ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "clinical trial"

  • Abstract Number: 1752 • ACR Convergence 2021

    Efficacy of Voclosporin in Recent Onset Lupus Nephritis

    Meggan Mackay1, Matt Truman2, Nicole England2, Vanessa Birardi3 and Paola Mina-Osorio4, 1Feinstein Institutes for Medical Research, Manhasset, NY, 2Aurinia Pharmaceuticals Inc., Victoria, BC, Canada, 3Aurinia Pharmaceuticals Inc, Rockville, MD, 4Aurinia Pharmaceuticals Inc., New York, NY

    Background/Purpose: Voclosporin is a novel calcineurin inhibitor recently approved for the treatment of adults with active lupus nephritis (LN) in combination with background immunosuppressive therapy.…
  • Abstract Number: 1823 • ACR Convergence 2021

    Efficacy of Upadacitinib in Patients with Active Psoriatic Arthritis and a Low or High Swollen Joint Count: A Subgroup Analysis of 2 Phase 3 Studies

    Laure Gossec1, Dafna Gladman2, Erin McDearmon-Blondell3, Philipp Sewerin4, Christopher Ritchlin5, Dai Feng6, Apinya Lertratanakul7, Roberto Ranza8, Lai-Shan Tam9, Antonio Marchesoni10, Laura Coates11 and Peter Nash12, 1Sorbonne Université; APHP, Rheumatology Department, Pitié-Salpêtrière Hospital, Paris, France, 2Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3AbbVie Inc., Elmhurst, IL, 4Department and Hiller Research Unit of Rheumatology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany, 5Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, 6AbbVie Inc., East Brunswick, NJ, 7AbbVie Inc., North Chicago, IL, 8Hospital de Clinicas, Universidade Federal de Uberlândia, Uberlandia, MG, Brazil, 9Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China (People's Republic), 10Dipartimento di Reumatologia, ASST Gaetano Pini-CTO, Milano, Italy, 11Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 12Griffith University, Brisbane, Australia

    Background/Purpose: Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on…
  • Abstract Number: 0497 • ACR Convergence 2021

    Efficacy in Patient Subgroups in the INCREASE Trial, a Phase III Trial to Evaluate Inhaled Treprostinil in Patients with Pulmonary Hypertension Due to Parenchymal Lung Disease

    Victor Tapson1, Steven Nathan2, Reda Girgis3, James Runo4, Remzi Bag5, Arunabh Talwar6, Peter Smith7, Lisa Edwards7, Christine Park7 and Aaron Waxman8, 1Cedars-Sinai, Los Angeles, CA, 2Inova Fairfax, Falls Church, VA, 3Michigan State University, Lansing, MI, 4University of Wisconsin, Madison, WI, 5University of Chicago, Chicago, IL, 6Hofstra Northwell School of Medicine, Hempstead, NY, 7United Therapeutics Corporation, Durham, NC, 8Brigham and Women's Hospital, Boston, MA

    Background/Purpose: INCREASE was a 16-week trial evaluating the safety and efficacy of inhaled treprostinil (iTRE) in patients with pulmonary hypertension associated with interstitial lung disease…
  • Abstract Number: 1240 • ACR Convergence 2021

    Biomarker Driven Dissection of Inflammation Modulatory Effects of Upadacitinib versus Abatacept in Patients with Active Rheumatoid Arthritis Refractory to Biologic DMARDs

    Fang Cai1, Thierry Sornasse2, Feng Hong3, Heidi Camp4, Koji Kato5 and Iain McInnes6, 1AbbVie, Redwood City, CA, 2AbbVie Inc, Redwood City, CA, 3AbbVie, Worcester, MA, 4AbbVie Inc., North Chicago, IL, 5AbbVie Inc, Shinagawa- Ku, Japan, 6University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom

    Background/Purpose: In patients with active rheumatoid arthritis (RA) refractory to biologic DMARDs (bDMARD-IR), a phase 3, double-blind and active-controlled study (SELECT-CHOICE) demonstrated that upadacitinib (UPA)…
  • Abstract Number: 1396 • ACR Convergence 2021

    Baricitinib in Relapsing Giant Cell Arteritis: A Prospective Open-Label Single-Institution Study

    Matthew Koster1, Cynthia Crowson2, Rachel Giblon1, Ali Duarte-Garcia1, Jane Jaquith1, Cornelia M. Weyand1 and Kenneth Warrington3, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Eyota, MN, 3Mayo Clinic, Rochester, Minnesota

    Background/Purpose: Pre-clinical giant cell arteritis (GCA) mouse models have demonstrated effective suppression of arterial wall lesional T-cells through inhibition of Janus kinase 3 (JAK3) and…
  • Abstract Number: 1697 • ACR Convergence 2021

    Clinical Outcomes up to Week 48 of Filgotinib Treatment in an Ongoing Long-term Extension Trial of RA Patients with Inadequate Response to MTX Initially Treated with Filgotinib or Adalimumab During the Phase 3 Parent Trial

    Bernard Combe1, Yoshiya Tanaka2, Paul Emery3, Alena Pechonkina4, Albert Kuo4, Qi Gong4, Katrien Van Beneden5, Vijay Rajendran6 and Hendrik Schulze-Koops7, 1CHU Montpellier Montpellier University, Montpellier, France, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and Leeds NIHR Biomedical Research Centre, Leeds, United Kingdom, 4Gilead Sciences, Inc., Foster City, CA, 5Galapagos, NV, Mechelen, Belgium, 6Galapagos NV, Mechelen, Belgium, 7Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, University of Munich, Munich, Germany

    Background/Purpose: The preferential Janus kinase (JAK)-1 inhibitor filgotinib (FIL) is approved for treatment of moderately to severely active RA in Europe and Japan. We assessed…
  • Abstract Number: 1755 • ACR Convergence 2021

    Increasing Participation of Underrepresented Groups in Lupus Clinical Trials: Insights from Qualitative Interviews with Patients and Physicians

    Saira Sheikh1, Maria Naylor2, Becky Lane2, Jennifer Sacks2, Janine Gaiha-Rohrbach2 and Cherie Butts2, 1University of North Carolina Thurston Arthritis Research Center, and Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 2Biogen, Cambridge, MA

    Background/Purpose: Systemic lupus erythematosus disproportionately affects Black/African American (AA) and Latino/a populations.1 Challenges to engage and include these populations in clinical trials (CTs) can be…
  • Abstract Number: 1834 • ACR Convergence 2021

    To What Extent Do Clinical Features of PsA Predict Achievement of Minimal Disease Activity at Week 24: A Post Hoc Analysis of the Phase III Clinical Trial Program of Guselkumab in a Bio-naïve Patient Population

    Marijn Vis1, Pascal Richette2, Ramirez Julio3, Marlies Neuhold4, Robert Wapenaar5, Elke Theander6, Wim Noel7, May Shawi8, Alexa Kollmeier9 and William Tillett10, 1Erasmus MC, Badhoevedorp, Netherlands, 2Lariboisiere Hospital, Paris, France, 3Hospital Universitari Clinic, Barcelona, Spain, 4Janssen-Cilag, Zug, Switzerland, 5Janssen-Cilag BV, Breda, Netherlands, 6Janssen Cilag, Lund, Sweden, 7Janssen Pharmaceutica, Vilvoorde, Belgium, 8Janssen Immunology Global Commercial Strategy Organization, Toronto, ON, Canada, 9Janssen Research & Development, LLC, La Jolla, CA, 10Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom

    Background/Purpose: Guselkumab (GUS), a human monoclonal antibody targeting the interleukin-23p19-subunit, has demonstrated efficacy across joint and skin endpoints at Week 24 (W24) in the Phase…
  • Abstract Number: 0112 • ACR Convergence 2021

    A Randomized Trial Showing No Differences in Patient Satisfaction with Telemedicine Delivered by Phone or Video During COVID-19 in Rheumatology and Other Medical Specialty Clinics

    Maria I. Danila1, Dongmei Sun2, Lesley Jackson1, Gary Cutter1, Elizabeth Jackson1, Eric Ford1, Erin DeLaney1, Amy Mudano1, Jeffrey Foster1, Giovanna Rosas1, Jeffrey Curtis3 and Kenneth Saag1, 1University of Alabama at Birmingham, Birmingham, AL, 2Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, 3Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: The COVID-19 pandemic has led to a significant shift to home-based telemedicine including video and phone-only visits in many medical specialties. However, patients may…
  • Abstract Number: 0603 • ACR Convergence 2021

    Barriers and Potential Solutions in the Recruitment and Retention of Older Patients in Clinical Trials – Lessons Learned from Six Large Multi-center Randomized Controlled Trials

    Thomas Buttgereit1, Andriko Palmowski1, Noah Forsat1, Maarten Boers2, Miles Witham3, Nicolas Rodondi4, Elisavet Moutzouri4, Antonio Jesus Quesada Navidad5, Arnoud van’t Hof6, Bart van der Worp7, Laura Coll-Planas8, Marieke Voshaar9, Maarten de Wit10, Jose Pereira da Silva11, Sven Stegemann12, Johannes Bijlsma13, Marcus Koeller14, Simon Mooijaart15, Patricia Kearney16 and Frank Buttgereit1, 1Charité – Universitätsmedizin Berlin, Berlin, Germany, 2Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, 3AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle upon Tyne Hospitals Trust, Newcastle, United Kingdom, 4Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland, 5CNIC – Spanish National Center for Cardiovascular Research, Madrid, 6Cardiology Department, Maastricht UMC, Maastricht, Netherlands, 7Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands, 8Fundació Salut i Envelliment, Universitat Autònoma de Barcelona, Barcelona, Spain, 9Department Psychology, Health and Technology, University of Twente, Twente, Netherlands, 10EULAR Patient Research Partner, Zaltbommel, Netherlands, 11University of Coimbra | UC · Clínica Universitária de Reumatologia. Faculty of Medicine, Columbia, Portugal, 12TU Graz, Institute for Process and Particle Engineering, Graz, Australia, 13Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, 14Faculty of Geriatric Medicine, Medical University of Vienna, Vienna, Austria, 15Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; Institute for Evidence-based Medicine in Old Age | IEMO, Leiden, Netherlands, 16School of Epidemiology and Public Health, University College Cork, Cork, Ireland

    Background/Purpose: Older people remain underrepresented in clinical trials, and evidence generated in younger populations cannot always be generalized to older patients.We aimed to identify key…
  • Abstract Number: 1241 • ACR Convergence 2021

    Comparison of the Effects of Upadacitinib Monotherapy with MTX on Protein Biomarkers in MTX-Naïve and MTX-Inadequate Responders in Patients with Active Rheumatoid Arthritis: Results from the SELECT-EARLY and SELECT‑MONOTHERAPY Phase 3 Studies

    Thierry Sornasse1, Heidi Camp2, Fang Cai3, Justin Klaff2 and Iain McInnes4, 1AbbVie Inc, Redwood City, CA, 2AbbVie Inc., North Chicago, IL, 3AbbVie, Redwood City, CA, 4University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom

    Background/Purpose: In MTX-naïve patients (SELECT-EARLY/M13-545 Phase 3 study) UPA 15 mg QD monotherapy (UPA Mono) demonstrated significant and clinically meaningful improvements in RA signs and…
  • Abstract Number: 1425 • ACR Convergence 2021

    Voclosporin for Lupus Nephritis: Interim Analysis of the AURORA 2 Extension Study

    Amit Saxena1, Christopher Mela2 and Antonia Coeshall3, 1NYU School of Medicine, New York, NY, 2Aurinia Pharmaceuticals Inc., Victoria, BC, Canada, 3Aurinia Pharmaceuticals Inc., Rockville

    Background/Purpose: Voclosporin, a novel calcineurin inhibitor (CNI), has been tested successfully in 2 pivotal trials in adult patients with lupus nephritis (LN). Previously reported results…
  • Abstract Number: 1700 • ACR Convergence 2021

    Pharmacokinetic Boosting to Enable Once-Daily Reduced Dose Tofacitinib

    Céleste van der Togt1, Lise Verhoef2, Nathan den Broeder3, Rob ter Heine3, Bart van den Bemt4 and Alfons den Broeder5, 1Sint Maartenskliniek, Ubbergen, Gelderland, Netherlands, 2Sint Maartenskliniek, Nijmegen, Netherlands, 3Radboud University Medical Centre, Nijmegen, Gelderland, Netherlands, 4Sint Maartenskliniek; Radboud University Medical Center, Ubbergen, Netherlands, 5Sint Maartenskliniek, Nijmegen, Gelderland, Netherlands

    Background/Purpose: Tofacitinib is an effective, yet costly, drug for treatment of RA and PsA. Tofacitinib is metabolized mainly by the cytochrome P450-enzyme CYP3A4, and the…
  • Abstract Number: 1765 • ACR Convergence 2021

    Should SLE Patients Entering Clinical Trials Be Required to Have at Least One BILAG A and/or Two BILAG B Domain Scores?

    Ewa Olech1, Faizi Hussain2 and Joan Merrill3, 1IQVIA, Las Vegas, NV, 2IQVIA, Redding, United Kingdom, 3Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: High placebo response rates have challenged interpretation of clinical trial results in SLE and may have contributed to failure of some effective treatments. One…
  • Abstract Number: 1856 • ACR Convergence 2021

    Serum IFN Score Predicts Long Term Outcome in Limited Cutaneous SSc

    Ranjitha Karanth1, Giuseppina Abignano2, Vishal Kakkar2, Rebecca Ross2, Christopher Denton3 and Francesco Del Galdo2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, LTHT, Leeds, United Kingdom, 2University of Leeds, Leeds, United Kingdom, 3University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom

    Background/Purpose: Limited cutaneous systemic sclerosis (lcSSc) carries a highly variable prognosis and to date there are no stratification tools to predict clinical outcomes. Evidence suggests…
  • « Previous Page
  • 1
  • …
  • 30
  • 31
  • 32
  • 33
  • 34
  • …
  • 44
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

Copyright Policy

View ACR Policies.

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology