¹, Alan Corin ¹, Karen Dingley ¹, J. Michael Ellis ¹, Rajula Gaur ¹, Lawrence Hamann ¹, John Malona ¹, Kofi Mensah ¹ and Maria Palmisano ¹, ¹Celgene Corporation, Summit, NJ, ²Celgene Corporation, Cambridge, MA
Background/Purpose: Post-transcriptional control of cytokine and chemokine gene expression is an important checkpoint during inflammation. The MAPKAPK2 (MK2) pathway in particular is critical in regulating…
Abstract Number: 1703 • 2019 ACR/ARP Annual Meeting
Increased Levels of IL-2 and IL-4 Promote Th17/Treg Immune Imbalance in Patients with Behcet’s Disease
Yue Liu¹, Yan Yang ¹, Rui Su ², Xinyu Zheng ³, Xiao-feng Li ⁴ and Cai-hong Wang ⁵, ¹Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China (People's Republic), ²Department of Rheumatology, the Second Hospital of Shanxi Medical University, Tai yuan, Shanxi, China (People's Republic), ³Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan , Shanxi, China, Tai Yuan, China (People's Republic), ⁴The Second Hospital of Shanxi Medical University, Taiyuan, China (People's Republic), ⁵The Second Hospital of Shanxi Medical University, Tai Yuan, China (People's Republic)
Background/Purpose: Behcet’s disease(BD) is a multisystem inflammatory disorder of unknown etiology.Improved understandings indicate the Th17/Treg immune imbalance may play a critical role in BD's pathogenesis,…
Abstract Number: 1764 • 2019 ACR/ARP Annual Meeting
CCL25, a Novel Fibroblast and Macrophage Chemoattractant That Potentiates RA Bone Erosion
Sadiq Umar¹, Katrien Raemdonck ¹, Karol Palasiewicz ¹, Michael Volin ², Shiva Arami ¹, Suncica Volkov ¹, Nadera Sweiss ¹, M Amin ³ and Shiva shahrara ¹, ¹University of Illinois at chicago, Chicago, IL, ²Department of Microbiology & Immunology, Midwestern University, Downer Grove, IL, ³University of Michigan, Ann Arbor, MI
Background/Purpose: Background/Purpose: CCL25 and its receptor CCR9 have been detected in the inflamed joint; however their role is undefined in rheumatoid arthritis (RA). Hence studies…
Abstract Number: 1772 • 2019 ACR/ARP Annual Meeting
Chronotherapy Using Baricitinib Attenuates Collagen-induced Arthritis in Mice
Arisa Yaekura¹, Kanta Morii ², Yuto Oketani ³, Ikumi Okumura ², Kenta Kaneshiro ⁴, Kohsuke Yoshida ², Yoshiko Kawasaki ⁵, Nao Shibanuma ⁵, Yoshitada Sakai ⁶ and Akira Hashiramoto ², ¹Kobe University Graduate School of Health Sciences, Kawanishi, Hyogo, Japan, ²Kobe University Graduate School of Health Sciences, Kobe, Hyogo, Japan, ³Kobe University Graduate School of Health Sciences, Himeji, Hyogo, Japan, ⁴Kobe University Graduate School of Health Sciences, Osaka, Osaka, Japan, ⁵Kobe Kaisei Hospital, Kobe, Hyogo, Japan, ⁶Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
Background/Purpose: Diurnal variations are observed in symptoms of rheumatoid arthritis (RA). Among them, “morning stiffness of joints” is closely reflects the daily medical condition of…
Abstract Number: 2418 • 2019 ACR/ARP Annual Meeting
Tofacitinib Inhibits Increased Inflammatory Marker Expression in a Human Salivary Cell Line Deficient in Autophagy: A Model of Sjögren’s Syndrome
María José Barrera ¹, Sergio Aguilera², Patricia Carvajal ³, Isabel Castro ⁴, Sergio González ⁵, Claudio Molina ¹, Soledad Matus ⁶, Daniela Jara ³ and María Julieta González ³, ¹Facultad de Odontología, Universidad San Sebastián, Santiago, Chile, ²Clínica INDISA, Santiago, Chile, ³ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile, ⁴Departamento Tecnología Médica, Universidad de Chile, Santiago, Chile, ⁵Escuela de Odontología, Universidad Mayor, Santiago, Chile, ⁶Fundación Ciencia & Vida, Santiago, Chile, Santiago, Chile
Background/Purpose: Sjögren’s syndrome (SS) is an immune-mediated exocrinopathy, where defects in autophagy could contribute to the pathogenesis. Minor labial salivary glands (MLSG) of primary SS…
Abstract Number: 2527 • 2019 ACR/ARP Annual Meeting
Cytokine and Autoantibody Profiles During Treatment with Belimumab in Patients with Systemic Lupus Erythematosus
Ioannis Parodis¹, Emil Åkerström ¹, Christopher Sjöwall ², Azita Sohrabian ³, Andreas Jönsen ⁴, Alvaro Gomez ¹, Martina Frodlund ², Agneta Zickert ¹, Anders Bengtsson ⁴, Johan Rönnelid ³ and Iva Gunnarsson ¹, ¹Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden, ³Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁴Lund University, Lund, Sweden
Background/Purpose: The anti-BAFF monoclonal belimumab is approved for the treatment of systemic lupus erythematosus (SLE) since 2011. Effects of belimumab on anti-double stranded (ds)DNA levels,…
Abstract Number: 155 • 2018 ACR/ARHP Annual Meeting
Polyfunctional Synovial T-Cell Responses and Synovial Invasiveness Repressed By Blockade of Phosphodiesterase 4
Sarah M. Wade¹, Mary Canavan¹, Trudy McGarry¹, Siobhan C. Wade¹, Ronan Mullan², Douglas J. Veale³ and Ursula Fearon¹, ¹Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ²Department of Rheumatology,, Tallaght Hospital, Dublin, Ireland, ³Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland
Background/Purpose: Genetic and functional studies strongly support the role of T-cells in PsA pathophysiology. Effective targeting of T-cells requires a detailed understanding of their phenotypic…
Abstract Number: 1743 • 2018 ACR/ARHP Annual Meeting
Serum Markers Potentially Associated with PAH in Systemic Sclerosis; A Targeted Screening Approach
Anders Heiervang Tennøe¹, Håvard Fretheim², Oyvind Midtvedt², Torhild Garen², Thor Ueland³, Pål Aukrust², Arne K Andreassen², Einar Gude², Øyvind Molberg² and Anna-Maria Hoffmann-Vold², ¹Rheumatology, Oslo University Hospital, Oslo, Norway, ²Oslo University Hospital, Oslo, Norway, ³Research Institute of Internal Medicine Research, Oslo University Hospital, Oslo, Norway
Background/Purpose: Pulmonary arterial hypertension (PAH) is a feared complication in systemic sclerosis (SSc). Detection of PAH at a preclinical stage is important as early diagnosis…
Abstract Number: 809 • 2018 ACR/ARHP Annual Meeting
The Lymphangiogenetic Factors VEGF-C, CCL21 and Ang-2 Are Associated with Pulmonary Arterial Hypertension in Systemic Sclerosis
Henriette Didriksen¹, Håvard Fretheim¹, Vyacheslav Palchevskiy², Arne K Andreassen¹, Torhild Garen¹, Oyvind Midtvedt¹, Einar Gude¹, John A Belperio³, Øyvind Molberg¹ and Anna-Maria Hoffmann-Vold¹, ¹Oslo University Hospital, Oslo, Norway, ²University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Systemic sclerosis (SSc) is characterized by abnormalities in vascular pathways and lymphatic vessels with pulmonary hypertension as a major complication. Vascular endothelial growth factor…
Abstract Number: 1938 • 2018 ACR/ARHP Annual Meeting
A Phase IIb Dose-Ranging Study of Anti-GM-CSF with Methotrexate Treatment in Patients with Rheumatoid Arthritis (RA) and an Inadequate Response to Methotrexate
Chris Buckley¹, Jesus A Simon Campos², Sergey Yakushin³, Vyacheslav Zhdan⁴, Katherine Davy⁵, David Inman⁶, Elena Fisheleva^7,8, Anubha Gupta⁸, Mark Layton⁹, Nina Mitchell^7,8, Jatin Patel¹⁰, Russell Williamson⁶ and Paul-Peter Tak¹¹, ¹University of Birmingham, Birmingham, United Kingdom, ²Hospital CEM/BIOCEM, Merida, Mexico, ³Ryazan Regional Clinical Cardiology Dispensary, Ryazan, Russian Federation, ⁴M.V.Sklifosovskyi Poltava Regional Clinical Hospital, Poltava, Ukraine, ⁵Statistics, GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, ⁶GlaxoSmithKline, Stockley Park, United Kingdom, ⁷Currently at Biomarin UK Ltd, London, United Kingdom, ⁸GlaxoSmithKline, Stevenage, United Kingdom, ⁹ImmunoInflammation, ImmunoInflammation, GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, ¹⁰ImmunoInflammation, GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, ¹¹University of Cambridge, Cambridge and GlaxoSmithKline, Stevenage, United Kingdom
Background/Purpose: GSK3196165 is a high-affinity anti-GM-CSF cytokine IgG mAb currently in development for RA, with reported efficacy using IV dosing. This study evaluated the efficacy…
Abstract Number: 842 • 2018 ACR/ARHP Annual Meeting
Interleukin 17 Receptor D (IL-17RD) Is Regulated By Pro-Inflammatory Cytokines and Plays a Role in the Development of Collagen-Induced Arthritis
M Molendijk¹, A Otten-Mus², P Asmawidjaja³, Dominique Baeten⁴ and Erik Lubberts⁵, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology and Clinical Immunology, AMC, Amsterdam, Netherlands, ⁵Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: Interleukin-17 Receptor D (IL-17RD) otherwise known as similar expression of fibroblast growth factor genes (SEF) is often described as an inhibitor of multiple signaling…
Abstract Number: 2040 • 2018 ACR/ARHP Annual Meeting
Galectin-3 Is a Regulator of 4-1BB/CD137 Activity and Associates with Outcome in Rheumatoid Arthritis.
Morten Aagaard Nielsen¹, Tue Wenzel Kragstrup², Kristian Stengaard-Pedersen³, Kim Hørslev-Petersen⁴, Merete Lund Hetland⁵, Mikkel Østergaard⁶, Peter Junker⁷, Malene Hvid⁸, Ulf Nilsson⁹, John Stegmayr¹⁰, Hakon Leffler¹¹ and Bent Deleuran¹, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Randers Regional Hospital, Randers, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Department of Clinical Medicine, Aarhus, Denmark, ⁴King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, ⁵Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, The DANBIO Registry, Glostrup, Denmark, ⁶Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ⁷Department of Rheumatology C, Odense University Hospital, Odense, Denmark, ⁸Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁹Deptment of Chemistry, Center for analysis and Synthesis, Lund, Sweden, ¹⁰Department of Laboratory Medicine, Division of Microbiology, Immunology, and Glycobiology (MIG), Lund University, LUND, Sweden, ¹¹Department of Laboratory Medicine, Division of Microbiology, Immunology and Glycobiology - MIG, Lund University, LUND, Sweden
Background/Purpose: Galectin-3 (Gal-3) and the co-stimulatory T cell receptor and glycoprotein 4-1BB are both considered important in inflammation and immune responses. This had led to…
Abstract Number: 844 • 2018 ACR/ARHP Annual Meeting
Differential Roles of Tnfα-TNFR1 and Tnfα-TNFR2 in the Differentiation and Function of Induced CD4+Foxp3+ Treg Cells in Autoimmune Diseases
SONGGUO ZHENG¹, Su-juan Yang², Julie Wang¹ and Rayford June¹, ¹Medicine, Milton S. Hershey Medical School at Penn State University, HERSHEY, PA, ²Medicine, The Third Affiliated Hospital at Sun Yat-sen University, Guangzhou, China
Background/Purpose: Tumor Necrosis Factor (TNF) α exerts it pro-inflammatory or anti-inflammatory function. This study hypothesizes that TNFα has multi-function through binding the different receptor 1…

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