Abstracts tagged "Collagen"

Abstract Number: 129 • 2018 ACR/ARHP Annual Meeting
Rnaseq Analysis of Human Skin in Organ Culture Identifies Collagen 22A1 As a TGF-β Early Response Gene
Tomoya Watanabe¹, Logan Mlakar², Jonathan Heywood³, Willian da Silveira⁴, Gary Hardiman⁵ and Carol A. Feghali-Bostwick⁶, ¹Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumataology, Medical University of South Carolina, Chareston, SC, ⁴Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine, Medical University of South Carolina, Division of Rheumatology and Immunology, Charleston, SC
Background/Purpose: Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysregulation, vasculopathy, and organ fibrosis. Skin fibrosis causes high morbidity and impaired…
Abstract Number: 997 • 2018 ACR/ARHP Annual Meeting
The Effects of the Jak-Stat Signal Pathway Inhibition on Collagen Biosynthesis in Fibroblast Cell Culture
Mehtap ŞAHİN¹, Hüseyin AYDIN¹, Ahmet ALTUN², Mehmet Emin DERİN³ and Ali Şahin⁴, ¹Biochemistry, Cumhuriyet University Medical Faculty, sivas, Turkey, ²Pharmacology, Cumhuriyet University Medical Faculty, sivas, Turkey, ³Rheumatology-internal medicine, Cumhuriyet University Medical Faculty, sivas, Turkey, ⁴Department of Rheumatology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
Background/Purpose: Uncontrolled collagen synthesis and deposition occur in various diseases such as hepatic fibrosis, scleroderma.Tofacitinib is a selective JAK-kinase (1/3)inhibitor.Currently it is used in the…
Abstract Number: 1019 • 2018 ACR/ARHP Annual Meeting
Involvement of Mast Cells in the Pathogenesis of Sjögren’s Syndrome By Induction of Tissue Fibrosis Via Fibroblast Collagen Synthesis
Shinjiro Kaieda¹, Kyoko Fujimoto², Masaki Tominaga³, Masaki Okamoto⁴, Tomoaki Hoshino⁵ and Hiroaki Ida⁶, ¹Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, ²Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, ³Kurume University School of Medicine, Kurume, Japan, ⁴Medicine, Kurume University School of Medicine, Kurume, Japan, ⁵Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, ⁶Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan
Background/Purpose: There is an emerging view that mast cells may play a pivotal role in several inflammatory and autoimmune diseases. However, the role of mast…
Abstract Number: 1045 • 2018 ACR/ARHP Annual Meeting
The Coll2-1 Peptide of Collagen Type II: A New Actor of Synovitis in Osteoarthritis
Cécile Lambert¹, Didier Borderie², Jean-Emile Dubuc³, François Rannou² and Yves Henrotin^4,5, ¹Bone and Cartilage Research Unit, University of Liege, Liege, Belgium, ²Inserm umr 1124, Laboratory of pharmacology, toxicology and cell signaling, University Paris Descartes, Paris, France, ³Orthopaedic Department, University Clinics St Luc, Brussels, Belgium, ⁴Physical Therapy and Rehabilitation, Princess Paola Hospital, Marche-en-Famenne, Belgium, ⁵Bone and Cartilage Research Unit, University of Liege, Liège, Belgium
Background/Purpose: We evaluated the inflammatory effect of Coll2-1 peptide in osteoarthritic synoviocytes and rats by comparing peptide-induced inflammatory reaction with the one induced by bovine…
Abstract Number: 2035 • 2018 ACR/ARHP Annual Meeting
Effect of Baricitinib on Joint-Related Biomarkers in Patients with Moderate-to-Severe Rheumatoid Arthritis
Christian S. Thudium¹, Anne C. Bay-Jensen¹, Suntara Cahya², Ernst R. Dow², Morten A. Karsdal¹, Alisa E. Koch², Wenling Zhang² and Robert J. Benschop², ¹Nordic Bioscience, Herlev, Denmark, ²Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Baricitinib (bari) is an oral selective inhibitor of Janus kinase (JAK) 1 and JAK2. In the phase 3 study RA-BUILD (NCT01721057), once-daily bari yielded…
Abstract Number: 44 • 2018 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target in Patients with Rheumatoid Arthritis
Lisa Goschl¹, Victoria Saferding², Johan Bäcklund³, Clemens Scheinecker⁴, Josef S. Smolen⁵, Günter Steiner⁶, Wilfried Ellmeier¹ and Michael Bonelli⁷, ¹Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, ²Medical University of Vienna, Austria, Vienna, Austria, ³Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁴Medical University of Vienna, Divison of Rheumatology, Vienna, Austria, ⁵Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, ⁶Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Austria, Vienna, Austria, ⁷Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Despite enormous efforts to develop new therapeutic strategies for treatment of rheumatoid arthritis (RA), the large number of non responding patients to currently available…
Abstract Number: 46 • 2018 ACR/ARHP Annual Meeting
Organic Dust Inhalants Shift Immune Responses and Extracellular Matrix Balance between Synovium and Lung in the Collagen-Induced Arthritis Mouse Model
Michael J. Duryee¹, Jill Poole², Amy Nelson³, Katherine Janike², Lynell W. Klassen⁴, James R. O'Dell⁴, Bryant R. England⁵, Ted R. Mikuls⁶ and Geoffrey M. Thiele⁷, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Medicine, University of Nebraska Medical Center, Omaha, NE, ³Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁷University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Emerging evidence suggests that the lungs may be an initiating site of autoimmunity leading to RA with organic inhalant exposures such as those…
Abstract Number: 58 • 2018 ACR/ARHP Annual Meeting
Inhibition of Lipid Phosphatase SHIP1 Expands Myeloid-Derived Suppressor Cells and Attenuates Rheumatoid Arthritis in Mice
Eui Young So¹, Changqi Sun², Patrycja M Dubielecka¹, Anthony M. Reginato³ and Olin D. Liang¹, ¹Division of Hematology/Oncology, Rhode Island Hospital, Providence, RI, ²Division of Rheumatology, Rhode Island Hosital/The Warren Alpert School of Medicine of Brown University, Providence, RI, ³Division of Rheumatology, Rhode Island Hospital, Providence, RI
Background/Purpose: The SH2-containing inositol-5’-phosphatase-1 (SHIP1) controls PI3K initiated signaling by limiting membrane recruitment and activation of AKT. SHIP1 knockout in mice leads to an increase…
Abstract Number: 465 • 2017 ACR/ARHP Annual Meeting
Basement Membrane Remodeling in Rheumatoid Arthritis Associates with Disease Activity, Response to IL-6 Inhibitor Treatment and Radiographic Progression: Analysis of Two Phase III Clinical Trials
Natasja Stæhr Gudman¹, Pernille Juhl¹, Christian S. Thudium², Peter Junker³, Anne Sofie Siebuhr⁴, Inger Byrjalsen¹, Morten Karsdal⁵ and Anne C. Bay-Jensen⁴, ¹Nordic Bioscience, Herlev, Denmark, ²Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Department of Rheumatology C, Odense University Hospital, Odense, Denmark, ⁴Rheumatology, Nordic Bioscience, Herlev, Denmark, ⁵Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) is associated with neovascularization of the synovial membrane and increased risk of cardiovascular co-morbidity. The extra cellular matrix below the endothelial…
Abstract Number: 489 • 2017 ACR/ARHP Annual Meeting
Endotypic Clustering of Rheumatoid Arthritis Patients through the Use of Tissue Specific Serum Biomarkers Identifies Structural Progressors
Joseph Patrick Michele Blair¹, Cecilie Liv Bager¹, Line Mærsk Staunstrup¹, Henning Bay Nielsen¹, Morten Karsdal² and Anne-C. Bay-Jensen³, ¹ProScion, Herlev, Denmark, ²Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ³Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Treatment of RA patients is guided by measures of disease activity such as DAS28, best practice recommendation, and less often by a treat-to-target approach.…
Abstract Number: 762 • 2017 ACR/ARHP Annual Meeting
M10, a Caspase Cleavage Product of the Hepatocyte Growth Factor Receptor, Downregulates Bone Morphogenetic Protein-9-Induced Smad1/5/8 Phosphorylation and Collagen Production in Human Lung Fibroblasts
Atsushi Noguchi, Ilia Atanelishvili, Tanjina Akter, Richard M. Silver and Galina S. Bogatkevich, Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: We recently identified M10, a caspase cleavage product of the hepatocyte growth factor receptor, as an anti-fibrotic peptide that interacts with Smad2 and inhibits…
Abstract Number: 1226 • 2017 ACR/ARHP Annual Meeting
Association of Dorsal Flat Vertebra/Platyspondylia As a Form of Vertebral Dysplasia within Type II Collage Disorders
Pilar Ahijado-Guzman¹, Raul Veiga², Miguel Cantalejo¹, Justo Ruiz³ and Antonio Zapatero³, ¹Rheumatology Unit. Fuenlabrada’s Hospital, Madrid, Madrid, Spain, ²Rheumatology Unit. Fuenlabrada’s Hospital, Madrid, Fuenlabrada, Spain, ³Department of Internal Medicine. Fuenlabrada’s Hospital, Madrid, Madrid, Spain
Background/Purpose: Defects in the type II collagen gene are described. These predispose humans to various phenotypic combinations in families with skeletal dysplasia, and/or disease by…
Abstract Number: 1725 • 2017 ACR/ARHP Annual Meeting
Insulin-like Growth Factor Binding Protein-4 Exerts Anti-Fibrotic Effects and Its Levels Are Reduced in SSc-Associated Lung Fibrosis
Yunyun Su¹, Stanley Hoffman² and Carol A. Feghali-Bostwick³, ¹Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, charleston, SC, ²Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ³Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: The Insulin-like growth factor (IGF) system plays an important role in cellular growth, proliferation, differentiation, apoptosis and transformation; IGF binding proteins (IGFBP) exert cell…
Abstract Number: 1930 • 2017 ACR/ARHP Annual Meeting
Interleukin 1β Decreases Capacity for Repair Human Cartilage Lesions By Mesenchymal Stromal Cells on Collagen/Proteoglycan Scaffolds
Clara Sanjurjo-Rodríguez¹, ROCÍO CASTRO-VIÑUELAS², Tamara Hermida-Gómez³, ISAAC FUENTES BOQUETE⁴, Francisco Javier De Toro Santos⁵, Francisco J Blanco⁶ and SILVIA MARIA DÍAZ-PRADO⁴, ¹of Biomedical Sciences, Medicine and Physiotherapy., Cell Therapy and Regenerative Medicine Group. Universidade da Coruña. INIBIC. CIBER-BBN., A CORUÑA, Spain, ²Biomedical Sciences. Medicine and Physiotherapy, Cell Therapy and Regenerative Medicine Group. Universidade da Coruña. INIBIC., A CORUÑA, Spain, ³Rheumatology, INIBIC. Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. CIBER-BBN., A Coruña, Spain, ⁴Biomedical Sciences, Medicine and Physiotherapy, Cell Therapy and Regenerative Medicine Group. Universidade da Coruña. INIBIC. CIBER-BBN., A CORUÑA, Spain, ⁵Reumatology, Cell Therapy and Regenerative Medicine Group. Universidade da Coruña. INIBIC. CIBER-BBN. Complejo Hospitalario Universitario A Coruña (SERGAS)., La Coruña, Spain, ⁶Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: There is controversy about the effect of catabolic cytokines in regenerative medicine. The purpose of this study was to evaluate the effect of interleukin…
Abstract Number: 2688 • 2017 ACR/ARHP Annual Meeting
Collagen Metabolite Biomarker Levels Are Associated with the Amount of Fibrosis in Internal Organs in Systemic Sclerosis Patients
Anne Sofie Siebuhr¹, Satoshi Kubo², Pernille Juhl³, K Nakano⁴, S Nakayamada⁵, Morten Karsdal⁶, Anne-C. Bay-Jensen⁷ and Yoshiya Tanaka⁸, ¹the first department of internal medicine, University of occupational and environmental health, Fukuoka, Japan, ²The first department of internal medicine, University of Occupational en environmental Health, Fukuoka, Japan, ³Nordic Bioscience, Herlev, Denmark, ⁴the first department of internal medicin, University of occupational and environmental health, fukuoka, Japan, ⁵The first department of internal medicine, University of Occupational and environmental Health, fukuoka, Japan, ⁶Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ⁷Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark, ⁸The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Biomarkers that can monitor the fibrotic burden will aid in trial enrichment and personalized health care in SSc. SSc is associated with internal organ…

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