Abstracts tagged "Cohort Study"

Abstract Number: 1506 • ACR Convergence 2022
Multimorbidity in Psoriasis as a Risk Factor for Psoriatic Arthritis: A Population-Based Study
Paras Karmacharya¹, Rikesh Chakradhar², Alexis Ogdie³, John Davis⁴, Tina Gunderson⁴, Cassondra Hulshizer⁴, Kerry Wright⁴, Megha M. Tollefson⁵, Ali Duarte-Garcia⁴, Delamo Bekele⁴, Hilal Maradit Kremers⁴, Floranne Ernste⁴ and Cynthia Crowson⁶, ¹Vanderbilt University, Nashville, TN, ²St. Christopher's Hospital, Philadelphia, ³Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁴Mayo Clinic, Rochester, MN, ⁵Mayo Clinic, Rochester, ⁶Mayo Clinic, Eyota, MN
Background/Purpose: Psoriasis is a systemic inflammatory disorder associated with cardiometabolic and other comorbidities. Psoriasis frequently precedes development of psoriatic arthritis (PsA), and comorbidities in psoriasis…
Abstract Number: 1923 • ACR Convergence 2022
Co-fluctuations of Knee Pain Between Knees in the Same Person: Data from the Osteoarthritis Initiative (OAI)
Martin Englund¹, Tuhina Neogi² and Aleksandra Turkiewicz¹, ¹Lund University, Lund, Sweden, ²Boston University School of Medicine, Boston, MA
Background/Purpose: Pain in knee osteoarthritis (OA) is often known to fluctuate. However, there is limed knowledge of the pain fluctuations in between knees within the…
Abstract Number: 2158 • ACR Convergence 2022
A Decade of Caring for SSc Patients: Do Outcomes Improve? Data from the Leiden CCISS Cohort
Sophie Liem¹, Saad Ahmed², Jacopo Ciaffi³, Liesbeth Beaart-van de Voorde⁴, Anne Schouffoer⁵, J Geelhoed⁶, Nina Ajmone Marsan⁷, Tom Huizinga⁸ and Jeska de Vries-Bouwstra⁸, ¹LUMC, Leiden, Netherlands, ²Leiden University Medical Centre, Leiden, Netherlands, ³IRCCS Istituto Ortopedico Rizzoli, Bologna/Leiden University Medical Center, Bologna, Italy, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Leiden University Medical Center/Haga Teaching Hospital, Leiden, Netherlands, ⁶Leiden University Medical Center, Pulmonology, Leiden, Zuid-Holland, Netherlands, ⁷Leiden University Medical Center, Cardiology, Leiden, Netherlands, ⁸Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Combined Care in Systemic Sclerosis (CCISS) is a prospective cohort of patients referred to Leiden University Medical Center for Raynaud's Phenomenon (RP), a suspicion…
Abstract Number: 0109 • ACR Convergence 2022
The Impact of Marginalization on Health Outcomes in Childhood-onset Systemic Lupus Erythematosus
Ibrahim Mohamed¹, Hardil Bhatt², Paris Moaf³, Lawrence Ng³, Dragana Ostojic-Aitkens³, Bryan Maguire³, Deborah Levy⁴, Linda Hiraki⁵, Alene Toulany⁶, Chelsea DeCoste⁷ and Andrea Knight⁸, ¹The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, ON, Canada 3Institute of Biomedical Engineering, University of Toronto, Brampton, ON, Canada, ²Temerty Faculty of Medicine, Toronto, ON, Canada, ³The Hospital for Sick Children, Toronto, ON, Canada, ⁴Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁵The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, ⁶The Hospital for Sick Children, Division of Adolescent Medicine, Department of Paediatrics, University of Toronto,, Toronto, ON, Canada, ⁷IWK Health Centre, Halifax, NS, Canada, ⁸The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada
Background/Purpose: Adolescents with childhood-onset systemic lupus erythematosus (cSLE) face challenges in managing their disease and mental health. There is increasing evidence that community-level social and…
Abstract Number: 0715 • ACR Convergence 2022
Safety and Immunogenicity of Mixed COVID19 Vaccine Regimens in Immune-mediated Inflammatory Diseases: An Observational Cohort
Carol Hitchon¹, Christine Mesa², Charles N Bernstein¹, Catherine Card², RuthAnn Marrie¹, Sheila O'Brien³ and John Kim², ¹University of Manitoba, Winnipeg, MB, Canada, ²Public Health Agency of Canada, Winnipeg, MB, Canada, ³Canada Blood Services, Ottawa, Canada
Background/Purpose: Data on immunogenicity and safety of COVID-19 vaccination strategies exist for the general population, however, such data are limited for immunocompromised people including those…
Abstract Number: 1134 • ACR Convergence 2022
Genome-wide Association Study Identifies Novel Loci for Leukopenia Among TPMT and NUDT15 Normal Metabolizers Taking Azathioprine
Jacy Zanussi, Puran Nepal, Alyson Dickson, Laura Daniel, Peter Straub, Tyne Miller-Fleming, Wei-Qi Wei, Adriana Hung, Nancy Cox, Vivian Kawai, Jonathan Mosley, Michael Stein, QiPing Feng, Ge Liu, Ran Tao and Cecilia Chung, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Azathioprine is a thiopurine drug used for the treatment of several inflammatory and autoimmune conditions. However, its use is limited due to side effects,…
Abstract Number: 1514 • ACR Convergence 2022
Self-referral Strategy for Early Diagnosis of Axial Spondyloarthritis- Preliminary Analysis from Finding Axial Spondyloarthritis Study
Abhijeet Danve, Yale University, New Haven, CT
Background/Purpose: Lack of timely rheumatology referral for suspected axial spondyloarthritis (axSpA) is a major contributor to delayed diagnosis in patients with chronic back pain (CBP).…
Abstract Number: 1924 • ACR Convergence 2022
Reading the Waves: Identifying Distinct Phenotypes of Multisystem Inflammatory Syndrome in Children During the 2020-2021 COVID-19 Pandemic
Thomas Renson¹, Nils Forkert¹, Kimberly Amador¹, Paivi Miettunen¹, Simon Parsons¹, Muhammed Dhalla¹, Nicole Johnson², Nadia Luca², Heinrike Schmeling¹, Rebeka Stevenson¹, Marinka Twilt¹, Lorraine Hamiwka¹ and Susanne Benseler¹, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²University of Calgary, Calgary, AB, Canada
Background/Purpose: The COVID-19-associated multisystem inflammatory syndrome in children (MIS-C) is characterized by Kawasaki disease (KD)-like mucocutaneous features. The clinical course is often unpredictable. The goals…
Abstract Number: 2216 • ACR Convergence 2022
JAK Inhibitors and Risk of Cancer
Amandine Gouverneur¹, Jérôme Avouac², Clément Prati³, Jean-Luc Cracowski⁴, Thierry schaeverbeke⁵, Antoine Pariente¹ and Marie-Elise Truchetet⁵, ¹Université de Bordeaux, Bordeaux, France, ²University of Paris, Paris, France, ³Service de rhumatologie, CHU de Besançon, Besançon, France, ⁴Université de Grenoble, Grenoble, France, ⁵CHU de Bordeaux, Bordeaux, France
Background/Purpose: Recent concerns have been raised about potential increase of cancer risk under JAK inhibitors (JAKi) especially tofacitinib. Discrepant findings have been given by randomized…
Abstract Number: 0125 • ACR Convergence 2022
Baseline Characteristics in Patients with Eosinophilic Granulomatosis with Polyangiitis in the U.S. Initiating Mepolizumab
Jared Silver¹, Arijita Deb², Elizabeth Packnett³, Donna McMorrow³, Cynthia Morrow³ and Michael Bogart¹, ¹GlaxoSmithKline, Research Triangle Park, NC, ²GlaxoSmithKline, Upper Providence, PA, ³IBM Watson Health, Cambridge, MA
Background/Purpose: EGPA is a multisystem disorder often characterized clinically by asthma, chronic rhinosinusitis, and prominent eosinophilia, and histopathologically by eosinophil-rich, necrotizing , granulomatous vasculitis of…
Abstract Number: 0719 • ACR Convergence 2022
Effect of Patient-reported Outcomes on Changes in DMARD Therapy Among Rheumatoid Arthritis Patients Treated in Routine Clinical Practice
Lauren Stevens¹, Kyra Mulder², Zhaohui Su², Pam Kumparatana², Jessica Paulus² and Stefan Weiss³, ¹OM1, Inc., Lexington, KY, ²OM1, Inc., Boston, MA, ³OM1, Inc., Chapel Hill, NC
Background/Purpose: Patient-reported outcomes (PROs) are being increasingly utilized in clinical trials to assess the impact of treatment on symptom control and patient quality of life.…
Abstract Number: 1186 • ACR Convergence 2022
The Trajectory of Multimorbidity in Patients with Systemic Lupus Erythematosus in the United States
Ali Duarte-Garcia¹, Maria Stevens², Herbert Heien², Gabriel Figueroa Parra¹, Jose A Meade-Aguilar¹, Molly M. Jeffery², Uma Thanarajasingam¹, Cynthia Crowson³ and Rozalina McCoy², ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, ³Mayo Clinic, Eyota, MN
Background/Purpose: The presence of multiple chronic conditions (multimorbidity) is associated with disability and premature death. We determined the trajectory of multimorbidity in SLE compared to…
Abstract Number: 1591 • ACR Convergence 2022
Overall and Post-vaccination Prevalence of Severe COVID-19-related Events Among Commercially Insured Patients with Systemic Lupus Erythematosus and the General U.S. Population
Sandra Sze-jung Wu¹, Gelareh Atefi², Meghan Moynihan³, Kristin Evans³, Liisa Palmer³, Michael Pollack², Christine Dube⁴ and Cassandra Calabrese⁵, ¹AstraZeneca, Hockessin, DE, ²AstraZeneca, Wilmington, DE, ³Merative, Cambridge, MA, ⁴AstraZeneca, Torrington, CT, ⁵Cleveland Clinic Foundation, Cleveland Heights, OH
Background/Purpose: To assess the prevalence of severe COVID-19 (COVID) overall and following vaccination among patients with systemic lupus erythematosus (SLE) and the general population, and…
Abstract Number: 1957 • ACR Convergence 2022
Detangling Heterogeneity in Contemporary Undifferentiated Arthritis – a Large Cohort Study Using Latent Class Analysis
Nikolet den Hollander¹, Marloes Verstappen², Bastiaan van Dijk³, Annette van der Helm-van Mil⁴ and Hanna van Steenbergen³, ¹Leids Universitair Medisch Centrum, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Leiden University Medical Centre (LUMC), Leiden, Netherlands, ⁴Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands
Background/Purpose: Undifferentiated arthritis (UA) is considered to be heterogenous and consists of subgroups, this notion is affirmed by differences in disease course, varying from spontaneous…
Abstract Number: 2225 • ACR Convergence 2022
Physical Inactivity Is Associated with Increased Expression of T Cell Inflammatory Genes in Systemic Lupus
Sarah Patterson¹, Sebastian Cruz Gonzalez², Alexandra Tsitsiklis², Cristina Lanata³, Lenka Maliskova⁴, Chun Ye¹, Zachary Cutts⁴, Jinoos Yazdany⁵, Maria Dall'Era⁶, Lindsey Criswell⁷, Charles Langelier², Patricia Katz⁵ and Marina Sirota⁸, ¹University of California, San Francisco, San Francisco, CA, ²UCSF, San Francisco, CA, ³NIH, Washington, DC, ⁴University of California, San Francisco, San Francisco, ⁵UCSF, San Rafael, CA, ⁶University of California, Division of Rheumatology, San Francisco, CA, ⁷National Human Genome Research Institute, NIH, Bethesda, MD, ⁸UCSF, SF
Background/Purpose: Prior studies show an independent association between greater physical activity and lower inflammatory markers among adults in the general population, but the impact of…

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