Abstract Number: 2035 • 2018 ACR/ARHP Annual Meeting
Effect of Baricitinib on Joint-Related Biomarkers in Patients with Moderate-to-Severe Rheumatoid Arthritis
Background/Purpose: Baricitinib (bari) is an oral selective inhibitor of Janus kinase (JAK) 1 and JAK2. In the phase 3 study RA-BUILD (NCT01721057), once-daily bari yielded…Abstract Number: 44 • 2018 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target in Patients with Rheumatoid Arthritis
Background/Purpose: Despite enormous efforts to develop new therapeutic strategies for treatment of rheumatoid arthritis (RA), the large number of non responding patients to currently available…Abstract Number: 46 • 2018 ACR/ARHP Annual Meeting
Organic Dust Inhalants Shift Immune Responses and Extracellular Matrix Balance between Synovium and Lung in the Collagen-Induced Arthritis Mouse Model
Background/Purpose: Emerging evidence suggests that the lungs may be an initiating site of autoimmunity leading to RA with organic inhalant exposures such as those…Abstract Number: 58 • 2018 ACR/ARHP Annual Meeting
Inhibition of Lipid Phosphatase SHIP1 Expands Myeloid-Derived Suppressor Cells and Attenuates Rheumatoid Arthritis in Mice
Background/Purpose: The SH2-containing inositol-5’-phosphatase-1 (SHIP1) controls PI3K initiated signaling by limiting membrane recruitment and activation of AKT. SHIP1 knockout in mice leads to an increase…Abstract Number: 120 • 2018 ACR/ARHP Annual Meeting
An Orally Available Highly Selective 5-Hydroxytryptamine 2B Receptor Antagonist Ameliorating Pulmonary and Dermal Fibrosis in Preclinical Models of Systemic Sclerosis
Background/Purpose: Serotonin or 5-hydroxytryptamine (5-HT) is well known as a stimulator of tissue fibrosis and a significant role of peripheral 5-HT2B receptors in fibrosis has…Abstract Number: 129 • 2018 ACR/ARHP Annual Meeting
Rnaseq Analysis of Human Skin in Organ Culture Identifies Collagen 22A1 As a TGF-β Early Response Gene
Background/Purpose: Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysregulation, vasculopathy, and organ fibrosis. Skin fibrosis causes high morbidity and impaired…Abstract Number: 997 • 2018 ACR/ARHP Annual Meeting
The Effects of the Jak-Stat Signal Pathway Inhibition on Collagen Biosynthesis in Fibroblast Cell Culture
Background/Purpose: Uncontrolled collagen synthesis and deposition occur in various diseases such as hepatic fibrosis, scleroderma.Tofacitinib is a selective JAK-kinase (1/3)inhibitor.Currently it is used in the…Abstract Number: 1019 • 2018 ACR/ARHP Annual Meeting
Involvement of Mast Cells in the Pathogenesis of Sjögren’s Syndrome By Induction of Tissue Fibrosis Via Fibroblast Collagen Synthesis
Background/Purpose: There is an emerging view that mast cells may play a pivotal role in several inflammatory and autoimmune diseases. However, the role of mast…Abstract Number: 465 • 2017 ACR/ARHP Annual Meeting
Basement Membrane Remodeling in Rheumatoid Arthritis Associates with Disease Activity, Response to IL-6 Inhibitor Treatment and Radiographic Progression: Analysis of Two Phase III Clinical Trials
Background/Purpose: Rheumatoid arthritis (RA) is associated with neovascularization of the synovial membrane and increased risk of cardiovascular co-morbidity. The extra cellular matrix below the endothelial…Abstract Number: 489 • 2017 ACR/ARHP Annual Meeting
Endotypic Clustering of Rheumatoid Arthritis Patients through the Use of Tissue Specific Serum Biomarkers Identifies Structural Progressors
Background/Purpose: Treatment of RA patients is guided by measures of disease activity such as DAS28, best practice recommendation, and less often by a treat-to-target approach.…Abstract Number: 762 • 2017 ACR/ARHP Annual Meeting
M10, a Caspase Cleavage Product of the Hepatocyte Growth Factor Receptor, Downregulates Bone Morphogenetic Protein-9-Induced Smad1/5/8 Phosphorylation and Collagen Production in Human Lung Fibroblasts
Background/Purpose: We recently identified M10, a caspase cleavage product of the hepatocyte growth factor receptor, as an anti-fibrotic peptide that interacts with Smad2 and inhibits…Abstract Number: 1226 • 2017 ACR/ARHP Annual Meeting
Association of Dorsal Flat Vertebra/Platyspondylia As a Form of Vertebral Dysplasia within Type II Collage Disorders
Background/Purpose: Defects in the type II collagen gene are described. These predispose humans to various phenotypic combinations in families with skeletal dysplasia, and/or disease by…Abstract Number: 1725 • 2017 ACR/ARHP Annual Meeting
Insulin-like Growth Factor Binding Protein-4 Exerts Anti-Fibrotic Effects and Its Levels Are Reduced in SSc-Associated Lung Fibrosis
Background/Purpose: The Insulin-like growth factor (IGF) system plays an important role in cellular growth, proliferation, differentiation, apoptosis and transformation; IGF binding proteins (IGFBP) exert cell…Abstract Number: 1930 • 2017 ACR/ARHP Annual Meeting
Interleukin 1β Decreases Capacity for Repair Human Cartilage Lesions By Mesenchymal Stromal Cells on Collagen/Proteoglycan Scaffolds
Background/Purpose: There is controversy about the effect of catabolic cytokines in regenerative medicine. The purpose of this study was to evaluate the effect of interleukin…Abstract Number: 2688 • 2017 ACR/ARHP Annual Meeting
Collagen Metabolite Biomarker Levels Are Associated with the Amount of Fibrosis in Internal Organs in Systemic Sclerosis Patients
Background/Purpose: Biomarkers that can monitor the fibrotic burden will aid in trial enrichment and personalized health care in SSc. SSc is associated with internal organ…
ACR Meeting Abstracts