Abstracts tagged "Clinical"

Abstract Number: 198 • 2014 ACR/ARHP Annual Meeting
Implant Survival and Patient-Reported Outcomes after Total Hip Arthroplasty in Young Patients with JIA
Ishaan Swarup¹, Ella Christoph¹, Lisa A. Mandl², Susan M. Goodman² and Mark P. Figgie³, ¹Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Orthopedics, Hospital for Special Surgery, New York, NY
Background/Purpose : Juvenile Idiopathic Arthritis (JIA) is a common rheumatologic disease in children that often persists into adulthood. The hip joint is commonly involved, and…
Abstract Number: 74 • 2014 ACR/ARHP Annual Meeting
Influence of the Polymorphism IL1ß (-511 A/C) and IL6 (- 174 G/C) on the Activity, Radiographic Damage and Clinical Forms of Patients with Psoriatic Arthritis (PSA)
Tatiana Carranco¹, Noelia Cubino², Clara Cieza-Borrela³, Ismael Calero³, Maria Dolores Sanchez³, C. Hidalgo-Calleja⁴, Alba Quesada³, Andres Plata³, Agustin Diaz Alvarez³, Ricardo Usategui⁵, Rogelio Gonzalez⁵, C.a. Montilla-Morales⁴ and J. Del Pino-Montes⁴, ¹Reumathology, HOSPITAL CLINICO UNIVERSITARIO DE SALAMANCA, SALAMANCA, Spain, ²INTERNAL MEDICINE, HOSPITAL CLINICO UNIVERSITARIO DE SALAMANCA, SALAMANCA, Spain, ³HOSPITAL CLINICO UNIVERSITARIO DE SALAMANCA, SALAMANCA, Spain, ⁴University of Salamanca Hospital, Salamanca, Spain, ⁵IBSAL, SALAMANCA, Spain
Background/Purpose: PSA is a chronic inflammatory disease associated to psoriasis which affects the joints, vertebrae and enthesis. Interleukin-1 is an inflammatory cytokine. A higher expression…
Abstract Number: L6 • 2014 ACR/ARHP Annual Meeting
A PHASE 2, Randomized, Double-Blind Comparison of the Efficacy and Safety of PF-04171327 (1, 5, 10, 15 mg QD) Vs 5 and 10 Mg Prednisone QD or Placebo in Subjects with Rheumatoid Arthritis (RA) over 8 Weeks Followed By a 4-Week Taper of Study Drug
Vibeke Strand¹, Frank Buttgereit², Dorothy McCabe³, Sheela Kolluri³, Brinda Tammara³, Ricardo Rojo³ and Judith Hey-Hadavi^3,4, ¹Biopharmaceutical Consultant, Portola Valley, CA, ²Charité University Hospital, Berlin, Germany, ³Pfizer Inc, New York, NY, ⁴Pfizer Inc, NewYork, NY
Background/Purpose: PF-04171327 is a dissociated agonist of the glucocorticoid receptor (DAGR), a selective high-affinity partial agonist of the GR with potent anti-inflammatory activity at exposures…
Abstract Number: 2904 • 2014 ACR/ARHP Annual Meeting
Clinical and Radiological Features of Down’s Arthropathy
Charlene Foley, Orla Killeen and Emma Jane MacDermott, The National Centre for Paediatric Rheumatology, Dublin, Ireland
Background/Purpose The ‘Arthropathy of Down syndrome’ was first described in 1984. Three decades on we still have limited literature on the clinical & radiological features…
Abstract Number: 125 • 2013 ACR/ARHP Annual Meeting
Correlation Of Findings In Clinical and High Resolution Ultrasonography Examinations Of The Painful Shoulder
Raphael Micheroli¹, Diego Kyburz², Adrian Ciurea³, Beat Dubs⁴, Martin Toniolo², Samuel Bisig⁵ and Giorgio Tamborrini⁶, ¹Faculty of Medicine, University of Zurich, Zurich, Switzerland, ²Department of Rheumatology, University Hospital of Zurich, Zurich, Switzerland, ³Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, ⁴Sonography Institute Bethanien Zurich, Zurich, Switzerland, ⁵Swiss Federal Institute of Technology Zurich, Zurich, Switzerland, ⁶Department of Rheumatology and Musculoskeletal Ultrasound, Bethesda Hospital Basel, Basel, Switzerland
Background/Purpose: High resolution ultrasonography (HRUS) is a non-painful and non-invasive imaging technique which is increasingly used for evaluating patients with musculoskeletal disorders. In particular, HRUS…
Abstract Number: 2527 • 2013 ACR/ARHP Annual Meeting
Association Of Nail Dystrophy With Capillaroscopic Abnormalities, Anti-Endothelial Cell Antibody, Endothelin-1, Activity and Chronicity In Systemic Lupus Erythematosus
Violeta Higuera¹, Luis M. Amezcua-Guerra², Felipe Massó³, Mariana Patlan⁴, Hugo Montoya⁵, Araceli Paez⁴ and Luis H. Silveira⁶, ¹Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico city, Mexico, ²Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, ³Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, ⁴Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico city, Mexico, ⁵Instituto Nacional de Cardiologia Ignacio Chavez, Mexico city, Mexico, ⁶Rheumatology, Instituto Nacional Cardiología Ignacio Chávez, Mexico City, Mexico
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology, characterized by a broad spectrum of clinical manifestations. There is a large…
Abstract Number: 2309 • 2013 ACR/ARHP Annual Meeting
Quantifying The Gap Between General Population Guidelines and Expert Opinion For Cardiovascular Risk Management In Rheumatic Disease Patients
Katherine P. Liao¹, Jonathan Brown², Jonathan S. Coblyn³, Paul Cohen², Jorge Plutzky² and Daniel H. Solomon⁴, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Cardiology, Brigham and Women's Hospital, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA
Background/Purpose: Cardiovascular (CV) risk is higher among rheumatic disease patients than the general population. However, CV risk management guidelines calibrated for the rheumatic disease population…
Abstract Number: 2131 • 2013 ACR/ARHP Annual Meeting
Osteoarthritis Pain: Variability and Clinical Correlations
Thomas J. Schnitzer¹, Renita Yeasted², Leijan Huang³, Jennifer Duffecy⁴, Mark Begale⁴ and A. Vania Apkarian³, ¹PM&R and Int Med, Northwestern University, Chicago, IL, ²PM&R, Northwestern University, Chicago, IL, ³Physiology, Northwestern University, Chicago, IL, ⁴Preventive Medicine, Northwestern University, Chicago, IL
Background/Purpose: Although osteoarthritis (OA) is an intensely studied model of chronic pain, little is known about the temporal dynamics of OA pain intensity and how…
Abstract Number: 2062 • 2013 ACR/ARHP Annual Meeting
Clinical Features and Outcome In Polymyositis Vs. Dermatomyositis Patients With The Anti-Jo-1 Autoantibody
Rohit Aggarwal¹, Diane Koontz², Zengbiao Qi³ and Chester V. Oddis⁴, ¹Medicine / Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The clinical characteristics of dermatomyositis (DM) patients possessing the anti-Jo-1 autoantibody (autoAb) are not well known. We analyzed the clinical features and prognosis of…
Abstract Number: 1796 • 2013 ACR/ARHP Annual Meeting
12-Week Results Of a Phase 2b Dose-Ranging Study Of Baricitinib, An Oral JAK1/ JAK2 Inhibitor In Japanese Patients With Rheumatoid Arthritis On Background Methotrexate Therapy
Yoshiya Tanaka¹, Kahaku Emoto², Mika Tsujimoto², Douglas E. Schlichting³ and William Macias³, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²Eli Lilly Japan K.K., Kobe, Japan, ³Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Baricitinib (formerly LY3009104/INCB028050), a novel, oral inhibitor of JAK1 and JAK2 in the JAK-STAT signaling pathway, has been evaluated in a 12-week blinded phase…
Abstract Number: 1336 • 2013 ACR/ARHP Annual Meeting
The Safety and Feasibility Of a Treat-To-Target Strategy Aimed At Achieving a Simplified Disease Activity Index Of ¡Ü3.3 While Administering Entecavir In Rheumatoid Arthritis Complicated By Hepatitis B Virus
Yukitomo Urata¹, Yoshihide Nakamura^2,3 and Ken-ichi Furukawa⁴, ¹Seihoku Central Hospital, United Municipalities of Tsugaru, Gosyogawara, Japan, ²Hirosaki University Graduate School of Medicine, Hirosaki, Japan, ³Orthopaedic Surgery, Seihoku Central Hospital, United Municipalities of Tsugaru, Gosyogawara, Japan, ⁴Pharmacology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
Background/Purpose: To elucidate the safety and feasibility of a treat-to-target (T2T) strategy aimed at achieving a simplified disease activity index (SDAI) of ≤3.3 while administering…
Abstract Number: 1305 • 2013 ACR/ARHP Annual Meeting
Clinical Joint Involvement Is Decisive For Radiographic Progression
Miriam Gärtner¹, Farideh Alasti², Gabriela Supp¹, Josef S. Smolen³ and Daniel Aletaha¹, ¹Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: Today’s therapeutic targets in rheumatoid arthritis (RA) are remission or low disease activity, but it was shown that joint damage may continue to progress…
Abstract Number: 33 • 2013 ACR/ARHP Annual Meeting
B Cell Receptor Signaling As A Potential Clinical Parameter In Lupus
Michael Faludi¹, Christian A. Pineau², Evelyne Vinet¹, Ann E. Clarke³, Sasha Bernatsky⁴, Joyce Rauch² and Emil P. Nashi⁵, ¹McGill University Health Center, Montreal, QC, Canada, ²Rheumatology, McGill University Health Center, Montreal, QC, Canada, ³Division of Rheumatology, University of Calgary, Alberta, Calgary, AB, Canada, ⁴Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada, ⁵Immunology and Rheumatology, McGill University Health Center, Montreal, QC, Canada
Background/Purpose: B cells are central to SLE. Signaling through the B cell receptor (BCR) controls critical processes at various stages of B cell development. Murine…
Abstract Number: 1116 • 2012 ACR/ARHP Annual Meeting
Diagnostic Value of Internal Rotation Measurement in Patients with Cam- and Pincer-Type Deformities of the Hip
Stephan Reichenbach¹, Michael Leunig², Stefan Werlen³, Andreas Limacher¹, Christian W. Pfirrmann⁴, Reinhold Ganz⁵ and Peter Jüni¹, ¹University of Bern, Bern, Switzerland, ²Schulthess Clinic, Zurich, Switzerland, ³Hospital Sonnenhof, Bern, Switzerland, ⁴Balgrist University Hospital, Zurich, Switzerland, ⁵Department of Orthopedic Surgery, University of Bern, Bern, Switzerland
Background/Purpose: It has been proposed that femoroacetabular impingement (FAI) causes early osteoarthritis (OA) in non-dysplastic hips. FAI occurs predominantly in two different types, ”cam” or…
Abstract Number: 1107 • 2012 ACR/ARHP Annual Meeting
Baseline Knee Flexion Pain, Age and Joint Line Tenderness Predict the Progression of Asymptomatic, Radiographic Knee Osteoarthritis to Symptomatic Knee Osteoarthritis Over 5 Years
Abhiram Gande¹ and James J. Irrgang², ¹Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee Osteoarthritis (OA) is the most prevalent form of OA. Historically, not all people who have tell-tale signs of radiographic knee osteoarthritis progress to…

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