Abstracts tagged "Clinical research methods"

Abstract Number: 2254 • 2019 ACR/ARP Annual Meeting
The Urge for Mobile Apps in Rheumatology – a German Patient Perspective
Johannes Knitza¹, Christina Raab ¹, Antonia Lambrecht ¹, David Simon ², Melanie Hagen ¹, Sara Bayat ¹, Georg Schett ³, Arnd Kleyer ¹ and Axel Hueber ⁴, ¹Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ²Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany, ³Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany; Sektion Rheumatologie, Sozialstiftung Bamberg, Klinikum Bamberg, Bamberg, Germany, Erlangen, Germany
Background/Purpose: Mobile health applications have the potential of saving costs, empowering patients and improving treatment outcomes. Furthermore, the use of medical apps in routine care…
Abstract Number: 2412 • 2019 ACR/ARP Annual Meeting
Use of Minimal Important Difference (MID) in Randomized Clinical Trials of Pain in Osteoarthritis
Lavalley Michael¹, Matthew Parkes ², Daniel White ³, Stephan Reichebach ⁴, Timothy McAlindon ⁵ and David Felson ⁶, ¹Boston University, Boston, ²University of Manchester, Manchester, England, United Kingdom, ³University of Delaware, Newark, DE, ⁴University of Bern, Bern, Switzerland, ⁵Tufts Medical Center, Boston, MA, ⁶Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Minimal important differences (MID), based on within-subject evaluation of attaining an improvement in a continuous outcome such as a pain scale, are important for…
Abstract Number: 2587 • 2019 ACR/ARP Annual Meeting
Prognostic Role of Measurement of Renal Resistive Index in Systemic Sclerosis
shefali sharma¹, Arghya Chattopadhyay ², siddharth Jain ², Varun Dhir ³, mahesh Prakash ³ and manish Rathi ², ¹Dr., Chandigarh, Chandigarh, India, ²Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India, ³Post Graduate Institute of Medical Education and Research, Chandigarh, India
Background/Purpose: Spectrum of vascular involvement in systemic sclerosis (SSc) is diverse like Raynaud’s phenomenon, digital ulcers, pulmonary hypertension and renal disease. Recognition of markers of…
Abstract Number: 278 • 2018 ACR/ARHP Annual Meeting
The Effect of Patient, Prescriber and Region on the Initiation of First Biologic for Rheumatoid Arthritis: A Longitudinal Population Study
Mark Tatangelo¹, George A. Tomlinson², Michael Paterson³, Nick Bansback⁴, Tara Gomes¹, Alex Kopp³, Vandana Ahluwalia⁵ and Claire Bombardier⁶, ¹University of Toronto, Toronto, ON, Canada, ²Medicine, Mount Sinai Hospital, Toronto, ON, Canada, ³Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ⁴St Paul's Hospital, Centre for Health Evaluation and Outcomes Sciences, Vancouver, BC, Canada, ⁵Ontario Rheumatology Association, Brampton, ON, Canada, ⁶Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Prescribing the first biologic for rheumatoid arthritis is an important decision for physicians, payers, and patients with costs and clinical implications. Our aim was…
Abstract Number: 2193 • 2018 ACR/ARHP Annual Meeting
Online Direct-to-Patient Recruitment for Systemic Lupus Erythematosus Results in Rapid Enrollment
June Fujimoto, Lilian Borisov, Kristen Warren and Robert Terbrueggen, DxTerity, Rancho Dominguez, CA
Background/Purpose: For precision medicine to address the dynamic nature of autoimmune diseases, more frequent measurements of disease activity and therapy response are needed. We report…
Abstract Number: 2700 • 2018 ACR/ARHP Annual Meeting
Rescuing Standard Analyses of Immunosuppresive Rescue Therapy in Randomized Controlled Trials: Alternative Approaches in a Scleroderma Clinical Trial
Cathie Spino¹, Robert A. Parker² and Dinesh Khanna³, ¹Biostatistics, University of Michigan, Ann Arbor, MI, ²Medicine-Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI
Background/Purpose: Placebo-controlled clinical trials are the gold standard to provide the highest-quality evidence of treatment efficacy; however, in early SSc, requiring participants to take long-term…
Abstract Number: 2179 • 2017 ACR/ARHP Annual Meeting
Comparing Observed with Expected Assessments of Osteoarthritic Pain over Time: Application of Successive Prediction to Data from the Osteoarthritis Initiative
Steven Mongin¹, Naoko Onizuka², Lisa Langsetmo³ and Anna Shmagel⁴, ¹Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, ²Medicine, University of Minnesota, Minneapolis, MN, ³University of Minnesota School of Public Health, Minneapolis, MN, ⁴Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN
Background/Purpose: High variability in patient-reported outcome scores presents a major challenge in the design and interpretation of clinical studies in osteoarthritis (OA). We present a…
Abstract Number: 2610 • 2017 ACR/ARHP Annual Meeting
Quantiferon Testing in a Clinical Trial of Systemic Lupus Erythematosus
Niti Goel¹, Stephen Wax², Amy Kao², Russell Reeve³ and Marsha Mackey⁴, ¹QuintilesIMS, Duke University School of Medicine, Durham, NC, ²EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA), Billerica, MA, ³QuintilesIMS, Durham, NC, ⁴QuintilesIMS, Rockville, MD
Background/Purpose: Tuberculosis (TB) has been reported to occur at a higher rate in SLE patients than in the general population. As a result, most clinical…
Abstract Number: 299 • 2016 ACR/ARHP Annual Meeting
Minimally Important Differences for Four Patient-Reported Outcomes Measurement Information System (PROMIS) Short Forms: Physical Function, Pain Interference, Depression, and Anxiety Among Adults with Knee Osteoarthritis
Augustine Lee¹, Lori Lyn Price², Jeffrey Driban³, William F. Harvey¹, Timothy E. McAlindon⁴, Angie Mae Rodday⁵ and Chenchen Wang¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Clinical Care Research, Tufts Medical Center, Boston, MA, ³Tufts Medical Center, Boston, MA, ⁴Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁵Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA
Background/Purpose: Patient-Reported Outcomes Measurement Information System (PROMIS) provides reliable, valid measures of health status to resolve many challenges with comparability and interpretability in OA.…
Abstract Number: 451 • 2016 ACR/ARHP Annual Meeting
Cross-Sectional and Longitudinal Construct Validity for the Improved Health Assessment Questionnaire Among Adults with Knee Osteoarthritis
Mei Chung¹, Augustine C. Lee², John B. Wong³, Xingyi Han⁴ and Chenchen Wang², ¹Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Tufts Medical Center, Boston, MA, ⁴Public Health and Community Medicine, Tufts University, Boston, MA
Background/Purpose: The improved Health Assessment Questionnaire (iHAQ) is a novel version of the HAQ (ACR-recommended metric of physical function for RA) based on Item…
Abstract Number: 2349 • 2016 ACR/ARHP Annual Meeting
Longitudinal Construct Validity for Four Patient-Reported Outcomes Measurement Information System (PROMIS) Short Forms: Physical Function, Pain Interference, Depression, and Anxiety Among Adults with Knee Osteoarthritis
Augustine C. Lee¹, Lori Lyn Price², Jeffrey B. Driban¹, William F. Harvey¹, Timothy E. McAlindon³, Angie Mae Rodday⁴, Hans E. Knopp⁵ and Chenchen Wang¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Physical Medicine and Rehabilitation, Tufts Medical Center, Boston, MA
Background/Purpose: Patient-Reported Outcomes Measurement Information System (PROMIS) provides clinicians and researchers access to reliable, valid measures of health status to resolve many challenges associated…
Abstract Number: 784 • 2015 ACR/ARHP Annual Meeting
Electronic Health Record (EHR) As a Powerful Tool to Establish Clinical Research Lupus Cohorts
Srilatha Kothandaraman¹, Frederick Ramsey², David Fleece³, Aaron Sorenson², Lai Ping⁴, Srikanth Mukkera¹, King Goh¹ and Roberto Caricchio⁵, ¹Rheumatology, Temple University, Philadelphia, PA, ²Clinical Sciences, Temple University, Philadelphia, PA, ³Pediatrics, Temple University, Philadelphia, PA, ⁴Temple University, Philadelphia, PA, ⁵Medicine, Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Enhancing a typical EHR through implementation and utilization of research-validated instruments is termed Electronic Data Capture (EDC). EDC is found to be more efficient…
Abstract Number: 1873 • 2015 ACR/ARHP Annual Meeting
Inter and Intrarater Reliability of the Modified Rodnan Skin Score in Early Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Veronica J. Berrocal², Shervin Assassi³, Elana J. Bernstein⁴, Robyn T. Domsic⁵, Faye N. Hant⁶, Monique E. Hinchcliff⁷, Elena Schiopu⁸, Virginia D. Steen⁹, Tracy M. Frech¹⁰ and Dinesh Khanna¹¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Div of Rheumatology, University of Michigan, Ann Arbor, MI, ³Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁸University of Michigan, Ann Arbor, MI, ⁹Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁰Div of Rheumatology, University of Utah, Salt Lake City, UT, ¹¹Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: The Modified Rodnan Skin Score (MRSS) is a semiquantitative assessment of skin thickness which is a commonly used outcome measure in Systemic Sclerosis (SSc)…
Abstract Number: 2968 • 2015 ACR/ARHP Annual Meeting
Interrater Reliability of Nailfold Capillaroscopy in Systemic Sclerosis Using Widefield Microscopy
Jessica K. Gordon¹, Meng Zhang², Shervin Assassi³, Elana J. Bernstein⁴, Robyn T. Domsic⁵, Faye N. Hant⁶, Monique E. Hinchcliff⁷, Dinesh Khanna⁸, Ami A. Shah⁹, Victoria K. Shanmugam^10,11, Virginia D. Steen¹² and Tracy M. Frech¹³, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ³Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁸Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁰Director, Division of Rheumatology, The George Washington University, Washington, DC, ¹¹Division of Rheumatology, The George Washington University, Washington, DC, ¹²Rheumatology, Georgetown University Medical Center, Washington, DC, ¹³Div of Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: The presence of nailfold capillary (NFC) abnormality is part of the 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis (SSc). NFC findings include the presence…
Abstract Number: 2338 • 2014 ACR/ARHP Annual Meeting
Cost-Effectiveness and Yield of Different Recruitment Strategies Utilized in an Exercise Trial of Fibromyalgia Patients
Anna Schmid¹, William F. Harvey¹, Lori Lyn Price² and Chenchen Wang¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA
Background/Purpose In a large-scale clinical trial with a long-term outcome, it is essential to use recruitment strategies that are both cost-effective and likely to yield…

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