ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "Collagen"

  • Abstract Number: 0062 • ACR Convergence 2024

    Pro-Fibrotic Effects of Malondialdehyde-Acetaldehyde-Adducted and/or Citrullinated Proteins on Macrophages and Human Lung Fibroblasts

    Lauren Klingemann1, Nozima Aripova1, Nigina Aripova2, Michael Duryee1, Carlos Hunter1, Jill Poole1, Bryant England1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2WUSTL, St. Louis, MO

    Background/Purpose: Clinically evident rheumatoid arthritis-associated interstitial lung disease (RA-ILD) affects approximately 10-15% of patients with rheumatoid arthritis (RA) and accounts for the most overrepresented cause…
  • Abstract Number: 0459 • ACR Convergence 2024

    Tocilizumab Demonstrates Superior Inhibition of MMP-Mediated Basement Membrane Collagen Degradation Compared to Methotrexate or Placebo

    Dovile Sinkeviciute1, Sofie Falkenloeve Madsen2, Nicolas Willumsen3, Patryk Drobinski3, Morten Karsdal3 and Anne-Christine Bay-Jensen3, 1Nordic Bioscience, Herlev, Hovedstaden, Denmark, 2University of Copenhagen, Copenhagen N, Denmark, 3Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) pathogenesis involves a range of immune cells, for instance T-cells, neutrophils and macrophages. They produce proinflammatory factors, such as proteolytic enzymes,…
  • Abstract Number: 0957 • ACR Convergence 2024

    Increased Collagen Deposition and Altered Immune Cell Profiles Are Present in Early and Late Stage Systemic Sclerosis with Gastrointestinal Involvement

    Laura Much1, Elena Pachera2, Andrea Laimbacher1, Henriette Didriksen3, Lars Aabakken4, Knut Ea Lundin4, Lumeng Li1, Astrid Hofman1, Pietro Bearzi5, Sophie Wagner6, Michael Scharl7, Øyvind Molberg8, Håvard Fretheim9, Oliver Distler10 and Anna-Maria Hoffmann-Vold9, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2University Hospital Zurich, Zurich, Switzerland, 3Oslo University Hospital, Moss, Norway, 4Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland, 6University of Zurich, Schlieren, Switzerland, 7Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 8Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 9Oslo University Hospital, Oslo, Norway, 10Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland

    Background/Purpose: Gastrointestinal tract (GIT) involvement is highly prevalent among patients with systemic sclerosis (SSc) and is associated with high morbidity and mortality. However, treatment options…
  • Abstract Number: 0863 • ACR Convergence 2023

    Phenotype and Energy Metabolism Differ Between Osteoarthritic Chondrocytes from Male Compared to Female Patients

    Lekha Jain, Caitlin Jardim, Richard Yulo, Scott Bolam, A Paul Monk, Jacob Munro, Rocco Pitto, Jade Tamatea, Nicola Dalbeth and Raewyn Poulsen, University of Auckland, Auckland, New Zealand

    Background/Purpose: Changes in chondrocyte phenotype and energy metabolism occur in osteoarthritis (OA). The prevalence of OA is higher in females compared to males however whether…
  • Abstract Number: 0892 • ACR Convergence 2023

    Single-Cell RNA Sequencing Reveals Keratinocytes and Fibroblasts Drive Hippo and TGFb Dysregulation and Fibrosis in Epidermal Overexpression of VGLL3 in Cutaneous Lupus

    Mehrnaz Gharaee-Kermani1, Allison Billi1, Jacob Martens1, Marisa Hildebrandt1, Amanda Victory1, Mitra Maz2, Shannon Loftus1, J. Michelle Kahlenberg1 and Johann E. Gudjonsson1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Fibrosis is characterized by collagen deposition, fibro/myofibroblast (MYOFB) accumulation, and extracellular matrix remodeling. In some subtypes of cutaneous lupus erythematosus (CLE), particularly discoid lupus…
  • Abstract Number: 0952 • ACR Convergence 2023

    Unraveling the Role of MiR-181 in Skin Fibrosis Pathogenesis by Targeting NUDT21

    Tingting Mills1, Minghua Wu2, Hydia Puente3, Jerry Alonso4, Julio charles4, Maureen Mayes4 and Shervin Assassi5, 1Biochemistry Department, University of Texas McGovern Medical School, Houston, TX, 2Department of Internal Medicine, Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, 3UTHealth-Houston, Houston, TX, 4Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX, 5University of Texas McGovern Medical School at Houston, Houston, TX

    Background/Purpose: Nudix Hydrolase 21 (NUDT21, also known as CFIm25) is a master regulator of alternative polyadenylation. Previous studies have revealed that NUDT21 is significantly decreased…
  • Abstract Number: 0954 • ACR Convergence 2023

    Non-canonical WNTA Promotes Cytoskeletal Rearrangement and Integrin Alpha V Clustering via JNK and ROCK to Control the Activation of Latent TGFβ

    Thuong Trinh-Minh1, Chih-Wei Chen2, Cuong Tran Manh1, yi-nan Li1, Honglin Zhu3, Debomita Chakraborty4, Yun Zhang1, Simon Rauber5, Clara Dees5, Christina Bergmann6, Alexander Kreuter7, Christiane Reuter8, Florian Groeber-Becker8, Beate Eckes9, Oliver Distler10, Andreas Ramming11, Georg Schett12 and Joerg Distler1, 1Clinic for Rheumatology University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany; Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany, 23 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 33 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany. 5 Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China, 43 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 53 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 6Department Internal Medicine, University Hospital Erlangen, Germany, Erlangen, Germany, 7Clinic for Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Clinic, Oberhausen, Germany, 8Translational Center for Regenerative Therapies, Fraunhofer Institute for Silicate Research (ISC) Würzburg, Würzburg, Germany, 9Translational Matrix Biology, University of Cologne, Cologne, Germany. 9 Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Köln, Germany, 10Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 11Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 12Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disorder with vasculopathy, inflammation, and fibrosis of the skin and organs. Fibrosis is caused by the abnormal…
  • Abstract Number: 1147 • ACR Convergence 2023

    Blood-Based Biomarkers of Inflammation and Tissue Remodeling Can Discriminate Between Rheumatoid Arthritis, Psoriasis, and Psoriatic Arthritis and Are Associated with Hand Function

    Helena Port I Linares1, Birte Coppers2, Sara Bayat2, Godonou Elie-Tino2, Larissa Valor-Mendez2, David Simon2, Filippo Fagni2, Giulia Corte2, Anne-Christine Bay-Jensen3, Koray Tascilar2, Axel Hueber4, Verena Schoenau2, Michael Sticherling5, Simon Heinrich6, Daniela Bohr2, Georg Schett7, Arnd Kleyer8, Sigrid Leyendecker6, Signe Holm Nielsen3 and Anna-Maria Liphardt9, 1Nordic Bioscience A/S / University of Copenhagen, Copenhagen, Denmark, 2Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology / Deutsches Zentrum Immuntherapie, Erlangen, Germany, 3Nordic Bioscience, Herlev, Denmark, 4Division of Rheumatology, Klinikum Nürnberg, Paracelsus Medical University / Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Nürnberg, Germany, 5Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, 6Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Institute of Applied Dynamics, Erlangen, Germany, 7Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 8University Hospital Erlangen, Erlangen, Germany, 9Friedrich-Alexander-University Erlangen-Nuremberg, Internal Medicine 3 - Rheumatology and Immunology, University Hospital Erlangen, Erlangen, Germany

    Background/Purpose: Inflammatory musculoskeletal diseases including rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are characterized by physical function impairment due to progressive inflammatory and structural changes.…
  • Abstract Number: 1745 • ACR Convergence 2023

    Chronic Inflammation and Collagen IV Fragment Canstatin Influence Rheumatoid Arthritis Synovial Fibroblast and Endothelial Cell Interactions in Vitro and in Vivo

    Corinna Heck1, Sophie Haun1, Daria Kürsammer1, Klaus Frommer1, Mona Arnold1, Markus Rickert2, Katrin Susanne Lips3, Stefan Rehart4, Ulf Müller-Ladner1 and Elena Neumann1, 1Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 2Dept. of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, 3Justus Liebig University Gießen, Department of Experimental Trauma Surgery, Giessen, Germany, 4Dept. of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital Frankfurt, Frankfurt, Germany

    Background/Purpose: In the inflamed synovium of RA patients, increased and altered angiogenesis is a pathological feature. Key players are chronically activated RA synovial fibroblasts (RASF),…
  • Abstract Number: 2368 • ACR Convergence 2023

    Is Skin Disease a Local Manifestation of Systemic Tissue Turnover? Serological Collagen Biomarkers Provide Important Information on Skin Diseases Arising from Mutations in Collagen Genes

    Signe Holm Nielsen1, Matej Anđelić2, Dovile Sinkeviciute1, Anne-Christine Bay-Jensen1 and Morten Karsdal1, 1Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Copenhagen, Denmark

    Background/Purpose: Collagens are the main constituents of the skin. Genetic mutations in type VI, VII, and XVII collagen cause skin diseases, such as atopic dermatitis,…
  • Abstract Number: 2503 • ACR Convergence 2023

    Cytokines Regulate the Fibrotic Response of Growth Factors in Joint Fibroblast-like Synoviocytes

    Sofie Falkenløve Madsen1, Mikkel Rathsach Andersen2, Alexander Scheller Madrid2, Signe Holm Nielsen3, Morten Karsdal3, Christian Thudium3 and Anne-Christine Bay-Jensen3, 1University of Copenhagen, Herlev, Denmark, 2Herlev-Gentofte Hospital, Gentofte, Denmark, 3Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) and osteoarthritis (OA) are characterized by inflammation, joint swelling, stiffness, and pain. A fibroid phenotype has been identified in RA, where…
  • Abstract Number: 0029 • ACR Convergence 2022

    Characterizing the Anti-fibrotic Effect of Tofacitinib in TGF-β Stimulated Fibroblast-like Synoviocytes from Patients with OA

    Sofie Falkenløve Madsen1, Sarah Madsen2, Elle Hollaar3, Thorbjørn Gantzel4, Anne-Christine Bay-Jensen3 and Christian Thudium3, 1University of Copenhagen / Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, University of Copenhagen, Herlev, Denmark, 3Nordic Bioscience, Herlev, Denmark, 4Gentofte Hospital, Gentofte, Denmark

    Background/Purpose: Many osteoarthritis (OA) patients develop fibrosis of the synovial membrane leading to joint swelling, stiffness, and pain. Synovial fibroblasts activated in the synovial membrane…
  • Abstract Number: 0620 • ACR Convergence 2022

    Neovascularization Is Altered by Rheumatoid Arthritis Synovial Fibroblasts and Canstatin in Vitro and in Vivo

    Corinna Heck1, Daria Kürsammer1, Klaus Frommer2, Mona Arnold3, Stefan Rehart4, Ulf Müller-Ladner5 and Elena Neumann3, 1Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Bad Nauheim, Germany, 2Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Bad Nauheim, Germany, 3JLU Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 4Agaplesion Markus Hospital, Dpt of Orthopaedics and Trauma Surgery, Frankfurt, Germany, 5JLU Campus KK, Bad Nauheim, Germany

    Background/Purpose: In the pathogenesis of rheumatoid arthritis (RA), neovascularization is increased in the activated and inflamed synovium. RA synovial fibroblasts (RASF) are key players in…
  • Abstract Number: 1215 • ACR Convergence 2022

    Identifying a Pain Signature in Classical Ehlers-Danlos Syndrome: Preliminary Results from Questionnaires and Experimental Pain Testing

    Marlies Colman, Inge De Wandele, Lies Rombaut, Delfien Syx, Fransiska Malfait and Jessica Van Oosterwijck, Ghent University, Ghent, Belgium

    Background/Purpose: Chronic pain is one of the most common complaints of individuals with Ehlers-Danlos syndrome (EDS) and the effects of the existing therapeutical modalities are…
  • Abstract Number: 1610 • ACR Convergence 2022

    Are Serological Protease-mediated Peptides of Tissue Remodeling and Inflammation the New Disease Activity Biomarkers in Psoriatic Arthritis Patients?

    Solveig S. Groen1, Signe Holm Nielsen2, Anne-Christine Bay-Jensen2, Mozhgan Rasti3, Darshini Ganatra3, Katerina Oikonomopoulou3 and Vinod Chandran4, 1Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, 2Nordic Bioscience, Herlev, Denmark, 3Schroeder Arthritis Institute, Krembil Research Institute, Toronto, ON, Canada, 4Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose: Inflammatory and degenerative processes in the joint tissues are hallmarks of patients with psoriatic arthritis (PsA). Here, proteases play a major role in remodeling…
  • 1
  • 2
  • 3
  • …
  • 6
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology