complement Archives - Page 8 of 10 - ACR Meeting Abstracts

Abstract Number: 1017 • 2018 ACR/ARHP Annual Meeting
Autoantigen Pentraxin-3 Is an Inflammatory Cytokine Storms Suppressor By Switching Monocytes Pyroptosis to Apoptosis in a Complement-Dependent Manner in Rheumatoid Arthritis
Xuan Zhang¹ and Xunyao Wu², ¹Rheumatology, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital, beijing, China
Background/Purpose: A delayed diagnoses and therapy of ACPA (Anti cyclic citrullinated peptide antibody)-negative RA patients might be associated with effective serum biomarkers in clinic. Methods:…
Abstract Number: 1098 • 2018 ACR/ARHP Annual Meeting
Comparative Analysis of the Total Proteome of the Skin Lesions from Cutaneous Lupus Erythematosus (CLE) and Dermatomyositis (DM)
Timothy B. Niewold¹, Alexander Meves², Julia S. Lehman³, Karin Popovic-Silwerfeldt⁴, Cristine Charlesworth⁵, Marie Wahren-Herlenius⁶, Elisabet Svenungsson⁷ and Vilija Oke⁸, ¹Colton Center for Autoimmunity, New York University, New York, NY, ²Cancer Cenetr, Dermatology, Mayo Clinic, Rochester, MN, ³Pathology and Dermatology, Mayo Clinic College of Medicine and Science, Rochester, MN, MN, ⁴Department of Clinical Sciences, Dermatology Clinic, Danderyds Hospital,, Stockholm, Sweden, ⁵Mayo Clinic, Rochester, MN, ⁶Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁷Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ⁸Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Cutaneous lupus erythematosus (CLE) and dermatomyositis (DM) are autoimmune diseases. The histopathological pattern of skin involvement can be similar, i.e. interface dermatitis, but the…
Abstract Number: 1708 • 2018 ACR/ARHP Annual Meeting
Serum Complement Regulatory Proteins and Disease Activity of Systemic Lupus Erythematosus
Min-Hua Tseng¹ and Jing-Long Huang², ¹Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ²Medicine, Chang-Gung University, Taoyuan city, Taiwan
Background/Purpose: Although aberrant complement activation is involved in the pathogenesis of systemic lupus erythematosus (SLE), the role of complement regulatory proteins in disease activity of…
Abstract Number: 2030 • 2018 ACR/ARHP Annual Meeting
Patients with Childhood-Onset SLE (cSLE) and Hypertension Have Consistently Higher Serum Concentrations of C3 and C4 Than Those without Hypertension
Evan Mulvihill¹, Stacy P. Ardoin², Susan D Thompson³, Bi Zhou⁴, Gakit Yu⁵, Nora G. Singer⁶, Deborah M. Levy⁷, Hermine I. Brunner⁸, Yee Ling Wu⁹, Haikady Nagaraja¹⁰, Laura E. Schanberg¹¹ and Chack-Yung Yu², ¹Pediatrics and Rheumatology, Nationwide Children's Hospital, Columbus, OH, ²Division of Rheumatology, Nationwide Children’s Hospital, Columbus, OH, ³Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁵Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ⁶Departments of Medicine and Pediatrics, Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, Cleveland, OH, ⁷Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ⁸Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁹Department of Microbiology and Immunology, Loyola University Chicago, Chicago, IL, ¹⁰College of Public Health, The Ohio State University, Columbus, OH, ¹¹Duke University Medical Center, Durham, NC
Background/Purpose: Chronic systemic inflammation, mediated in part by complement, and inadequate vascular repair mechanisms affect patients with cSLE from a young age and are associated…
Abstract Number: 670 • 2017 ACR/ARHP Annual Meeting
Membrane Attack Complex (MAC) Deposition in Lupus Nephritis Is Associated with Hypertension and Poor Clinical Response to Treatment
Shudan Wang¹, Ming Wu², Luis Chiriboga³, Briana Zeck⁴ and H. Michael Belmont⁵, ¹Department of Medicine, Division of Rheumatology, New York University School Medicine, New York City, NY, ²New York University School of Medicine, New York, NY, ³Pathology, New York University School Medicine, New York, NY, ⁴Pathology, New York University School Medicine, New York City, NY, ⁵Medicine, New York University School of Medicine, New York, NY
Background/Purpose: LN is characterized by deposition of immune complexes in the kidney. Activation of the classical complement pathway by dsDNA is believed to play a…
Abstract Number: 1077 • 2017 ACR/ARHP Annual Meeting
The Lectin Pathway of the Complement System Is Activated in Patients with Systemic Lupus Erythematosus
Anne Troldborg^1,2, Steffen Thiel³, Marten Trendelenburg⁴, Justa Friebus-Kardash⁵, Josephine Nehring⁵, Rudi Steffensen⁶, Søren Werner Karlskov Hansen⁷, Magdalena Janina Laska¹, Bent Deleuran⁸, Jens Christian Jensenius¹, Anne Voss⁹ and Kristian Stengaard-Pedersen¹⁰, ¹Biomedicine, Aarhus University, Aarhus, Denmark, ²clinical medicine, Aarhus University, Aarhus, Denmark, ³Institute of Biomedicine, Aarhus University, Aarhus, DK, Aarhus, Denmark, ⁴Department of Biomedicine, Division of Internal Medicine, Basel, Switzerland, ⁵University Hospital Basel, Division of Internal Medicine, Basel, Switzerland, ⁶Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ⁷Department of Cancer and Inflammation Research, University of Souther Denmark, Odense, Denmark, ⁸Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁹Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁰Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: The pathogenesis of Systemic Lupus Erythematosus (SLE) involves complement activation. It is well established that activation of complement through the classical pathway (CP) and…
Abstract Number: 1671 • 2017 ACR/ARHP Annual Meeting
Complement C4 Gene Copy Number Variations Bestow Large Ranges of Serum C4 Protein Levels in Chinese Patients with Systemic Lupus Erythematosus (SLE) and Contribute to Organ and Cardiovascular Damages over Time
Chi Chiu Mok¹, Emily King², Bi Zhou³, Gakit Yu⁴, Yee Ling Wu⁵ and CHACK-YUNG Yu⁶, ¹Rheumatology, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Pediatrics, Nationwide Children's Hospital, Columbus, OH, ³Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁴Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ⁵Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ⁶Pediatrics, Ohio State Univ, Columbus, OH
Background/Purpose: Human SLE is characterized by fluctuating serum levels of complement proteins. There are frequent copy number variations (CNVs) of complement C4A and C4B genes…
Abstract Number: 1842 • 2017 ACR/ARHP Annual Meeting
Subsetting Systemic Lupus Erythematosus By Interferon Gene Signatures and Serologies (anti-dsDNA and Low Complement) Uncovers Significant Clinical Diversity
Michelle Petri¹, Steven Watts², Richard Higgs², MaryAnn Morgan-Cox² and Matthew D Linnik³, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Eli Lilly and Company, Indianapolis, IN, ³Immunology, Lilly Biotechnology Center, San Diego, CA
Background/Purpose: Personalized therapy in systemic lupus erythematosus (SLE) will require identifying SLE subsets that will benefit from different targeted therapies. Belimumab, for example, has…
Abstract Number: 129 • 2017 Pediatric Rheumatology Symposium
Cell-bound Complement Activation Products Correlate with Disease Activity in Childhood-onset Systemic Lupus Erythematosus
Joyce Hui-Yuen¹, Derren Barken², John Conklin³, Tyler O'Malley⁴, Andrew Eichenfield⁵, Amy Starr⁶, Lisa F. Imundo⁷, Thierry Dervieux⁴ and Anca Askanase⁸, ¹Cohen Children's Medical Center of New York, Lake Success, NY, ²Exagen Diagnostics, Vista, CA, ³1261 Liberty Way Suite C, Exagen Diagnostics, Vista, CA, ⁴Research and Development, Exagen Diagnostics, Vista, CA, ⁵Columbia University Medical Center, New York, NY, ⁶Pediatric Rheumatology, Columbia University Medical Center, New York, NY, ⁷Pediatrics, Columbia University Medical Center, New York, NY, ⁸Rheumatology, Columbia University Medical Center, New York, NY
Background/Purpose: Elevated levels of cell-bound complement activation products (C4d deposition on erythrocytes [EC4d] and B lymphocytes [BC4d], CB-CAPs) have been demonstrated to be sensitive and…
Abstract Number: 149 • 2017 Pediatric Rheumatology Symposium
Deficiency of Complement C4A or Low Copy Number of Total C4 Genes, HLA-DRB1*15 and HLA-DRB1*03 Are Strong Genetic Risk Factors for Pediatric SLE of European Descent
Stacy Ardoin¹, Pinar Ozge Avar Aydin², Lai Hin Kimi Chan³, Katherine Lintner⁴, Yee Ling Wu^5,6, Rabheh Aziz¹, Anjali Patwardhan^7,8, Evan Mulvihill¹, Gakit Yu⁹, Bi Zhou¹⁰, Emeli Lundstrom¹¹, Leonid Padyukov¹², Kyla Driest¹³, Cagri Yildirim-Toruner¹³, Sharon Bout-Tabaku¹³, Charles Spencer¹⁴, Gloria Higgins¹, Sampath Prahalad¹⁵, Hermine Brunner¹⁶ and Chack-Yung Yu^10,17, ¹Pediatrics and Rheumatology, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ²Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Pediatrics, Emory University School of Medicine, Atlanta, GA, ⁴Pediatrics, Nationwide Children's Hospital, Columbus, OH, ⁵The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁶Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ⁷Pediatric Rheumatology, Nationwide Childrens Hospital, Columbus, OH, ⁸Pediatric Rheumatology, Nationwide Children's Hospital, Columbia, MO, ⁹Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ¹⁰Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ¹¹Rheumatology, Karolinska Institute, Stockholm, Switzerland, ¹²Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden, ¹³Rheumatology, Nationwide Children's Hospital, Columbus, OH, ¹⁴Rheumatology, Nationwide Childrens Hospital/OSU, Columbus, OH, ¹⁵Pediatrics, Emory Children's Center, Atlanta, GA, ¹⁶Rheumatology, PRCSG, Cincinnati, OH, ¹⁷Pediatrics, Ohio State Univ, Columbus, OH
Background/Purpose: A complete genetic deficiency of complement C4 almost always leads to the pathogenesis of systemic lupus erythematosus (SLE) with childhood onset, although its prevalence…
Abstract Number: 2958 • 2016 ACR/ARHP Annual Meeting
Hypocomplementemic Urticarial Vasculitis (HUV) Syndrome in Two Geographically Defined Populations of Sweden
Christopher Sjöwall¹, Thomas Mandl² and Aladdin Mohammad^3,4, ¹Linköping University, Department of Clinical and Experimental Medicine Rheumatology/AIR, Linköping, Sweden, ²Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital, Rheumatology, Malmö, Sweden, Malmö, Sweden, ³Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Rheumatology, Lund, Sweden, Lund, Sweden, ⁴Addenbrooke’s Hospital, Vasculitis and Lupus Clinic, Cambridge, UK, Cambridge, United Kingdom
Background/Purpose: Since first described by McDuffie et al. in 1973, hypocomplementemic urticarial vasculitis (HUV) syndrome has been recognized as a specific autoimmune disorder involving at…
Abstract Number: 2992 • 2016 ACR/ARHP Annual Meeting
In Systemic Lupus Erythematosus with Antiphospholipid Antibodies, Hypocomplementemia Associates with Thrombosis
Laura Durcan¹, Wei Fu² and Michelle Petri³, ¹University of Washington, Seattle, WA, ²Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, MD, ³Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Hypocomplementemia is a common phenomenon in systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APS). Robust mechanistic data implicate complement activation in antiphospholipid antibody…
Abstract Number: 282 • 2016 ACR/ARHP Annual Meeting
From ‘immune Mediated Necrotizing Myopathy’ to ‘antibody-Mediated Necrotizing Myositis: Towards the Pathogenic Role of Anti-SRP and Anti-Hmgcr Antibodies’
Yves Allenbach¹, Louiza Arouche-Delaperche², Corinna Preusse³, Gillian Butler Browne², Nicolas Champtiaux⁴, Kuberaka Mariampillai⁵, Aude Rigolet⁶, Peter Hufnagl⁷, Norman Zerbe⁸, Thierry Maisonobe⁹, Damien Amelin², Sarah Leonard-louis¹⁰, Charles Duyckaerts¹¹, Bruno Eymard¹², Hans-Hilmar Goebel³, Laurent Drouot¹³, Olivier Boyer¹⁴, Olivier Benveniste^2,5 and Werner Stenzel³, ¹Pitié-Salpêtrière University Hospital, AP-HP, Department of Internal Medicine and Clinical Immunology, Paris, France, Paris, France, ²Sorbonne Universités UPMC Univ Paris 06, Myology research center, INSERM UMRS974, CNRS FRE3617, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, ³Charité - Universitätsmedizin, Department of Neuropathology, Berlin, Germany, Berlin, Germany, ⁴Department de Internal Medicine and Clinical Immunology, Hôpital Pitié-Salpêtrière, AP-PH, UPMC, Paris, France, ⁵Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Department of Internal Medicine and Clinical Immunology, Hospital University Department: inflammation, immunopathology and biotherapy (DHU i2B), Paris, France, Paris, France, ⁶Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, ⁷Pathology departmen, Charite Hospital, Berlin, Germany, ⁸Department of Pathology, Charite Hospital, Berlin, Germany, ⁹Pitié-Salpêtrière University Hospital, AP-HP, Department of Neuropathology, Paris, France, Paris, France, ¹⁰Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Department of Neuropathology, Paris, France, Paris, France, ¹¹Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ¹²Department of Neurology, Hôpital Pitié-Salpêtrière, AP-PH, UPMC, Paris, France, ¹³Immunology, INSERM U905, University of Rouen, Rouen, France, ¹⁴Immunology, Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France
Background/Purpose: Immune mediated necrotizing myopathy (IMNM) has been recently added as a new entity among dermatomyositis, polymyositis and sporadic inclusion body myositis. IMNM is defined…
Abstract Number: 463 • 2016 ACR/ARHP Annual Meeting
Deficiency of Transmembrane Protein VISTA (V-domain Immunoglobulin Suppressor of T-cell Activation) Ameliorates Murine Collagen-II Antibody-Induced Arthritis
Roy Fava^1,2, Sabrina Ceeraz³, Susan Eszterhas⁴, Petra Sergent³, Christopher Burns⁵ and Mathew Vincenti^6,7, ¹Research, Department of Veterans Affairs, White River Junction, VT, ²Department of Medicinee, Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Microbiology/Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁴Research, Department of Veterans Affairs, white River Junction, VT, ⁵Section of Rheumatology, Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁶Department of Veterans Affairs, White River Junction, VT, ⁷Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH
Background/Purpose: The transmembrane protein VISTA, is a member of the B7/CD28 family of immune modulator proteins and can function as a negative immune checkpoint regulator…
Abstract Number: 751 • 2016 ACR/ARHP Annual Meeting
Complement C4d Split Products on Erythrocytes Are Associated with Composite Measure of Disease Activity in Systemic Lupus Erythematosus Subjects Receiving Methotrexate and Hydroxychloroquine
Michelle Petri¹, Ying Qu², John Conklin³, Kelley Brady⁴, Robert Apilado⁵ and Thierry Dervieux⁶, ¹Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ²Exagen Diagnostics, Vista, CA, ³1261 Liberty Way Suite C, Exagen Diagnostics, Vista, CA, ⁴R&D, Exagen Diagnostics, Vista, CA, United Kingdom, ⁵Exagen Diagnostics, vista, CA, United Kingdom, ⁶Research and Development, Exagen Diagnostics, Vista, CA
Background/Purpose: We evaluated the relationships between disease activity measures and C4d split products on erythrocytes (EC4d) in SLE subjects from a subset of the Hopkins…

Abstracts tagged "complement"

Autoantigen Pentraxin-3 Is an Inflammatory Cytokine Storms Suppressor By Switching Monocytes Pyroptosis to Apoptosis in a Complement-Dependent Manner in Rheumatoid Arthritis

Comparative Analysis of the Total Proteome of the Skin Lesions from Cutaneous Lupus Erythematosus (CLE) and Dermatomyositis (DM)

Serum Complement Regulatory Proteins and Disease Activity of Systemic Lupus Erythematosus

Patients with Childhood-Onset SLE (cSLE) and Hypertension Have Consistently Higher Serum Concentrations of C3 and C4 Than Those without Hypertension

Membrane Attack Complex (MAC) Deposition in Lupus Nephritis Is Associated with Hypertension and Poor Clinical Response to Treatment

The Lectin Pathway of the Complement System Is Activated in Patients with Systemic Lupus Erythematosus

Complement C4 Gene Copy Number Variations Bestow Large Ranges of Serum C4 Protein Levels in Chinese Patients with Systemic Lupus Erythematosus (SLE) and Contribute to Organ and Cardiovascular Damages over Time

Subsetting Systemic Lupus Erythematosus By Interferon Gene Signatures and Serologies (anti-dsDNA and Low Complement) Uncovers Significant Clinical Diversity

Cell-bound Complement Activation Products Correlate with Disease Activity in Childhood-onset Systemic Lupus Erythematosus

Deficiency of Complement C4A or Low Copy Number of Total C4 Genes, HLA-DRB115 and HLA-DRB103 Are Strong Genetic Risk Factors for Pediatric SLE of European Descent

Hypocomplementemic Urticarial Vasculitis (HUV) Syndrome in Two Geographically Defined Populations of Sweden

In Systemic Lupus Erythematosus with Antiphospholipid Antibodies, Hypocomplementemia Associates with Thrombosis

From ‘immune Mediated Necrotizing Myopathy’ to ‘antibody-Mediated Necrotizing Myositis: Towards the Pathogenic Role of Anti-SRP and Anti-Hmgcr Antibodies’

Deficiency of Transmembrane Protein VISTA (V-domain Immunoglobulin Suppressor of T-cell Activation) Ameliorates Murine Collagen-II Antibody-Induced Arthritis

Complement C4d Split Products on Erythrocytes Are Associated with Composite Measure of Disease Activity in Systemic Lupus Erythematosus Subjects Receiving Methotrexate and Hydroxychloroquine