Abstracts tagged "cytokines"

Abstract Number: 73 • 2017 ACR/ARHP Annual Meeting
Regulation of Th17 Cell Responses By IL-25
Sophie Archer, Ash Maroof, Meryn Griffiths and Stevan Shaw, UCB Pharma, Slough, United Kingdom
Background/Purpose: IL-17A is a Th17 proinflammatory cytokine that contributes to the pathophysiology of several immune-mediated inflammatory diseases including PsA; while previously underestimated, there is increasing…
Abstract Number: 1672 • 2017 ACR/ARHP Annual Meeting
Cytokines and Autoantibody Cluster-Interaction in Systemic Lupus Erythematosus. a Systems Medicine Approach
Julian Barahona-Correa, Yovana Pacheco, Diana M. Monsalve, Manuel Rojas, Yhojan Rodríguez, Juliana Saavedra, Mónica Rodríguez-Jiménez, Ruben Mantilla, Carolina Ramírez-Santana, Nicolás Molano-González and Juan-Manuel Anaya, Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia
Background/Purpose: Evidence supports the existence of different sub-phenotypes and the pivotal role of cytokines and autoantibodies in systemic lupus erythematosus (SLE). Cytokines interact in a…
Abstract Number: 2598 • 2017 ACR/ARHP Annual Meeting
The Effects of Tai Chi on Inflammatory Mediator Secretion in Systemic Lupus Erythematosus
Juliette Yedimenko¹, Evelyn Thomas², Brian Snoad³, Juhi Sharma², Misha Mobeen², Holly Steigelman¹, Alexa Meara⁴, Giancarlo R. Valiente⁵, Stacy P. Ardoin⁶, Nicole Powell⁷, John Sheridan⁷, Wael Jarjour⁸ and Nicholas A. Young³, ¹The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University, Columbus, OH, ³Department of Internal Medicine, Division of Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Internal Medicine/Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Pediatric & Adult Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁷Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, ⁸Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Exercise and psychological stress have been shown to produce opposite effects on immunomodulation. Prior studies in patients with Systemic Lupus Erythematosus (SLE) have demonstrated…
Abstract Number: 81 • 2017 ACR/ARHP Annual Meeting
Selective Inhibition of the Immunoproteasome Subunit LMP7 Is Not Sufficient for Blocking Cytokine Production or Attenuating Progression of Experimental Arthritis
Eric Lowe¹, Janet Anderl¹, R Andrea Fan¹, Henry W. B. Johnson², Christopher J Kirk³ and Tony Muchamuel⁴, ¹Biology, Kezar Life Sciences, South San Francisco, CA, ²Medicinal Chemistry, Kezar Life Sciences, South San Francisco, CA, ³Kezar Life Sciences, South San Francisco, CA, ⁴Pharmacology and Toxicology, Kezar Life Sciences, South San Francisco, CA
Background/Purpose: The proteasome inhibitor (PI) PR-957/ONX 0914 blocks cytokine production in vitro and attenuates disease progression in experimental models of rheumatoid arthritis (RA) (Nature Medicine…
Abstract Number: 1738 • 2017 ACR/ARHP Annual Meeting
The Pattern of Proinflamatory Cytokine Expression By CD4+ T Lymphocytes Segregates the Clinical Response to Methotrexate in Recently Diagnosed Rheumatoid Arthritis Patients
Jorge Monserrat Sanz¹, Ana Maria Gómez Lahoz², Cristina Bohórquez Heras³, Maria Dolores Sosa Reina², Atusa Movasat³, Ana Pérez Gómez³, Lucía Ruiz Gutiérrez³, Ana Sánchez Atrio³, Eduardo Cuende Quintana³, Maria José León³, David Diaz², Fernando Albarrán Hernández³ and Melchor Alvarez-Mon^2,3, ¹Laboratory of Inmune System Diseases, Deparment of Medicine and Medical Specialties. IRYCIS. University of Alcalá. Madrid. Spain, Alcalá de Henares. Madrid, Spain, ²Laboratory of Inmune System Diseases, Deparment of Medicine and Medical Specialties. IRYCIS. University of Alcalá. Madrid. Spain, Alcalá de Henares, Madrid, Spain, ³University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology Department, Alcalá de Henares, Madrid, Spain
Background/Purpose: Mechanisms regulating the autoimmune response in rheumatoid arthritis (RA) are not well understood. However, it is known that T CD4+ lymphocytes play a pivotal…
Abstract Number: 2698 • 2017 ACR/ARHP Annual Meeting
IL-21-mTOR Axis Blocks the Differentiation and Function of SLE Tregs Via Suppression of Autophagy
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Mechanistic target of rapamycin (mTOR) activation has emerged as a prominent mediator of pro-inflammatory T-cell expansion and regulatory T (Treg) cell depletion in systemic…
Abstract Number: 83 • 2017 ACR/ARHP Annual Meeting
Whole Blood Stimulations Identify Elevated T Cell Cytokines and Altered Granulocyte/Dendritic Cell Signaling in SLE Patients with Variable Disease Activity
Samantha Slight-Webb¹, Krista M. Bean¹, Holden T. Maecker², Paul J. Utz³, Judith A. James⁴ and Joel M. Guthridge⁵, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Medicine, Stanford University School of Medicine, Stanford, CA, ⁴Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, OKC, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by loss of immune tolerance to self-antigens and periods of waxing and waning disease. The clinical aspects of…
Abstract Number: 1782 • 2017 ACR/ARHP Annual Meeting
Mycophenolic Acid Decreases IL-10 and IL-6 Production By B Cells of Granulomatosis with Polyangiitis Patients and Healthy Controls in Vitro
Anouk von Borstel¹, Wayel H. Abdulahad², Abraham Rutgers², Judith Land², Coen A. Stegeman¹, Peter Heeringa³ and Jan-Stephan F. Sanders¹, ¹Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Granulomatosis with polyangiitis (GPA) is a relapsing autoimmune disease affecting small- to medium-sized blood vessels. B cells are thought to play an important antibody-independent…
Abstract Number: 2711 • 2017 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T Cells Are an Important Source of TNF in Rheumatoid Arthritis
Diahann Jansen¹, Elizabeth Klinken¹, Hendrik Nel¹, Soi Cheng Law¹, Hester Koppejan², Marjolijn Hameetman³, Ligong Liu⁴, Alexandra Corbett⁵, Sidonia Eckle⁵, David Fairlie⁴, Rene E.M. Toes⁶, Floris van Gaalen⁷, Jamie Rossjohn^8,9,10, James McCluskey⁵ and Ranjeny Thomas¹, ¹The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Australia, ²Department of Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia, ⁵Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia, ⁶Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁷Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁸Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia, ⁹Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, ¹⁰Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
Background/Purpose: CD8+ T cells have been described to comprise up to 40% of the rheumatoid arthritis (RA) synovial T cell compartment but their pathogenic function…
Abstract Number: 466 • 2017 ACR/ARHP Annual Meeting
Plasma Cytokines at Diagnosis May Predict Non-Response to Methotrexate in Patients with Early Rheumatoid Arthritis
Martin Pelletier¹, Paul R. Fortin^1,2, Marie-Pier Longchamps¹, Geneviève Parent¹, Hadrien Benk-Fortin¹, Anne-Sophie Julien³, Nathalie Amiable¹, Emmanuelle Rollet-Labelle¹, Laetitia Michou², Louis Bessette² and Philippe A. Tessier¹, ¹Infectious Diseases and Immunity Research Division, CHU de Québec-Université Laval Research Center, Québec, QC, Canada, ²Division of Rheumatology, Department of Medicine, CHU de Québec-Université Laval, Québec, QC, Canada, ³Clinical Research Platform, CHU de Québec-Université Laval Research Center, Québec, QC, Canada
Background/Purpose: Methotrexate (MTX) is the first line treatment for patients with rheumatoid arthritis (RA). For over 30% of patients, MTX fails to diminish DAS28 score…
Abstract Number: 1793 • 2017 ACR/ARHP Annual Meeting
Interleukin-17 Is Not a Determinant for the Pro- or Anti-Inflammatory Character of Interleukin-22 in Experimental Arthritis
Debbie M. Roeleveld¹, Loreto Parga Vidal², Monique M. Helsen², Birgitte Walgreen³, Bianka Marklein⁴, Karl Skriner⁵, Martin Hegen⁶, Peter L. van Lent², Fons A.J. van de Loo², Wim B. van den Berg², Peter M. van der Kraan² and Marije I. Koenders², ¹Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Experimental, Radboud university medical center, Nijmegen, Netherlands, ⁴Humboldt University and Free University, Berlin, Germany, ⁵Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, ⁶Inflammation and Immunology Research Unit, Pfizer, Cambridge, MA
Background/Purpose: High interleukin-22 (IL-22) levels are detected in serum and synovial fluid of rheumatoid arthritis (RA) patients and have been shown to positively correlate with…
Abstract Number: 2794 • 2017 ACR/ARHP Annual Meeting
Apolipoprotein B Binds to Enolase-1 and Aggravates Inflammation in Rheumatoid Arthritis
Joo Youn Lee¹, Min Jueng Kang¹, Ji Yong Choi², Ji Soo Park³, Jin Kyun Park^1,2, Eun Young Lee⁴, Eun Bong Lee⁵, Thomas Pap⁶, Eugene Yi¹ and Yeong Wook Song^1,2, ¹Department of Molecular medicine and biopharmaceutical science, Seoul National University, seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, Korea, Republic of (South), ³Department of Molecular medicine and biopharmaceutical science, Seoul National University, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University, seoul, Korea, Republic of (South), ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and joint destruction. Monocytes and synovial macrophages are key players in…
Abstract Number: 565 • 2017 ACR/ARHP Annual Meeting
Fatigue in Primary Sjögren’s Syndrome (pSS) Is Associated with Lower Levels of Proinflammatory Cytokines: A Validation Study
Kristen Davies¹, Kamran Mirza¹, Jessica Tarn², Nadia Howard Tripp³, Robert J. Moots⁴, Nagui Gendi⁵, Michele Bombardieri⁶, Costantino Pitzalis⁶, Nurhan Sutcliffe⁶, Simon Bowman⁷, Neil J. McHugh⁸, John McLaren⁹, Devesh Mewar¹⁰, David Coady¹¹, Kirsten MacKay¹², Susan Knight¹³, Monica Gupta¹⁴, Marian Regan¹⁵, Cathy Lawson¹⁶, Jacqueline Andrews¹⁷, Peter Lanyon¹⁸, Mohammed Akil¹⁹, Elizabeth Price²⁰, Annie Cooper²¹, Frances Hall²², Theodoros Dimitroulas²³, Gavin Clunie²⁴, Saravanan Vadivelu²⁵, Ian Giles²⁶, Bhaskar Dasgupta²⁷, Steve Young-Min²⁸, Dennis Lendrem^29,30 and Wan-Fai Ng^2,31, ¹Institute of Cellular Medicine, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, ²Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, ³Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-upon-Tyne, United Kingdom, ⁴University of Liverpool, Liverpool, UK, Liverpool, United Kingdom, ⁵Basildon and Thurrock University Hospital, Basildon, UK, Basildon, United Kingdom, ⁶Barts Health NHS Trust & Barts and the London School of Medicine & Dentistry, London, UK, London, United Kingdom, ⁷Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, Birmingham, United Kingdom, ⁸Royal National Hospital for Rheumatic Diseases, Bath, UK, Bath, United Kingdom, ⁹NHS Fife, Kirkcaldy, UK, Kirkcaldy, United Kingdom, ¹⁰Royal Liverpool University Hospital, Liverpool, UK, Liverpool, United Kingdom, ¹¹Sunderland Royal Hospital, Sunderland, UK, Sunderland, United Kingdom, ¹²Torbay Hospital, Torquay, UK, Torquay, United Kingdom, ¹³Macclesfield General Hospital, Macclesfield, UK, macclesfield, United Kingdom, ¹⁴Gartnavel General Hospital, Glasgow, UK, Glasgow, United Kingdom, ¹⁵Royal Derby Hospital, Derby, UK, Derby, United Kingdom, ¹⁶Harrogate District Hospital, Harrogate, UK, Harrogate, United Kingdom, ¹⁷Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom, ¹⁸Nottingham University Hospitals NHS Trust, Nottingham, UK, Nottingham, United Kingdom, ¹⁹Royal Hallamshire Hospital, Sheffield, UK, Sheffield, United Kingdom, ²⁰Great Western Hospital, Swindon, UK, Swindon, United Kingdom, ²¹Royal Hampshire County Hospital, Winchester, UK, Winchester, United Kingdom, ²²Addenbrooke’s Hospital, Cambridge, UK, Cambridge, United Kingdom, ²³Dudley Group of Hospitals NHS Foundation Trust, Dudley, UK, Dudley, United Kingdom, ²⁴Ipswich Hospital NHS Trust, Ipswich, UK, Ipswich, United Kingdom, ²⁵Queen Elizabeth Hospital, Gateshead, UK, Gateshead, United Kingdom, ²⁶Centre for Rheumatology, University College London, Centre for Rheumatology, University College London, UK, London, United Kingdom, ²⁷Rheumatology, Southend University Hospital NHS Foundation Trust, Southend, UK, Westcliff-on-Sea, United Kingdom, ²⁸Queen Alexander Hospital, Portsmouth, UK, Portsmouth, United Kingdom, ²⁹Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle, United Kingdom, ³⁰Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-upon-Tyne, United Kingdom, ³¹Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune rheumatic disease causing various symptoms including dryness, fatigue and pain. Previous work by our group has…
Abstract Number: 1794 • 2017 ACR/ARHP Annual Meeting
Overexpression of Interleuk-22 Induces Expression of the Negative Immune-Regulator SOCS3 and Potently Reduces Collagen-Induced Arthritis in Mice
Debbie M. Roeleveld¹, Monique M. Helsen², Birgitte Walgreen³, Elly Vitters², Fons A.J. van de Loo², Peter L. van Lent², Wim B. van den Berg², Peter M. van der Kraan² and Marije I. Koenders², ¹Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Experimental, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: High interleukin-22 (IL-22) levels are detected in serum and synovial fluid of rheumatoid arthritis (RA) patients and have been shown to positively correlate with…
Abstract Number: 2801 • 2017 ACR/ARHP Annual Meeting
Effects of Anti-IL17 Blockade with Secukinumab on Systemic and Local Immune Responses: A Mechanism-of-Action Study in Peripheral Spondyloarthritis
Leonieke van Mens¹, Marleen van de Sande², Silvia Menegatti³, Iris Blijdorp¹, Jet de Jong², Inka Fluri⁴, Talia Latuhihin¹, Arno van Kuijk⁵, Nataliya Yeremenko⁴ and Dominique Baeten¹, ¹AMC, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Immunology, Immunoregulation Unit, Institut Pasteur, Paris, France, ⁴Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, ⁵Reade, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands
Background/Purpose: IL-17A blockade is an effective therapy for AS and PsA, the prototypical forms of spondyloarthritis(SpA). How IL-17A blockade affects the systemic and local immune…

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